{"id":"https://openalex.org/W2018318072","doi":"https://doi.org/10.1002/anie.200704780","title":"Exogenous Agents that Target Transmembrane Domains of Proteins","display_name":"Exogenous Agents that Target Transmembrane Domains of Proteins","publication_year":2008,"publication_date":"2008-03-03","ids":{"openalex":"https://openalex.org/W2018318072","doi":"https://doi.org/10.1002/anie.200704780","mag":"2018318072","pmid":"https://pubmed.ncbi.nlm.nih.gov/18318029"},"language":"en","primary_location":{"id":"doi:10.1002/anie.200704780","doi":"https://doi.org/10.1002/anie.200704780","is_oa":false,"landing_page_url":"https://doi.org/10.1002/anie.200704780","pdf_url":null,"source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025581121","display_name":"Hang Hubert Yin","orcid":"https://orcid.org/0000-0002-9762-4818","observed_orcids":["https://orcid.org/0000-0002-9762-4818"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hang Yin","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Colorado at Boulder, 215 UCB, Boulder, CO 80309-0215, USA. hang.yin@colorado.edu","Department of Chemistry and Biochemistry, University of Colorado at Boulder, 215 UCB, Boulder, CO 80309-0215, USA, Fax: (+1)\u2009303-492-5894 http://www.colorado.edu/chem/yinlab/"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Colorado at Boulder, 215 UCB, Boulder, CO 80309-0215, USA. hang.yin@colorado.edu","institution_ids":["https://openalex.org/I188538660"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Colorado at Boulder, 215 UCB, Boulder, CO 80309-0215, USA, Fax: (+1)\u2009303-492-5894 http://www.colorado.edu/chem/yinlab/","institution_ids":["https://openalex.org/I188538660"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025581121"],"corresponding_institution_ids":["https://openalex.org/I188538660"],"apc_list":{"value":5510,"currency":"USD","value_usd":5510},"apc_paid":null,"fwci":0.1546,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.11001032,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"47","issue":"15","first_page":"2744","last_page":"2752"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"transmembrane domain","score":0.8539999723434448},{"id":"https://openalex.org/keywords/membrane-proteins","display_name":"membrane proteins","score":0.996999979019165},{"id":"https://openalex.org/keywords/probe-molecules","display_name":"probe molecules","score":0.35199999809265137},{"id":"https://openalex.org/keywords/membrane-protein-structure","display_name":"membrane protein structure","score":0.38999998569488525},{"id":"https://openalex.org/keywords/bacterial-membranes","display_name":"bacterial membranes","score":0.5910000205039978},{"id":"https://openalex.org/keywords/mammalian-cell-membranes","display_name":"mammalian cell membranes","score":0.921999990940094}],"concepts":[{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.8737980127334595},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.6993961930274963},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.6605366468429565},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5108677744865417},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5024983882904053},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.4456256628036499},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4083092510700226},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3650916516780853},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34341636300086975},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16046428680419922}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/anie.200704780","doi":"https://doi.org/10.1002/anie.200704780","is_oa":false,"landing_page_url":"https://doi.org/10.1002/anie.200704780","pdf_url":null,"source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},{"id":"pmid:18318029","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18318029","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie (International ed. in English)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.5699999928474426,"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":85,"referenced_works":["https://openalex.org/W1499270645","https://openalex.org/W1510774549","https://openalex.org/W1879047861","https://openalex.org/W1964060428","https://openalex.org/W1964681919","https://openalex.org/W1969025574","https://openalex.org/W1969126565","https://openalex.org/W1969787762","https://openalex.org/W1971500863","https://openalex.org/W1972343197","https://openalex.org/W1973424040","https://openalex.org/W1978045911","https://openalex.org/W1983102499","https://openalex.org/W1983521156","https://openalex.org/W1987841618","https://openalex.org/W1988703402","https://openalex.org/W1988791617","https://openalex.org/W1991594572","https://openalex.org/W1993760285","https://openalex.org/W2000510012","https://openalex.org/W2000880755","https://openalex.org/W2001012906","https://openalex.org/W2010163679","https://openalex.org/W2010928503","https://openalex.org/W2018982114","https://openalex.org/W2022923144","https://openalex.org/W2025768773","https://openalex.org/W2025859600","https://openalex.org/W2030457887","https://openalex.org/W2031179671","https://openalex.org/W2031644342","https://openalex.org/W2032242863","https://openalex.org/W2039874250","https://openalex.org/W2040585305","https://openalex.org/W2048142144","https://openalex.org/W2048690045","https://openalex.org/W2049331965","https://openalex.org/W2050749891","https://openalex.org/W2051425608","https://openalex.org/W2052112948","https://openalex.org/W2052300481","https://openalex.org/W2055886323","https://openalex.org/W2060769144","https://openalex.org/W2061801991","https://openalex.org/W2063044149","https://openalex.org/W2065464482","https://openalex.org/W2065921660","https://openalex.org/W2068772440","https://openalex.org/W2074182813","https://openalex.org/W2076228202","https://openalex.org/W2076444761","https://openalex.org/W2079230562","https://openalex.org/W2080301705","https://openalex.org/W2082287275","https://openalex.org/W2082364599","https://openalex.org/W2087870820","https://openalex.org/W2088880328","https://openalex.org/W2092964767","https://openalex.org/W2095092694","https://openalex.org/W2095441352","https://openalex.org/W2096211374","https://openalex.org/W2101810621","https://openalex.org/W2104477830","https://openalex.org/W2107335002","https://openalex.org/W2117572030","https://openalex.org/W2119587675","https://openalex.org/W2120903461","https://openalex.org/W2122836610","https://openalex.org/W2127162389","https://openalex.org/W2140113197","https://openalex.org/W2143632667","https://openalex.org/W2145000518","https://openalex.org/W2148134632","https://openalex.org/W2148724380","https://openalex.org/W2151363352","https://openalex.org/W2152270594","https://openalex.org/W2153262655","https://openalex.org/W2154382529","https://openalex.org/W2155147384","https://openalex.org/W2157177111","https://openalex.org/W2163865126","https://openalex.org/W2164316626","https://openalex.org/W2164440923","https://openalex.org/W4230736766","https://openalex.org/W4231282669"],"related_works":["https://openalex.org/W2025055322","https://openalex.org/W2130267476","https://openalex.org/W1971776877","https://openalex.org/W2600739471","https://openalex.org/W4286851769","https://openalex.org/W2001091655","https://openalex.org/W2103415025","https://openalex.org/W2098437895","https://openalex.org/W4396741519","https://openalex.org/W2492528632"],"abstract_inverted_index":{"Although":[0],"membrane":[1,73],"proteins":[2,10],"account":[3],"for":[4],"approximately":[5],"one":[6],"third":[7],"of":[8,20,43,69,72,87],"all":[9],"encoded":[11],"in":[12,35,64,82],"the":[13,16,29,41,55,66],"human":[14],"genome,":[15],"functions":[17],"and":[18,77,89],"structures":[19],"their":[21],"transmembrane":[22,38,67],"domains":[23,39,68],"are":[24],"much":[25],"less":[26],"understood":[27],"than":[28],"water-soluble":[30],"regions.":[31],"A":[32],"major":[33,58],"hurdle":[34],"studying":[36],"these":[37],"is":[40],"lack":[42],"appropriate":[44],"exogenous":[45],"agents":[46],"that":[47],"can":[48],"be":[49],"used":[50],"as":[51],"specific":[52],"probes.":[53],"Despite":[54],"daunting":[56],"challenges,":[57],"strides":[59],"have":[60,79],"recently":[61],"been":[62,80],"made":[63],"targeting":[65],"a":[70],"variety":[71],"proteins.":[74],"High":[75],"affinity":[76],"selectivity":[78],"achieved":[81],"model":[83],"biophysical":[84],"systems,":[85],"membranes":[86],"bacteria,":[88],"mammalian":[90],"cells.":[91]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}