{"id":"https://openalex.org/W2018383191","doi":"https://doi.org/10.1038/jid.2012.43","title":"The Human Skin Barrier Is Organized as Stacked Bilayers of Fully Extended Ceramides with Cholesterol Molecules Associated with the Ceramide Sphingoid Moiety","display_name":"The Human Skin Barrier Is Organized as Stacked Bilayers of Fully Extended Ceramides with Cholesterol Molecules Associated with the Ceramide Sphingoid Moiety","publication_year":2012,"publication_date":"2012-04-26","ids":{"openalex":"https://openalex.org/W2018383191","doi":"https://doi.org/10.1038/jid.2012.43","mag":"2018383191","pmid":"https://pubmed.ncbi.nlm.nih.gov/22534876"},"language":"en","primary_location":{"id":"doi:10.1038/jid.2012.43","doi":"https://doi.org/10.1038/jid.2012.43","is_oa":true,"landing_page_url":"https://doi.org/10.1038/jid.2012.43","pdf_url":null,"source":{"id":"https://openalex.org/S28607811","display_name":"Journal of Investigative Dermatology","issn_l":"0022-202X","issn":["0022-202X","1523-1747"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1038/jid.2012.43","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071566508","display_name":"Ichiro Iwai","orcid":"https://orcid.org/0000-0002-7301-8688","observed_orcids":["https://orcid.org/0000-0002-7301-8688"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210123820","display_name":"Shiseido Group (Japan)","ror":"https://ror.org/03da3g825","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210123820"]}],"countries":["JP","SE"],"is_corresponding":false,"raw_author_name":"Ichiro Iwai","raw_affiliation_strings":["Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden","Shiseido Research Center, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Shiseido Research Center, Yokohama, Japan","institution_ids":["https://openalex.org/I4210123820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046929411","display_name":"Hong\u2010Mei Han","orcid":"https://orcid.org/0000-0002-3920-4209","observed_orcids":["https://orcid.org/0000-0002-3920-4209"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"HongMei Han","raw_affiliation_strings":["Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034624283","display_name":"Lianne den Hollander","orcid":"https://orcid.org/0000-0003-0569-7399","observed_orcids":["https://orcid.org/0000-0003-0569-7399"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lianne den Hollander","raw_affiliation_strings":["Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071051399","display_name":"Stina Svensson","orcid":"https://orcid.org/0000-0003-2808-6072","observed_orcids":["https://orcid.org/0000-0003-2808-6072"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Stina Svensson","raw_affiliation_strings":["Center for Image Analysis, Swedish University of Agricultural Sciences, Uppsala, Sweden","Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Image Analysis, Swedish University of Agricultural Sciences, Uppsala, Sweden","institution_ids":["https://openalex.org/I298625061"]},{"raw_affiliation_string":"Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042983233","display_name":"Lars\u2010G\u00f6ran \u00d6fverstedt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142637625","display_name":"Okinawa Institute of Science and Technology Graduate University","ror":"https://ror.org/02qg15b79","country_code":"JP","type":"education","lineage":["https://openalex.org/I142637625"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Lars-G\u00f6ran \u00d6fverstedt","raw_affiliation_strings":["Structural Cellular Biology Unit, Okinawa Institute of Science and Technology, Okinawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Cellular Biology Unit, Okinawa Institute of Science and Technology, Okinawa, Japan","institution_ids":["https://openalex.org/I142637625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035172720","display_name":"Jamshed Anwar","orcid":"https://orcid.org/0000-0003-1721-0330","observed_orcids":["https://orcid.org/0000-0003-1721-0330"]},"institutions":[{"id":"https://openalex.org/I139894009","display_name":"University of Bradford","ror":"https://ror.org/00vs8d940","country_code":"GB","type":"education","lineage":["https://openalex.org/I139894009"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jamshed Anwar","raw_affiliation_strings":["Institute of Pharmaceutical Innovation, University of Bradford, Bradford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Innovation, University of Bradford, Bradford, United Kingdom","institution_ids":["https://openalex.org/I139894009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017975271","display_name":"Jonathan Richard Brewer","orcid":"https://orcid.org/0000-0002-3444-1715","observed_orcids":["https://orcid.org/0000-0002-3444-1715"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jonathan Brewer","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Membrane Biophysics and Biophotonics group/MEMPHYS\u2013Center for Biomembrane Physics, University of Southern Denmark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Membrane Biophysics and Biophotonics group/MEMPHYS\u2013Center for Biomembrane Physics, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011959319","display_name":"Maria Bloksgaard","orcid":"https://orcid.org/0000-0002-4474-9553","observed_orcids":["https://orcid.org/0000-0002-4474-9553"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Maria Bloksgaard","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Membrane Biophysics and Biophotonics group/MEMPHYS\u2013Center for Biomembrane Physics, University of Southern Denmark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Membrane Biophysics and Biophotonics group/MEMPHYS\u2013Center for Biomembrane Physics, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043264245","display_name":"Aurelie Laloeuf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Aurelie Laloeuf","raw_affiliation_strings":["Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010599059","display_name":"Daniel Nosek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Daniel Nosek","raw_affiliation_strings":["Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden","Dermatology Clinic, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Dermatology Clinic, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069325199","display_name":"Sergej Masich","orcid":"https://orcid.org/0000-0002-5510-9631","observed_orcids":["https://orcid.org/0000-0002-5510-9631"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Sergej Masich","raw_affiliation_strings":["Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002764364","display_name":"Lu\u00eds A. Bagatolli","orcid":"https://orcid.org/0000-0002-4727-8611","observed_orcids":["https://orcid.org/0000-0002-4727-8611"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Luis A. Bagatolli","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Membrane Biophysics and Biophotonics group/MEMPHYS\u2013Center for Biomembrane Physics, University of Southern Denmark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Membrane Biophysics and Biophotonics group/MEMPHYS\u2013Center for Biomembrane Physics, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082538035","display_name":"Ulf Skoglund","orcid":"https://orcid.org/0000-0002-3407-0053","observed_orcids":["https://orcid.org/0000-0002-3407-0053"]},"institutions":[{"id":"https://openalex.org/I142637625","display_name":"Okinawa Institute of Science and Technology Graduate University","ror":"https://ror.org/02qg15b79","country_code":"JP","type":"education","lineage":["https://openalex.org/I142637625"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ulf Skoglund","raw_affiliation_strings":["Structural Cellular Biology Unit, Okinawa Institute of Science and Technology, Okinawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Cellular Biology Unit, Okinawa Institute of Science and Technology, Okinawa, Japan","institution_ids":["https://openalex.org/I142637625"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022651422","display_name":"Lars P.O. Norlen","orcid":"https://orcid.org/0000-0002-8049-2556","observed_orcids":["https://orcid.org/0000-0002-8049-2556"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Lars Norl\u00e9n","raw_affiliation_strings":["Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden","Dermatology Clinic, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Dermatology Clinic, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5022651422"],"corresponding_institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":{"value":3800,"currency":"USD","value_usd":3800},"fwci":14.4455,"has_fulltext":false,"cited_by_count":241,"citation_normalized_percentile":{"value":0.99865175,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"132","issue":"9","first_page":"2215","last_page":"2225"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.5067999958992004,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.5067999958992004,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.4165000021457672,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skin-barrier","display_name":"skin barrier","score":0.9570000171661377},{"id":"https://openalex.org/keywords/stratum-corneum","display_name":"stratum corneum","score":0.9789999723434448},{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.8560000061988831},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.9909999966621399},{"id":"https://openalex.org/keywords/lipid-bilayers","display_name":"lipid bilayers","score":0.6840000152587891},{"id":"https://openalex.org/keywords/skin-permeability","display_name":"skin permeability","score":0.6269999742507935},{"id":"https://openalex.org/keywords/molecular-modeling","display_name":"molecular modeling","score":0.6510000228881836},{"id":"https://openalex.org/keywords/hydration-and-dehydration","display_name":"hydration and dehydration","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.9454730749130249},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.871628999710083},{"id":"https://openalex.org/C2778370115","wikidata":"https://www.wikidata.org/wiki/Q2038676","display_name":"Stratum corneum","level":2,"score":0.6930699944496155},{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.6133111715316772},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5702815651893616},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.5534074902534485},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.5111787915229797},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.4942967891693115},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.44606485962867737},{"id":"https://openalex.org/C2991981033","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Skin barrier","level":2,"score":0.4303785562515259},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3570241928100586},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.35439905524253845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16442745923995972},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.15310001373291016},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09713634848594666},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.09527823328971863},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013107","descriptor_name":"Sphingolipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/jid.2012.43","doi":"https://doi.org/10.1038/jid.2012.43","is_oa":true,"landing_page_url":"https://doi.org/10.1038/jid.2012.43","pdf_url":null,"source":{"id":"https://openalex.org/S28607811","display_name":"Journal of Investigative Dermatology","issn_l":"0022-202X","issn":["0022-202X","1523-1747"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology","raw_type":"journal-article"},{"id":"pmid:22534876","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22534876","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of investigative dermatology","raw_type":"Journal Article"},{"id":"pmh:oai:sdu.dk:openaire_cris_publications/1bb090c5-1dc1-4ede-9b61-2b21bcbe2db3","doi":null,"is_oa":false,"landing_page_url":"https://portal.findresearcher.sdu.dk/da/publications/1bb090c5-1dc1-4ede-9b61-2b21bcbe2db3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400423","display_name":"University of Southern Denmark Research Portal (University of Southern Denmark)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177969490","host_organization_name":"University of Southern Denmark","host_organization_lineage":["https://openalex.org/I177969490"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iwai, I, Han, H, Hollander, L D, Svensson, S, Ofverstedt, L-G, Anwar, J, Brewer, J, M\u00f8lgaard, M B, Laloeuf, A, Nosek, D, Masich, S, Bagatolli, L A, Skoglund, U & Norl\u00e9n, L 2012, 'The Human Skin Barrier Is Organized as Stacked Bilayers of Fully Extended Ceramides with Cholesterol Molecules Associated with the Ceramide Sphingoid Moiety', Journal of Investigative Dermatology, vol. 132, no. 9, pp. 2215-2225. https://doi.org/10.1038/jid.2012.43","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:eprints.lancs.ac.uk:62166","doi":null,"is_oa":false,"landing_page_url":"https://eprints.lancs.ac.uk/id/eprint/62166/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401916","display_name":"Lancaster EPrints (Lancaster University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67415387","host_organization_name":"Lancaster University","host_organization_lineage":["https://openalex.org/I67415387"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/jid.2012.43","doi":"https://doi.org/10.1038/jid.2012.43","is_oa":true,"landing_page_url":"https://doi.org/10.1038/jid.2012.43","pdf_url":null,"source":{"id":"https://openalex.org/S28607811","display_name":"Journal of Investigative Dermatology","issn_l":"0022-202X","issn":["0022-202X","1523-1747"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322327","display_name":"Knut och Alice Wallenbergs Stiftelse","ror":"https://ror.org/004hzzk67"},{"id":"https://openalex.org/F4320323299","display_name":"Norges Forskningsr\u00e5d","ror":"https://ror.org/00epmv149"},{"id":"https://openalex.org/F4320324618","display_name":"Svenska L\u00e4kares\u00e4llskapet","ror":"https://ror.org/016ks4x90"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1826842517","https://openalex.org/W1964849222","https://openalex.org/W1966354202","https://openalex.org/W1969506921","https://openalex.org/W1971966415","https://openalex.org/W1975532575","https://openalex.org/W1993229863","https://openalex.org/W1994349257","https://openalex.org/W2000819908","https://openalex.org/W2008652678","https://openalex.org/W2020904190","https://openalex.org/W2021621463","https://openalex.org/W2026029590","https://openalex.org/W2032066103","https://openalex.org/W2033921570","https://openalex.org/W2038371009","https://openalex.org/W2038438016","https://openalex.org/W2041846125","https://openalex.org/W2048658013","https://openalex.org/W2054534151","https://openalex.org/W2055010027","https://openalex.org/W2061372560","https://openalex.org/W2062337964","https://openalex.org/W2080685651","https://openalex.org/W2086223459","https://openalex.org/W2087663913","https://openalex.org/W2094428069","https://openalex.org/W2103972113","https://openalex.org/W2105539783","https://openalex.org/W2143857102","https://openalex.org/W2143928908","https://openalex.org/W2154026288","https://openalex.org/W2158612420","https://openalex.org/W2169484065","https://openalex.org/W2220320118"],"related_works":["https://openalex.org/W2466825990","https://openalex.org/W4234383623","https://openalex.org/W1851270643","https://openalex.org/W2030208813","https://openalex.org/W2735564299","https://openalex.org/W2799749633","https://openalex.org/W2050470249","https://openalex.org/W2166886279","https://openalex.org/W2793147758","https://openalex.org/W3093603328"],"abstract_inverted_index":{"The":[0,81],"skin":[1,72,129],"barrier":[2,20],"is":[3,22],"fundamental":[4],"to":[5],"terrestrial":[6],"life":[7],"and":[8,14,78,119,122,134,138,144],"its":[9,56],"evolution;":[10],"it":[11],"upholds":[12],"homeostasis":[13],"protects":[15],"against":[16],"the":[17,28,32,42,45,49,106,113,128],"environment.":[18],"Skin":[19],"capacity":[21],"controlled":[23],"by":[24],"lipids":[25,82],"that":[26],"fill":[27],"extracellular":[29],"space":[30],"of":[31,44,48,70,96],"skin's":[33,50,114],"surface":[34],"layer--the":[35],"stratum":[36],"corneum.":[37],"Here":[38],"we":[39],"report":[40],"on":[41],"determination":[43],"molecular":[46,76],"organization":[47],"lipid":[51],"matrix":[52],"in":[53,55,85,91],"situ,":[54],"near-native":[57],"state,":[58],"using":[59],"a":[60,92],"methodological":[61],"approach":[62],"combining":[63],"very":[64],"high":[65],"magnification":[66],"cryo-electron":[67],"microscopy":[68],"(EM)":[69],"vitreous":[71],"section":[73],"defocus":[74],"series,":[75],"modeling,":[77],"EM":[79],"simulation.":[80],"are":[83],"organized":[84],"an":[86],"arrangement":[87,111],"not":[88],"previously":[89],"described":[90],"biological":[93],"system-stacked":[94],"bilayers":[95],"fully":[97],"extended":[98],"ceramides":[99],"(CERs)":[100],"with":[101,105],"cholesterol":[102],"molecules":[103],"associated":[104],"CER":[107],"sphingoid":[108],"moiety.":[109],"This":[110],"rationalizes":[112],"low":[115],"permeability":[116],"toward":[117,120,132],"water":[118],"hydrophilic":[121],"lipophilic":[123],"substances,":[124],"as":[125,127],"well":[126],"barrier's":[130],"robustness":[131],"hydration":[133],"dehydration,":[135],"environmental":[136],"temperature":[137],"pressure":[139],"changes,":[140],"stretching,":[141],"compression,":[142],"bending,":[143],"shearing.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":29},{"year":2016,"cited_by_count":23},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
