{"id":"https://openalex.org/W2018316528","doi":"https://doi.org/10.1111/j.1471-4159.1982.tb08004.x","title":"Factors Contributing to the Poor Myelination in the Brain of the Snell Dwarf Mouse","display_name":"Factors Contributing to the Poor Myelination in the Brain of the Snell Dwarf Mouse","publication_year":1982,"publication_date":"1982-12-01","ids":{"openalex":"https://openalex.org/W2018316528","doi":"https://doi.org/10.1111/j.1471-4159.1982.tb08004.x","mag":"2018316528","pmid":"https://pubmed.ncbi.nlm.nih.gov/6292367"},"language":"en","primary_location":{"id":"doi:10.1111/j.1471-4159.1982.tb08004.x","doi":"https://doi.org/10.1111/j.1471-4159.1982.tb08004.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.1982.tb08004.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111643676","display_name":"Tetsuya Noguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tetsuya Noguchi","raw_affiliation_strings":["Department of Physiology, School of Medicine, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014365950","display_name":"Tetsuro Sugisaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuro Sugisaki","raw_affiliation_strings":["Department of Physiology, School of Medicine, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031500573","display_name":"Ken Takamatsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken Takamatsu","raw_affiliation_strings":["Department of Physiology, School of Medicine, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113439244","display_name":"Yasuzo Tsukada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuzo Tsukada","raw_affiliation_strings":["Department of Physiology, School of Medicine, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111643676"],"corresponding_institution_ids":["https://openalex.org/I203951103"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":1.3743,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.75725594,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"6","first_page":"1693","last_page":"1699"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/snell-dwarf-mice","display_name":"Snell dwarf mice","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hypomyelination","display_name":"hypomyelination","score":0.9620000123977661},{"id":"https://openalex.org/keywords/brain-myelination","display_name":"brain myelination","score":0.7889999747276306},{"id":"https://openalex.org/keywords/oligodendrocyte-proliferation","display_name":"oligodendrocyte proliferation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/growth-hormone-deficiency","display_name":"growth hormone deficiency","score":0.9330000281333923},{"id":"https://openalex.org/keywords/myelin-synthesis","display_name":"myelin synthesis","score":0.6499999761581421},{"id":"https://openalex.org/keywords/dna-content","display_name":"DNA content","score":0.7580000162124634},{"id":"https://openalex.org/keywords/glial-proliferation","display_name":"glial cell proliferation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/pituitary-gland","display_name":"pituitary gland","score":0.5809999704360962},{"id":"https://openalex.org/keywords/cerebrum","display_name":"cerebrum","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C533869091","wikidata":"https://www.wikidata.org/wiki/Q75855","display_name":"Cerebrum","level":3,"score":0.8296281099319458},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7086284160614014},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.7025623321533203},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6389545202255249},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6167577505111694},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.609433114528656},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.585088849067688},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2874581217765808},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22231391072273254},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14816713333129883},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11596649885177612},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07913967967033386}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D009186","descriptor_name":"Myelin Sheath","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010903","descriptor_name":"Pituitary Gland, Anterior","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015087","descriptor_name":"2',3'-Cyclic-Nucleotide Phosphodiesterases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1471-4159.1982.tb08004.x","doi":"https://doi.org/10.1111/j.1471-4159.1982.tb08004.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.1982.tb08004.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:6292367","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6292367","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:ssbb1982-2118","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/ssbb1982/1119","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Subject Strain Bibliography 1982","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W10073932","https://openalex.org/W1491685093","https://openalex.org/W1573843901","https://openalex.org/W1775749144","https://openalex.org/W1896066594","https://openalex.org/W1906197854","https://openalex.org/W1969744128","https://openalex.org/W1973580558","https://openalex.org/W1978239826","https://openalex.org/W1993635910","https://openalex.org/W2002247516","https://openalex.org/W2003120408","https://openalex.org/W2029131039","https://openalex.org/W2032391956","https://openalex.org/W2032552530","https://openalex.org/W2038824559","https://openalex.org/W2040924690","https://openalex.org/W2044718482","https://openalex.org/W2044830474","https://openalex.org/W2050362059","https://openalex.org/W2061513641","https://openalex.org/W2069911118","https://openalex.org/W2072656543","https://openalex.org/W2079645945","https://openalex.org/W2082352178","https://openalex.org/W2087331857","https://openalex.org/W2089640124","https://openalex.org/W2119216843","https://openalex.org/W2123055918","https://openalex.org/W2128068572","https://openalex.org/W2164167794","https://openalex.org/W2166110652","https://openalex.org/W2283859270","https://openalex.org/W4239853578","https://openalex.org/W4300524345"],"related_works":["https://openalex.org/W2092130731","https://openalex.org/W2009971712","https://openalex.org/W1993635910","https://openalex.org/W2003688881","https://openalex.org/W2061513641","https://openalex.org/W2051957432","https://openalex.org/W2045238228","https://openalex.org/W2131343799","https://openalex.org/W1987439153","https://openalex.org/W2031573899"],"abstract_inverted_index":{"Conventional":[0],"histological":[1],"examination":[2,24],"of":[3,25,27,39,45,69,90,103,116,148,153,170,192,221,238,245,272],"the":[4,19,40,43,52,59,63,67,70,82,87,91,100,114,117,133,139,145,149,160,180,189,195,203,212,218,228,239,246,253,258],"pituitary":[5],"does":[6],"not":[7,143],"distinguish":[8],"Snell":[9,32,71],"dwarf":[10,72,118,247],"mutants":[11],"(dw/dw)":[12],"from":[13,106,179],"their":[14],"normal":[15],"littermates":[16],"(+/?)":[17],"in":[18,36,51,62,66,86,113,124,132,144,159,174,215,227,242,257],"neonatal":[20,53],"stage.":[21,54],"However,":[22],"immunohistochemical":[23,78],"pituitaries":[26],"litters":[28],"born":[29],"to":[30,57,75,129,168,207,235,265],"heterozygous":[31],"parents":[33],"revealed":[34],"that":[35,169,252],"approximately":[37],"25%":[38],"glands":[41],"examined,":[42],"number":[44],"positive":[46],"cells":[47],"was":[48,121,127,166,233],"very":[49],"low":[50],"We":[55],"attempted":[56],"delineate":[58],"events":[60],"resulting":[61],"poor":[64,254],"myelination":[65,255],"brain":[68,88,120,136],"mouse,":[73,162],"and":[74,93,105,135,182],"devise":[76],"an":[77],"method":[79],"for":[80],"identifying":[81],"mutant":[83,161,259],"neonate.":[84],"Differences":[85,173],"weights":[89],"dw/dw":[92,181,196],"+/?":[94,183,204],"mice":[95,184,197,205],"first":[96,185],"became":[97,186],"apparent":[98,187],"on":[99,109,188,217],"10th":[101,190],"day":[102,191,220],"age,":[104,222],"this":[107],"time":[108],"no":[110,199],"further":[111,200],"increase":[112],"weight":[115],"mouse":[119],"recorded.":[122],"Increase":[123],"CNPase":[125,164],"activity":[126,165],"found":[128,256],"be":[130],"suppressed":[131,234],"cerebrum":[134,178,229,260],"stem":[137],"throughout":[138],"developmental":[140],"stage,":[141],"but":[142,163],"other":[146],"parts":[147,244],"brain.":[150,248],"The":[151],"yield":[152],"isolated":[154],"myelin":[155],"decreased":[156],"by":[157,270],"58%":[158],"equivalent":[167],"control":[171,240],"myelin.":[172],"DNA":[175,213],"content":[176],"per":[177],"age.":[193],"Henceforth,":[194],"showed":[198],"increase,":[201],"although":[202],"continued":[206],"increase.":[208],"[3H]Thymidine":[209],"incorporation":[210],"into":[211],"fraction":[214],"vivo":[216],"7th":[219],"when":[223],"glial":[224],"cell":[225],"proliferation":[226,268],"is":[230,261],"most":[231],"active,":[232],"about":[236],"50%":[237],"level":[241],"all":[243],"These":[249],"findings":[250],"indicate":[251],"a":[262],"hypomyelination":[263],"due":[264],"reduce":[266],"oligodendroglial":[267],"caused":[269],"lack":[271],"circulating":[273],"growth":[274],"hormone.":[275]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
