{"id":"https://openalex.org/W2018336983","doi":"https://doi.org/10.1210/jcem-66-3-611","title":"Long Term Pulsatile Growth Hormone (GH)-Releasing Hormone Therapy in Children With GH Deficiency*","display_name":"Long Term Pulsatile Growth Hormone (GH)-Releasing Hormone Therapy in Children With GH Deficiency*","publication_year":1988,"publication_date":"1988-03-01","ids":{"openalex":"https://openalex.org/W2018336983","doi":"https://doi.org/10.1210/jcem-66-3-611","mag":"2018336983","pmid":"https://pubmed.ncbi.nlm.nih.gov/3127420"},"language":"en","primary_location":{"id":"doi:10.1210/jcem-66-3-611","doi":"https://doi.org/10.1210/jcem-66-3-611","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-66-3-611","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111877642","display_name":"Louis C. K. Low","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800810863","display_name":"Queen Mary Hospital","ror":"https://ror.org/02xkx3e48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2800810863"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"L. C. K. LOW","raw_affiliation_strings":["Department of Pediatrics, University of Hong Kong, Queen Mary Hospital","Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong","Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Hong Kong, Queen Mary Hospital","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052010636","display_name":"C. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800810863","display_name":"Queen Mary Hospital","ror":"https://ror.org/02xkx3e48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2800810863"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"C. WANG","raw_affiliation_strings":["Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong; Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037","Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong","Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong; Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111520650","display_name":"P.T. Cheung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800810863","display_name":"Queen Mary Hospital","ror":"https://ror.org/02xkx3e48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2800810863"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"P. T. CHEUNG","raw_affiliation_strings":["Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong; Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037","Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong","Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong; Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"P. HO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800810863","display_name":"Queen Mary Hospital","ror":"https://ror.org/02xkx3e48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2800810863"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"P. HO","raw_affiliation_strings":["Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong; Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037","Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong","Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong; Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112489379","display_name":"Karen S.L. Lam","orcid":"https://orcid.org/0000-0001-5757-541X","observed_orcids":["https://orcid.org/0000-0001-5757-541X"]},"institutions":[{"id":"https://openalex.org/I2800810863","display_name":"Queen Mary Hospital","ror":"https://ror.org/02xkx3e48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2800810863"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"K. S. L. LAM","raw_affiliation_strings":["Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong; Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037","Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong","Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong; Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016131158","display_name":"R. T. T. YOUNG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800810863","display_name":"Queen Mary Hospital","ror":"https://ror.org/02xkx3e48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2800810863"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"R. T. T. YOUNG","raw_affiliation_strings":["Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong; Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037","Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong","Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong; Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108434427","display_name":"CK Yeung","orcid":"https://orcid.org/0009-0007-4647-5502","observed_orcids":["https://orcid.org/0009-0007-4647-5502"]},"institutions":[{"id":"https://openalex.org/I2800810863","display_name":"Queen Mary Hospital","ror":"https://ror.org/02xkx3e48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2800810863"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"C. Y. YEUNG","raw_affiliation_strings":["Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong; Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037","Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong","Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong; Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077195123","display_name":"NICHOLAS C. LING","orcid":"https://orcid.org/0000-0002-0853-7035","observed_orcids":["https://orcid.org/0000-0002-0853-7035"]},"institutions":[{"id":"https://openalex.org/I2800810863","display_name":"Queen Mary Hospital","ror":"https://ror.org/02xkx3e48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2800810863"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"N. LING","raw_affiliation_strings":["Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong; Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037","Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong","Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong; Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Departments of Pediatrics (L.C.K.L., P.T.C., C.Y.Y.) and Medicine (C.W., P.H., K.S.L.L., R.T.T.Y.), University of Hong Kong Queen Mary Hospital, Hong Kong","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Laboratories for Neuroendocrinology, Salk Institute (N.L.) La Jolla, California, 92037","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":3.9695,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.93838863,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"66","issue":"3","first_page":"611","last_page":"617"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-hormone-deficiency","display_name":"growth hormone deficiency","score":0.9430000185966492},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.7350000143051147},{"id":"https://openalex.org/keywords/growth-rate","display_name":"growth rate","score":0.6610000133514404},{"id":"https://openalex.org/keywords/height-gain","display_name":"height gain","score":0.7379999756813049},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.7120000123977661},{"id":"https://openalex.org/keywords/predictors-of-treatment-response","display_name":"predictors of treatment response","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C79191276","wikidata":"https://www.wikidata.org/wiki/Q7259620","display_name":"Pulsatile flow","level":2,"score":0.8204593062400818},{"id":"https://openalex.org/C2779952775","wikidata":"https://www.wikidata.org/wiki/Q369262","display_name":"Growth hormone deficiency","level":4,"score":0.662025511264801},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.6166285872459412},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5426071882247925},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5298293232917786},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5226019024848938},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.5151230692863464},{"id":"https://openalex.org/C2780275930","wikidata":"https://www.wikidata.org/wiki/Q1628266","display_name":"Hormone therapy","level":4,"score":0.4542929530143738},{"id":"https://openalex.org/C2994100043","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Human growth hormone","level":4,"score":0.4188990890979767},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.37501686811447144},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.05350455641746521},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.05085042119026184},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006130","descriptor_name":"Growth Disorders","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006130","descriptor_name":"Growth Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D013007","descriptor_name":"Growth Hormone-Releasing Hormone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013007","descriptor_name":"Growth Hormone-Releasing Hormone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1210/jcem-66-3-611","doi":"https://doi.org/10.1210/jcem-66-3-611","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-66-3-611","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:3127420","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3127420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:hub.hku.hk:10722/170232","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10722/170232","pdf_url":null,"source":{"id":"https://openalex.org/S4377196271","display_name":"The HKU Scholars Hub (University of Hong Kong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I889458895","host_organization_name":"University of Hong Kong","host_organization_lineage":["https://openalex.org/I889458895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311061","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1565139074","https://openalex.org/W1972083618","https://openalex.org/W1991015313","https://openalex.org/W1992859412","https://openalex.org/W1993192586","https://openalex.org/W2016733772","https://openalex.org/W2020651834","https://openalex.org/W2025490706","https://openalex.org/W2030421011","https://openalex.org/W2031365635","https://openalex.org/W2056071336","https://openalex.org/W2056679025","https://openalex.org/W2057885232","https://openalex.org/W2062363382","https://openalex.org/W2071501634","https://openalex.org/W2075384439","https://openalex.org/W2075950300","https://openalex.org/W2077462935","https://openalex.org/W2082968531","https://openalex.org/W2090540664","https://openalex.org/W2092217414","https://openalex.org/W2124632379","https://openalex.org/W2136710045","https://openalex.org/W2145988372","https://openalex.org/W2336653813","https://openalex.org/W4255599868"],"related_works":["https://openalex.org/W2124632379","https://openalex.org/W2056886563","https://openalex.org/W2062363382","https://openalex.org/W2141367394","https://openalex.org/W2016667351","https://openalex.org/W2437924009","https://openalex.org/W2136710045","https://openalex.org/W2316641937","https://openalex.org/W1996340058","https://openalex.org/W1983015178"],"abstract_inverted_index":{"We":[0],"treated":[1,136],"seven":[2,98],"GH-deficient":[3],"children":[4],"with":[5,100,137],"3-hourly":[6],"1":[7,44,80,111],"microgram/kg":[8],"sc":[9,48,187],"pulses":[10],"of":[11,46,61,82,97,110,116,194],"GHRH-(1-44)":[12],"for":[13,19],"6":[14,21],"months":[15,78],"and":[16,35,71,79,152,180],"2":[17,77],"micrograms/kg.pulse":[18],"another":[20],"months.":[22],"Four":[23],"patients":[24,119],"had":[25,126,148],"a":[26,58,143],"serum":[27,170,177,183],"GH":[28,151,171,184],"response":[29,172,185],"to":[30,40,67,124,161,173],"iv":[31,41,174],"GHRH":[32,42,49,88,125,156,163,188],"before":[33],"treatment,":[34,83],"an":[36,127],"additional":[37],"patient":[38],"responded":[39],"after":[43,76],"month":[45],"pulsatile":[47,87],"administration.":[50],"The":[51,140,168],"mean":[52,60],"cumulative":[53],"growth":[54,94,131],"velocity":[55],"increased":[56],"from":[57,104],"pretreatment":[59,169],"2.7":[62],"+/-":[63,69,73],"0.2":[64],"(+/-":[65],"SE)":[66],"8.4":[68],"2.5":[70],"5.4":[72],"0.7":[74],"cm/yr":[75],"yr":[81],"respectively.":[84],"Low":[85],"dose":[86],"therapy":[89,189],"was":[90],"effective":[91],"in":[92,95,129],"promoting":[93],"five":[96],"children,":[99],"height":[101],"gain":[102],"ranging":[103],"4.4-7.5":[105],"cm":[106],"at":[107],"the":[108,117,176,181],"end":[109],"yr's":[112],"therapy.":[113],"Only":[114],"one":[115],"two":[118],"who":[120,147],"did":[121,158],"not":[122,159,191],"respond":[123,160],"improvement":[128],"linear":[130],"when":[132],"they":[133],"were":[134,190],"subsequently":[135],"synthetic":[138,166],"GH.":[139,167],"other":[141],"patient,":[142],"16.5-yr-old":[144],"pubertal":[145],"girl":[146],"both":[149],"satisfactory":[150],"somatomedin-C":[153,178],"responses":[154],"during":[155,186],"therapy,":[157],"either":[162],"or,":[164],"later,":[165],"GHRH,":[175],"concentrations,":[179],"peak":[182],"reliable":[192],"predictors":[193],"clinical":[195],"response.":[196]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
