{"id":"https://openalex.org/W2018298188","doi":"https://doi.org/10.1023/b:biry.0000022067.63532.b8","title":"Hypermethylation of 5\u2032-Region of the Human Calcitonin Gene in Leukemias: Structural Features and Diagnostic Significance","display_name":"Hypermethylation of 5\u2032-Region of the Human Calcitonin Gene in Leukemias: Structural Features and Diagnostic Significance","publication_year":2004,"publication_date":"2004-03-01","ids":{"openalex":"https://openalex.org/W2018298188","doi":"https://doi.org/10.1023/b:biry.0000022067.63532.b8","mag":"2018298188","pmid":"https://pubmed.ncbi.nlm.nih.gov/15061703"},"language":"en","primary_location":{"id":"doi:10.1023/b:biry.0000022067.63532.b8","doi":"https://doi.org/10.1023/b:biry.0000022067.63532.b8","is_oa":false,"landing_page_url":"https://doi.org/10.1023/b:biry.0000022067.63532.b8","pdf_url":null,"source":{"id":"https://openalex.org/S71215691","display_name":"Biochemistry (Moscow)","issn_l":"0006-2979","issn":["0006-2979","0320-9725","1608-3040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry (Moscow)","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112453260","display_name":"D. V. Marinich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. V. Marinitch","raw_affiliation_strings":["Research Institute of Hematology and Blood Transfusion, Minsk 223059, Belarus'. rihbtgapa@gtp.by","Research Institute of Hematology and Blood Transfusion, Minsk, Belarus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Hematology and Blood Transfusion, Minsk 223059, Belarus'. rihbtgapa@gtp.by","institution_ids":[]},{"raw_affiliation_string":"Research Institute of Hematology and Blood Transfusion, Minsk, Belarus","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045361936","display_name":"I. A. Vorobyev","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. A. Vorobyev","raw_affiliation_strings":["Research Institute of Hematology and Blood Transfusion, Dolginovsky Trakt 160, Minsk, 223059, Belarus","Research Institute of Hematology and Blood Transfusion, Minsk, Belarus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Hematology and Blood Transfusion, Dolginovsky Trakt 160, Minsk, 223059, Belarus","institution_ids":[]},{"raw_affiliation_string":"Research Institute of Hematology and Blood Transfusion, Minsk, Belarus","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001942377","display_name":"J. A. Holmes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. A. Holmes","raw_affiliation_strings":["Department of Hematology, Queen Elizabeth Hospital, Birmingham, B152TH, UK","Department of Hematology, Queen Elizabeth Hospital, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Queen Elizabeth Hospital, Birmingham, B152TH, UK","institution_ids":["https://openalex.org/I2799307867"]},{"raw_affiliation_string":"Department of Hematology, Queen Elizabeth Hospital, Birmingham, UK","institution_ids":["https://openalex.org/I2799307867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025819456","display_name":"\u041d. \u0421. \u0417\u0430\u0445\u0430\u0440\u0447\u0435\u043d\u043a\u043e","orcid":"https://orcid.org/0000-0002-1769-5449","observed_orcids":["https://orcid.org/0000-0002-1769-5449"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N. S. Zakharchenko","raw_affiliation_strings":["Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Pushchino Branch, Russian Academy of Sciences, Pushchino, 142290, Moscow Region, Russia","Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Pushchino Branch, Russian Academy of Sciences, Pushchino, Moscow Region, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Pushchino Branch, Russian Academy of Sciences, Pushchino, 142290, Moscow Region, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]},{"raw_affiliation_string":"Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Pushchino Branch, Russian Academy of Sciences, Pushchino, Moscow Region, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101746272","display_name":"Olga V. Dyachenko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"O. V. Dyachenko","raw_affiliation_strings":["Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Pushchino Branch, Russian Academy of Sciences, Pushchino, 142290, Moscow Region, Russia","Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Pushchino Branch, Russian Academy of Sciences, Pushchino, Moscow Region, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Pushchino Branch, Russian Academy of Sciences, Pushchino, 142290, Moscow Region, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]},{"raw_affiliation_string":"Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Pushchino Branch, Russian Academy of Sciences, Pushchino, Moscow Region, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113479722","display_name":"Y\u0430. I. Buryanov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Ya. I. Buryanov","raw_affiliation_strings":["Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Pushchino Branch, Russian Academy of Sciences, Pushchino, 142290, Moscow Region, Russia","Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Pushchino Branch, Russian Academy of Sciences, Pushchino, Moscow Region, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Pushchino Branch, Russian Academy of Sciences, Pushchino, 142290, Moscow Region, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]},{"raw_affiliation_string":"Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Pushchino Branch, Russian Academy of Sciences, Pushchino, Moscow Region, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101498671","display_name":"\u0422. \u0412. \u0428\u0435\u0432\u0447\u0443\u043a","orcid":"https://orcid.org/0000-0003-3859-0264","observed_orcids":["https://orcid.org/0000-0003-3859-0264"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"T. V. Shevchuk","raw_affiliation_strings":["Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Pushchino Branch, Russian Academy of Sciences, Pushchino, 142290, Moscow Region, Russia","Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Pushchino Branch, Russian Academy of Sciences, Pushchino, Moscow Region, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Pushchino Branch, Russian Academy of Sciences, Pushchino, 142290, Moscow Region, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]},{"raw_affiliation_string":"Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Pushchino Branch, Russian Academy of Sciences, Pushchino, Moscow Region, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5113479722"],"corresponding_institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"],"apc_list":null,"apc_paid":null,"fwci":1.2797,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.79653393,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"69","issue":"3","first_page":"340","last_page":"349"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.5532000064849854,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.5532000064849854,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.4147999882698059,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcitonin-gene","display_name":"calcitonin gene","score":0.968999981880188},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/cpg-hypermethylation","display_name":"CpG hypermethylation","score":0.949999988079071},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.7570000290870667},{"id":"https://openalex.org/keywords/myeloid-leukemia","display_name":"myeloid leukemia","score":0.9480000138282776},{"id":"https://openalex.org/keywords/lymphoid-leukemia","display_name":"lymphoid leukemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/molecular-relapse","display_name":"molecular relapse","score":0.6000000238418579},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7770000100135803},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.6940000057220459},{"id":"https://openalex.org/keywords/hematological-remission","display_name":"hematologic remission","score":0.8949999809265137},{"id":"https://openalex.org/keywords/dna-methylation-patterns","display_name":"DNA methylation patterns","score":0.47699999809265137}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7768232226371765},{"id":"https://openalex.org/C2779627488","wikidata":"https://www.wikidata.org/wiki/Q315860","display_name":"Calcitonin","level":2,"score":0.6709818840026855},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6580508351325989},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.6068841814994812},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5474985837936401},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5159045457839966},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.470303475856781},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4342687129974365},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4189292788505554},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3149840235710144},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28922250866889954},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18573841452598572},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1523037552833557}],"mesh":[{"descriptor_ui":"D002116","descriptor_name":"Calcitonin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018365","descriptor_name":"Neoplasm, Residual","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024506","descriptor_name":"5' Flanking Region","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1023/b:biry.0000022067.63532.b8","doi":"https://doi.org/10.1023/b:biry.0000022067.63532.b8","is_oa":false,"landing_page_url":"https://doi.org/10.1023/b:biry.0000022067.63532.b8","pdf_url":null,"source":{"id":"https://openalex.org/S71215691","display_name":"Biochemistry (Moscow)","issn_l":"0006-2979","issn":["0006-2979","0320-9725","1608-3040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry (Moscow)","raw_type":"journal-article"},{"id":"pmid:15061703","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15061703","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry. Biokhimiia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W115186932","https://openalex.org/W186495160","https://openalex.org/W1539051820","https://openalex.org/W1552528612","https://openalex.org/W1570564802","https://openalex.org/W1592505990","https://openalex.org/W1968391853","https://openalex.org/W1971617142","https://openalex.org/W1973222089","https://openalex.org/W1983826530","https://openalex.org/W1995823084","https://openalex.org/W2036566832","https://openalex.org/W2052765429","https://openalex.org/W2055604145","https://openalex.org/W2064654049","https://openalex.org/W2084118479","https://openalex.org/W2104557589","https://openalex.org/W2109408189","https://openalex.org/W2117752410","https://openalex.org/W2144634347","https://openalex.org/W2166075028","https://openalex.org/W2167892931","https://openalex.org/W2396892382","https://openalex.org/W2956108462","https://openalex.org/W4248754259"],"related_works":["https://openalex.org/W2003995954","https://openalex.org/W2956108462","https://openalex.org/W2403033557","https://openalex.org/W1995823084","https://openalex.org/W115186932","https://openalex.org/W2396892382","https://openalex.org/W1570564802","https://openalex.org/W2065050283","https://openalex.org/W2085578219","https://openalex.org/W2365361026"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
