{"id":"https://openalex.org/W2018247411","doi":null,"title":"The analgesic and anticonvulsant effects of piperine in mice.","display_name":"The analgesic and anticonvulsant effects of piperine in mice.","publication_year":2013,"publication_date":"2013-12-01","ids":{"openalex":"https://openalex.org/W2018247411","mag":"2018247411","pmid":"https://pubmed.ncbi.nlm.nih.gov/24388894"},"language":"en","primary_location":{"id":"pmid:24388894","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24388894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051065508","display_name":"Ishfaq Ali Bukhari","orcid":"https://orcid.org/0000-0002-5671-2395","observed_orcids":["https://orcid.org/0000-0002-5671-2395"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"I A Bukhari","raw_affiliation_strings":["Department of Physiology, Pharmacology Unit, College of Medicine, King Saud University, Riyadh, Saudi Arabia. iabukhari@ksu.edu.sa","Department of Physiology, Pharmacology Unit, College of Medicine, King Saud University, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Pharmacology Unit, College of Medicine, King Saud University, Riyadh, Saudi Arabia. iabukhari@ksu.edu.sa","institution_ids":["https://openalex.org/I28022161"]},{"raw_affiliation_string":"Department of Physiology, Pharmacology Unit, College of Medicine, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005465511","display_name":"Nela Pivac","orcid":"https://orcid.org/0000-0003-3591-4868","observed_orcids":["https://orcid.org/0000-0003-3591-4868"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Pivac","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M S Alhumayyd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M S Alhumayyd","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024349400","display_name":"Abdul Latif Mahesar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A L Mahesar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5078608805","display_name":"Anwarul Hassan Gilani","orcid":"https://orcid.org/0000-0001-6477-2227","observed_orcids":["https://orcid.org/0000-0001-6477-2227"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A H Gilani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1124,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.84293359,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"64","issue":"6","first_page":"789","last_page":"94"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13037","display_name":"Piperaceae Chemical and Biological Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13037","display_name":"Piperaceae Chemical and Biological Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/piperine","display_name":"piperine","score":1.0},{"id":"https://openalex.org/keywords/black-pepper","display_name":"black pepper","score":0.9879999756813049},{"id":"https://openalex.org/keywords/analgesic-activity","display_name":"analgesic activity","score":0.8600000143051147},{"id":"https://openalex.org/keywords/anticonvulsant-activity","display_name":"anticonvulsant activity","score":0.996999979019165},{"id":"https://openalex.org/keywords/acetic-acid-writhing-test","display_name":"acetic acid-induced writhing","score":0.9449999928474426},{"id":"https://openalex.org/keywords/tail-flick-test","display_name":"tail-flick test","score":0.7689999938011169},{"id":"https://openalex.org/keywords/pentylenetetrazole-induced-seizures","display_name":"pentylenetetrazole-induced seizures","score":0.9670000076293945},{"id":"https://openalex.org/keywords/picrotoxin-induced-seizures","display_name":"picrotoxin-induced seizures","score":0.9879999756813049},{"id":"https://openalex.org/keywords/opioid-pathway","display_name":"opioid pathway","score":0.6060000061988831},{"id":"https://openalex.org/keywords/gabaergic-pathway","display_name":"GABAergic pathway","score":0.9869999885559082},{"id":"https://openalex.org/keywords/naloxone-reversal","display_name":"naloxone reversal","score":0.8730000257492065},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.460999995470047},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.6769999861717224},{"id":"https://openalex.org/keywords/pain","display_name":"pain","score":0.9399999976158142}],"concepts":[{"id":"https://openalex.org/C2780133158","wikidata":"https://www.wikidata.org/wiki/Q414501","display_name":"Piperine","level":2,"score":0.9746532440185547},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7681874632835388},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.7303507328033447},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6976893544197083},{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.6142100691795349},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.5935593247413635},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.5124149918556213},{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.4875020682811737},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22105970978736877},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.1722675859928131},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13336503505706787},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09044986963272095},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009270","descriptor_name":"Naloxone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009292","descriptor_name":"Narcotic Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010433","descriptor_name":"Pentylenetetrazole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010852","descriptor_name":"Picrotoxin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019342","descriptor_name":"Acetic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029222","descriptor_name":"Piper nigrum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052117","descriptor_name":"Benzodioxoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D053284","descriptor_name":"Polyunsaturated Alkamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:24388894","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24388894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},{"id":"pmh:oai:ecommons.aku.edu:pakistan_fhs_mc_bbs-1170","doi":null,"is_oa":false,"landing_page_url":"https://ecommons.aku.edu/pakistan_fhs_mc_bbs/171","pdf_url":null,"source":{"id":"https://openalex.org/S4377196301","display_name":"eCommons - AKU (Aga Khan University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118185606","host_organization_name":"Aga Khan University","host_organization_lineage":["https://openalex.org/I118185606"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Biological & Biomedical Sciences","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W119002651","https://openalex.org/W1152299788","https://openalex.org/W1965657519","https://openalex.org/W1970703479","https://openalex.org/W1980782557","https://openalex.org/W1982200255","https://openalex.org/W1988491813","https://openalex.org/W1994089027","https://openalex.org/W1999594077","https://openalex.org/W2003575206","https://openalex.org/W2010248759","https://openalex.org/W2020613944","https://openalex.org/W2028622457","https://openalex.org/W2032654952","https://openalex.org/W2038331446","https://openalex.org/W2043433989","https://openalex.org/W2045831821","https://openalex.org/W2050627849","https://openalex.org/W2060046818","https://openalex.org/W2065234222","https://openalex.org/W2066229966","https://openalex.org/W2071050539","https://openalex.org/W2075524775","https://openalex.org/W2076305091","https://openalex.org/W2085809725","https://openalex.org/W2087728768","https://openalex.org/W2090960741","https://openalex.org/W2092208252","https://openalex.org/W2097828712","https://openalex.org/W2118265985","https://openalex.org/W2155286629","https://openalex.org/W2255182761","https://openalex.org/W2278365557","https://openalex.org/W2419257910","https://openalex.org/W2527257106"],"related_works":["https://openalex.org/W2567356446","https://openalex.org/W1994089027","https://openalex.org/W7223455926","https://openalex.org/W4399997723","https://openalex.org/W2001114003","https://openalex.org/W119002651","https://openalex.org/W2381646459","https://openalex.org/W4401856519","https://openalex.org/W7099805550","https://openalex.org/W2073707173"],"abstract_inverted_index":{"Piperine,":[0],"is":[1],"the":[2,24,34,84,92,100,121,135,144,175,204,215],"major":[3],"active":[4],"principal":[5],"of":[6,26,41,50,74,94,124,127,138,177,207,218],"black":[7,12,208,219],"pepper.":[8],"In":[9,99],"traditional":[10],"medicine,":[11],"pepper":[13,220],"has":[14],"been":[15],"used":[16],"as":[17],"an":[18],"analgesic,":[19],"anti-inflammatory":[20],"agent":[21],"and":[22,38,47,65,78,106,110,141,151,155,167,190,197,223],"in":[23,35,43,54,88,120,143,181,214,221],"treatment":[25],"epilepsy.":[27,224],"This":[28],"study":[29],"was":[30],"conducted":[31],"to":[32,91],"evaluate":[33],"vivo":[36],"analgesic":[37,46,136,189],"anticonvulsant":[39,48,191],"effects":[40,49,137,192],"piperine":[42,51,75,104,140,187,202],"mice.":[44,125,182],"The":[45,70],"were":[52],"studied":[53],"mice":[55],"using":[56],"acetic":[57,85],"acid-induced":[58,86],"writhing,":[59],"tail":[60,101,145],"flick":[61,102,146],"assay,":[62,103],"pentylenetetrazole":[63],"(PTZ)-":[64],"picrotoxin":[66],"(PIC)-induced":[67],"seizures":[68,180],"models.":[69],"intraperitoneal":[71],"(i.p.)":[72],"administration":[73],"(30,":[76,149],"50":[77,107,150],"70":[79,152],"mg/kg)":[80],"significantly":[81,172],"inhibited":[82],"(P<0.01)":[83,119,173],"writhing":[87],"mice,":[89],"similar":[90],"effect":[93],"indomethacin":[95],"(20":[96],"mg/kg":[97,132],"i.p.).":[98],"(30":[105,164],"mg/kg,":[108,113,153,161,165,170],"i.p.)":[109,114,154,166,171],"morphine":[111,142],"(5":[112,131],"caused":[115],"a":[116],"significant":[117],"increase":[118],"reaction":[122],"time":[123],"Pre-treatment":[126],"animals":[128],"with":[129],"naloxone":[130],"i.p.),":[133,162],"reversed":[134],"both":[139],"assay.":[147],"Piperine":[148],"standard":[156],"drugs,":[157],"valproic":[158],"acid":[159],"(200":[160],"carbamazepine":[163],"diazepam":[168],"(1":[169],"delayed":[174],"onset":[176],"PTZ-and":[178],"PIC-induced":[179],"These":[183],"findings":[184],"indicate":[185],"that":[186],"exhibits":[188],"possibly":[193],"mediated":[194],"via":[195],"opioid":[196],"GABA-ergic":[198],"pathways":[199],"respectively.":[200],"Moreover,":[201],"being":[203],"main":[205],"constituent":[206],"pepper,":[209],"may":[210],"be":[211],"contributing":[212],"factor":[213],"medicinal":[216],"uses":[217],"pain":[222]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-10-10T00:00:00"}
