{"id":"https://openalex.org/W2018337406","doi":"https://doi.org/10.1073/pnas.1936124100","title":"Cellulosome assembly revealed by the crystal structure of the cohesin\u2013dockerin complex","display_name":"Cellulosome assembly revealed by the crystal structure of the cohesin\u2013dockerin complex","publication_year":2003,"publication_date":"2003-11-17","ids":{"openalex":"https://openalex.org/W2018337406","doi":"https://doi.org/10.1073/pnas.1936124100","mag":"2018337406","pmid":"https://pubmed.ncbi.nlm.nih.gov/14623971","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/283503"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1936124100","doi":"https://doi.org/10.1073/pnas.1936124100","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1936124100","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2018337406"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC283503","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089977518","display_name":"Ana Lu\u00edsa Carvalho","orcid":"https://orcid.org/0000-0002-3824-0240","observed_orcids":["https://orcid.org/0000-0002-3824-0240"]},"institutions":[{"id":"https://openalex.org/I4210138594","display_name":"Rede de Qu\u00edmica e Tecnologia","ror":"https://ror.org/04j14t006","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210138594"]},{"id":"https://openalex.org/I4405253863","display_name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal","ror":"https://ror.org/015hr2538","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405253863"]},{"id":"https://openalex.org/I4405264366","display_name":"Universidade T\u00e9cnica de Lisboa","ror":"https://ror.org/01qc02b16","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405264366"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ana L. Carvalho","raw_affiliation_strings":["Rede de Qu\u00edmica e Tecnologia/Centro de Qu\u00edmica Fina e Biotecnologia (REQUIMTE/CQFB), Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal; Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade T\u00e9cnica de Lisboa, Rua Professor Cid dos Santos, 1300-477 Lisboa, Portugal; Department of Biological and Nutritional Sciences and School of Cell and Molecular Biosciences, University of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rede de Qu\u00edmica e Tecnologia/Centro de Qu\u00edmica Fina e Biotecnologia (REQUIMTE/CQFB), Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal; Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade T\u00e9cnica de Lisboa, Rua Professor Cid dos Santos, 1300-477 Lisboa, Portugal; Department of Biological and Nutritional Sciences and School of Cell and Molecular Biosciences, University of","institution_ids":["https://openalex.org/I4210138594","https://openalex.org/I4405253863","https://openalex.org/I4405264366","https://openalex.org/I83558840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026451504","display_name":"Fernando M. V. Dias","orcid":"https://orcid.org/0000-0001-8109-2063","observed_orcids":["https://orcid.org/0000-0001-8109-2063"]},"institutions":[{"id":"https://openalex.org/I4210138594","display_name":"Rede de Qu\u00edmica e Tecnologia","ror":"https://ror.org/04j14t006","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210138594"]},{"id":"https://openalex.org/I4405253863","display_name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal","ror":"https://ror.org/015hr2538","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405253863"]},{"id":"https://openalex.org/I4405264366","display_name":"Universidade T\u00e9cnica de Lisboa","ror":"https://ror.org/01qc02b16","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405264366"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Fernando M. V. Dias","raw_affiliation_strings":["Rede de Qu\u00edmica e Tecnologia/Centro de Qu\u00edmica Fina e Biotecnologia (REQUIMTE/CQFB), Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal; Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade T\u00e9cnica de Lisboa, Rua Professor Cid dos Santos, 1300-477 Lisboa, Portugal; Department of Biological and Nutritional Sciences and School of Cell and Molecular Biosciences, University of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rede de Qu\u00edmica e Tecnologia/Centro de Qu\u00edmica Fina e Biotecnologia (REQUIMTE/CQFB), Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal; Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade T\u00e9cnica de Lisboa, Rua Professor Cid dos Santos, 1300-477 Lisboa, Portugal; Department of Biological and Nutritional Sciences and School of Cell and Molecular Biosciences, University of","institution_ids":["https://openalex.org/I4210138594","https://openalex.org/I4405253863","https://openalex.org/I4405264366","https://openalex.org/I83558840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005492234","display_name":"Jos\u00e9 A. M. Prates","orcid":"https://orcid.org/0000-0003-1032-5987","observed_orcids":["https://orcid.org/0000-0003-1032-5987"]},"institutions":[{"id":"https://openalex.org/I4210138594","display_name":"Rede de Qu\u00edmica e Tecnologia","ror":"https://ror.org/04j14t006","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210138594"]},{"id":"https://openalex.org/I4405253863","display_name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal","ror":"https://ror.org/015hr2538","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405253863"]},{"id":"https://openalex.org/I4405264366","display_name":"Universidade T\u00e9cnica de Lisboa","ror":"https://ror.org/01qc02b16","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405264366"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 A. M. Prates","raw_affiliation_strings":["Rede de Qu\u00edmica e Tecnologia/Centro de Qu\u00edmica Fina e Biotecnologia (REQUIMTE/CQFB), Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal; Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade T\u00e9cnica de Lisboa, Rua Professor Cid dos Santos, 1300-477 Lisboa, Portugal; Department of Biological and Nutritional Sciences and School of Cell and Molecular Biosciences, University of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rede de Qu\u00edmica e Tecnologia/Centro de Qu\u00edmica Fina e Biotecnologia (REQUIMTE/CQFB), Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal; Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade T\u00e9cnica de Lisboa, Rua Professor Cid dos Santos, 1300-477 Lisboa, Portugal; Department of Biological and Nutritional Sciences and School of Cell and Molecular Biosciences, University of","institution_ids":["https://openalex.org/I4210138594","https://openalex.org/I4405253863","https://openalex.org/I4405264366","https://openalex.org/I83558840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032081863","display_name":"Tibor Nagy","orcid":"https://orcid.org/0000-0002-4451-0796","observed_orcids":["https://orcid.org/0000-0002-4451-0796"]},"institutions":[{"id":"https://openalex.org/I4210138594","display_name":"Rede de Qu\u00edmica e Tecnologia","ror":"https://ror.org/04j14t006","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210138594"]},{"id":"https://openalex.org/I4405253863","display_name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal","ror":"https://ror.org/015hr2538","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405253863"]},{"id":"https://openalex.org/I4405264366","display_name":"Universidade T\u00e9cnica de Lisboa","ror":"https://ror.org/01qc02b16","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405264366"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Tibor Nagy","raw_affiliation_strings":["Rede de Qu\u00edmica e Tecnologia/Centro de Qu\u00edmica Fina e Biotecnologia (REQUIMTE/CQFB), Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal; Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade T\u00e9cnica de Lisboa, Rua Professor Cid dos Santos, 1300-477 Lisboa, Portugal; Department of Biological and Nutritional Sciences and School of Cell and Molecular Biosciences, University of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rede de Qu\u00edmica e Tecnologia/Centro de Qu\u00edmica Fina e Biotecnologia (REQUIMTE/CQFB), Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal; Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade T\u00e9cnica de Lisboa, Rua Professor Cid dos Santos, 1300-477 Lisboa, Portugal; Department of Biological and Nutritional Sciences and School of Cell and Molecular Biosciences, University of","institution_ids":["https://openalex.org/I4210138594","https://openalex.org/I4405253863","https://openalex.org/I4405264366","https://openalex.org/I83558840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059560909","display_name":"Harry John Gilbert","orcid":"https://orcid.org/0000-0003-3597-2347","observed_orcids":["https://orcid.org/0000-0003-3597-2347"]},"institutions":[{"id":"https://openalex.org/I4210138594","display_name":"Rede de Qu\u00edmica e Tecnologia","ror":"https://ror.org/04j14t006","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210138594"]},{"id":"https://openalex.org/I4405253863","display_name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal","ror":"https://ror.org/015hr2538","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405253863"]},{"id":"https://openalex.org/I4405264366","display_name":"Universidade T\u00e9cnica de Lisboa","ror":"https://ror.org/01qc02b16","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405264366"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Harry J. Gilbert","raw_affiliation_strings":["Rede de Qu\u00edmica e Tecnologia/Centro de Qu\u00edmica Fina e Biotecnologia (REQUIMTE/CQFB), Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal; Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade T\u00e9cnica de Lisboa, Rua Professor Cid dos Santos, 1300-477 Lisboa, Portugal; Department of Biological and Nutritional Sciences and School of Cell and Molecular Biosciences, University of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rede de Qu\u00edmica e Tecnologia/Centro de Qu\u00edmica Fina e Biotecnologia (REQUIMTE/CQFB), Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal; Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade T\u00e9cnica de Lisboa, Rua Professor Cid dos Santos, 1300-477 Lisboa, Portugal; Department of Biological and Nutritional Sciences and School of Cell and Molecular Biosciences, University of","institution_ids":["https://openalex.org/I4210138594","https://openalex.org/I4405253863","https://openalex.org/I4405264366","https://openalex.org/I83558840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009478169","display_name":"G.J. Davies","orcid":"https://orcid.org/0000-0002-7343-776X","observed_orcids":["https://orcid.org/0000-0002-7343-776X"]},"institutions":[{"id":"https://openalex.org/I4210138594","display_name":"Rede de Qu\u00edmica e Tecnologia","ror":"https://ror.org/04j14t006","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210138594"]},{"id":"https://openalex.org/I4405253863","display_name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal","ror":"https://ror.org/015hr2538","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405253863"]},{"id":"https://openalex.org/I4405264366","display_name":"Universidade T\u00e9cnica de Lisboa","ror":"https://ror.org/01qc02b16","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405264366"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Gideon J. Davies","raw_affiliation_strings":["Rede de Qu\u00edmica e Tecnologia/Centro de Qu\u00edmica Fina e Biotecnologia (REQUIMTE/CQFB), Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal; Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade T\u00e9cnica de Lisboa, Rua Professor Cid dos Santos, 1300-477 Lisboa, Portugal; Department of Biological and Nutritional Sciences and School of Cell and Molecular Biosciences, University of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rede de Qu\u00edmica e Tecnologia/Centro de Qu\u00edmica Fina e Biotecnologia (REQUIMTE/CQFB), Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal; Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade T\u00e9cnica de Lisboa, Rua Professor Cid dos Santos, 1300-477 Lisboa, Portugal; Department of Biological and Nutritional Sciences and School of Cell and Molecular Biosciences, University of","institution_ids":["https://openalex.org/I4210138594","https://openalex.org/I4405253863","https://openalex.org/I4405264366","https://openalex.org/I83558840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021225439","display_name":"Lu\u00eds M. A. Ferreira","orcid":"https://orcid.org/0000-0002-3543-9166","observed_orcids":["https://orcid.org/0000-0002-3543-9166"]},"institutions":[{"id":"https://openalex.org/I4210138594","display_name":"Rede de Qu\u00edmica e Tecnologia","ror":"https://ror.org/04j14t006","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210138594"]},{"id":"https://openalex.org/I4405253863","display_name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal","ror":"https://ror.org/015hr2538","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405253863"]},{"id":"https://openalex.org/I4405264366","display_name":"Universidade T\u00e9cnica de Lisboa","ror":"https://ror.org/01qc02b16","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405264366"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Lu\u00eds M. A. Ferreira","raw_affiliation_strings":["Rede de Qu\u00edmica e Tecnologia/Centro de Qu\u00edmica Fina e Biotecnologia (REQUIMTE/CQFB), Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal; Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade T\u00e9cnica de Lisboa, Rua Professor Cid dos Santos, 1300-477 Lisboa, Portugal; Department of Biological and Nutritional Sciences and School of Cell and Molecular Biosciences, University of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rede de Qu\u00edmica e Tecnologia/Centro de Qu\u00edmica Fina e Biotecnologia (REQUIMTE/CQFB), Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal; Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade T\u00e9cnica de Lisboa, Rua Professor Cid dos Santos, 1300-477 Lisboa, Portugal; Department of Biological and Nutritional Sciences and School of Cell and Molecular Biosciences, University of","institution_ids":["https://openalex.org/I4210138594","https://openalex.org/I4405253863","https://openalex.org/I4405264366","https://openalex.org/I83558840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001383675","display_name":"Maria Jo\u00e3o Rom\u00e3o","orcid":"https://orcid.org/0000-0002-3004-0543","observed_orcids":["https://orcid.org/0000-0002-3004-0543"]},"institutions":[{"id":"https://openalex.org/I4210138594","display_name":"Rede de Qu\u00edmica e Tecnologia","ror":"https://ror.org/04j14t006","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210138594"]},{"id":"https://openalex.org/I4405253863","display_name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal","ror":"https://ror.org/015hr2538","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405253863"]},{"id":"https://openalex.org/I4405264366","display_name":"Universidade T\u00e9cnica de Lisboa","ror":"https://ror.org/01qc02b16","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405264366"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Maria J. Rom\u00e3o","raw_affiliation_strings":["Rede de Qu\u00edmica e Tecnologia/Centro de Qu\u00edmica Fina e Biotecnologia (REQUIMTE/CQFB), Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal; Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade T\u00e9cnica de Lisboa, Rua Professor Cid dos Santos, 1300-477 Lisboa, Portugal; Department of Biological and Nutritional Sciences and School of Cell and Molecular Biosciences, University of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rede de Qu\u00edmica e Tecnologia/Centro de Qu\u00edmica Fina e Biotecnologia (REQUIMTE/CQFB), Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal; Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade T\u00e9cnica de Lisboa, Rua Professor Cid dos Santos, 1300-477 Lisboa, Portugal; Department of Biological and Nutritional Sciences and School of Cell and Molecular Biosciences, University of","institution_ids":["https://openalex.org/I4210138594","https://openalex.org/I4405253863","https://openalex.org/I4405264366","https://openalex.org/I83558840"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069105565","display_name":"Carlos M. G. A. Fontes","orcid":"https://orcid.org/0000-0002-1219-9753","observed_orcids":["https://orcid.org/0000-0002-1219-9753"]},"institutions":[{"id":"https://openalex.org/I4210138594","display_name":"Rede de Qu\u00edmica e Tecnologia","ror":"https://ror.org/04j14t006","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210138594"]},{"id":"https://openalex.org/I4405253863","display_name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal","ror":"https://ror.org/015hr2538","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405253863"]},{"id":"https://openalex.org/I4405264366","display_name":"Universidade T\u00e9cnica de Lisboa","ror":"https://ror.org/01qc02b16","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405264366"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Carlos M. G. A. Fontes","raw_affiliation_strings":["Rede de Qu\u00edmica e Tecnologia/Centro de Qu\u00edmica Fina e Biotecnologia (REQUIMTE/CQFB), Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal; Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade T\u00e9cnica de Lisboa, Rua Professor Cid dos Santos, 1300-477 Lisboa, Portugal; Department of Biological and Nutritional Sciences and School of Cell and Molecular Biosciences, University of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rede de Qu\u00edmica e Tecnologia/Centro de Qu\u00edmica Fina e Biotecnologia (REQUIMTE/CQFB), Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal; Centro Interdisciplinar de Investiga\u00e7\u00e3o em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade T\u00e9cnica de Lisboa, Rua Professor Cid dos Santos, 1300-477 Lisboa, Portugal; Department of Biological and Nutritional Sciences and School of Cell and Molecular Biosciences, University of","institution_ids":["https://openalex.org/I4210138594","https://openalex.org/I4405253863","https://openalex.org/I4405264366","https://openalex.org/I83558840"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.5662,"has_fulltext":false,"cited_by_count":269,"citation_normalized_percentile":{"value":0.98847737,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"100","issue":"24","first_page":"13809","last_page":"13814"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.4099000096321106,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.4099000096321106,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.2280000001192093,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10869","display_name":"Polysaccharides and Plant Cell Walls","score":0.12999999523162842,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellulosome","display_name":"cellulosome","score":0.9850000143051147},{"id":"https://openalex.org/keywords/clostridium-thermocellum","display_name":"Clostridium thermocellum","score":0.9959999918937683},{"id":"https://openalex.org/keywords/plant-cell-wall-degradation","display_name":"plant cell wall degradation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cross-species-recognition","display_name":"cross-species recognition","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C115821613","wikidata":"https://www.wikidata.org/wiki/Q21103063","display_name":"Cohesin","level":4,"score":0.9809408187866211},{"id":"https://openalex.org/C2776029434","wikidata":"https://www.wikidata.org/wiki/Q5058394","display_name":"Cellulosome","level":5,"score":0.9729171991348267},{"id":"https://openalex.org/C2776061948","wikidata":"https://www.wikidata.org/wiki/Q3681172","display_name":"Clostridium thermocellum","level":4,"score":0.9475194215774536},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47653207182884216},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4465576410293579},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4365922510623932},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.414612740278244},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3832848370075226},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38010528683662415},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.3326048254966736},{"id":"https://openalex.org/C141603559","wikidata":"https://www.wikidata.org/wiki/Q410324","display_name":"Cellulase","level":3,"score":0.26633304357528687},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.24406376481056213},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.18355587124824524}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002480","descriptor_name":"Cellulase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002480","descriptor_name":"Cellulase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002480","descriptor_name":"Cellulase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003013","descriptor_name":"Clostridium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003013","descriptor_name":"Clostridium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1073/pnas.1936124100","doi":"https://doi.org/10.1073/pnas.1936124100","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1936124100","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:279720","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC283503","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:14623971","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14623971","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:283503","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC283503/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmh:oai:run.unl.pt:10362/63329","doi":null,"is_oa":true,"landing_page_url":"https://www.scopus.com/pages/publications/0345564859","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"doi:10.25405/ncl.34611606","doi":"https://doi.org/10.25405/ncl.34611606","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34611606","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25405/ncl.34611606.v1","doi":"https://doi.org/10.25405/ncl.34611606.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34611606.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:279720","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC283503","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1485836510","https://openalex.org/W1571243084","https://openalex.org/W1793573788","https://openalex.org/W1968329759","https://openalex.org/W1974497021","https://openalex.org/W1984636178","https://openalex.org/W1991143485","https://openalex.org/W1995017064","https://openalex.org/W1999336080","https://openalex.org/W2000662339","https://openalex.org/W2001641653","https://openalex.org/W2006223695","https://openalex.org/W2019619237","https://openalex.org/W2023950901","https://openalex.org/W2029045342","https://openalex.org/W2037092573","https://openalex.org/W2038840577","https://openalex.org/W2052899292","https://openalex.org/W2064384838","https://openalex.org/W2065932593","https://openalex.org/W2078149273","https://openalex.org/W2082553848","https://openalex.org/W2089103294","https://openalex.org/W2099172250","https://openalex.org/W2125815517","https://openalex.org/W2132411280","https://openalex.org/W2147665045","https://openalex.org/W2155658282"],"related_works":["https://openalex.org/W1998408013","https://openalex.org/W7220978085","https://openalex.org/W2076810772","https://openalex.org/W2033362014","https://openalex.org/W2065932593","https://openalex.org/W2149592755","https://openalex.org/W2785908870","https://openalex.org/W2795052524","https://openalex.org/W4392956783","https://openalex.org/W2100220734"],"abstract_inverted_index":{"The":[0,89,190],"utilization":[1],"of":[2,23,45,71,79,101,104,110,119,162,178,188,198,216],"organized":[3],"supramolecular":[4],"assemblies":[5],"to":[6,138,180],"exploit":[7],"the":[8,21,40,46,72,77,80,93,102,105,108,111,116,120,133,149,163,181,186,196,210],"synergistic":[9],"interactions":[10],"afforded":[11],"by":[12],"close":[13],"proximity,":[14],"both":[15,160],"for":[16,20,42,195,209],"enzymatic":[17,56],"synthesis":[18],"and":[19,125,183,204,214],"degradation":[22,44],"recalcitrant":[24],"substrates,":[25],"is":[26,142,151],"an":[27,55,193],"emerging":[28],"theme":[29],"in":[30,153,169],"cellular":[31],"biology.":[32],"Anaerobic":[33],"bacteria":[34],"harness":[35],"a":[36,59,170,175,207],"multiprotein":[37],"complex,":[38],"termed":[39],"\"cellulosome,\"":[41],"efficient":[43],"plant":[47],"cell":[48],"wall.":[49],"This":[50],"megadalton":[51],"catalytic":[52,218],"machine":[53],"organizes":[54],"consortium":[57],"on":[58],"multifaceted":[60],"molecular":[61],"scaffold":[62],"whose":[63],"\"cohesin\"":[64],"domains":[65,70],"interact":[66,166],"with":[67,99,128,167],"corresponding":[68],"\"dockerin\"":[69],"enzymes.":[73],"Here":[74],"we":[75],"report":[76],"structure":[78,109,179,191],"cohesin-dockerin":[81,202],"complex":[82],"from":[83],"Clostridium":[84],"thermocellum":[85],"at":[86],"2.2-A":[87],"resolution.":[88],"data":[90],"show":[91],"that":[92,159],"beta-sheet":[94],"cohesin":[95,112],"domain":[96],"interacts":[97],"predominantly":[98],"one":[100],"helices":[103],"dockerin.":[106],"Whereas":[107],"remains":[113],"essentially":[114],"unchanged,":[115],"loop-helix-helix-loop-helix":[117],"motif":[118],"dockerin":[121,150,164],"undergoes":[122],"conformational":[123],"change":[124],"ordering":[126],"compared":[127],"its":[129],"solution":[130],"structure,":[131],"although":[132],"classical":[134],"12-residue":[135],"EF-hand":[136],"coordination":[137],"two":[139],"calcium":[140],"ions":[141],"maintained.":[143],"Significantly,":[144],"internal":[145,155],"sequence":[146],"duplication":[147],"within":[148],"manifested":[152],"near-perfect":[154],"twofold":[156],"symmetry,":[157],"suggesting":[158],"\"halves\"":[161],"may":[165],"cohesins":[168],"similar":[171],"manner,":[172],"thus":[173,205],"providing":[174],"higher":[176],"level":[177],"cellulosome":[182],"possibly":[184],"explaining":[185],"presence":[187],"\"polycellulosomes.\"":[189],"provides":[192,206],"explanation":[194],"lack":[197],"cross-species":[199],"recognition":[200],"between":[201],"pairs":[203],"blueprint":[208],"rational":[211],"design,":[212],"construction,":[213],"exploitation":[215],"these":[217],"assemblies.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}