{"id":"https://openalex.org/W2018333108","doi":"https://doi.org/10.1002/biot.201000068","title":"Hepatoprotective effect of oleuropein in mice: Mechanisms uncovered by gene expression profiling","display_name":"Hepatoprotective effect of oleuropein in mice: Mechanisms uncovered by gene expression profiling","publication_year":2010,"publication_date":"2010-09-01","ids":{"openalex":"https://openalex.org/W2018333108","doi":"https://doi.org/10.1002/biot.201000068","mag":"2018333108","pmid":"https://pubmed.ncbi.nlm.nih.gov/20845385"},"language":"en","primary_location":{"id":"doi:10.1002/biot.201000068","doi":"https://doi.org/10.1002/biot.201000068","is_oa":false,"landing_page_url":"https://doi.org/10.1002/biot.201000068","pdf_url":null,"source":{"id":"https://openalex.org/S31411064","display_name":"Biotechnology Journal","issn_l":"1860-6768","issn":["1860-6768","1860-7314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101432882","display_name":"Yunjung Kim","orcid":"https://orcid.org/0000-0001-9080-4739","observed_orcids":["https://orcid.org/0000-0001-9080-4739"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yunjung Kim","raw_affiliation_strings":["Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University, Seoul, Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102864915","display_name":"Youngshim Choi","orcid":"https://orcid.org/0000-0002-0735-6072","observed_orcids":["https://orcid.org/0000-0002-0735-6072"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Youngshim Choi","raw_affiliation_strings":["Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University, Seoul, Korea","Yonsei university"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University, Seoul, Korea","institution_ids":["https://openalex.org/I193775966"]},{"raw_affiliation_string":"Yonsei university","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100637703","display_name":"Taesun Park","orcid":"https://orcid.org/0000-0002-9752-9407","observed_orcids":["https://orcid.org/0000-0002-9752-9407"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Taesun Park","raw_affiliation_strings":["Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University, Seoul, Korea","institution_ids":["https://openalex.org/I193775966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100637703"],"corresponding_institution_ids":["https://openalex.org/I193775966"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":0.4432,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.56634077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"5","issue":"9","first_page":"950","last_page":"960"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10909","display_name":"Edible Oils Quality and Analysis","score":0.6348000168800354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10909","display_name":"Edible Oils Quality and Analysis","score":0.6348000168800354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.22609999775886536,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oleuropein","display_name":"oleuropein","score":1.0},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.8669999837875366},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/olive-leaf-extract","display_name":"olive leaf extract","score":0.7799999713897705},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8809999823570251},{"id":"https://openalex.org/keywords/hepatic-gene-expression","display_name":"hepatic gene expression","score":0.828000009059906},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.9779999852180481},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7900000214576721},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.984000027179718},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7649999856948853},{"id":"https://openalex.org/keywords/lipogenesis","display_name":"lipogenesis","score":0.6600000262260437},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.7319999933242798},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.30300000309944153}],"concepts":[{"id":"https://openalex.org/C2777957096","wikidata":"https://www.wikidata.org/wiki/Q402625","display_name":"Oleuropein","level":3,"score":0.755666196346283},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5082401633262634},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5061387419700623},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.49709513783454895},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47679996490478516},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.41765740513801575},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4017554223537445},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2651176154613495},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20449066162109375},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.09305530786514282},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0737663209438324},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004041","descriptor_name":"Dietary Fats","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004041","descriptor_name":"Dietary Fats","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011714","descriptor_name":"Pyrans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D039823","descriptor_name":"Iridoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054647","descriptor_name":"Nutrigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057888","descriptor_name":"Iridoid Glucosides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/biot.201000068","doi":"https://doi.org/10.1002/biot.201000068","is_oa":false,"landing_page_url":"https://doi.org/10.1002/biot.201000068","pdf_url":null,"source":{"id":"https://openalex.org/S31411064","display_name":"Biotechnology Journal","issn_l":"1860-6768","issn":["1860-6768","1860-7314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Journal","raw_type":"journal-article"},{"id":"pmid:20845385","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20845385","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W38979642","https://openalex.org/W1665938856","https://openalex.org/W1924602449","https://openalex.org/W1963616233","https://openalex.org/W1972587487","https://openalex.org/W1972709924","https://openalex.org/W1976825731","https://openalex.org/W1977105764","https://openalex.org/W1978021683","https://openalex.org/W1979383399","https://openalex.org/W1979962393","https://openalex.org/W1982328176","https://openalex.org/W1992045933","https://openalex.org/W1995821360","https://openalex.org/W1998522719","https://openalex.org/W2001146181","https://openalex.org/W2001683663","https://openalex.org/W2006221512","https://openalex.org/W2013807245","https://openalex.org/W2021292700","https://openalex.org/W2023701777","https://openalex.org/W2029992695","https://openalex.org/W2032878070","https://openalex.org/W2037742489","https://openalex.org/W2039081870","https://openalex.org/W2053012302","https://openalex.org/W2059992589","https://openalex.org/W2060990419","https://openalex.org/W2064362934","https://openalex.org/W2067729127","https://openalex.org/W2069262764","https://openalex.org/W2078176020","https://openalex.org/W2078253837","https://openalex.org/W2079862618","https://openalex.org/W2081070477","https://openalex.org/W2088993691","https://openalex.org/W2089542725","https://openalex.org/W2097127479","https://openalex.org/W2098494341","https://openalex.org/W2100433915","https://openalex.org/W2103017472","https://openalex.org/W2106317671","https://openalex.org/W2127314696","https://openalex.org/W2131316166","https://openalex.org/W2135810057","https://openalex.org/W2137506791","https://openalex.org/W2140012153","https://openalex.org/W2140871020","https://openalex.org/W2146735845","https://openalex.org/W2150091098","https://openalex.org/W2152201022","https://openalex.org/W2153368559","https://openalex.org/W2155235961","https://openalex.org/W2161197995","https://openalex.org/W2162422715","https://openalex.org/W2167144145","https://openalex.org/W2167743390","https://openalex.org/W2168526937","https://openalex.org/W2171475196","https://openalex.org/W2278834190"],"related_works":["https://openalex.org/W4400256765","https://openalex.org/W2064935325","https://openalex.org/W3000040012","https://openalex.org/W2037493506","https://openalex.org/W2002322251","https://openalex.org/W4398178592","https://openalex.org/W4415694683","https://openalex.org/W3006699217","https://openalex.org/W6939594397","https://openalex.org/W7171732903"],"abstract_inverted_index":{"Oleuropein,":[0],"an":[1],"active":[2],"constituent":[3],"of":[4,10,44,74,117,125,140,143,154,171,208],"olive":[5],"leaf,":[6],"has":[7],"a":[8,82,141],"variety":[9],"pharmacological":[11],"activities":[12],"associated":[13],"with":[14,53,106],"its":[15],"capacity":[16],"to":[17,26,63,99,168],"scavenge":[18],"reactive":[19],"oxygen":[20],"species.":[21],"Oleuropein":[22],"is":[23],"also":[24],"reported":[25],"have":[27],"protective":[28],"effects":[29,207],"against":[30],"non-alcoholic":[31],"fatty":[32,128],"liver":[33],"disease":[34],"(NAFLD)":[35],"in":[36,147,186],"vivo.":[37],"In":[38,133],"this":[39,75],"study,":[40],"gene":[41],"expression":[42,139],"profiling":[43],"hepatic":[45,114,127,144],"tissues":[46],"was":[47,110],"examined,":[48],"and":[49,131,152,158,180,193,196],"transcription":[50],"factors":[51],"(TFs)":[52],"target":[54],"genes":[55,119,145,173],"that":[56,120,166,200,203],"were":[57,61,79,97,184],"modulated":[58],"by":[59,182],"oleuropein":[60,105,136,183,209],"identified":[62],"gain":[64],"insights":[65],"into":[66],"the":[67,71,108,113,118,122,126,135,138,148,169,172,187,201,205],"molecular":[68],"mechanisms":[69,202],"for":[70,90],"hepatoprotective":[72],"action":[73],"compound.":[76],"C57BL/6N":[77],"mice":[78],"fed":[80],"either":[81],"high-fat":[83],"diet":[84],"(HFD)":[85],"or":[86],"0.03%":[87],"oleuropein-supplemented":[88],"HFD":[89,109],"10":[91],"weeks,":[92],"after":[93],"which":[94,107,198],"their":[95],"livers":[96],"subjected":[98],"oligo":[100],"DNA":[101],"microarray":[102],"analysis.":[103],"The":[104,162],"supplemented":[111],"reduced":[112,137],"mRNA":[115],"level":[116],"encoded":[121],"key":[123],"regulators":[124],"acid":[129],"uptake":[130],"transport.":[132],"addition,":[134],"number":[142],"involved":[146],"oxidative":[149],"stress":[150],"responses":[151],"detoxification":[153],"lipid":[155],"peroxidation":[156],"products":[157],"proinflammatory":[159],"cytokine":[160],"genes.":[161],"(putative)":[163],"candidate":[164],"TFs":[165],"bound":[167],"promoters":[170],"regulated":[174],"at":[175],"least":[176],"threefold":[177],"(both":[178],"up":[179],"down)":[181],"implicated":[185],"lipogenesis,":[188],"inflammation,":[189],"insulin":[190],"resistance,":[191],"fibrosis,":[192],"cell":[194],"proliferation":[195],"differentiation,":[197],"implies":[199],"underlie":[204],"beneficial":[206],"on":[210],"NAFLD":[211],"may":[212],"be":[213],"multifactorial.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}