{"id":"https://openalex.org/W2018177276","doi":"https://doi.org/10.1016/j.molbrainres.2004.06.015","title":"Distribution and MK-801-induced expression of serine racemase mRNA in rat brain by real-time quantitative PCR","display_name":"Distribution and MK-801-induced expression of serine racemase mRNA in rat brain by real-time quantitative PCR","publication_year":2004,"publication_date":"2004-08-04","ids":{"openalex":"https://openalex.org/W2018177276","doi":"https://doi.org/10.1016/j.molbrainres.2004.06.015","mag":"2018177276","pmid":"https://pubmed.ncbi.nlm.nih.gov/15337321"},"language":"en","primary_location":{"id":"doi:10.1016/j.molbrainres.2004.06.015","doi":"https://doi.org/10.1016/j.molbrainres.2004.06.015","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.molbrainres.2004.06.015","pdf_url":null,"source":{"id":"https://openalex.org/S158036907","display_name":"Molecular Brain Research","issn_l":"0169-328X","issn":["0169-328X","1872-6941"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Brain Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016554197","display_name":"Masanobu Yoshikawa","orcid":"https://orcid.org/0000-0001-9010-9867","observed_orcids":["https://orcid.org/0000-0001-9010-9867"]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masanobu Yoshikawa","raw_affiliation_strings":["Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa 259-1143, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa 259-1143, Japan","institution_ids":["https://openalex.org/I1314466530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102266943","display_name":"Tomomi Kobayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomomi Kobayashi","raw_affiliation_strings":["Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa 259-1143, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa 259-1143, Japan","institution_ids":["https://openalex.org/I1314466530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111746579","display_name":"Tetsuo Oka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuo Oka","raw_affiliation_strings":["Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa 259-1143, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa 259-1143, Japan","institution_ids":["https://openalex.org/I1314466530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103691101","display_name":"Mitsuru Kawaguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149564915","display_name":"Tokyo Dental College","ror":"https://ror.org/0220f5b41","country_code":"JP","type":"education","lineage":["https://openalex.org/I149564915"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuru Kawaguchi","raw_affiliation_strings":["Department of Pharmacology, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba 261-8502, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba 261-8502, Japan","institution_ids":["https://openalex.org/I149564915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5106082485","display_name":"Atsushi Hashimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Atsushi Hashimoto","raw_affiliation_strings":["Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa 259-1143, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa 259-1143, Japan","institution_ids":["https://openalex.org/I1314466530"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5106082485"],"corresponding_institution_ids":["https://openalex.org/I1314466530"],"apc_list":null,"apc_paid":null,"fwci":1.7188,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.81473482,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"128","issue":"1","first_page":"90","last_page":"94"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serine-racemase","display_name":"serine racemase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mk-801","display_name":"MK-801","score":0.9359999895095825},{"id":"https://openalex.org/keywords/nmda-receptor-antagonist","display_name":"NMDA receptor antagonists","score":0.7879999876022339},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.7990000247955322},{"id":"https://openalex.org/keywords/brain-regions","display_name":"brain regions","score":0.6290000081062317},{"id":"https://openalex.org/keywords/glutamate-metabolism","display_name":"glutamate metabolism","score":0.7310000061988831},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7873679399490356},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.7323490381240845},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.7143770456314087},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.6128668785095215},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.5279760956764221},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5175118446350098},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4610850214958191},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39683741331100464},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36869800090789795},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31313687562942505},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2466021180152893}],"mesh":[{"descriptor_ui":"D000099300","descriptor_name":"Serine Racemase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016291","descriptor_name":"Dizocilpine Maleate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018691","descriptor_name":"Excitatory Amino Acid Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019998","descriptor_name":"Racemases and Epimerases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019998","descriptor_name":"Racemases and Epimerases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.molbrainres.2004.06.015","doi":"https://doi.org/10.1016/j.molbrainres.2004.06.015","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.molbrainres.2004.06.015","pdf_url":null,"source":{"id":"https://openalex.org/S158036907","display_name":"Molecular Brain Research","issn_l":"0169-328X","issn":["0169-328X","1872-6941"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Brain Research","raw_type":"journal-article"},{"id":"pmid:15337321","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15337321","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain research. Molecular brain research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1483800511","https://openalex.org/W1486774900","https://openalex.org/W1593023392","https://openalex.org/W1754931819","https://openalex.org/W1793612468","https://openalex.org/W1813674710","https://openalex.org/W1847132166","https://openalex.org/W1970720920","https://openalex.org/W1983474487","https://openalex.org/W1986195427","https://openalex.org/W1987923616","https://openalex.org/W1988798831","https://openalex.org/W2002672156","https://openalex.org/W2010158663","https://openalex.org/W2015054796","https://openalex.org/W2016451199","https://openalex.org/W2025022408","https://openalex.org/W2041620154","https://openalex.org/W2043725810","https://openalex.org/W2046151253","https://openalex.org/W2047901827","https://openalex.org/W2048181000","https://openalex.org/W2050814939","https://openalex.org/W2055979287","https://openalex.org/W2060374594","https://openalex.org/W2061790070","https://openalex.org/W2067831960","https://openalex.org/W2075086160","https://openalex.org/W2124439293","https://openalex.org/W2134812217","https://openalex.org/W2143111880","https://openalex.org/W2154524303","https://openalex.org/W2264566180"],"related_works":["https://openalex.org/W1986110171","https://openalex.org/W1993708184","https://openalex.org/W2022872154","https://openalex.org/W2337262450","https://openalex.org/W1988853094","https://openalex.org/W2065064659","https://openalex.org/W6885142384","https://openalex.org/W7046629329","https://openalex.org/W1983517229","https://openalex.org/W2025022408"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}