{"id":"https://openalex.org/W2018205338","doi":"https://doi.org/10.1016/0092-8674(80)90240-8","title":"The chromosomal arrangement of human \u03b1-like globin genes: Sequence homology and \u03b1-globin gene deletions","display_name":"The chromosomal arrangement of human \u03b1-like globin genes: Sequence homology and \u03b1-globin gene deletions","publication_year":1980,"publication_date":"1980-05-01","ids":{"openalex":"https://openalex.org/W2018205338","doi":"https://doi.org/10.1016/0092-8674(80)90240-8","mag":"2018205338","pmid":"https://pubmed.ncbi.nlm.nih.gov/6446404"},"language":"en","primary_location":{"id":"doi:10.1016/0092-8674(80)90240-8","doi":"https://doi.org/10.1016/0092-8674(80)90240-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0092-8674(80)90240-8","pdf_url":null,"source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015684868","display_name":"Joyce Lauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joyce Lauer","raw_affiliation_strings":["Division of Biology California Institute of Technology Pasadena, California 91125 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology California Institute of Technology Pasadena, California 91125 USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111969595","display_name":"Che-Kun James Shen","orcid":"https://orcid.org/0000-0001-6515-5837","observed_orcids":["https://orcid.org/0000-0001-6515-5837"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Che-Kun James Shen","raw_affiliation_strings":["Division of Biology California Institute of Technology Pasadena, California 91125 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology California Institute of Technology Pasadena, California 91125 USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091116725","display_name":"Tom Maniatis","orcid":"https://orcid.org/0000-0002-2722-8633","observed_orcids":["https://orcid.org/0000-0002-2722-8633"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tom Maniatis","raw_affiliation_strings":["Division of Biology California Institute of Technology Pasadena, California 91125 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology California Institute of Technology Pasadena, California 91125 USA","institution_ids":["https://openalex.org/I122411786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I122411786"],"apc_list":{"value":11400,"currency":"USD","value_usd":11400},"apc_paid":null,"fwci":44.9925,"has_fulltext":false,"cited_by_count":524,"citation_normalized_percentile":{"value":0.99862259,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"20","issue":"1","first_page":"119","last_page":"130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.07569999992847443,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-globin-gene","display_name":"alpha-globin gene","score":0.9160000085830688},{"id":"https://openalex.org/keywords/zeta-globin-gene","display_name":"zeta-globin gene","score":0.8960000276565552},{"id":"https://openalex.org/keywords/gene-clusters","display_name":"gene clusters","score":0.5509999990463257},{"id":"https://openalex.org/keywords/sequence-homology","display_name":"sequence homology","score":0.9589999914169312},{"id":"https://openalex.org/keywords/alpha-thalassemia","display_name":"alpha-thalassemia","score":0.7919999957084656},{"id":"https://openalex.org/keywords/alpha-globin-gene-deletion","display_name":"alpha-globin gene deletion","score":0.8450000286102295},{"id":"https://openalex.org/keywords/unequal-crossing-over","display_name":"unequal crossover","score":0.9610000252723694},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"gene duplication","score":0.8880000114440918},{"id":"https://openalex.org/keywords/hemoglobin-evolution","display_name":"hemoglobin evolution","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.819177508354187},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7031931281089783},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.6942708492279053},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6729211807250977},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.5647348165512085},{"id":"https://openalex.org/C36857842","wikidata":"https://www.wikidata.org/wiki/Q1501261","display_name":"Gene cluster","level":3,"score":0.5514112114906311},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5147690773010254},{"id":"https://openalex.org/C170673058","wikidata":"https://www.wikidata.org/wiki/Q780686","display_name":"Restriction map","level":4,"score":0.5134831070899963},{"id":"https://openalex.org/C125996951","wikidata":"https://www.wikidata.org/wiki/Q412234","display_name":"Globin","level":3,"score":0.4904186427593231},{"id":"https://openalex.org/C133307689","wikidata":"https://www.wikidata.org/wiki/Q48749","display_name":"Southern blot","level":3,"score":0.4716555178165436},{"id":"https://openalex.org/C84148353","wikidata":"https://www.wikidata.org/wiki/Q863908","display_name":"Nucleic acid sequence","level":3,"score":0.43404752016067505}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002872","descriptor_name":"Chromosome Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004274","descriptor_name":"DNA, Recombinant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005809","descriptor_name":"Genes, Regulator","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005914","descriptor_name":"Globins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010582","descriptor_name":"Bacteriophage lambda","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0092-8674(80)90240-8","doi":"https://doi.org/10.1016/0092-8674(80)90240-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0092-8674(80)90240-8","pdf_url":null,"source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},{"id":"pmid:6446404","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6446404","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1619099205","https://openalex.org/W1973455868","https://openalex.org/W1980825607","https://openalex.org/W1985831025","https://openalex.org/W1990663996","https://openalex.org/W1995812802","https://openalex.org/W1996507241","https://openalex.org/W1997554941","https://openalex.org/W2006555144","https://openalex.org/W2008456630","https://openalex.org/W2017118249","https://openalex.org/W2018972218","https://openalex.org/W2027570726","https://openalex.org/W2028525826","https://openalex.org/W2030213956","https://openalex.org/W2030249934","https://openalex.org/W2032343668","https://openalex.org/W2033967078","https://openalex.org/W2035271897","https://openalex.org/W2035966532","https://openalex.org/W2048137516","https://openalex.org/W2052276649","https://openalex.org/W2054684040","https://openalex.org/W2060503413","https://openalex.org/W2063450941","https://openalex.org/W2063939932","https://openalex.org/W2068609723","https://openalex.org/W2069445267","https://openalex.org/W2069526940","https://openalex.org/W2070767026","https://openalex.org/W2073365804","https://openalex.org/W2074412959","https://openalex.org/W2080131469","https://openalex.org/W2083231300","https://openalex.org/W2089629262","https://openalex.org/W2119243350","https://openalex.org/W2123311993","https://openalex.org/W2124350202","https://openalex.org/W2162780621","https://openalex.org/W2180581282","https://openalex.org/W2214716537","https://openalex.org/W4213369627"],"related_works":["https://openalex.org/W7081575214","https://openalex.org/W2064497626","https://openalex.org/W2088811356","https://openalex.org/W1987759538","https://openalex.org/W1515565736","https://openalex.org/W2047483119","https://openalex.org/W2048137516","https://openalex.org/W2049561326","https://openalex.org/W1501296437","https://openalex.org/W1990946747"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}