{"id":"https://openalex.org/W2018289980","doi":"https://doi.org/10.1042/bj20050494","title":"Expression of UCP3 in CHO cells does not cause uncoupling, but controls mitochondrial activity in the presence of glucose","display_name":"Expression of UCP3 in CHO cells does not cause uncoupling, but controls mitochondrial activity in the presence of glucose","publication_year":2005,"publication_date":"2005-12-12","ids":{"openalex":"https://openalex.org/W2018289980","doi":"https://doi.org/10.1042/bj20050494","mag":"2018289980","pmid":"https://pubmed.ncbi.nlm.nih.gov/16178820","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1383702"},"language":"en","primary_location":{"id":"doi:10.1042/bj20050494","doi":"https://doi.org/10.1042/bj20050494","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20050494","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1383702","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017435110","display_name":"Julien Mozo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Julien Mozo","raw_affiliation_strings":["BIOTRAM (Transporteurs Mitochondriaux et M\u00e9tabolisme) CNRS UPR9078, Facult\u00e9 de M\u00e9decine Ren\u00e9 Descartes Paris 5, site Necker, 156 rue de Vaugirard 75730 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOTRAM (Transporteurs Mitochondriaux et M\u00e9tabolisme) CNRS UPR9078, Facult\u00e9 de M\u00e9decine Ren\u00e9 Descartes Paris 5, site Necker, 156 rue de Vaugirard 75730 Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387156284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004962594","display_name":"Gilles Ferry","orcid":"https://orcid.org/0000-0003-0689-7923","observed_orcids":["https://orcid.org/0000-0003-0689-7923"]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gilles Ferry","raw_affiliation_strings":["Institut de Recherches Servier, 125 chemin de Ronde, 78290 Croissy-sur-Seine, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherches Servier, 125 chemin de Ronde, 78290 Croissy-sur-Seine, France","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057221466","display_name":"Aur\u00e9lie Stud\u00e9ny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Aur\u00e9lie Studeny","raw_affiliation_strings":["Institut de Recherches Servier, 125 chemin de Ronde, 78290 Croissy-sur-Seine, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherches Servier, 125 chemin de Ronde, 78290 Croissy-sur-Seine, France","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035489054","display_name":"Claire Pecqueur","orcid":"https://orcid.org/0000-0002-7612-1672","observed_orcids":["https://orcid.org/0000-0002-7612-1672"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Claire Pecqueur","raw_affiliation_strings":["BIOTRAM (Transporteurs Mitochondriaux et M\u00e9tabolisme) CNRS UPR9078, Facult\u00e9 de M\u00e9decine Ren\u00e9 Descartes Paris 5, site Necker, 156 rue de Vaugirard 75730 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOTRAM (Transporteurs Mitochondriaux et M\u00e9tabolisme) CNRS UPR9078, Facult\u00e9 de M\u00e9decine Ren\u00e9 Descartes Paris 5, site Necker, 156 rue de Vaugirard 75730 Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387156284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087399727","display_name":"Marianne Rodriguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marianne Rodriguez","raw_affiliation_strings":["Institut de Recherches Servier, 125 chemin de Ronde, 78290 Croissy-sur-Seine, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherches Servier, 125 chemin de Ronde, 78290 Croissy-sur-Seine, France","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021383328","display_name":"Jean Albert Boutin","orcid":"https://orcid.org/0000-0003-0068-7204","observed_orcids":["https://orcid.org/0000-0003-0068-7204"]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean\u00a0A. Boutin","raw_affiliation_strings":["Institut de Recherches Servier, 125 chemin de Ronde, 78290 Croissy-sur-Seine, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherches Servier, 125 chemin de Ronde, 78290 Croissy-sur-Seine, France","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004962893","display_name":"Fr\u00e9d\u00e9ric Bouillaud","orcid":"https://orcid.org/0000-0002-7518-9237","observed_orcids":["https://orcid.org/0000-0002-7518-9237"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9ric Bouillaud","raw_affiliation_strings":["BIOTRAM (Transporteurs Mitochondriaux et M\u00e9tabolisme) CNRS UPR9078, Facult\u00e9 de M\u00e9decine Ren\u00e9 Descartes Paris 5, site Necker, 156 rue de Vaugirard 75730 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOTRAM (Transporteurs Mitochondriaux et M\u00e9tabolisme) CNRS UPR9078, Facult\u00e9 de M\u00e9decine Ren\u00e9 Descartes Paris 5, site Necker, 156 rue de Vaugirard 75730 Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387156284"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017435110","https://openalex.org/A5035489054"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387156284"],"apc_list":null,"apc_paid":null,"fwci":2.3746,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.8860616,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"393","issue":"1","first_page":"431","last_page":"439"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ucp3","display_name":"UCP3","score":0.8500000238418579},{"id":"https://openalex.org/keywords/ucp1","display_name":"UCP1","score":0.9049999713897705},{"id":"https://openalex.org/keywords/ucp2","display_name":"UCP2","score":0.7919999957084656},{"id":"https://openalex.org/keywords/mitochondrial-uncoupling","display_name":"mitochondrial uncoupling","score":0.8889999985694885},{"id":"https://openalex.org/keywords/proton-transport","display_name":"proton transport","score":0.7879999876022339},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.6700000166893005},{"id":"https://openalex.org/keywords/oligomycin","display_name":"oligomycin","score":0.7409999966621399},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.9369999766349792},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.7160000205039978},{"id":"https://openalex.org/keywords/mitochondrial-superoxide","display_name":"mitochondrial superoxide","score":0.5740000009536743},{"id":"https://openalex.org/keywords/pyruvate-transport","display_name":"pyruvate transport","score":0.8899999856948853},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.6959999799728394},{"id":"https://openalex.org/keywords/atp-production","display_name":"ATP production","score":0.492000013589859},{"id":"https://openalex.org/keywords/cho-cells","display_name":"CHO cells","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C2779299233","wikidata":"https://www.wikidata.org/wiki/Q7864100","display_name":"UCP3","level":5,"score":0.9663508534431458},{"id":"https://openalex.org/C2779406938","wikidata":"https://www.wikidata.org/wiki/Q24720289","display_name":"Uncoupling protein","level":4,"score":0.863675594329834},{"id":"https://openalex.org/C2779134199","wikidata":"https://www.wikidata.org/wiki/Q1076381","display_name":"Oligomycin","level":4,"score":0.6854839324951172},{"id":"https://openalex.org/C81979416","wikidata":"https://www.wikidata.org/wiki/Q419493","display_name":"Thermogenin","level":4,"score":0.6546295881271362},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5929359197616577},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5806901454925537},{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.504731297492981},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5043414831161499},{"id":"https://openalex.org/C151279926","wikidata":"https://www.wikidata.org/wiki/Q965695","display_name":"Thermogenesis","level":3,"score":0.4702547788619995},{"id":"https://openalex.org/C112243037","wikidata":"https://www.wikidata.org/wiki/Q22327117","display_name":"ATP synthase","level":3,"score":0.462270587682724},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.4315034747123718},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.42697668075561523},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39969998598098755},{"id":"https://openalex.org/C2780642333","wikidata":"https://www.wikidata.org/wiki/Q901269","display_name":"Brown adipose tissue","level":3,"score":0.26587581634521484},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.212193101644516},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.10820302367210388},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08429431915283203},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.08318087458610535},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071247","descriptor_name":"Uncoupling Protein 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071256","descriptor_name":"Uncoupling Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009840","descriptor_name":"Oligomycins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014475","descriptor_name":"Uncoupling Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1042/bj20050494","doi":"https://doi.org/10.1042/bj20050494","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20050494","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1383702","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1383702","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:16178820","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16178820","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-00136148v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00136148","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochemical Journal, 2006, 393 (Pt 1), pp.431-9. ⟨10.1042/BJ20050494⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1383702","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1383702","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W99927065","https://openalex.org/W331117150","https://openalex.org/W1503600099","https://openalex.org/W1523078511","https://openalex.org/W1557140781","https://openalex.org/W1594539479","https://openalex.org/W1849928642","https://openalex.org/W1900866157","https://openalex.org/W1911339081","https://openalex.org/W1969152810","https://openalex.org/W1975323382","https://openalex.org/W1978776261","https://openalex.org/W1979526053","https://openalex.org/W1980608195","https://openalex.org/W1981258844","https://openalex.org/W1981783025","https://openalex.org/W1983729336","https://openalex.org/W1983872288","https://openalex.org/W1986003236","https://openalex.org/W1986399270","https://openalex.org/W1987695736","https://openalex.org/W2008172969","https://openalex.org/W2017431702","https://openalex.org/W2025664849","https://openalex.org/W2027059985","https://openalex.org/W2027687342","https://openalex.org/W2028132430","https://openalex.org/W2032814494","https://openalex.org/W2036573181","https://openalex.org/W2040780517","https://openalex.org/W2045838525","https://openalex.org/W2053260773","https://openalex.org/W2055191740","https://openalex.org/W2057498089","https://openalex.org/W2065646103","https://openalex.org/W2071437082","https://openalex.org/W2077523167","https://openalex.org/W2081562544","https://openalex.org/W2081961922","https://openalex.org/W2083385526","https://openalex.org/W2100151397","https://openalex.org/W2112821460","https://openalex.org/W2128569391","https://openalex.org/W2132358997","https://openalex.org/W2136689463","https://openalex.org/W2141950542","https://openalex.org/W2147128975","https://openalex.org/W2152286327","https://openalex.org/W2154682611","https://openalex.org/W2156172044","https://openalex.org/W2165343587","https://openalex.org/W2168456227","https://openalex.org/W2417201701"],"related_works":["https://openalex.org/W2044042557","https://openalex.org/W4238499171","https://openalex.org/W4245389374","https://openalex.org/W2018720754","https://openalex.org/W2796845031","https://openalex.org/W1984856445","https://openalex.org/W2020410746","https://openalex.org/W2104645520","https://openalex.org/W2025664849","https://openalex.org/W2027059985"],"abstract_inverted_index":{"The":[0,13,53],"proton-transport":[1],"activity":[2],"of":[3,16,32,59,63,70,76,83,93,96,134,137,150,166],"UCP1":[4],"(uncoupling":[5],"protein":[6],"1)":[7],"triggers":[8],"mitochondrial":[9,33,155],"uncoupling":[10],"and":[11,21,126,130],"thermogenesis.":[12],"exact":[14],"role":[15],"its":[17],"close":[18,101],"homologues,":[19],"UCP2":[20],"UCP3,":[22],"is":[23,159],"unclear.":[24],"Mounting":[25],"evidence":[26,49],"associates":[27],"them":[28],"with":[29,111,116],"the":[30,57,68,74,77,84,91,94,106,112,117,132,162],"control":[31,154],"superoxide":[34],"production.":[35],"Using":[36],"CHO":[37],"(Chinese-hamster":[38],"ovary)":[39],"cells":[40],"stably":[41],"expressing":[42],"UCP3":[43],"or":[44],"UCP1,":[45],"we":[46],"found":[47],"no":[48],"for":[50],"respiration":[51,75],"uncoupling.":[52],"explanation":[54],"lies":[55],"in":[56,105,131],"absence":[58,133],"an":[60],"appropriate":[61,135],"activator":[62],"UCP":[64],"protonophoric":[65],"function.":[66],"Accordingly,":[67],"addition":[69],"retinoic":[71],"acid":[72],"uncouples":[73],"UCP1-expressing":[78],"clone,":[79],"but":[80,146],"not":[81,142],"that":[82,153],"UCP3-expressing":[85,108],"ones.":[86],"In":[87],"a":[88],"glucose-containing":[89],"medium,":[90],"extent":[92],"hyperpolarization":[95],"mitochondria":[97,127],"by":[98,168],"oligomycin":[99],"was":[100],"to":[102],"22":[103],"mV":[104],"five":[107],"clones,":[109],"contrasting":[110],"variable":[113],"values":[114],"observed":[115],"15":[118],"controls.":[119],"Our":[120],"observations":[121],"suggest":[122],"that,":[123],"when":[124],"glycolysis":[125],"generate":[128],"ATP,":[129],"activators":[136],"proton":[138],"transport,":[139],"UCPs":[140],"do":[141],"transport":[143,165],"protons":[144],"(uncoupling),":[145],"rather":[147],"other":[148],"ions":[149],"physiological":[151],"relevance":[152],"activity.":[156],"A":[157],"model":[158],"proposed":[160],"using":[161],"known":[163],"passive":[164],"pyruvate":[167],"UCP1.":[169]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}