{"id":"https://openalex.org/W2018391522","doi":"https://doi.org/10.1159/000012022","title":"Serum Pro-Gastrin-Releasing Peptide Is a Useful Marker for Treatment Monitoring and Survival in Small-Cell Lung Cancer","display_name":"Serum Pro-Gastrin-Releasing Peptide Is a Useful Marker for Treatment Monitoring and Survival in Small-Cell Lung Cancer","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2018391522","doi":"https://doi.org/10.1159/000012022","mag":"2018391522","pmid":"https://pubmed.ncbi.nlm.nih.gov/10461062"},"language":"en","primary_location":{"id":"doi:10.1159/000012022","doi":"https://doi.org/10.1159/000012022","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000012022","pdf_url":null,"source":{"id":"https://openalex.org/S198727964","display_name":"Oncology","issn_l":"0030-2414","issn":["0030-2414","1423-0232"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042736030","display_name":"Noriaki Sunaga","orcid":"https://orcid.org/0000-0002-5966-4579","observed_orcids":["https://orcid.org/0000-0002-5966-4579"]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noriaki Sunaga","raw_affiliation_strings":["Department of Internal Medicine, National Nishi-Gunma Hospital, Gunma, Japan","Department of Internal Medicine, National Nishi-Gunma Hospital, and","First Department of Internal Medicine, Gunma University School of Medicine, Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, National Nishi-Gunma Hospital, Gunma, Japan","institution_ids":[]},{"raw_affiliation_string":"Department of Internal Medicine, National Nishi-Gunma Hospital, and","institution_ids":[]},{"raw_affiliation_string":"First Department of Internal Medicine, Gunma University School of Medicine, Gunma, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006813944","display_name":"Satoshi Tsuchiya","orcid":"https://orcid.org/0000-0002-8406-5869","observed_orcids":["https://orcid.org/0000-0002-8406-5869"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satoshi Tsuchiya","raw_affiliation_strings":["Department of Internal Medicine, National Nishi-Gunma Hospital, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, National Nishi-Gunma Hospital, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111666855","display_name":"Koichi Minato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi Minato","raw_affiliation_strings":["First Department of Internal Medicine, Gunma University School of Medicine, Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Gunma University School of Medicine, Gunma, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103091919","display_name":"Satoru Watanabe","orcid":"https://orcid.org/0000-0002-2092-2972","observed_orcids":["https://orcid.org/0000-0002-2092-2972"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satoru Watanabe","raw_affiliation_strings":["Department of Internal Medicine, National Nishi-Gunma Hospital, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, National Nishi-Gunma Hospital, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088664123","display_name":"Naoto Fueki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoto Fueki","raw_affiliation_strings":["First Department of Internal Medicine, Gunma University School of Medicine, Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Gunma University School of Medicine, Gunma, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hideki Hoshino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Hoshino","raw_affiliation_strings":["First Department of Internal Medicine, Gunma University School of Medicine, Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Gunma University School of Medicine, Gunma, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023722058","display_name":"Takeyuki Makimoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takeyuki Makimoto","raw_affiliation_strings":["Department of Internal Medicine, National Nishi-Gunma Hospital, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, National Nishi-Gunma Hospital, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110386990","display_name":"Shinichi Ishihara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shinichi Ishihara","raw_affiliation_strings":["Department of Internal Medicine, National Nishi-Gunma Hospital, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, National Nishi-Gunma Hospital, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065536577","display_name":"Ryusei Saito","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryusei Saito","raw_affiliation_strings":["Department of Internal Medicine, National Nishi-Gunma Hospital, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, National Nishi-Gunma Hospital, and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110150961","display_name":"Masatomo Mori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masatomo Mori","raw_affiliation_strings":["First Department of Internal Medicine, Gunma University School of Medicine, Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Gunma University School of Medicine, Gunma, Japan","institution_ids":["https://openalex.org/I165735259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.413,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.61364312,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"57","issue":"2","first_page":"143","last_page":"148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/progastrin-releasing-peptide","display_name":"progastrin-releasing peptide","score":0.9350000023841858},{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.7009999752044678},{"id":"https://openalex.org/keywords/neuron-specific-enolase","display_name":"neuron-specific enolase","score":0.9340000152587891},{"id":"https://openalex.org/keywords/treatment-monitoring","display_name":"treatment monitoring","score":0.7419999837875366},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.5690000057220459},{"id":"https://openalex.org/keywords/recurrence-prediction","display_name":"recurrence prediction","score":0.9290000200271606},{"id":"https://openalex.org/keywords/limited-disease","display_name":"limited disease","score":0.5289999842643738},{"id":"https://openalex.org/keywords/extensive-stage-disease","display_name":"extensive disease","score":0.9850000143051147},{"id":"https://openalex.org/keywords/diagnostic-specificity","display_name":"diagnostic specificity","score":0.5690000057220459},{"id":"https://openalex.org/keywords/lung-cancer-histological-type","display_name":"lung cancer histological type","score":0.5879999995231628},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.6819999814033508},{"id":"https://openalex.org/keywords/survival-prediction","display_name":"survival prediction","score":0.5299999713897705},{"id":"https://openalex.org/keywords/treatment-response-biomarkers","display_name":"treatment response biomarkers","score":0.4830000102519989},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9430000185966492},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C2776998989","wikidata":"https://www.wikidata.org/wiki/Q642462","display_name":"Gastrin-releasing peptide","level":5,"score":0.7938050627708435},{"id":"https://openalex.org/C188618488","wikidata":"https://www.wikidata.org/wiki/Q24776639","display_name":"Enolase","level":3,"score":0.7206753492355347},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.6488568782806396},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5990059971809387},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5853022933006287},{"id":"https://openalex.org/C2779292878","wikidata":"https://www.wikidata.org/wiki/Q738170","display_name":"Small-cell carcinoma","level":3,"score":0.5550419092178345},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5505896806716919},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5420928001403809},{"id":"https://openalex.org/C2778911148","wikidata":"https://www.wikidata.org/wiki/Q15979047","display_name":"Large cell","level":4,"score":0.5190413594245911},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.5014915466308594},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.47051185369491577},{"id":"https://openalex.org/C2781447364","wikidata":"https://www.wikidata.org/wiki/Q584992","display_name":"Tumor marker","level":3,"score":0.4428303837776184},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4206704795360565},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4165803790092468},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39550212025642395},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33090752363204956},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2453552782535553},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.21914014220237732},{"id":"https://openalex.org/C2778448772","wikidata":"https://www.wikidata.org/wiki/Q349427","display_name":"Bombesin","level":4,"score":0.15805524587631226},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000012022","doi":"https://doi.org/10.1159/000012022","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000012022","pdf_url":null,"source":{"id":"https://openalex.org/S198727964","display_name":"Oncology","issn_l":"0030-2414","issn":["0030-2414","1423-0232"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology","raw_type":"journal-article"},{"id":"pmid:10461062","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10461062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W58897769","https://openalex.org/W349515076","https://openalex.org/W1530797390","https://openalex.org/W1580788756","https://openalex.org/W1811569847","https://openalex.org/W1855306719","https://openalex.org/W1952165941","https://openalex.org/W1966344005","https://openalex.org/W1969608892","https://openalex.org/W1971583390","https://openalex.org/W1979300931","https://openalex.org/W1998150326","https://openalex.org/W2000575979","https://openalex.org/W2012603088","https://openalex.org/W2019344324","https://openalex.org/W2031956553","https://openalex.org/W2038252730","https://openalex.org/W2043073430","https://openalex.org/W2070684099","https://openalex.org/W2078470769","https://openalex.org/W2084090520","https://openalex.org/W2118780301","https://openalex.org/W2137115482","https://openalex.org/W2161351539","https://openalex.org/W2167805334","https://openalex.org/W2411943342"],"related_works":["https://openalex.org/W1952165941","https://openalex.org/W2347970792","https://openalex.org/W2223208186","https://openalex.org/W3031135580","https://openalex.org/W2128695457","https://openalex.org/W2391004485","https://openalex.org/W2758889181","https://openalex.org/W1985792484","https://openalex.org/W3031685602","https://openalex.org/W3029038305"],"abstract_inverted_index":{"We":[0],"investigated":[1],"the":[2,18,99,105,114,120,125,133,202,218,227,245,261,268,276,285,291,299,310,323],"usefulness":[3],"of":[4,20,63,81,88,102,108,140,158,169,184,196,204,208,231,244,278,284,322,339],"serum":[5,64,228,269,328],"pro-gastrin-releasing":[6],"peptide":[7],"(Pro-GRP)":[8],"as":[9,303],"a":[10,336],"tumor":[11],"marker":[12,338],"for":[13,341],"diagnosis,":[14],"treatment":[15,238,256,289,294,302,342],"monitoring":[16,343],"and":[17,22,55,66,75,129,146,153,162,173,179,189,254,333,344],"prediction":[19],"relapse":[21],"prognosis":[23],"in":[24,113,119,124,132,142,171],"patients":[25,37,43,150,175,220,263,281,311],"with":[26,38,44,48,51,57,201,221,264],"small-cell":[27,45,115],"lung":[28,40,103],"cancer":[29,41],"(SCLC).":[30],"Serum":[31],"samples":[32],"were":[33,70,110,151,160,176,186,234,248,272],"obtained":[34],"from":[35],"127":[36],"primary":[39],"(48":[42],"carcinoma,":[46],"31":[47],"adenocarcinoma,":[49],"36":[50],"squamous":[52,126],"cell":[53,127,135],"carcinoma":[54],"11":[56,246],"large-cell":[58],"carcinoma).":[59],"The":[60,79,137,166,193,320],"cutoff":[61],"levels":[62,139,230,271,300],"Pro-GRP":[65,82,109,141,170,209,229,270,286,329],"neuron-specific":[67],"enolase":[68],"(NSE)":[69],"set":[71],"at":[72,213,275],"46":[73],"pg/ml":[74],"10":[76],"ng/ml,":[77,164],"respectively.":[78,165,192],"specificity":[80,332],"was":[83,210,295,314],"significantly":[84,235,250,306],"higher":[85],"than":[86,308],"that":[87,207,327],"NSE":[89,159,185,197],"(Pro-GRP:":[90],"93.7%,":[91],"NSE:":[92],"65.8%,":[93],"p":[94],"<":[95,240,318],"0.01).":[96,319],"According":[97],"to":[98,199,290],"histological":[100],"type":[101],"cancer,":[104],"positive":[106,167,194],"rates":[107,168],"75%":[111],"(36/48)":[112],"carcinomas,":[116],"9.7%":[117],"(3/31)":[118],"adenocarcinomas,":[121],"5.6%":[122],"(2/36)":[123],"carcinomas":[128],"0%":[130],"(0/10)":[131],"large":[134],"carcinomas.":[136],"median":[138],"limited":[143],"disease":[144,148],"(LD)":[145],"extensive":[147],"(ED)":[149],"199":[152],"295.5":[154],"pg/ml,":[155],"whereas":[156,182,206,242],"those":[157,183,243],"14.8":[161],"29.3":[163],"LD":[172],"ED":[174],"80.0%":[177],"(16/20)":[178],"71.4%":[180],"(20/28),":[181],"70.0%":[187],"(14/20)":[188],"89.3%":[190],"(25/28),":[191],"rate":[195],"tended":[198],"elevate":[200],"progression":[203],"disease,":[205],"already":[211],"high":[212,331],"an":[214],"early":[215],"stage.":[216],"Among":[217],"29":[219],"SCLC":[222,265,340],"who":[223,266],"could":[224,334],"be":[225,335],"followed,":[226],"18":[232],"responders":[233],"decreased":[236],"after":[237,255,288],"(p":[239,257,317],"0.01),":[241],"nonresponders":[247],"not":[249],"different":[251],"between":[252],"before":[253,293,301],"=":[258],"0.72).":[259],"In":[260],"9":[262],"relapsed,":[267],"again":[273],"elevated":[274],"time":[277],"relapse.":[279],"Seventeen":[280],"whose":[282,312],"ratio":[283,313],"level":[287,292],"below":[296],"50%":[297,316],"(taking":[298],"100%)":[304],"survived":[305],"longer":[307],"did":[309],"over":[315],"results":[321],"present":[324],"study":[325],"suggest":[326],"has":[330],"useful":[337],"prognosis.":[345]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}