{"id":"https://openalex.org/W2018304238","doi":"https://doi.org/10.1016/0049-3848(87)90032-6","title":"Toxicological studies with recombinant hirudin","display_name":"Toxicological studies with recombinant hirudin","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W2018304238","doi":"https://doi.org/10.1016/0049-3848(87)90032-6","mag":"2018304238","pmid":"https://pubmed.ncbi.nlm.nih.gov/2459036"},"language":"en","primary_location":{"id":"doi:10.1016/0049-3848(87)90032-6","doi":"https://doi.org/10.1016/0049-3848(87)90032-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0049-3848(87)90032-6","pdf_url":null,"source":{"id":"https://openalex.org/S134546602","display_name":"Thrombosis Research","issn_l":"0049-3848","issn":["0049-3848","1879-2472"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057782600","display_name":"H.\u2010P. Kl\u00f6cking","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154835","display_name":"Medizinische Akademie Erfurt","ror":"https://ror.org/04dmvwm54","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210154835"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H.-P. Kl\u00f6cking","raw_affiliation_strings":["Institute of Pharmacology and Toxicology, Medical Academy Erfurt, GDR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology and Toxicology, Medical Academy Erfurt, GDR","institution_ids":["https://openalex.org/I4210154835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022060626","display_name":"J\u00fcrgen G\u00fcttner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. G\u00fcttner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063956844","display_name":"Ericka L. Fink","orcid":"https://orcid.org/0000-0002-3683-4571","observed_orcids":["https://orcid.org/0000-0002-3683-4571"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Fink","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4080,"currency":"USD","value_usd":4080},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0935744,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"45","issue":"1-2","first_page":"39","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.8076000213623047,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.8076000213623047,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13767","display_name":"Leech Biology and Applications","score":0.1468999981880188,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recombinant-hirudin","display_name":"recombinant hirudin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/anticoagulant-toxicity","display_name":"anticoagulant toxicity","score":0.796999990940094},{"id":"https://openalex.org/keywords/subacute-toxicity","display_name":"subacute toxicity","score":0.6159999966621399},{"id":"https://openalex.org/keywords/bleeding-complications","display_name":"bleeding complications","score":0.6320000290870667},{"id":"https://openalex.org/keywords/platelets","display_name":"platelets","score":0.7990000247955322},{"id":"https://openalex.org/keywords/leukocytes","display_name":"leukocytes","score":0.6880000233650208},{"id":"https://openalex.org/keywords/erythrocytes","display_name":"erythrocytes","score":0.796999990940094},{"id":"https://openalex.org/keywords/antibody-production","display_name":"antibody production","score":0.8140000104904175},{"id":"https://openalex.org/keywords/histopathology","display_name":"histopathology","score":0.7839999794960022},{"id":"https://openalex.org/keywords/ld50","display_name":"LD50","score":0.7549999952316284},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C2778271848","wikidata":"https://www.wikidata.org/wiki/Q386715","display_name":"Hirudin","level":4,"score":0.92852783203125},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.6928374767303467},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.526890754699707},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5111649632453918},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5057356357574463},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.499922513961792},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48821404576301575},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40943869948387146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30948007106781006},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30840522050857544},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.1860296130180359},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14628326892852783},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006403","descriptor_name":"Hematologic Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006629","descriptor_name":"Hirudins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014556","descriptor_name":"Urine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/0049-3848(87)90032-6","doi":"https://doi.org/10.1016/0049-3848(87)90032-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0049-3848(87)90032-6","pdf_url":null,"source":{"id":"https://openalex.org/S134546602","display_name":"Thrombosis Research","issn_l":"0049-3848","issn":["0049-3848","1879-2472"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis Research","raw_type":"journal-article"},{"id":"pmid:2459036","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2459036","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia haematologica (Leipzig, Germany : 1928)","raw_type":"Journal Article"},{"id":"mag:2428321300","doi":null,"is_oa":false,"landing_page_url":"https://europepmc.org/article/MED/2459036","pdf_url":null,"source":{"id":"https://openalex.org/S2755493720","display_name":"Folia haematologica (Germany)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310321861","host_organization_name":"Akademische Verlagsgesellschaft","host_organization_lineage":["https://openalex.org/P4310321861"],"host_organization_lineage_names":["Akademische Verlagsgesellschaft"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Folia haematologica (Germany)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.800000011920929,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2418474461","https://openalex.org/W2386274893","https://openalex.org/W1972088566","https://openalex.org/W2023371690","https://openalex.org/W2810125610","https://openalex.org/W1974962738","https://openalex.org/W2089028330","https://openalex.org/W2031195996","https://openalex.org/W3029982837","https://openalex.org/W2390931371"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
