{"id":"https://openalex.org/W2018200770","doi":"https://doi.org/10.1371/journal.pntd.0002527","title":"Over-Expression of 60s Ribosomal L23a Is Associated with Cellular Proliferation in SAG Resistant Clinical Isolates of Leishmania donovani","display_name":"Over-Expression of 60s Ribosomal L23a Is Associated with Cellular Proliferation in SAG Resistant Clinical Isolates of Leishmania donovani","publication_year":2013,"publication_date":"2013-12-05","ids":{"openalex":"https://openalex.org/W2018200770","doi":"https://doi.org/10.1371/journal.pntd.0002527","mag":"2018200770","pmid":"https://pubmed.ncbi.nlm.nih.gov/24340105","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3855005"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pntd.0002527","doi":"https://doi.org/10.1371/journal.pntd.0002527","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0002527","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002527&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Neglected Tropical Diseases","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2018200770"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002527&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107341473","display_name":"Sanchita Das","orcid":"https://orcid.org/0000-0002-6933-7723","observed_orcids":["https://orcid.org/0000-0002-6933-7723"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sanchita Das","raw_affiliation_strings":["Division of Parasitology, CSIR-Central Drug Research Institute, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Parasitology, CSIR-Central Drug Research Institute, Lucknow, India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103764035","display_name":"Priyanka Shah","orcid":"https://orcid.org/0009-0001-5356-5473","observed_orcids":["https://orcid.org/0009-0001-5356-5473"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Priyanka Shah","raw_affiliation_strings":["Molecular and Structural Biology, CSIR-Central Drug Research Institute, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Structural Biology, CSIR-Central Drug Research Institute, Lucknow, India","institution_ids":["https://openalex.org/I185249246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106922905","display_name":"Rajendra Kumar Baharia","orcid":"https://orcid.org/0000-0001-6517-6566","observed_orcids":["https://orcid.org/0000-0001-6517-6566"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rajendra K. Baharia","raw_affiliation_strings":["Division of Parasitology, CSIR-Central Drug Research Institute, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Parasitology, CSIR-Central Drug Research Institute, Lucknow, India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rati Tandon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rati Tandon","raw_affiliation_strings":["Division of Parasitology, CSIR-Central Drug Research Institute, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Parasitology, CSIR-Central Drug Research Institute, Lucknow, India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026679953","display_name":"Prashant S. Khare","orcid":"https://orcid.org/0000-0001-5792-3082","observed_orcids":["https://orcid.org/0000-0001-5792-3082","https://orcid.org/0009-0009-1747-2446"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prashant Khare","raw_affiliation_strings":["Division of Parasitology, CSIR-Central Drug Research Institute, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Parasitology, CSIR-Central Drug Research Institute, Lucknow, India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005151809","display_name":"Shyam Sundar","orcid":"https://orcid.org/0000-0001-9988-582X","observed_orcids":["https://orcid.org/0000-0001-9988-582X","https://orcid.org/0009-0006-5705-9371"]},"institutions":[{"id":"https://openalex.org/I51317819","display_name":"Institute of Medical Sciences","ror":"https://ror.org/04y75dx46","country_code":"IN","type":"education","lineage":["https://openalex.org/I51317819","https://openalex.org/I91357014"]},{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shyam Sundar","raw_affiliation_strings":["Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India","institution_ids":["https://openalex.org/I51317819","https://openalex.org/I91357014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082449126","display_name":"Amogh A. Sahasrabuddhe","orcid":"https://orcid.org/0000-0002-5985-0734","observed_orcids":["https://orcid.org/0000-0002-5985-0734"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Amogh A. Sahasrabuddhe","raw_affiliation_strings":["Molecular and Structural Biology, CSIR-Central Drug Research Institute, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Structural Biology, CSIR-Central Drug Research Institute, Lucknow, India","institution_ids":["https://openalex.org/I185249246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073707664","display_name":"Mohammad Imran Siddiqi","orcid":"https://orcid.org/0000-0001-5655-5484","observed_orcids":["https://orcid.org/0000-0001-5655-5484"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"M. I. Siddiqi","raw_affiliation_strings":["Molecular and Structural Biology, CSIR-Central Drug Research Institute, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Structural Biology, CSIR-Central Drug Research Institute, Lucknow, India","institution_ids":["https://openalex.org/I185249246"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076603228","display_name":"Anuradha Dube","orcid":"https://orcid.org/0000-0002-5122-400X","observed_orcids":["https://orcid.org/0000-0002-5122-400X"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Anuradha Dube","raw_affiliation_strings":["Division of Parasitology, CSIR-Central Drug Research Institute, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Parasitology, CSIR-Central Drug Research Institute, Lucknow, India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5076603228"],"corresponding_institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"],"apc_list":{"value":2670,"currency":"USD","value_usd":2670},"apc_paid":{"value":2670,"currency":"USD","value_usd":2670},"fwci":2.4953,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.8799451,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"7","issue":"12","first_page":"e2527","last_page":"e2527"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leishmania-donovani","display_name":"Leishmania donovani","score":0.9879999756813049},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.4869999885559082},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/clinical-isolates","display_name":"clinical isolates","score":0.847000002861023},{"id":"https://openalex.org/keywords/miltefosine","display_name":"miltefosine","score":0.7839999794960022},{"id":"https://openalex.org/keywords/cytosolic-proteins","display_name":"cytosolic proteins","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C2781333301","wikidata":"https://www.wikidata.org/wiki/Q1950752","display_name":"Leishmania donovani","level":4,"score":0.9323498010635376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7023083567619324},{"id":"https://openalex.org/C38062823","wikidata":"https://www.wikidata.org/wiki/Q3408228","display_name":"Ribosomal protein","level":5,"score":0.5148105025291443},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.5101826190948486},{"id":"https://openalex.org/C2776114741","wikidata":"https://www.wikidata.org/wiki/Q415625","display_name":"Paromomycin","level":4,"score":0.4454852342605591},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4049207866191864},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3700413107872009},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.24941971898078918},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19667941331863403},{"id":"https://openalex.org/C2778689377","wikidata":"https://www.wikidata.org/wiki/Q2046113","display_name":"Visceral leishmaniasis","level":3,"score":0.18853852152824402},{"id":"https://openalex.org/C2776555147","wikidata":"https://www.wikidata.org/wiki/Q331283","display_name":"Leishmaniasis","level":2,"score":0.17669808864593506},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.13787934184074402},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1146339476108551},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11396393179893494},{"id":"https://openalex.org/C2777787772","wikidata":"https://www.wikidata.org/wiki/Q45355603","display_name":"Aminoglycoside","level":3,"score":0.07357349991798401},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000967","descriptor_name":"Antimony Sodium Gluconate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000981","descriptor_name":"Antiprotozoal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007893","descriptor_name":"Leishmania donovani","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007893","descriptor_name":"Leishmania donovani","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007893","descriptor_name":"Leishmania donovani","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D007893","descriptor_name":"Leishmania donovani","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D008647","descriptor_name":"Mesocricetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012269","descriptor_name":"Ribosomal Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pntd.0002527","doi":"https://doi.org/10.1371/journal.pntd.0002527","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0002527","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002527&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Neglected Tropical Diseases","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2843650","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3855005","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24340105","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24340105","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS neglected tropical diseases","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3855005","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3855005/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Negl Trop Dis","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.788.1386","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.788.1386","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/07/9b/pntd.0002527.PMC3855005.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:09839479f56242b88978096ccae328c4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/09839479f56242b88978096ccae328c4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Neglected Tropical Diseases, Vol 7, Iss 12, p e2527 (2013)","raw_type":"article"},{"id":"doi:10.60692/1ny0e-sym49","doi":"https://doi.org/10.60692/1ny0e-sym49","is_oa":true,"landing_page_url":"https://doi.org/10.60692/1ny0e-sym49","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/k1479-qfe70","doi":"https://doi.org/10.60692/k1479-qfe70","is_oa":true,"landing_page_url":"https://doi.org/10.60692/k1479-qfe70","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pntd.0002527","doi":"https://doi.org/10.1371/journal.pntd.0002527","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0002527","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002527&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Neglected Tropical Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"},{"id":"https://openalex.org/F4320320767","display_name":"University Grants Commission","ror":"https://ror.org/04p800546"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018200770.pdf","grobid_xml":"https://content.openalex.org/works/W2018200770.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1586861498","https://openalex.org/W1963542761","https://openalex.org/W1968220278","https://openalex.org/W1974261306","https://openalex.org/W1985771322","https://openalex.org/W2000440226","https://openalex.org/W2002252754","https://openalex.org/W2003792568","https://openalex.org/W2018289835","https://openalex.org/W2020079503","https://openalex.org/W2029362668","https://openalex.org/W2032279079","https://openalex.org/W2043318295","https://openalex.org/W2044619935","https://openalex.org/W2047598985","https://openalex.org/W2047752700","https://openalex.org/W2049003194","https://openalex.org/W2050480989","https://openalex.org/W2055195559","https://openalex.org/W2060081146","https://openalex.org/W2065283382","https://openalex.org/W2069131106","https://openalex.org/W2082667898","https://openalex.org/W2090630669","https://openalex.org/W2099752571","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2103502223","https://openalex.org/W2105105987","https://openalex.org/W2107277218","https://openalex.org/W2114360920","https://openalex.org/W2123180215","https://openalex.org/W2123224327","https://openalex.org/W2125483721","https://openalex.org/W2127172433","https://openalex.org/W2128698122","https://openalex.org/W2128833512","https://openalex.org/W2134403063","https://openalex.org/W2138228714","https://openalex.org/W2145613496","https://openalex.org/W2152855843","https://openalex.org/W2154591666","https://openalex.org/W2156414842","https://openalex.org/W2160888554","https://openalex.org/W2168350246","https://openalex.org/W2169234947","https://openalex.org/W2169301888","https://openalex.org/W2334748582","https://openalex.org/W2798078005","https://openalex.org/W7075708377"],"related_works":["https://openalex.org/W1675974269","https://openalex.org/W2015535225","https://openalex.org/W2002319836","https://openalex.org/W2128698122","https://openalex.org/W1981402963","https://openalex.org/W2047752700","https://openalex.org/W2120521174","https://openalex.org/W2109458685"],"abstract_inverted_index":{"BACKGROUND:":[0],"Sodium":[1],"antimony":[2],"gluconate":[3],"(SAG)":[4],"unresponsiveness":[5],"of":[6,16,25,33,74,90,140,175,184,194,202,214,223,236],"Leishmania":[7],"donovani":[8],"(Ld)":[9],"had":[10],"effectively":[11],"compromised":[12],"the":[13,26,52,160,168,172,182,185,195,199,205,210,221,224,230,245],"chemotherapeutic":[14],"potential":[15,201],"SAG.":[17],"60s":[18,75],"ribosomal":[19,76,212],"L23a":[20,77],"(60sRL23a),":[21],"identified":[22],"as":[23,35,85,87],"one":[24],"over-expressed":[27,136],"protein":[28,225],"in":[29,46,49,81,106,113,121,131,137,177,226],"different":[30,82],"resistant":[31,84,107,161],"strains":[32,89],"L.donovani":[34,91,141],"observed":[36,126],"with":[37,63],"differential":[38],"proteomics":[39],"studies":[40],"indicates":[41,219],"towards":[42,159,187,220],"its":[43,60,144],"possible":[44],"involvement":[45],"SAG":[47,64,83,148,178],"resistance":[48,65],"L.donovani.":[50,132],"In":[51],"present":[53],"study":[54,165,217,242],"60sRL23a":[55,133,176,203],"has":[56],"been":[57],"characterized":[58],"for":[59,118,167],"probable":[61],"association":[62],"mechanism.":[66,247],"METHODOLOGY":[67],"AND":[68],"PRINCIPAL":[69],"FINDINGS:":[70],"The":[71,216],"expression":[72,174],"profile":[73,146],"(60sRL23a)":[78],"was":[79,101,110,125,134,154],"checked":[80],"well":[86],"sensitive":[88,138,179],"clinical":[92],"isolates":[93],"by":[94,233],"real-time":[95],"PCR":[96],"and":[97,100,116,124,151,153,190,208,228,238],"western":[98],"blotting":[99],"found":[102,155],"to":[103,127,142,156,243],"be":[104,157],"up-regulated":[105],"strains.":[108],"Ld60sRL23a":[109],"cloned,":[111],"expressed":[112],"E.coli":[114],"system":[115],"purified":[117],"raising":[119],"antibody":[120],"swiss":[122],"mice":[123],"have":[128],"cytosolic":[129],"localization":[130],"further":[135,197,240],"strain":[139],"check":[143],"sensitivity":[145,183],"against":[147],"(Sb":[149],"V":[150],"III)":[152],"altered":[158],"mode.":[162],"CONCLUSION/SIGNIFICANCE:":[163],"This":[164],"reports":[166],"first":[169],"time":[170],"that":[171],"over":[173],"parasite":[180,186,206],"decreases":[181],"SAG,":[188],"miltefosine":[189],"paramomycin.":[191],"Growth":[192],"curve":[193],"tranfectants":[196],"indicated":[198],"proliferative":[200],"assisting":[204],"survival":[207],"reaffirming":[209],"extra":[211],"role":[213,222],"60sRL23a.":[215],"thus":[218],"lowering":[227],"redistributing":[229],"drug":[231],"pressure":[232],"increased":[234],"proliferation":[235],"parasites":[237],"warrants":[239],"longitudinal":[241],"understand":[244],"underlying":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}