{"id":"https://openalex.org/W2018211396","doi":"https://doi.org/10.1371/journal.pone.0044828","title":"Crystal Structures of Human CaMKI\u03b1 Reveal Insights into the Regulation Mechanism of CaMKI","display_name":"Crystal Structures of Human CaMKI\u03b1 Reveal Insights into the Regulation Mechanism of CaMKI","publication_year":2012,"publication_date":"2012-09-20","ids":{"openalex":"https://openalex.org/W2018211396","doi":"https://doi.org/10.1371/journal.pone.0044828","mag":"2018211396","pmid":"https://pubmed.ncbi.nlm.nih.gov/23028635","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3447817"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0044828","doi":"https://doi.org/10.1371/journal.pone.0044828","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0044828","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0044828&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0044828&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071172448","display_name":"Manwu Zha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]},{"id":"https://openalex.org/I4391767724","display_name":"State Key Laboratory of Molecular Biology","ror":"https://ror.org/0308wzx30","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4391767724"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Manwu Zha","raw_affiliation_strings":["State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210121447","https://openalex.org/I4391767724"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101622975","display_name":"Chen Zhong","orcid":"https://orcid.org/0000-0003-2794-3247","observed_orcids":["https://orcid.org/0000-0003-2794-3247"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]},{"id":"https://openalex.org/I4391767724","display_name":"State Key Laboratory of Molecular Biology","ror":"https://ror.org/0308wzx30","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4391767724"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["CN","FI"],"is_corresponding":false,"raw_author_name":"Chen Zhong","raw_affiliation_strings":["State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China","University of Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210121447","https://openalex.org/I4391767724"]},{"raw_affiliation_string":"University of Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ying Ou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]},{"id":"https://openalex.org/I4391767724","display_name":"State Key Laboratory of Molecular Biology","ror":"https://ror.org/0308wzx30","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4391767724"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["CN","FI"],"is_corresponding":false,"raw_author_name":"Ying Ou","raw_affiliation_strings":["State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China","University of Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210121447","https://openalex.org/I4391767724"]},{"raw_affiliation_string":"University of Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100784707","display_name":"Li Han","orcid":"https://orcid.org/0000-0001-9013-8414","observed_orcids":["https://orcid.org/0000-0001-9013-8414","https://orcid.org/0009-0003-0280-5398"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]},{"id":"https://openalex.org/I4391767724","display_name":"State Key Laboratory of Molecular Biology","ror":"https://ror.org/0308wzx30","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4391767724"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["CN","FI"],"is_corresponding":false,"raw_author_name":"Li Han","raw_affiliation_strings":["State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China","University of Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210121447","https://openalex.org/I4391767724"]},{"raw_affiliation_string":"University of Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082786518","display_name":"Jianchuan Wang","orcid":"https://orcid.org/0000-0002-4632-9413","observed_orcids":["https://orcid.org/0000-0002-4632-9413"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]},{"id":"https://openalex.org/I4391767724","display_name":"State Key Laboratory of Molecular Biology","ror":"https://ror.org/0308wzx30","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4391767724"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["CN","FI"],"is_corresponding":false,"raw_author_name":"Jianchuan Wang","raw_affiliation_strings":["State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China","University of Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210121447","https://openalex.org/I4391767724"]},{"raw_affiliation_string":"University of Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112512641","display_name":"Jianping Ding","orcid":"https://orcid.org/0000-0001-7029-7346","observed_orcids":["https://orcid.org/0000-0001-7029-7346"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]},{"id":"https://openalex.org/I4391767724","display_name":"State Key Laboratory of Molecular Biology","ror":"https://ror.org/0308wzx30","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4391767724"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianping Ding","raw_affiliation_strings":["State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210121447","https://openalex.org/I4391767724"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5112512641"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210121447","https://openalex.org/I4391767724"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.21,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.4669082,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"7","issue":"9","first_page":"e44828","last_page":"e44828"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.050700001418590546,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoinhibition","display_name":"autoinhibition","score":0.6909999847412109},{"id":"https://openalex.org/keywords/activation-segment","display_name":"activation segment","score":0.9589999914169312},{"id":"https://openalex.org/keywords/atp-binding","display_name":"ATP binding","score":0.6589999794960022},{"id":"https://openalex.org/keywords/nucleotide-binding-site","display_name":"nucleotide binding site","score":0.8090000152587891},{"id":"https://openalex.org/keywords/substrate-binding-site","display_name":"substrate binding site","score":0.703000009059906},{"id":"https://openalex.org/keywords/kinase-regulation","display_name":"kinase regulation","score":0.5809999704360962},{"id":"https://openalex.org/keywords/apo-structure","display_name":"apo structure","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C29688787","wikidata":"https://www.wikidata.org/wiki/Q409145","display_name":"Calmodulin","level":3,"score":0.6181449294090271},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5938827991485596},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5736461877822876},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.5290053486824036},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.47149011492729187},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44145455956459045},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4320528507232666},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38372838497161865},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3548608720302582},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3110208809375763},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21005281805992126},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08368772268295288},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001051","descriptor_name":"Apoenzymes","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D001051","descriptor_name":"Apoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001051","descriptor_name":"Apoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001051","descriptor_name":"Apoenzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054729","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D054729","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054729","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054729","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0044828","doi":"https://doi.org/10.1371/journal.pone.0044828","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0044828","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0044828&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3447817","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3447817","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23028635","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23028635","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.815.8010","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.815.8010","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/fd/1f/pone.0044828.PMC3447817.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:e13ae3e8044e4dfb95a368d322795d02","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e13ae3e8044e4dfb95a368d322795d02","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 9, p e44828 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/119748","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/Crystal_Structures_of_Human_CaMKI_Reveal_Insights_into_the_Regulation_Mechanism_of_CaMKI/119748","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0044828","doi":"https://doi.org/10.1371/journal.pone.0044828","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0044828","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0044828&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2155292458","display_name":"\u4eba\u6e90\u9499\u8c03\u7d20\u4f9d\u8d56\u6027\u2160\u578b\u86cb\u767d\u6fc0\u9176\u7ed3\u6784\u548c\u529f\u80fd\u7684\u7814\u7a76","funder_award_id":"30800171","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"},{"id":"https://openalex.org/F4320336234","display_name":"Beijing Synchrotron Radiation Facility","ror":"https://ror.org/047phn973"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018211396.pdf","grobid_xml":"https://content.openalex.org/works/W2018211396.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W254452930","https://openalex.org/W1500240510","https://openalex.org/W1539796472","https://openalex.org/W1985744441","https://openalex.org/W1988241285","https://openalex.org/W1989492234","https://openalex.org/W1992945955","https://openalex.org/W1995017064","https://openalex.org/W1998977808","https://openalex.org/W2003635901","https://openalex.org/W2012008233","https://openalex.org/W2018802747","https://openalex.org/W2030205108","https://openalex.org/W2038840577","https://openalex.org/W2044425186","https://openalex.org/W2056106327","https://openalex.org/W2057347947","https://openalex.org/W2061874168","https://openalex.org/W2065365771","https://openalex.org/W2067405360","https://openalex.org/W2069187446","https://openalex.org/W2074112908","https://openalex.org/W2075451080","https://openalex.org/W2081704409","https://openalex.org/W2089643893","https://openalex.org/W2090020715","https://openalex.org/W2095412720","https://openalex.org/W2096039018","https://openalex.org/W2096286606","https://openalex.org/W2100794900","https://openalex.org/W2103802238","https://openalex.org/W2113939077","https://openalex.org/W2119931639","https://openalex.org/W2128307445","https://openalex.org/W2131174104","https://openalex.org/W2138072853","https://openalex.org/W2144081223","https://openalex.org/W2146605352","https://openalex.org/W2169834283"],"related_works":["https://openalex.org/W7095849642","https://openalex.org/W2057347947","https://openalex.org/W2074112908","https://openalex.org/W2023129668","https://openalex.org/W2018802747","https://openalex.org/W1500240510","https://openalex.org/W1869675653","https://openalex.org/W2956263531","https://openalex.org/W1989492234","https://openalex.org/W2012014599"],"abstract_inverted_index":{"Human":[0],"calcium/calmodulin-dependent":[1],"protein":[2],"kinase":[3],"I":[4],"(CaMKI)":[5],"plays":[6],"pivotal":[7],"roles":[8],"in":[9,41,45,73,146],"the":[10,54,65,83,91,98,112,118,122,133,136,139,143,147],"nervous":[11],"system.":[12],"The":[13],"activity":[14],"of":[15,37,135,149],"human":[16],"CaMKI":[17],"is":[18,94,115],"regulated":[19],"by":[20],"a":[21,29,58],"regulatory":[22,113,137],"region":[23,114],"including":[24],"an":[25,50,87,108,126],"autoinhibitory":[26,66],"segment":[27,56,67,93,100],"and":[28,44,71,81,97,121,142],"CaM-binding":[30,99],"segment.":[31],"We":[32],"report":[33],"here":[34],"four":[35],"structures":[36],"three":[38],"CaMKI\u03b1":[39],"truncates":[40],"apo":[42],"form":[43],"complexes":[46],"with":[47,64],"ATP.":[48],"In":[49,86,107],"apo,":[51],"autoinhibited":[52],"structure,":[53,90,111],"activation":[55,92,140],"adopts":[57],"unique":[59],"helical":[60],"conformation":[61],"which":[62],"together":[63],"constrains":[68],"helices":[69],"\u03b1C":[70],"\u03b1D":[72],"inactive":[74,89],"conformations,":[75],"sequesters":[76],"Thr177":[77],"from":[78,117],"being":[79],"phosphorylated,":[80],"occludes":[82],"substrate-binding":[84],"site.":[85],"ATP-bound,":[88,109],"largely":[95],"disordered":[96],"protrudes":[101],"out":[102],"ready":[103],"for":[104],"CaM":[105],"binding.":[106],"active":[110,127],"dissociated":[116],"catalytic":[119,123],"core":[120],"site":[124,145],"assumes":[125],"conformation.":[128],"Detailed":[129],"structural":[130],"analyses":[131],"reveal":[132],"interplay":[134],"region,":[138],"segment,":[141],"nucleotide-binding":[144],"regulation":[148],"CaMKI.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}