{"id":"https://openalex.org/W2018205277","doi":"https://doi.org/10.1158/0008-5472.sabcs13-p2-09-01","title":"Abstract P2-09-01: Targeting BCL-2 with the BH3 mimetic ABT-199 in ER-positive breast cancer","display_name":"Abstract P2-09-01: Targeting BCL-2 with the BH3 mimetic ABT-199 in ER-positive breast cancer","publication_year":2013,"publication_date":"2013-12-15","ids":{"openalex":"https://openalex.org/W2018205277","doi":"https://doi.org/10.1158/0008-5472.sabcs13-p2-09-01","mag":"2018205277"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.sabcs13-p2-09-01","doi":"https://doi.org/10.1158/0008-5472.sabcs13-p2-09-01","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.sabcs13-p2-09-01","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079753000","display_name":"Geoffrey John Lindeman","orcid":"https://orcid.org/0000-0001-9386-2416","observed_orcids":["https://orcid.org/0000-0001-9386-2416"]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I1331142282","display_name":"Royal Women's Hospital","ror":"https://ror.org/03grnna41","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1331142282"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"GJ Lindeman","raw_affiliation_strings":["The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","The Royal Melbourne Hospital, Parkville, VIC, Australia","The Royal Women's Hospital, Parkville, VIC, Australia","The University of Melbourne, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I196021976"]},{"raw_affiliation_string":"The Royal Melbourne Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756"]},{"raw_affiliation_string":"The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1331142282"]},{"raw_affiliation_string":"The University of Melbourne, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088501406","display_name":"F Vaillant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I1331142282","display_name":"Royal Women's Hospital","ror":"https://ror.org/03grnna41","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1331142282"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"F Vaillant","raw_affiliation_strings":["The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","The Royal Melbourne Hospital, Parkville, VIC, Australia","The Royal Women's Hospital, Parkville, VIC, Australia","The University of Melbourne, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I196021976"]},{"raw_affiliation_string":"The Royal Melbourne Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756"]},{"raw_affiliation_string":"The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1331142282"]},{"raw_affiliation_string":"The University of Melbourne, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009131786","display_name":"Delphine M\u00e9rino","orcid":"https://orcid.org/0000-0002-8075-6275","observed_orcids":["https://orcid.org/0000-0002-8075-6275"]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I1331142282","display_name":"Royal Women's Hospital","ror":"https://ror.org/03grnna41","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1331142282"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"D Merino","raw_affiliation_strings":["The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","The Royal Melbourne Hospital, Parkville, VIC, Australia","The Royal Women's Hospital, Parkville, VIC, Australia","The University of Melbourne, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I196021976"]},{"raw_affiliation_string":"The Royal Melbourne Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756"]},{"raw_affiliation_string":"The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1331142282"]},{"raw_affiliation_string":"The University of Melbourne, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012356212","display_name":"L Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I1331142282","display_name":"Royal Women's Hospital","ror":"https://ror.org/03grnna41","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1331142282"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"L Lee","raw_affiliation_strings":["The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","The Royal Melbourne Hospital, Parkville, VIC, Australia","The Royal Women's Hospital, Parkville, VIC, Australia","The University of Melbourne, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I196021976"]},{"raw_affiliation_string":"The Royal Melbourne Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756"]},{"raw_affiliation_string":"The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1331142282"]},{"raw_affiliation_string":"The University of Melbourne, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050129791","display_name":"Kelsey A. Breslin","orcid":"https://orcid.org/0000-0003-4616-8215","observed_orcids":["https://orcid.org/0000-0003-4616-8215"]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I1331142282","display_name":"Royal Women's Hospital","ror":"https://ror.org/03grnna41","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1331142282"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"K Breslin","raw_affiliation_strings":["The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","The Royal Melbourne Hospital, Parkville, VIC, Australia","The Royal Women's Hospital, Parkville, VIC, Australia","The University of Melbourne, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I196021976"]},{"raw_affiliation_string":"The Royal Melbourne Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756"]},{"raw_affiliation_string":"The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1331142282"]},{"raw_affiliation_string":"The University of Melbourne, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076938587","display_name":"Bhupinder Pal","orcid":"https://orcid.org/0000-0002-3684-4331","observed_orcids":["https://orcid.org/0000-0002-3684-4331"]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I1331142282","display_name":"Royal Women's Hospital","ror":"https://ror.org/03grnna41","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1331142282"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"B Pal","raw_affiliation_strings":["The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","The Royal Melbourne Hospital, Parkville, VIC, Australia","The Royal Women's Hospital, Parkville, VIC, Australia","The University of Melbourne, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I196021976"]},{"raw_affiliation_string":"The Royal Melbourne Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756"]},{"raw_affiliation_string":"The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1331142282"]},{"raw_affiliation_string":"The University of Melbourne, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015434839","display_name":"Matthew E. Ritchie","orcid":"https://orcid.org/0000-0002-7383-0609","observed_orcids":["https://orcid.org/0000-0002-7383-0609"]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I1331142282","display_name":"Royal Women's Hospital","ror":"https://ror.org/03grnna41","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1331142282"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"ME Ritchie","raw_affiliation_strings":["The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","The Royal Melbourne Hospital, Parkville, VIC, Australia","The Royal Women's Hospital, Parkville, VIC, Australia","The University of Melbourne, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I196021976"]},{"raw_affiliation_string":"The Royal Melbourne Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756"]},{"raw_affiliation_string":"The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1331142282"]},{"raw_affiliation_string":"The University of Melbourne, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054704071","display_name":"Gordon K. Smyth","orcid":"https://orcid.org/0000-0001-9221-2892","observed_orcids":["https://orcid.org/0000-0001-9221-2892"]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I1331142282","display_name":"Royal Women's Hospital","ror":"https://ror.org/03grnna41","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1331142282"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"GK Smyth","raw_affiliation_strings":["The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","The Royal Melbourne Hospital, Parkville, VIC, Australia","The Royal Women's Hospital, Parkville, VIC, Australia","The University of Melbourne, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I196021976"]},{"raw_affiliation_string":"The Royal Melbourne Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756"]},{"raw_affiliation_string":"The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1331142282"]},{"raw_affiliation_string":"The University of Melbourne, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061894681","display_name":"Michael Christie","orcid":"https://orcid.org/0000-0001-8006-6832","observed_orcids":["https://orcid.org/0000-0001-8006-6832"]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I1331142282","display_name":"Royal Women's Hospital","ror":"https://ror.org/03grnna41","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1331142282"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"M Christie","raw_affiliation_strings":["The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","The Royal Melbourne Hospital, Parkville, VIC, Australia","The Royal Women's Hospital, Parkville, VIC, Australia","The University of Melbourne, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I196021976"]},{"raw_affiliation_string":"The Royal Melbourne Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756"]},{"raw_affiliation_string":"The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1331142282"]},{"raw_affiliation_string":"The University of Melbourne, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087331538","display_name":"LJ Phillipson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I1331142282","display_name":"Royal Women's Hospital","ror":"https://ror.org/03grnna41","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1331142282"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"LJ Phillipson","raw_affiliation_strings":["The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","The Royal Melbourne Hospital, Parkville, VIC, Australia","The Royal Women's Hospital, Parkville, VIC, Australia","The University of Melbourne, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I196021976"]},{"raw_affiliation_string":"The Royal Melbourne Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756"]},{"raw_affiliation_string":"The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1331142282"]},{"raw_affiliation_string":"The University of Melbourne, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064831071","display_name":"Christopher J. Burns","orcid":"https://orcid.org/0000-0002-4463-4916","observed_orcids":["https://orcid.org/0000-0002-4463-4916"]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I1331142282","display_name":"Royal Women's Hospital","ror":"https://ror.org/03grnna41","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1331142282"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"CJ Burns","raw_affiliation_strings":["The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","The Royal Melbourne Hospital, Parkville, VIC, Australia","The Royal Women's Hospital, Parkville, VIC, Australia","The University of Melbourne, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I196021976"]},{"raw_affiliation_string":"The Royal Melbourne Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756"]},{"raw_affiliation_string":"The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1331142282"]},{"raw_affiliation_string":"The University of Melbourne, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076639901","display_name":"Gregory Bruce Mann","orcid":"https://orcid.org/0000-0002-2508-9203","observed_orcids":["https://orcid.org/0000-0002-2508-9203"]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I1331142282","display_name":"Royal Women's Hospital","ror":"https://ror.org/03grnna41","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1331142282"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"GB Mann","raw_affiliation_strings":["The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","The Royal Melbourne Hospital, Parkville, VIC, Australia","The Royal Women's Hospital, Parkville, VIC, Australia","The University of Melbourne, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I196021976"]},{"raw_affiliation_string":"The Royal Melbourne Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756"]},{"raw_affiliation_string":"The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1331142282"]},{"raw_affiliation_string":"The University of Melbourne, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047089703","display_name":"JE Visvader","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I1331142282","display_name":"Royal Women's Hospital","ror":"https://ror.org/03grnna41","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1331142282"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"JE Visvader","raw_affiliation_strings":["The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","The Royal Melbourne Hospital, Parkville, VIC, Australia","The Royal Women's Hospital, Parkville, VIC, Australia","The University of Melbourne, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The Royal Melbourne Hospital, Parkville, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I196021976"]},{"raw_affiliation_string":"The Royal Melbourne Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756"]},{"raw_affiliation_string":"The Royal Women's Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1331142282"]},{"raw_affiliation_string":"The University of Melbourne, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"24_Supplement","first_page":"P2","last_page":"09"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.796999990940094},{"id":"https://openalex.org/keywords/bh3-mimetics","display_name":"BH3 mimetics","score":0.8610000014305115},{"id":"https://openalex.org/keywords/venetoclax","display_name":"venetoclax","score":0.9890000224113464},{"id":"https://openalex.org/keywords/abt-737","display_name":"ABT-737","score":0.9940000176429749},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.8769999742507935},{"id":"https://openalex.org/keywords/luminal-b","display_name":"luminal B","score":0.9100000262260437},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":0.9430000185966492},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8410000205039978},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7160000205039978},{"id":"https://openalex.org/keywords/endocrine-therapy","display_name":"endocrine therapy","score":0.7039999961853027},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.9049999713897705},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.8709999918937683},{"id":"https://openalex.org/keywords/bcl2-inhibitors","display_name":"BCL-2 inhibitor","score":0.5149999856948853},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.3700000047683716},{"id":"https://openalex.org/keywords/tumor-response","display_name":"tumor response","score":0.3269999921321869},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8349999785423279},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7005587816238403},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.5870733857154846},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5723663568496704},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5342480540275574},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5256251692771912},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.483221173286438},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.45694053173065186},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.4228001832962036},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.41086316108703613},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34222090244293213},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.3418923020362854},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33269816637039185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2582589387893677},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.sabcs13-p2-09-01","doi":"https://doi.org/10.1158/0008-5472.sabcs13-p2-09-01","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.sabcs13-p2-09-01","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2071599920","https://openalex.org/W2085631531","https://openalex.org/W2098842169","https://openalex.org/W1966244030","https://openalex.org/W2044612154","https://openalex.org/W2165527798","https://openalex.org/W2024146249","https://openalex.org/W3178704504","https://openalex.org/W2564417534","https://openalex.org/W2944362203"],"abstract_inverted_index":{"Abstract":[0,480],"Background:":[1],"Impairment":[2],"of":[3,8,18,35,71,128,173,183,229,317,336,377,389,400,421,442],"apoptosis":[4],"is":[5,23,120,134,302],"a":[6,52,111,163,217,303,353,425,437,467],"hallmark":[7],"cancer":[9,381],"and":[10,81,99,162,179,212,216,252,293,296,357,369,413,431],"can":[11],"result":[12],"in":[13,25,32,104,124,136,195,247,261,277,333,363,445,449],"resistance":[14],"to":[15,43,57,143,150,269,312,346,367],"therapy.":[16],"Over-expression":[17],"the":[19,69,91,137,284,314,334,339,387,390],"pro-survival":[20,84],"protein":[21,454],"BCL-2":[22,39,83,132,286,301,401,453],"common":[24],"breast":[26,176,186,380,450],"cancer,":[27],"with":[28,102,155,236,283,329,351],"elevated":[29],"levels":[30],"found":[31,311,345],"approximately":[33],"85%":[34],"luminal":[36,138,152,174,191,201,378],"tumors.":[37],"Although":[38],"has":[40,55,116],"been":[41,77,117,383],"shown":[42,89],"be":[44,58,148,347,417],"an":[45],"important":[46],"prognostic":[47],"marker,":[48],"its":[49],"role":[50],"as":[51,207],"therapeutic":[53],"target":[54,151],"yet":[56],"fully":[59],"explored.":[60],"Small":[61],"molecule":[62],"inhibitors":[63,332,415],"termed":[64],"\u2018BH3":[65],"mimetics\u2019":[66],"that":[67,90,119,300,325,385,397,427],"mimic":[68],"action":[70],"pro-apoptotic":[72],"BH3-only":[73],"proteins":[74],"have":[75,87,382,395],"recently":[76],"developed.":[78],"These":[79],"bind":[80],"neutralize":[82],"proteins.":[85],"We":[86],"previously":[88],"BH3":[92,164,308,326,411,443],"mimetic":[93,165],"ABT-737":[94,238,368],"(which":[95],"neutralizes":[96],"BCL-2,":[97],"BCL-XL":[98,275],"BCL-W)":[100],"synergizes":[101],"docetaxel":[103],"BCL-2-positive":[105,200],"patient-derived":[106],"xenograft":[107,265,375],"(PDX)":[108],"models.":[109],"Recently,":[110],"potent":[112],"BCL-2-specific":[113],"inhibitor,":[114],"ABT-199,":[115],"developed":[118],"showing":[121],"considerable":[122],"promise":[123],"early":[125,446],"phase":[126,447],"studies":[127,448],"lymphoid":[129],"malignancies.":[130],"Since":[131],"expression":[133,214,276,457],"prominent":[135],"B":[139,153,175,202,379],"tumors,":[140,278],"we":[141,323,394],"sought":[142],"determine":[144],"whether":[145],"it":[146],"might":[147],"feasible":[149],"tumors":[154],"combination":[156,259],"therapy":[157,160,260,350],"comprising":[158],"endocrine":[159],"(tamoxifen)":[161],"(ABT-737":[166],"or":[167,244,455,462],"ABT-199),":[168],"using":[169],"novel":[170],"PDX":[171],"models":[172,203,376],"cancer.":[177,451],"Methods":[178],"Results:":[180],"A":[181],"panel":[182],"36":[184],"primary":[185,391],"tumor":[187,232,361],"xenografts":[188,233],"(including":[189],"15":[190],"tumors)":[192],"was":[193,281,344],"generated":[194],"immunocompromised":[196],"(NOG)":[197],"mice.":[198],"Three":[199],"(23T,":[204],"315T,":[205],"50T),":[206],"determined":[208,459],"by":[209,258,419,460],"Ki-67":[210],"immunostaining":[211],"gene":[213],"profiling,":[215],"control":[218],"BCL-2-positive,":[219],"ER-negative":[220],"model":[221],"(838T)":[222],"were":[223,234,255,310],"selected":[224],"for":[225,439,471],"further":[226,359],"study.":[227],"Cohorts":[228],"mice":[230],"bearing":[231],"treated":[235],"either":[237],"(50":[239,289],"mg/kg":[240,290],"i.p.":[241],"d1-10),":[242],"tamoxifen":[243,270,297,358,370,406],"both":[245,307,422,429],"agents":[246],"q21d":[248],"cycles.":[249],"Tumor":[250],"response":[251,362],"overall":[253],"survival":[254,423],"significantly":[256],"improved":[257],"all":[262],"three":[263],"ER-positive":[264],"models,":[266],"when":[267,365],"compared":[268,366],"alone":[271],"(p<0.005).":[272],"Despite":[273],"abundant":[274],"similar":[279],"efficacy":[280],"observed":[282,324],"selective":[285],"inhibitor":[287,355],"ABT-199":[288],"o.g.":[291],"d1-5":[292],"8-12":[294],"q21d)":[295],"(p<0.005),":[298],"revealing":[299],"crucial":[304],"target.":[305],"Unexpectedly,":[306],"mimetics":[309,327,412,444],"counteract":[313],"side":[315],"effect":[316],"tamoxifen-induced":[318],"endometrial":[319],"hyperplasia.":[320],"In":[321,338],"addition,":[322],"synergized":[328],"dual":[330],"PI3K/mTOR":[331,354,414],"induction":[335],"apoptosis.":[337],"315T":[340],"model,":[341],"where":[342],"AKT":[343],"activated,":[348],"triple":[349],"ABT-737,":[352],"(PKI-587)":[356],"augmented":[360],"vivo,":[364],"(p<0.004).":[371],"Discussion:":[372],"Patient":[373],"derived":[374,384],"recapitulate":[386],"phenotype":[388],"tumor.":[392],"Here":[393],"demonstrated":[396],"concomitant":[398],"targeting":[399,420],"confers":[402],"marked":[403],"benefit":[404],"above":[405],"alone.":[407],"Moreover,":[408],"synergy":[409],"between":[410],"could":[416,465],"exploited":[418],"pathways,":[424],"strategy":[426],"appeared":[428],"safe":[430],"effective.":[432],"Collectively,":[433],"our":[434],"findings":[435],"provide":[436,466],"rationale":[438],"clinical":[440],"evaluation":[441],"Here,":[452],"mRNA":[456],"(as":[458],"immunohistochemistry":[461],"RT-PCR,":[463],"respectively)":[464],"suitable":[468],"companion":[469],"biomarker":[470],"patient":[472],"selection.":[473],"Citation":[474],"Information:":[475],"Cancer":[476],"Res":[477],"2013;73(24":[478],"Suppl):":[479],"nr":[481],"P2-09-01.":[482]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}