{"id":"https://openalex.org/W2018198144","doi":"https://doi.org/10.1126/science.1846705","title":"Effect of Cytochrome P450 Arachidonate Metabolites on Ion Transport in Rabbit Kidney Loop of Henle","display_name":"Effect of Cytochrome P450 Arachidonate Metabolites on Ion Transport in Rabbit Kidney Loop of Henle","publication_year":1991,"publication_date":"1991-02-15","ids":{"openalex":"https://openalex.org/W2018198144","doi":"https://doi.org/10.1126/science.1846705","mag":"2018198144","pmid":"https://pubmed.ncbi.nlm.nih.gov/1846705"},"language":"en","primary_location":{"id":"doi:10.1126/science.1846705","doi":"https://doi.org/10.1126/science.1846705","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1846705","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111649491","display_name":"Bruno Escalante","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruno Escalante","raw_affiliation_strings":["Department of Pharmacology, New York Medical College, Valhalla, NY 10595"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, New York Medical College, Valhalla, NY 10595","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082847835","display_name":"David Erlij","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Erlij","raw_affiliation_strings":["Department of Physiology, State University of New York, Downstate Medical Center, Brooklyn, NY 11203"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, State University of New York, Downstate Medical Center, Brooklyn, NY 11203","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077198825","display_name":"John Russell Falck","orcid":"https://orcid.org/0000-0002-9219-7845","observed_orcids":["https://orcid.org/0000-0002-9219-7845"]},"institutions":[{"id":"https://openalex.org/I4210094379","display_name":"University of Texas Health Science Center at Dallas","ror":"https://ror.org/00q16t150","country_code":"US","type":"education","lineage":["https://openalex.org/I4210094379"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Falck","raw_affiliation_strings":["Department of Molecular Genetics, University of Texas, Health Science Center, Dallas, TX 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, University of Texas, Health Science Center, Dallas, TX 75235","institution_ids":["https://openalex.org/I4210094379"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109274394","display_name":"John C. McGiff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. McGiff","raw_affiliation_strings":["Department of Pharmacology, New York Medical College, Valhalla, NY 10595"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, New York Medical College, Valhalla, NY 10595","institution_ids":["https://openalex.org/I181190671"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.3992,"has_fulltext":false,"cited_by_count":213,"citation_normalized_percentile":{"value":0.98347808,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"251","issue":"4995","first_page":"799","last_page":"802"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.02710000053048134,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arachidonic-acid-metabolism","display_name":"arachidonic acid metabolism","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cytochrome-p450-monooxygenases","display_name":"cytochrome P450 monooxygenase","score":0.9610000252723694},{"id":"https://openalex.org/keywords/loop-of-henle","display_name":"loop of Henle","score":0.8199999928474426},{"id":"https://openalex.org/keywords/thick-ascending-limb","display_name":"thick ascending limb","score":0.949999988079071},{"id":"https://openalex.org/keywords/ion-transport","display_name":"ion transport","score":0.7269999980926514},{"id":"https://openalex.org/keywords/rubidium-uptake","display_name":"rubidium uptake","score":0.8920000195503235},{"id":"https://openalex.org/keywords/renal-medulla","display_name":"renal medulla","score":0.7160000205039978},{"id":"https://openalex.org/keywords/rabbit-kidney","display_name":"rabbit kidney","score":0.4560000002384186},{"id":"https://openalex.org/keywords/eicosanoids","display_name":"eicosanoids","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C13002179","wikidata":"https://www.wikidata.org/wiki/Q6901821","display_name":"Monooxygenase","level":4,"score":0.8625410199165344},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.7377445697784424},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6864562630653381},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.6099172234535217},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.5659255385398865},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5527938604354858},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5215221047401428},{"id":"https://openalex.org/C2776844834","wikidata":"https://www.wikidata.org/wiki/Q1813955","display_name":"Loop of Henle","level":4,"score":0.48427456617355347},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4652489125728607},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2833946645259857},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22903013229370117},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.205957293510437},{"id":"https://openalex.org/C2781231759","wikidata":"https://www.wikidata.org/wiki/Q58184","display_name":"Nephron","level":3,"score":0.0},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000254","descriptor_name":"Sodium-Potassium-Exchanging ATPase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005665","descriptor_name":"Furosemide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008138","descriptor_name":"Loop of Henle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008138","descriptor_name":"Loop of Henle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010042","descriptor_name":"Ouabain","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012414","descriptor_name":"Rubidium Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028021","descriptor_name":"Sodium-Potassium-Chloride Symporters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.1846705","doi":"https://doi.org/10.1126/science.1846705","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1846705","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:1846705","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1846705","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2170044055","display_name":"HORMONAL REGULATION OF BLOOD PRESSURE","funder_award_id":"P01HL034300","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8094325304","display_name":"Prostaglandins: Kinins and Angiotensin Interactions","funder_award_id":"R01HL025394","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8954727045","display_name":"REGULATION OF TRANSPORT IN EPITHELIA","funder_award_id":"R01DK033612","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1498049218","https://openalex.org/W1544458354","https://openalex.org/W1977703364","https://openalex.org/W1978340945","https://openalex.org/W2023033845","https://openalex.org/W2091080408","https://openalex.org/W2276272824","https://openalex.org/W2320013301","https://openalex.org/W2400187764","https://openalex.org/W2402957919","https://openalex.org/W2404727953","https://openalex.org/W2408583570"],"related_works":["https://openalex.org/W2027461539","https://openalex.org/W2397618430","https://openalex.org/W2087294322","https://openalex.org/W2018118459","https://openalex.org/W1921231008","https://openalex.org/W2023033845","https://openalex.org/W2276272824","https://openalex.org/W2399921612","https://openalex.org/W1968240381","https://openalex.org/W2412938164"],"abstract_inverted_index":{"In":[0],"the":[1,5,10,45,74,87,94],"medullary":[2],"segment":[3],"of":[4,9,12,44,54,64,73,76,86,90],"thick":[6],"ascending":[7],"limb":[8],"loop":[11],"Henle":[13],"(mTALH),":[14],"arachidonic":[15],"acid":[16],"(AA)":[17],"is":[18],"metabolized":[19],"by":[20,61,69,84],"a":[21,51],"cytochrome":[22,65,70],"P450-dependent":[23],"monooxygenase":[24],"to":[25],"products":[26,89],"that":[27,58],"affect":[28],"ion":[29,36],"transport.":[30],"The":[31],"linkage":[32],"between":[33],"changes":[34],"in":[35,41,93],"transport":[37],"and":[38],"AA":[39,49,77,91],"metabolism":[40,92],"isolated":[42],"cells":[43],"mTALH":[46],"was":[47,59],"examined.":[48],"produced":[50],"concentration-dependent":[52],"inhibition":[53],"86Rb":[55,79],"uptake--an":[56],"effect":[57,75],"prevented":[60],"selective":[62],"blockade":[63,72],"P450":[66,71],"monooxygenases.":[67],"Inhibition":[68],"on":[78],"uptake":[80],"could":[81],"be":[82],"circumvented":[83],"addition":[85],"principal":[88],"mTALH.":[95]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}