{"id":"https://openalex.org/W2018380860","doi":"https://doi.org/10.1093/emboj/cdf551","title":"A phosphoserine/threonine\u2010binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation","display_name":"A phosphoserine/threonine\u2010binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation","publication_year":2002,"publication_date":"2002-10-09","ids":{"openalex":"https://openalex.org/W2018380860","doi":"https://doi.org/10.1093/emboj/cdf551","mag":"2018380860","pmid":"https://pubmed.ncbi.nlm.nih.gov/12374740","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/129083"},"language":"en","primary_location":{"id":"doi:10.1093/emboj/cdf551","doi":"https://doi.org/10.1093/emboj/cdf551","is_oa":true,"landing_page_url":"https://doi.org/10.1093/emboj/cdf551","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1093/emboj/cdf551","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1093/emboj/cdf551","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029136245","display_name":"Morten Fr\u00f6din","orcid":"https://orcid.org/0000-0003-3691-9820","observed_orcids":["https://orcid.org/0000-0003-3691-9820"]},"institutions":[{"id":"https://openalex.org/I2802086085","display_name":"Glostrup Hospital","ror":"https://ror.org/05p1frt18","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802086085","https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Morten Fr\u00f6din","raw_affiliation_strings":["Department of Clinical Biochemistry, Glostrup Hospital, DK-2600 Glostrup, Denmark. mf@dcb-glostrup.dk","Department of Clinical Biochemistry, Glostrup Hospital DK-2600 Glostrup Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, Glostrup Hospital, DK-2600 Glostrup, Denmark. mf@dcb-glostrup.dk","institution_ids":["https://openalex.org/I2802086085"]},{"raw_affiliation_string":"Department of Clinical Biochemistry, Glostrup Hospital DK-2600 Glostrup Denmark","institution_ids":["https://openalex.org/I2802086085"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Torben L. Antal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802086085","display_name":"Glostrup Hospital","ror":"https://ror.org/05p1frt18","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802086085","https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Torben L. Antal","raw_affiliation_strings":["Department of Clinical Biochemistry, Glostrup Hospital DK-2600 Glostrup Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, Glostrup Hospital DK-2600 Glostrup Denmark","institution_ids":["https://openalex.org/I2802086085"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bettina A. D\u00fcmmler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802086085","display_name":"Glostrup Hospital","ror":"https://ror.org/05p1frt18","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802086085","https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Bettina A. D\u00fcmmler","raw_affiliation_strings":["Department of Clinical Biochemistry, Glostrup Hospital DK-2600 Glostrup Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, Glostrup Hospital DK-2600 Glostrup Denmark","institution_ids":["https://openalex.org/I2802086085"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Claus J. Jensen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802086085","display_name":"Glostrup Hospital","ror":"https://ror.org/05p1frt18","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802086085","https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Claus J. Jensen","raw_affiliation_strings":["Department of Clinical Biochemistry, Glostrup Hospital DK-2600 Glostrup Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, Glostrup Hospital DK-2600 Glostrup Denmark","institution_ids":["https://openalex.org/I2802086085"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Maria Deak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I4210110201","display_name":"MRC Protein Phosphorylation and Ubiquitylation Unit","ror":"https://ror.org/01zg1tt02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I177639307","https://openalex.org/I4210087105","https://openalex.org/I4210110201","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Maria Deak","raw_affiliation_strings":["MRC Protein Phosphorylation Unit, MSI/WTB complex, University of Dundee Dow Street Dundee DD1 5EH UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Protein Phosphorylation Unit, MSI/WTB complex, University of Dundee Dow Street Dundee DD1 5EH UK","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I4210110201"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Steen Gammeltoft","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802086085","display_name":"Glostrup Hospital","ror":"https://ror.org/05p1frt18","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802086085","https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Steen Gammeltoft","raw_affiliation_strings":["Department of Clinical Biochemistry, Glostrup Hospital DK-2600 Glostrup Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, Glostrup Hospital DK-2600 Glostrup Denmark","institution_ids":["https://openalex.org/I2802086085"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007413056","display_name":"Ricardo M. Biondi","orcid":"https://orcid.org/0000-0002-8873-7167","observed_orcids":["https://orcid.org/0000-0002-8873-7167"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ricardo M. Biondi","raw_affiliation_strings":["Division of Signal Transduction Therapy, MSI/WTB complex, University of Dundee Dow Street Dundee DD1 5EH UK","Present address: PhosphoSites GmbH, Starterzentrum 3 D-66421 Homburg Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Signal Transduction Therapy, MSI/WTB complex, University of Dundee Dow Street Dundee DD1 5EH UK","institution_ids":["https://openalex.org/I177639307"]},{"raw_affiliation_string":"Present address: PhosphoSites GmbH, Starterzentrum 3 D-66421 Homburg Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029136245"],"corresponding_institution_ids":["https://openalex.org/I2802086085"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":null,"fwci":4.4935,"has_fulltext":true,"cited_by_count":276,"citation_normalized_percentile":{"value":0.9607384,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"21","issue":"20","first_page":"5396","last_page":"5407"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8877000212669373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8877000212669373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.1062999963760376,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/agc-protein-kinases","display_name":"AGC protein kinases","score":0.8840000033378601},{"id":"https://openalex.org/keywords/pdk1","display_name":"PDK1","score":0.871999979019165},{"id":"https://openalex.org/keywords/kinase-activation-mechanism","display_name":"kinase activation mechanism","score":0.8579999804496765},{"id":"https://openalex.org/keywords/rsk2","display_name":"RSK2","score":0.7429999709129333},{"id":"https://openalex.org/keywords/s6k1","display_name":"S6K1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/msk1","display_name":"MSK1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sgk1","display_name":"SGK1","score":1.0},{"id":"https://openalex.org/keywords/activation-loop","display_name":"activation loop","score":0.7379999756813049},{"id":"https://openalex.org/keywords/alphac-helix","display_name":"\u03b1C-helix","score":0.7049999833106995},{"id":"https://openalex.org/keywords/intramolecular-interactions","display_name":"intramolecular interactions","score":0.5299999713897705},{"id":"https://openalex.org/keywords/growth-factor-signaling","display_name":"growth factor signaling","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C2780307904","wikidata":"https://www.wikidata.org/wiki/Q2701649","display_name":"Phosphoserine","level":4,"score":0.852625846862793},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7004771828651428},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6435822248458862},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6118730902671814},{"id":"https://openalex.org/C2910050888","wikidata":"https://www.wikidata.org/wiki/Q4857068","display_name":"Protein-Serine-Threonine Kinases","level":4,"score":0.5945547223091125},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5451518893241882},{"id":"https://openalex.org/C2775880066","wikidata":"https://www.wikidata.org/wiki/Q186521","display_name":"Threonine","level":4,"score":0.5215291976928711},{"id":"https://openalex.org/C104551158","wikidata":"https://www.wikidata.org/wiki/Q7187581","display_name":"Phosphorylation cascade","level":5,"score":0.4972071945667267},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.49641281366348267},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47300297021865845},{"id":"https://openalex.org/C159479382","wikidata":"https://www.wikidata.org/wiki/Q18030801","display_name":"MAP2K7","level":5,"score":0.441830575466156},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.42177414894104004},{"id":"https://openalex.org/C137361374","wikidata":"https://www.wikidata.org/wiki/Q6714442","display_name":"MAP kinase kinase kinase","level":4,"score":0.4177752435207367},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.36791741847991943},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.3457232713699341},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.3074372410774231}],"mesh":[{"descriptor_ui":"D000099184","descriptor_name":"Serum-Glucocorticoid Regulated Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010768","descriptor_name":"Phosphoserine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010769","descriptor_name":"Phosphothreonine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038744","descriptor_name":"Ribosomal Protein S6 Kinases, 90-kDa","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D038744","descriptor_name":"Ribosomal Protein S6 Kinases, 90-kDa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D038744","descriptor_name":"Ribosomal Protein S6 Kinases, 90-kDa","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064413","descriptor_name":"3-Phosphoinositide-Dependent Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/emboj/cdf551","doi":"https://doi.org/10.1093/emboj/cdf551","is_oa":true,"landing_page_url":"https://doi.org/10.1093/emboj/cdf551","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1093/emboj/cdf551","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:562182","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/129083","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:129083","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/129083","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO J","raw_type":"Text"},{"id":"pmid:12374740","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12374740","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO journal","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/5d301640-5240-11dd-8d9f-000ea68e967b","doi":null,"is_oa":false,"landing_page_url":"https://curis.ku.dk/portal/da/publications/a-phosphoserinethreoninebinding-pocket-in-agc-kinases-and-pdk1-mediates-activation-by-hydrophobic-motif-phosphorylation(5d301640-5240-11dd-8d9f-000ea68e967b).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Fr\u00f6din, M, Antal, T L, D\u00fcmmler, B A, Jensen, C J, Deak, M, Gammeltoft, S & Biondi, R M 2002, 'A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation.', EMBO Journal, vol. 21, no. 20, pp. 5396-407.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/emboj/cdf551","doi":"https://doi.org/10.1093/emboj/cdf551","is_oa":true,"landing_page_url":"https://doi.org/10.1093/emboj/cdf551","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1093/emboj/cdf551","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310455","display_name":"Kr\u00e6ftens Bek\u00e6mpelse","ror":"https://ror.org/03ytt7k16"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018380860.pdf","grobid_xml":"https://content.openalex.org/works/W2018380860.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1591640849","https://openalex.org/W1726025741","https://openalex.org/W1971695868","https://openalex.org/W1973837499","https://openalex.org/W1986191025","https://openalex.org/W1990612610","https://openalex.org/W1992945955","https://openalex.org/W1993852996","https://openalex.org/W2004078164","https://openalex.org/W2004926623","https://openalex.org/W2015642465","https://openalex.org/W2017370430","https://openalex.org/W2017394099","https://openalex.org/W2022658303","https://openalex.org/W2033630329","https://openalex.org/W2041926656","https://openalex.org/W2042746242","https://openalex.org/W2058012673","https://openalex.org/W2066469176","https://openalex.org/W2067405360","https://openalex.org/W2079123009","https://openalex.org/W2080653934","https://openalex.org/W2085562786","https://openalex.org/W2091275711","https://openalex.org/W2105388112","https://openalex.org/W2131162745","https://openalex.org/W2142060283","https://openalex.org/W2146157811","https://openalex.org/W2147398227","https://openalex.org/W2149238710","https://openalex.org/W2162193671","https://openalex.org/W2165710306","https://openalex.org/W2169494292"],"related_works":["https://openalex.org/W2090256844","https://openalex.org/W2026602275","https://openalex.org/W2091275711","https://openalex.org/W2142060283","https://openalex.org/W2104326020","https://openalex.org/W2149238710","https://openalex.org/W2147680105","https://openalex.org/W1951802364","https://openalex.org/W2109497034","https://openalex.org/W2165710306"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":20}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}