{"id":"https://openalex.org/W2018304906","doi":"https://doi.org/10.1002/j.1552-4604.1980.tb02548.x","title":"Alteration of Pharmacokinetic Parameters for Pentobarbital by Ischemic Stroke and Reversion to Normal by Dexamethasone Treatment","display_name":"Alteration of Pharmacokinetic Parameters for Pentobarbital by Ischemic Stroke and Reversion to Normal by Dexamethasone Treatment","publication_year":1980,"publication_date":"1980-08-09","ids":{"openalex":"https://openalex.org/W2018304906","doi":"https://doi.org/10.1002/j.1552-4604.1980.tb02548.x","mag":"2018304906","pmid":"https://pubmed.ncbi.nlm.nih.gov/7430417"},"language":"en","primary_location":{"id":"doi:10.1002/j.1552-4604.1980.tb02548.x","doi":"https://doi.org/10.1002/j.1552-4604.1980.tb02548.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.1552-4604.1980.tb02548.x","pdf_url":null,"source":{"id":"https://openalex.org/S146237847","display_name":"The Journal of Clinical Pharmacology","issn_l":"0021-9754","issn":["0021-9754","0091-2700","0095-9863","1552-4604","2375-0839","2375-0928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://deepblue.lib.umich.edu/bitstream/2027.42/97147/1/j.1552-4604.1980.tb02548.x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111914500","display_name":"D.J. Weidler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D. J. WEIDLER","raw_affiliation_strings":["Division of Clinical Pharmacology, University of Miami School of Medicine, Miami, Fla","The University of Michigan Medical School, Ann Arbor, Mich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, University of Miami School of Medicine, Miami, Fla","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"The University of Michigan Medical School, Ann Arbor, Mich","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111766472","display_name":"Nader S. Jallad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. S. JALLAD","raw_affiliation_strings":["Division of Clinical Pharmacology, University of Miami School of Medicine, Miami, Fla"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, University of Miami School of Medicine, Miami, Fla","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019253871","display_name":"Keith L. Black","orcid":"https://orcid.org/0000-0002-0546-4934","observed_orcids":["https://orcid.org/0000-0002-0546-4934"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. L. BLACK","raw_affiliation_strings":["The University of Michigan Medical School, Ann Arbor, Mich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Michigan Medical School, Ann Arbor, Mich","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110938663","display_name":"John G. Wagner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. G. WAGNER","raw_affiliation_strings":["College of Pharmacy, The University of Michigan, Ann Arbor, Mich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, The University of Michigan, Ann Arbor, Mich","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111914500"],"corresponding_institution_ids":["https://openalex.org/I145608581","https://openalex.org/I27837315","https://openalex.org/I4210114445"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.13317264,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"8-9","first_page":"543","last_page":"551"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.5019999742507935,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.5019999742507935,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.1979999989271164,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.07840000092983246,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pentobarbital","display_name":"pentobarbital","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.8389999866485596},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9139999747276306},{"id":"https://openalex.org/keywords/plasma-half-life","display_name":"plasma half-life","score":0.906000018119812},{"id":"https://openalex.org/keywords/plasma-clearance","display_name":"plasma clearance","score":0.9639999866485596},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.6119999885559082},{"id":"https://openalex.org/keywords/middle-cerebral-artery-ligation","display_name":"middle cerebral artery ligation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/cats","display_name":"cats","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C2606647","wikidata":"https://www.wikidata.org/wiki/Q6827257","display_name":"Miami","level":2,"score":0.9275932908058167},{"id":"https://openalex.org/C63433958","wikidata":"https://www.wikidata.org/wiki/Q1774688","display_name":"Clinical pharmacology","level":2,"score":0.665463387966156},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4656423330307007},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4597821831703186},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33965864777565},{"id":"https://openalex.org/C159390177","wikidata":"https://www.wikidata.org/wiki/Q9161265","display_name":"Soil science","level":1,"score":0.0},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010424","descriptor_name":"Pentobarbital","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/j.1552-4604.1980.tb02548.x","doi":"https://doi.org/10.1002/j.1552-4604.1980.tb02548.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.1552-4604.1980.tb02548.x","pdf_url":null,"source":{"id":"https://openalex.org/S146237847","display_name":"The Journal of Clinical Pharmacology","issn_l":"0021-9754","issn":["0021-9754","0091-2700","0095-9863","1552-4604","2375-0839","2375-0928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:7430417","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7430417","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/97147","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2027.42/97147","pdf_url":"http://deepblue.lib.umich.edu/bitstream/2027.42/97147/1/j.1552-4604.1980.tb02548.x.pdf","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/97147","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2027.42/97147","pdf_url":"http://deepblue.lib.umich.edu/bitstream/2027.42/97147/1/j.1552-4604.1980.tb02548.x.pdf","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018304906.pdf","grobid_xml":"https://content.openalex.org/works/W2018304906.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W20507920","https://openalex.org/W571870702","https://openalex.org/W1518360142","https://openalex.org/W1534861568","https://openalex.org/W2003225109","https://openalex.org/W2009699574","https://openalex.org/W2015686356","https://openalex.org/W2031100131","https://openalex.org/W2046988336","https://openalex.org/W2058562851","https://openalex.org/W2072790326","https://openalex.org/W2075229829","https://openalex.org/W2075694455","https://openalex.org/W2077528978","https://openalex.org/W2091695839","https://openalex.org/W2094536692","https://openalex.org/W2095140444","https://openalex.org/W2110325718","https://openalex.org/W2136768511","https://openalex.org/W2154050921","https://openalex.org/W2169614850","https://openalex.org/W2324180327","https://openalex.org/W2410303863","https://openalex.org/W2415360335","https://openalex.org/W2917487006","https://openalex.org/W4206506054","https://openalex.org/W4231203013","https://openalex.org/W7118159788"],"related_works":["https://openalex.org/W2072790326","https://openalex.org/W2002966776","https://openalex.org/W2116163477","https://openalex.org/W2124938333","https://openalex.org/W2397214055","https://openalex.org/W2034639799","https://openalex.org/W2168903130","https://openalex.org/W2014772440","https://openalex.org/W2140561359","https://openalex.org/W7098709686"],"abstract_inverted_index":{"The":[0,41,127],"values":[1],"of":[2,14,24,54,71,76,88,118,129,132,153],"the":[3,25,68,85,99,102,116,130,151],"pharmacokinetic":[4,134],"parameters":[5,135],"for":[6,136],"pentobarbital":[7,38,104,137],"were":[8,16,46],"determined":[9],"in":[10,150],"18":[11,32],"cats,":[12],"12":[13],"which":[15,158],"subjected":[17],"to":[18,143,161],"acute":[19],"ischemic":[20,50,59,139,162],"stroke":[21,51,60,65,82,96,113,140,163],"by":[22,138,145],"ligation":[23],"left":[26],"middle":[27],"cerebral":[28],"artery":[29],"(LMCA).":[30],"All":[31],"ats":[33],"received":[34],"50":[35],"mg/kg":[36,56],"sodium":[37],"during":[39],"operation.":[40],"following":[42],"three":[43],"experimental":[44],"groups":[45],"formed:":[47],"control":[48],"(sham-operated);":[49],"plus":[52],"administration":[53,75],"4":[55],"dexamethasone;":[57],"and":[58,141,164],"without":[61],"dexamethasone":[62,77,91,108,121,146,165],"administration.":[63],"Ischemic":[64,81,95,112],"significantly":[66,83,97,114],"prolonged":[67],"plasma":[69,86,103],"half-life":[70],"pentobarbital,":[72,89],"but":[73,90,107,120],"concurrent":[74],"prevented":[78,92,109],"this":[79,93,110,125],"effect.":[80],"reduced":[84,115],"clearance":[87],"reduction.":[94,126],"increased":[98],"area":[100],"under":[101],"concentration-time":[105],"curve,":[106],"increase.":[111],"volume":[117],"distribution,":[119],"did":[122],"not":[123],"prevent":[124],"alterations":[128],"value":[131],"these":[133],"reversion":[142],"normal":[144],"treatment":[147],"are":[148],"discussed":[149],"light":[152],"certain":[154],"known":[155],"circulatory":[156],"changes":[157],"occur":[159],"secondary":[160],"treatment.":[166]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}