{"id":"https://openalex.org/W2018253255","doi":"https://doi.org/10.1021/np970507w","title":"Macrocyclic Diterpenoids from Euphorbia semiperfoliata","display_name":"Macrocyclic Diterpenoids from Euphorbia semiperfoliata","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W2018253255","doi":"https://doi.org/10.1021/np970507w","mag":"2018253255","pmid":"https://pubmed.ncbi.nlm.nih.gov/9644058"},"language":"he","primary_location":{"id":"doi:10.1021/np970507w","doi":"https://doi.org/10.1021/np970507w","is_oa":false,"landing_page_url":"https://doi.org/10.1021/np970507w","pdf_url":null,"source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033662911","display_name":"Giovanni Appendino","orcid":"https://orcid.org/0000-0002-4170-9919","observed_orcids":["https://orcid.org/0000-0002-4170-9919"]},"institutions":[{"id":"https://openalex.org/I4577782","display_name":"Technische Universit\u00e4t Berlin","ror":"https://ror.org/03v4gjf40","country_code":"DE","type":"education","lineage":["https://openalex.org/I4577782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Giovanni Appendino","raw_affiliation_strings":["Dipartimento di Scienza e Tecnologia del Farmaco, via Giuria 9, 10125 Torino, Italy, Institut f\u00fcr Organische Chemie, Technische Universit\u00e4t Berlin, Strasse des 17. Juni 135, 10623 Berlin, Germany, and Dipartimento di Scienze Botaniche, viale San Ignazio 13, 09123 Cagliari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienza e Tecnologia del Farmaco, via Giuria 9, 10125 Torino, Italy, Institut f\u00fcr Organische Chemie, Technische Universit\u00e4t Berlin, Strasse des 17. Juni 135, 10623 Berlin, Germany, and Dipartimento di Scienze Botaniche, viale San Ignazio 13, 09123 Cagliari, Italy","institution_ids":["https://openalex.org/I4577782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043888065","display_name":"Sven Jakupovic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4577782","display_name":"Technische Universit\u00e4t Berlin","ror":"https://ror.org/03v4gjf40","country_code":"DE","type":"education","lineage":["https://openalex.org/I4577782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sven Jakupovic","raw_affiliation_strings":["Dipartimento di Scienza e Tecnologia del Farmaco, via Giuria 9, 10125 Torino, Italy, Institut f\u00fcr Organische Chemie, Technische Universit\u00e4t Berlin, Strasse des 17. Juni 135, 10623 Berlin, Germany, and Dipartimento di Scienze Botaniche, viale San Ignazio 13, 09123 Cagliari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienza e Tecnologia del Farmaco, via Giuria 9, 10125 Torino, Italy, Institut f\u00fcr Organische Chemie, Technische Universit\u00e4t Berlin, Strasse des 17. Juni 135, 10623 Berlin, Germany, and Dipartimento di Scienze Botaniche, viale San Ignazio 13, 09123 Cagliari, Italy","institution_ids":["https://openalex.org/I4577782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090528914","display_name":"Gian Cesare Tron","orcid":"https://orcid.org/0000-0002-2394-400X","observed_orcids":["https://orcid.org/0000-0002-2394-400X"]},"institutions":[{"id":"https://openalex.org/I4577782","display_name":"Technische Universit\u00e4t Berlin","ror":"https://ror.org/03v4gjf40","country_code":"DE","type":"education","lineage":["https://openalex.org/I4577782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gian Cesare Tron","raw_affiliation_strings":["Dipartimento di Scienza e Tecnologia del Farmaco, via Giuria 9, 10125 Torino, Italy, Institut f\u00fcr Organische Chemie, Technische Universit\u00e4t Berlin, Strasse des 17. Juni 135, 10623 Berlin, Germany, and Dipartimento di Scienze Botaniche, viale San Ignazio 13, 09123 Cagliari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienza e Tecnologia del Farmaco, via Giuria 9, 10125 Torino, Italy, Institut f\u00fcr Organische Chemie, Technische Universit\u00e4t Berlin, Strasse des 17. Juni 135, 10623 Berlin, Germany, and Dipartimento di Scienze Botaniche, viale San Ignazio 13, 09123 Cagliari, Italy","institution_ids":["https://openalex.org/I4577782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032939799","display_name":"Jasmin Jakupovic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4577782","display_name":"Technische Universit\u00e4t Berlin","ror":"https://ror.org/03v4gjf40","country_code":"DE","type":"education","lineage":["https://openalex.org/I4577782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jasmin Jakupovic","raw_affiliation_strings":["Dipartimento di Scienza e Tecnologia del Farmaco, via Giuria 9, 10125 Torino, Italy, Institut f\u00fcr Organische Chemie, Technische Universit\u00e4t Berlin, Strasse des 17. Juni 135, 10623 Berlin, Germany, and Dipartimento di Scienze Botaniche, viale San Ignazio 13, 09123 Cagliari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienza e Tecnologia del Farmaco, via Giuria 9, 10125 Torino, Italy, Institut f\u00fcr Organische Chemie, Technische Universit\u00e4t Berlin, Strasse des 17. Juni 135, 10623 Berlin, Germany, and Dipartimento di Scienze Botaniche, viale San Ignazio 13, 09123 Cagliari, Italy","institution_ids":["https://openalex.org/I4577782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006377067","display_name":"Veronique Milon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4577782","display_name":"Technische Universit\u00e4t Berlin","ror":"https://ror.org/03v4gjf40","country_code":"DE","type":"education","lineage":["https://openalex.org/I4577782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Veronique Milon","raw_affiliation_strings":["Dipartimento di Scienza e Tecnologia del Farmaco, via Giuria 9, 10125 Torino, Italy, Institut f\u00fcr Organische Chemie, Technische Universit\u00e4t Berlin, Strasse des 17. Juni 135, 10623 Berlin, Germany, and Dipartimento di Scienze Botaniche, viale San Ignazio 13, 09123 Cagliari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienza e Tecnologia del Farmaco, via Giuria 9, 10125 Torino, Italy, Institut f\u00fcr Organische Chemie, Technische Universit\u00e4t Berlin, Strasse des 17. Juni 135, 10623 Berlin, Germany, and Dipartimento di Scienze Botaniche, viale San Ignazio 13, 09123 Cagliari, Italy","institution_ids":["https://openalex.org/I4577782"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047352524","display_name":"Mauro Ballero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4577782","display_name":"Technische Universit\u00e4t Berlin","ror":"https://ror.org/03v4gjf40","country_code":"DE","type":"education","lineage":["https://openalex.org/I4577782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mauro Ballero","raw_affiliation_strings":["Dipartimento di Scienza e Tecnologia del Farmaco, via Giuria 9, 10125 Torino, Italy, Institut f\u00fcr Organische Chemie, Technische Universit\u00e4t Berlin, Strasse des 17. Juni 135, 10623 Berlin, Germany, and Dipartimento di Scienze Botaniche, viale San Ignazio 13, 09123 Cagliari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienza e Tecnologia del Farmaco, via Giuria 9, 10125 Torino, Italy, Institut f\u00fcr Organische Chemie, Technische Universit\u00e4t Berlin, Strasse des 17. Juni 135, 10623 Berlin, Germany, and Dipartimento di Scienze Botaniche, viale San Ignazio 13, 09123 Cagliari, Italy","institution_ids":["https://openalex.org/I4577782"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4577782"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.3094,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.86380408,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"61","issue":"6","first_page":"749","last_page":"756"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12530","display_name":"Bioactive Natural Diterpenoids Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12530","display_name":"Bioactive Natural Diterpenoids Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13221","display_name":"Biological Activity of Diterpenoids and Biflavonoids","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrocyclic-diterpenoids","display_name":"macrocyclic diterpenoids","score":0.984000027179718},{"id":"https://openalex.org/keywords/spurge","display_name":"spurge","score":0.6159999966621399},{"id":"https://openalex.org/keywords/natural-product-isolation","display_name":"natural product isolation","score":0.6890000104904175},{"id":"https://openalex.org/keywords/conformational-analysis","display_name":"conformational analysis","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C2776710815","wikidata":"https://www.wikidata.org/wiki/Q59447","display_name":"Diterpene","level":2,"score":0.756653904914856},{"id":"https://openalex.org/C2994471683","wikidata":"https://www.wikidata.org/wiki/Q899274","display_name":"Carbon skeleton","level":2,"score":0.702229380607605},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6209040284156799},{"id":"https://openalex.org/C2779880300","wikidata":"https://www.wikidata.org/wiki/Q146567","display_name":"Euphorbia","level":2,"score":0.6024917364120483},{"id":"https://openalex.org/C2779047212","wikidata":"https://www.wikidata.org/wiki/Q156584","display_name":"Euphorbiaceae","level":2,"score":0.5511656403541565},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.5137782692909241},{"id":"https://openalex.org/C206103511","wikidata":"https://www.wikidata.org/wiki/Q426694","display_name":"Terpenoid","level":2,"score":0.4652844965457916},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44449272751808167},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.282077431678772},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1860172152519226},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.09805795550346375},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002240","descriptor_name":"Carbohydrate Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004224","descriptor_name":"Diterpenes","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013055","descriptor_name":"Spectrophotometry, Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019665","descriptor_name":"Euphorbiaceae","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/np970507w","doi":"https://doi.org/10.1021/np970507w","is_oa":false,"landing_page_url":"https://doi.org/10.1021/np970507w","pdf_url":null,"source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},{"id":"pmid:9644058","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9644058","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of natural products","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unica.it:11584/1595","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11584/1595","pdf_url":null,"source":{"id":"https://openalex.org/S4377196293","display_name":"UNICA IRIS Institutional Research Information System (University of Cagliari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172446870","host_organization_name":"University of Cagliari","host_organization_lineage":["https://openalex.org/I172446870"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1526242994","https://openalex.org/W1595898087","https://openalex.org/W1979458469","https://openalex.org/W1993458330","https://openalex.org/W2008030563","https://openalex.org/W2069229352","https://openalex.org/W2074943254","https://openalex.org/W2080163621","https://openalex.org/W2518052723","https://openalex.org/W2617069272"],"related_works":["https://openalex.org/W2074943254","https://openalex.org/W2128926458","https://openalex.org/W2985712891","https://openalex.org/W2034655596","https://openalex.org/W2086458408","https://openalex.org/W2465763772","https://openalex.org/W2202606736","https://openalex.org/W2205813066","https://openalex.org/W2018349143","https://openalex.org/W2022049747"],"abstract_inverted_index":{"In":[0],"addition":[1],"to":[2],"known":[3],"compounds,":[4],"the":[5,50,70],"aerial":[6],"parts":[7],"of":[8,29,54,64,80],"E.":[9,75],"semiperfoliata":[10,76],"afforded":[11],"an":[12],"abietanolide":[13],"(3),":[14],"13":[15],"jatrophane":[16],"polyesters":[17],"(4-9,":[18],"12,":[19],"14-19),":[20],"two":[21],"4-deoxyphorbol":[22],"diesters":[23],"(23,":[24],"24),":[25],"and":[26,49],"a":[27,35,77],"pair":[28],"epimeric":[30],"diterpenes":[31],"(21,":[32],"22)":[33],"with":[34],"novel":[36],"carbon":[37],"skeleton,":[38],"which":[39],"was":[40,67],"named":[41],"euphoperfoliane.":[42],"Structures":[43],"were":[44],"determined":[45],"by":[46],"spectroscopic":[47],"analysis,":[48],"main":[51],"conformational":[52],"features":[53],"jatropha-6(17),11-dienes":[55],"are":[56],"discussed":[57],"in":[58],"detail.":[59],"The":[60],"obtained":[61],"isolation":[62],"yield":[63],"several":[65],"jatrophanes":[66],"unprecedented":[68],"within":[69],"spurges":[71],"(Euphorbia":[72],"spp.),":[73],"making":[74],"unique":[78],"source":[79],"macrocyclic":[81],"diterpenoids.":[82]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}