{"id":"https://openalex.org/W2018388032","doi":"https://doi.org/10.4103/0970-5333.124582","title":"Pre-emptive analgesia: Recent trends and evidences","display_name":"Pre-emptive analgesia: Recent trends and evidences","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2018388032","doi":"https://doi.org/10.4103/0970-5333.124582","mag":"2018388032"},"language":"en","primary_location":{"id":"doi:10.4103/0970-5333.124582","doi":"https://doi.org/10.4103/0970-5333.124582","is_oa":true,"landing_page_url":"https://doi.org/10.4103/0970-5333.124582","pdf_url":null,"source":{"id":"https://openalex.org/S4210188869","display_name":"Indian Journal of Pain","issn_l":"0970-5333","issn":["0970-5333","2321-7820"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Pain","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.4103/0970-5333.124582","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108476059","display_name":"Abhijit Paul","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Abhijit Paul","raw_affiliation_strings":["Department of Anaesthesiology, Perioperative care and Pain Services, Medica Superspeciality Hospital, Mukundapur, Kolkata, West Bengal, India","Dr. Abhijit Paul, Department of Anaesthesiology Pain Medicine and Perioperative Care, Medica Superspeciality Hospitals, 127, Mukundapur, E. M. Bypass, Kolkata - 700 107, West Bengal, India. E-mail: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology, Perioperative care and Pain Services, Medica Superspeciality Hospital, Mukundapur, Kolkata, West Bengal, India","institution_ids":[]},{"raw_affiliation_string":"Dr. Abhijit Paul, Department of Anaesthesiology Pain Medicine and Perioperative Care, Medica Superspeciality Hospitals, 127, Mukundapur, E. M. Bypass, Kolkata - 700 107, West Bengal, India. E-mail: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100513081","display_name":"AmiyaK Mishra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"AmiyaK Mishra","raw_affiliation_strings":["Department of Anaesthesiology, Perioperative care and Pain Services, Medica Superspeciality Hospital, Mukundapur, Kolkata, West Bengal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology, Perioperative care and Pain Services, Medica Superspeciality Hospital, Mukundapur, Kolkata, West Bengal, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072104947","display_name":"Mumtaz Afzal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mumtaz Afzal","raw_affiliation_strings":["Department of Anaesthesiology, Perioperative care and Pain Services, Medica Superspeciality Hospital, Mukundapur, Kolkata, West Bengal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology, Perioperative care and Pain Services, Medica Superspeciality Hospital, Mukundapur, Kolkata, West Bengal, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111666845","display_name":"SiddharthaS Mookerjee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SiddharthaS Mookerjee","raw_affiliation_strings":["Department of Anaesthesiology, Perioperative care and Pain Services, Medica Superspeciality Hospital, Mukundapur, Kolkata, West Bengal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology, Perioperative care and Pain Services, Medica Superspeciality Hospital, Mukundapur, Kolkata, West Bengal, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112095979","display_name":"Kasturi H Bandyopadhyay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KasturiH Bandyopadhyay","raw_affiliation_strings":["Department of Anaesthesiology, Perioperative care and Pain Services, Medica Superspeciality Hospital, Mukundapur, Kolkata, West Bengal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology, Perioperative care and Pain Services, Medica Superspeciality Hospital, Mukundapur, Kolkata, West Bengal, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5108476059"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9648,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.85456391,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"27","issue":"3","first_page":"114","last_page":"114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11292","display_name":"Pediatric Pain Management Techniques","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preemptive-analgesia","display_name":"preemptive analgesia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/postoperative-pain","display_name":"postoperative pain","score":0.9909999966621399},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.8389999866485596},{"id":"https://openalex.org/keywords/ketamine","display_name":"ketamine","score":0.7749999761581421},{"id":"https://openalex.org/keywords/local-anesthetics","display_name":"local anesthetics","score":0.8209999799728394},{"id":"https://openalex.org/keywords/intraperitoneal-analgesia","display_name":"intraperitoneal analgesia","score":0.8669999837875366},{"id":"https://openalex.org/keywords/epidural-analgesia","display_name":"epidural analgesia","score":0.9620000123977661},{"id":"https://openalex.org/keywords/gabapentin","display_name":"gabapentin","score":0.953000009059906},{"id":"https://openalex.org/keywords/pregabalin","display_name":"pregabalin","score":1.0},{"id":"https://openalex.org/keywords/multimodal-analgesia","display_name":"multimodal analgesia","score":0.9110000133514404},{"id":"https://openalex.org/keywords/perioperative-immune-function","display_name":"perioperative immune function","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9042232036590576},{"id":"https://openalex.org/C2780795376","wikidata":"https://www.wikidata.org/wiki/Q243547","display_name":"Ketamine","level":2,"score":0.775383472442627},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.7542905211448669},{"id":"https://openalex.org/C2776608144","wikidata":"https://www.wikidata.org/wiki/Q410352","display_name":"Gabapentin","level":3,"score":0.7228775024414062},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.6825191974639893},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6171267032623291},{"id":"https://openalex.org/C2993997175","wikidata":"https://www.wikidata.org/wiki/Q81938","display_name":"Acute pain","level":2,"score":0.47510063648223877},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.46923261880874634},{"id":"https://openalex.org/C2778162923","wikidata":"https://www.wikidata.org/wiki/Q4990531","display_name":"Anesthetic","level":2,"score":0.45124551653862},{"id":"https://openalex.org/C2776468701","wikidata":"https://www.wikidata.org/wiki/Q412174","display_name":"Pregabalin","level":2,"score":0.42853862047195435},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.23834514617919922},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.07300233840942383},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.4103/0970-5333.124582","doi":"https://doi.org/10.4103/0970-5333.124582","is_oa":true,"landing_page_url":"https://doi.org/10.4103/0970-5333.124582","pdf_url":null,"source":{"id":"https://openalex.org/S4210188869","display_name":"Indian Journal of Pain","issn_l":"0970-5333","issn":["0970-5333","2321-7820"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Pain","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:41ff85cd98874a798683539c9f754c00","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/41ff85cd98874a798683539c9f754c00","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Indian Journal of Pain, Vol 27, Iss 3, Pp 114-120 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4103/0970-5333.124582","doi":"https://doi.org/10.4103/0970-5333.124582","is_oa":true,"landing_page_url":"https://doi.org/10.4103/0970-5333.124582","pdf_url":null,"source":{"id":"https://openalex.org/S4210188869","display_name":"Indian Journal of Pain","issn_l":"0970-5333","issn":["0970-5333","2321-7820"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Pain","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W136496541","https://openalex.org/W1510885169","https://openalex.org/W1554799602","https://openalex.org/W1589836668","https://openalex.org/W1794352460","https://openalex.org/W1969555447","https://openalex.org/W1975440521","https://openalex.org/W1985980801","https://openalex.org/W1994334998","https://openalex.org/W1996452051","https://openalex.org/W1999541308","https://openalex.org/W2019172037","https://openalex.org/W2026308876","https://openalex.org/W2031004040","https://openalex.org/W2031489310","https://openalex.org/W2033240361","https://openalex.org/W2037866403","https://openalex.org/W2039982019","https://openalex.org/W2042809547","https://openalex.org/W2043727245","https://openalex.org/W2057983296","https://openalex.org/W2058482352","https://openalex.org/W2062625412","https://openalex.org/W2086966697","https://openalex.org/W2087070430","https://openalex.org/W2087325302","https://openalex.org/W2094385986","https://openalex.org/W2103909695","https://openalex.org/W2112395136","https://openalex.org/W2121270079","https://openalex.org/W2132829674","https://openalex.org/W2136909022","https://openalex.org/W2144911177","https://openalex.org/W2149572214","https://openalex.org/W2154493320","https://openalex.org/W2162475674","https://openalex.org/W2169838852","https://openalex.org/W2211529852","https://openalex.org/W2313541031","https://openalex.org/W2321387443","https://openalex.org/W2418115079","https://openalex.org/W2421322169","https://openalex.org/W4249049705"],"related_works":["https://openalex.org/W2020960615","https://openalex.org/W91766717","https://openalex.org/W2056859631","https://openalex.org/W30129793","https://openalex.org/W1999737729","https://openalex.org/W2081017730","https://openalex.org/W4386320107","https://openalex.org/W2074631919","https://openalex.org/W7033350543","https://openalex.org/W2130348839"],"abstract_inverted_index":{"Preemptive":[0,140,167],"analgesia,":[1],"initiated":[2,27],"before":[3],"the":[4,11,16,36,42,145,202,217,234,240,245],"surgical":[5],"procedure":[6],"to":[7,18,33,78,125,157,183,222,229,233,238],"prevent":[8],"pain":[9,66,180,218,224],"in":[10,84,174,181],"early":[12],"postoperative":[13,128,149],"period":[14],"has":[15,132,170],"potential":[17,197],"be":[19],"more":[20],"effective":[21,112],"than":[22],"a":[23,133,137],"similar":[24,156],"analgesic":[25,154,200],"treatment":[26],"after":[28],"surgery.":[29],"This":[30],"article":[31],"aims":[32],"review":[34],"all":[35],"recent":[37],"published":[38],"evidences":[39],"that":[40,103,158,212],"assess":[41],"efficacy":[43,173],"of":[44,100,142,159,205,236,247],"this":[45],"enigmatic":[46],"concept.":[47],"Materials":[48],"and":[49,62,74,96,179,193],"Methods:":[50],"We":[51],"reviewed":[52],"original":[53],"research":[54],"articles,":[55],"case-reports,":[56],"meta-analyses,":[57],"randomized":[58],"control":[59],"trials":[60],"(RCTs),":[61],"reviews":[63],"based":[64],"on":[65],"physiology":[67],"for":[68],"preemptive":[69,199,248],"analgesia":[70,169],"from":[71,76],"Medline,":[72],"Medscape,":[73],"PubMed":[75],"1993":[77],"2013.":[79],"A":[80],"broad":[81],"free-text":[82],"search":[83],"English":[85],"was":[86],"undertaken":[87],"with":[88,119,201,244],"major":[89],"keywords":[90],"\"Preemptive":[91],"analgesia,\"":[92],"\"postoperative":[93],"pain,\"":[94],"\"preoperative,\"":[95],"\"preincisional\".":[97],"Results:":[98],"Review":[99],"publications":[101],"showed":[102],"intravenous":[104],"(IV)":[105],"nonsteroidal":[106],"anti-inflammatory":[107],"drugs":[108],"(NSAIDs)":[109],"are":[110],"quite":[111],"when":[113],"used":[114],"alone,":[115],"as":[116,118,136,163,198],"well":[117],"low":[120],"dose":[121],"iv":[122],"ketamine,":[123],"preemptively":[124],"provide":[126],"adequate":[127],"analgesia.":[129,249],"However,":[130,226],"ketamine":[131],"doubtful":[134],"role":[135],"standalone":[138],"agent.":[139],"administration":[141],"LA":[143],"at":[144],"incision":[146],"site":[147],"reduces":[148],"pain,":[150],"but":[151],"achieves":[152],"an":[153,231],"effect":[155],"postincisional":[160],"anesthetic":[161],"infiltration":[162],"does":[164],"intraperitoneal":[165],"administration.":[166],"epidural":[168],"proved":[171],"its":[172,206],"controlling":[175],"perioperative":[176],"immune":[177],"function":[178],"comparison":[182],"parenteral":[184],"opioids.":[185],"Gamma-amino":[186],"butyric":[187],"acid":[188],"(GABA)":[189],"analogues":[190],"like":[191],"gabapentin":[192],"pregabalin":[194],"have":[195],"great":[196],"added":[203],"advantage":[204],"anxiolytic":[207],"effect.":[208],"Conclusion:":[209],"Multimodal":[210],"approaches":[211],"address":[213],"multiple":[214],"sites":[215],"along":[216],"pathway":[219],"is":[220],"necessary":[221],"treat":[223],"adequately.":[225],"we":[227],"need":[228],"find":[230],"answer":[232],"question":[235],"how":[237],"obtain":[239],"maximal":[241],"clinical":[242],"benefits":[243],"use":[246]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}