{"id":"https://openalex.org/W2018244383","doi":"https://doi.org/10.1016/s0006-2952(98)00184-1","title":"Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action","display_name":"Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action","publication_year":1998,"publication_date":"1998-11-01","ids":{"openalex":"https://openalex.org/W2018244383","doi":"https://doi.org/10.1016/s0006-2952(98)00184-1","mag":"2018244383","pmid":"https://pubmed.ncbi.nlm.nih.gov/9825729"},"language":"en","primary_location":{"id":"doi:10.1016/s0006-2952(98)00184-1","doi":"https://doi.org/10.1016/s0006-2952(98)00184-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0006-2952(98)00184-1","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109096568","display_name":"Hagai Ginsburg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Hagai Ginsburg","raw_affiliation_strings":["Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Israel. HAGAI@VMS.HUJI.AC.IL","Department of Biological Chemistry, Institute of life Sciences, The Hebrew University of Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Israel. HAGAI@VMS.HUJI.AC.IL","institution_ids":["https://openalex.org/I197251160"]},{"raw_affiliation_string":"Department of Biological Chemistry, Institute of life Sciences, The Hebrew University of Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034625765","display_name":"Oleg Famin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Oleg Famin","raw_affiliation_strings":["Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel","Dept. of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel","institution_ids":["https://openalex.org/I197251160"]},{"raw_affiliation_string":"Dept. of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100444673","display_name":"Jianmin Zhang","orcid":"https://orcid.org/0000-0003-2141-6438","observed_orcids":["https://orcid.org/0000-0003-2141-6438"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Jianmin Zhang","raw_affiliation_strings":["Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel","Dept. of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel","institution_ids":["https://openalex.org/I197251160"]},{"raw_affiliation_string":"Dept. of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016743785","display_name":"Miriam Krugliak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Miriam Krugliak","raw_affiliation_strings":["Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel","Dept. of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel","institution_ids":["https://openalex.org/I197251160"]},{"raw_affiliation_string":"Dept. of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel","institution_ids":["https://openalex.org/I197251160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109096568"],"corresponding_institution_ids":["https://openalex.org/I197251160"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":17.5634,"has_fulltext":false,"cited_by_count":296,"citation_normalized_percentile":{"value":0.99331122,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"56","issue":"10","first_page":"1305","last_page":"1313"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chloroquine","display_name":"chloroquine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/amodiaquine","display_name":"amodiaquine","score":1.0},{"id":"https://openalex.org/keywords/heme-degradation","display_name":"heme degradation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9750000238418579},{"id":"https://openalex.org/keywords/hemozoin","display_name":"hemozoin","score":0.8100000023841858},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9700000286102295},{"id":"https://openalex.org/keywords/food-vacuoles","display_name":"food vacuoles","score":0.847000002861023},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7250000238418579},{"id":"https://openalex.org/keywords/trophozoite-stage","display_name":"trophozoite stage","score":0.7009999752044678},{"id":"https://openalex.org/keywords/heme-polymerization-inhibition","display_name":"heme polymerization inhibition","score":0.5189999938011169},{"id":"https://openalex.org/keywords/ion-homeostasis","display_name":"ion homeostasis","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C2776028358","wikidata":"https://www.wikidata.org/wiki/Q3144960","display_name":"Hemozoin","level":4,"score":0.9497644305229187},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.8927862644195557},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.738017201423645},{"id":"https://openalex.org/C2777425658","wikidata":"https://www.wikidata.org/wiki/Q422438","display_name":"Chloroquine","level":3,"score":0.6984909176826477},{"id":"https://openalex.org/C102568950","wikidata":"https://www.wikidata.org/wiki/Q127702","display_name":"Vacuole","level":3,"score":0.6983814835548401},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6590026021003723},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.6503620743751526},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44874921441078186},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.42690223455429077},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.425459086894989},{"id":"https://openalex.org/C125996951","wikidata":"https://www.wikidata.org/wiki/Q412234","display_name":"Globin","level":3,"score":0.414485901594162},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.3646233379840851},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.16772115230560303},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09574884176254272},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.07386428117752075},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.07282289862632751}],"mesh":[{"descriptor_ui":"D000655","descriptor_name":"Amodiaquine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002738","descriptor_name":"Chloroquine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0006-2952(98)00184-1","doi":"https://doi.org/10.1016/s0006-2952(98)00184-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0006-2952(98)00184-1","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},{"id":"pmid:9825729","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9825729","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W350698477","https://openalex.org/W1199623702","https://openalex.org/W1507958108","https://openalex.org/W1542749189","https://openalex.org/W1595362376","https://openalex.org/W1678977486","https://openalex.org/W1967615486","https://openalex.org/W1976954116","https://openalex.org/W1979046507","https://openalex.org/W1982416157","https://openalex.org/W1982454265","https://openalex.org/W1990357292","https://openalex.org/W1997554053","https://openalex.org/W1998835931","https://openalex.org/W2001455540","https://openalex.org/W2003590875","https://openalex.org/W2004261618","https://openalex.org/W2005772768","https://openalex.org/W2006250595","https://openalex.org/W2007416146","https://openalex.org/W2007845287","https://openalex.org/W2009503252","https://openalex.org/W2011352331","https://openalex.org/W2020216548","https://openalex.org/W2024708506","https://openalex.org/W2025765364","https://openalex.org/W2033540354","https://openalex.org/W2033907571","https://openalex.org/W2041423364","https://openalex.org/W2051690168","https://openalex.org/W2056660098","https://openalex.org/W2061962074","https://openalex.org/W2065314419","https://openalex.org/W2072349085","https://openalex.org/W2089762083","https://openalex.org/W2090395207","https://openalex.org/W2090632234","https://openalex.org/W2091471441","https://openalex.org/W2092404140","https://openalex.org/W2092604097","https://openalex.org/W2105668259","https://openalex.org/W2121356018","https://openalex.org/W2127112944","https://openalex.org/W2128378359","https://openalex.org/W2140795501","https://openalex.org/W2145241460","https://openalex.org/W2153217443","https://openalex.org/W2176557328","https://openalex.org/W2293662303","https://openalex.org/W2324948961","https://openalex.org/W2410129902","https://openalex.org/W4301423003"],"related_works":["https://openalex.org/W2076092692","https://openalex.org/W2022857214","https://openalex.org/W2086719696","https://openalex.org/W2049368235","https://openalex.org/W1971173704","https://openalex.org/W2056039473","https://openalex.org/W2114168178","https://openalex.org/W2030095784","https://openalex.org/W2016950428","https://openalex.org/W1977434858"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
