{"id":"https://openalex.org/W2018342879","doi":"https://doi.org/10.1038/nrn2494","title":"Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses","display_name":"Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses","publication_year":2008,"publication_date":"2008-09-19","ids":{"openalex":"https://openalex.org/W2018342879","doi":"https://doi.org/10.1038/nrn2494","mag":"2018342879","pmid":"https://pubmed.ncbi.nlm.nih.gov/18802446"},"language":"en","primary_location":{"id":"doi:10.1038/nrn2494","doi":"https://doi.org/10.1038/nrn2494","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrn2494","pdf_url":null,"source":{"id":"https://openalex.org/S26843219","display_name":"Nature reviews. Neuroscience","issn_l":"1471-003X","issn":["1471-003X","1471-0048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Neuroscience","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004136948","display_name":"Lars Bertram","orcid":"https://orcid.org/0000-0002-0108-124X","observed_orcids":["https://orcid.org/0000-0002-0108-124X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lars Bertram","raw_affiliation_strings":["Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Massachusetts General Hospital, 114 16th Street, Charlestown, Massachusetts 02129, USA. bertram@helix.mgh.harvard.edu","Department of Neurology, Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases (MIND), Massachusetts General Hospital, Charlestown, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Massachusetts General Hospital, 114 16th Street, Charlestown, Massachusetts 02129, USA. bertram@helix.mgh.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Neurology, Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases (MIND), Massachusetts General Hospital, Charlestown, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050004777","display_name":"Rudolph E. Tanzi","orcid":"https://orcid.org/0000-0002-7032-1454","observed_orcids":["https://orcid.org/0000-0002-7032-1454"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rudolph E. Tanzi","raw_affiliation_strings":["Department of Neurology, Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases (MIND), Massachusetts General Hospital, 114 16th Street, Charlestown, 02129, Massachusetts, USA","Department of Neurology, Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases (MIND), Massachusetts General Hospital, Charlestown, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases (MIND), Massachusetts General Hospital, 114 16th Street, Charlestown, 02129, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Neurology, Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases (MIND), Massachusetts General Hospital, Charlestown, USA","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004136948"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":7.8872,"has_fulltext":false,"cited_by_count":748,"citation_normalized_percentile":{"value":0.99546044,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"9","issue":"10","first_page":"768","last_page":"778"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease-genetics","display_name":"Alzheimer's disease genetics","score":0.9089999794960022},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.7490000128746033},{"id":"https://openalex.org/keywords/candidate-genes","display_name":"candidate genes","score":0.777999997138977},{"id":"https://openalex.org/keywords/meta-analysis","display_name":"meta-analysis","score":0.7089999914169312},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.8949999809265137},{"id":"https://openalex.org/keywords/presenilin-1","display_name":"presenilin 1","score":0.878000020980835},{"id":"https://openalex.org/keywords/psen2","display_name":"presenilin 2","score":1.0},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9950000047683716},{"id":"https://openalex.org/keywords/early-onset-familial-alzheimer-s-disease","display_name":"early-onset familial Alzheimer's disease","score":0.921999990940094},{"id":"https://openalex.org/keywords/late-onset-alzheimer-s-disease","display_name":"late-onset Alzheimer's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/disease-pathology","display_name":"disease pathology","score":0.6000000238418579},{"id":"https://openalex.org/keywords/metabolic-pathways","display_name":"metabolic pathways","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C2776485563","wikidata":"https://www.wikidata.org/wiki/Q18253272","display_name":"PSEN1","level":5,"score":0.8972125053405762},{"id":"https://openalex.org/C175344181","wikidata":"https://www.wikidata.org/wiki/Q907198","display_name":"Presenilin","level":4,"score":0.8331592082977295},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.746300995349884},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6523746252059937},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6040675640106201},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5838742852210999},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5668033957481384},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5239044427871704},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4512537717819214},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.4276782274246216},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.42428505420684814},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.42419371008872986},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.37285593152046204},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28719037771224976},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.16967377066612244},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10084730386734009}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015201","descriptor_name":"Meta-Analysis as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053763","descriptor_name":"Presenilins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/nrn2494","doi":"https://doi.org/10.1038/nrn2494","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrn2494","pdf_url":null,"source":{"id":"https://openalex.org/S26843219","display_name":"Nature reviews. Neuroscience","issn_l":"1471-003X","issn":["1471-003X","1471-0048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Neuroscience","raw_type":"journal-article"},{"id":"pmid:18802446","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18802446","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Neuroscience","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.979200005531311,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4035076488","display_name":"Identification and Characterization of Novel AD Genes","funder_award_id":"R37MH060009","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G6241966858","display_name":"SEARCH FOR NOVEL EARLY-ONSET ALZHEIMER'S GENES","funder_award_id":"R01AG023667","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":113,"referenced_works":["https://openalex.org/W84932084","https://openalex.org/W1513183398","https://openalex.org/W1569630040","https://openalex.org/W1686423757","https://openalex.org/W1834255231","https://openalex.org/W1867596925","https://openalex.org/W1964362098","https://openalex.org/W1969387743","https://openalex.org/W1969501720","https://openalex.org/W1970082506","https://openalex.org/W1971372076","https://openalex.org/W1976381342","https://openalex.org/W1977738320","https://openalex.org/W1978290642","https://openalex.org/W1980972277","https://openalex.org/W1982057809","https://openalex.org/W1983115003","https://openalex.org/W1984021443","https://openalex.org/W1984215778","https://openalex.org/W1989029077","https://openalex.org/W1993340435","https://openalex.org/W1994320218","https://openalex.org/W1999061258","https://openalex.org/W1999631936","https://openalex.org/W2004950789","https://openalex.org/W2005740454","https://openalex.org/W2006434674","https://openalex.org/W2007427893","https://openalex.org/W2008352401","https://openalex.org/W2009320319","https://openalex.org/W2009427803","https://openalex.org/W2012733162","https://openalex.org/W2013524758","https://openalex.org/W2016590297","https://openalex.org/W2016683781","https://openalex.org/W2017079501","https://openalex.org/W2017581860","https://openalex.org/W2017683017","https://openalex.org/W2021181758","https://openalex.org/W2021622661","https://openalex.org/W2022943439","https://openalex.org/W2027737529","https://openalex.org/W2028432634","https://openalex.org/W2032822445","https://openalex.org/W2033016640","https://openalex.org/W2034286717","https://openalex.org/W2039376160","https://openalex.org/W2041467022","https://openalex.org/W2041596767","https://openalex.org/W2042103517","https://openalex.org/W2045153164","https://openalex.org/W2046157835","https://openalex.org/W2046209489","https://openalex.org/W2046896098","https://openalex.org/W2051455922","https://openalex.org/W2052321977","https://openalex.org/W2053664358","https://openalex.org/W2054904323","https://openalex.org/W2058723245","https://openalex.org/W2058880763","https://openalex.org/W2062360332","https://openalex.org/W2065082115","https://openalex.org/W2067432590","https://openalex.org/W2067587881","https://openalex.org/W2069665561","https://openalex.org/W2072687035","https://openalex.org/W2073661142","https://openalex.org/W2076538102","https://openalex.org/W2083633251","https://openalex.org/W2083715632","https://openalex.org/W2085982774","https://openalex.org/W2087424142","https://openalex.org/W2090382713","https://openalex.org/W2094806530","https://openalex.org/W2095580234","https://openalex.org/W2098187463","https://openalex.org/W2099040516","https://openalex.org/W2102304594","https://openalex.org/W2102952062","https://openalex.org/W2107328434","https://openalex.org/W2107728076","https://openalex.org/W2111564049","https://openalex.org/W2112587738","https://openalex.org/W2112683645","https://openalex.org/W2115484612","https://openalex.org/W2119487442","https://openalex.org/W2121883535","https://openalex.org/W2123299380","https://openalex.org/W2125993125","https://openalex.org/W2128201302","https://openalex.org/W2128210695","https://openalex.org/W2131819352","https://openalex.org/W2133361358","https://openalex.org/W2139557860","https://openalex.org/W2139647754","https://openalex.org/W2145371252","https://openalex.org/W2145492845","https://openalex.org/W2146501109","https://openalex.org/W2150022733","https://openalex.org/W2150254407","https://openalex.org/W2150655508","https://openalex.org/W2153754152","https://openalex.org/W2154748402","https://openalex.org/W2154908140","https://openalex.org/W2162011270","https://openalex.org/W2166336042","https://openalex.org/W2166514496","https://openalex.org/W2166966137","https://openalex.org/W2170430546","https://openalex.org/W2192827948","https://openalex.org/W2522569907","https://openalex.org/W3174077129","https://openalex.org/W4238920409"],"related_works":["https://openalex.org/W2205957035","https://openalex.org/W2056786007","https://openalex.org/W2381791998","https://openalex.org/W2064579827","https://openalex.org/W2180213046","https://openalex.org/W4206844764","https://openalex.org/W2122670336","https://openalex.org/W2126570001","https://openalex.org/W2355760844","https://openalex.org/W2562127498"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":25},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":33},{"year":2021,"cited_by_count":26},{"year":2020,"cited_by_count":29},{"year":2019,"cited_by_count":34},{"year":2018,"cited_by_count":41},{"year":2017,"cited_by_count":46},{"year":2016,"cited_by_count":37},{"year":2015,"cited_by_count":41},{"year":2014,"cited_by_count":46},{"year":2013,"cited_by_count":59},{"year":2012,"cited_by_count":62}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
