{"id":"https://openalex.org/W2018147880","doi":"https://doi.org/10.1158/1538-7445.prca2012-ia19","title":"Abstract IA19: Cooperation between androgen receptor and Polycomb in prostate cancer","display_name":"Abstract IA19: Cooperation between androgen receptor and Polycomb in prostate cancer","publication_year":2012,"publication_date":"2012-02-06","ids":{"openalex":"https://openalex.org/W2018147880","doi":"https://doi.org/10.1158/1538-7445.prca2012-ia19","mag":"2018147880"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.prca2012-ia19","doi":"https://doi.org/10.1158/1538-7445.prca2012-ia19","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.prca2012-ia19","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036670708","display_name":"Jonathan C. Zhao","orcid":"https://orcid.org/0000-0002-3163-380X","observed_orcids":["https://orcid.org/0000-0002-3163-380X"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan C. Zhao","raw_affiliation_strings":["Northwestern University, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066877255","display_name":"Christine Runkle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Runkle","raw_affiliation_strings":["Northwestern University, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100639000","display_name":"Jianjun Yu","orcid":"https://orcid.org/0000-0001-9434-088X","observed_orcids":["https://orcid.org/0000-0001-9434-088X"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianjun Yu","raw_affiliation_strings":["Northwestern University, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080671979","display_name":"Longtao Wu","orcid":"https://orcid.org/0000-0003-3463-4127","observed_orcids":["https://orcid.org/0000-0003-3463-4127"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Longtao Wu","raw_affiliation_strings":["Northwestern University, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063204371","display_name":"Hongjian Jin","orcid":"https://orcid.org/0000-0003-3833-7170","observed_orcids":["https://orcid.org/0000-0003-3833-7170"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongjian Jin","raw_affiliation_strings":["Northwestern University, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003177689","display_name":"Timothy Michael Kuzel","orcid":"https://orcid.org/0000-0002-7523-2397","observed_orcids":["https://orcid.org/0000-0002-7523-2397"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Kuzel","raw_affiliation_strings":["Northwestern University, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030411648","display_name":"Chung Lee","orcid":"https://orcid.org/0000-0003-0855-4553","observed_orcids":["https://orcid.org/0000-0003-0855-4553"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chung Lee","raw_affiliation_strings":["Northwestern University, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026756753","display_name":"Jindan Yu","orcid":"https://orcid.org/0000-0002-2326-0409","observed_orcids":["https://orcid.org/0000-0002-2326-0409","https://orcid.org/0009-0002-2082-5141"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jindan Yu","raw_affiliation_strings":["Northwestern University, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"4_Supplement","first_page":"IA19","last_page":"IA19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":1.0},{"id":"https://openalex.org/keywords/polycomb","display_name":"Polycomb","score":0.7080000042915344},{"id":"https://openalex.org/keywords/ezh2","display_name":"EZH2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.906000018119812},{"id":"https://openalex.org/keywords/nov","display_name":"NOV","score":0.8209999799728394},{"id":"https://openalex.org/keywords/bivalent-histone-modifications","display_name":"bivalent histone modifications","score":0.7200000286102295},{"id":"https://openalex.org/keywords/enhancer-binding","display_name":"enhancer binding","score":0.6169999837875366},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tumor-suppressor-silencing","display_name":"tumor suppressor silencing","score":0.5809999704360962},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.781000018119812},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6927280426025391},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.6747258305549622},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6271224021911621},{"id":"https://openalex.org/C2777116130","wikidata":"https://www.wikidata.org/wiki/Q4082046","display_name":"Polycomb-group proteins","level":5,"score":0.5542235374450684},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.549608051776886},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.5378910899162292},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.5245283246040344},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.48070937395095825},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.47491371631622314},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.4699832499027252},{"id":"https://openalex.org/C2780914512","wikidata":"https://www.wikidata.org/wiki/Q25323943","display_name":"H3K4me3","level":5,"score":0.4613608717918396},{"id":"https://openalex.org/C154456304","wikidata":"https://www.wikidata.org/wiki/Q18027046","display_name":"FOXA1","level":4,"score":0.4471389353275299},{"id":"https://openalex.org/C2776915012","wikidata":"https://www.wikidata.org/wiki/Q17125871","display_name":"PRC2","level":5,"score":0.4409365653991699},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.42660409212112427},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.40563541650772095},{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.40108585357666016},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.38911664485931396},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35526055097579956},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.3535291254520416},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3326992392539978},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2387392222881317},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2220281958580017}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.prca2012-ia19","doi":"https://doi.org/10.1158/1538-7445.prca2012-ia19","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.prca2012-ia19","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2131836848","https://openalex.org/W2076194757","https://openalex.org/W2323539868","https://openalex.org/W2740446950","https://openalex.org/W2547586113","https://openalex.org/W2164718200","https://openalex.org/W2908943334","https://openalex.org/W2929595741","https://openalex.org/W2161879447","https://openalex.org/W2141198558"],"abstract_inverted_index":{"Abstract":[0],"Androgen":[1],"receptor":[2,296],"(AR)":[3],"is":[4,91,170,213],"a":[5,37,84,146,162,181,267],"hormone-activated":[6],"transcription":[7],"factor":[8],"that":[9,120,168,187,211],"plays":[10],"important":[11],"roles":[12],"in":[13,95,140,215,230,236,247,299,312],"prostate":[14,143,217,223,271,300],"development,":[15],"function,":[16],"as":[17,19,36,83,161,180,266],"well":[18],"malignant":[20],"transformation.":[21],"The":[22],"downstream":[23],"pathways":[24],"of":[25,64,71,123,128,155,245,263,305],"AR,":[26],"however,":[27],"are":[28,121,138],"incompletely":[29],"understood.":[30],"AR":[31,73,82,188,246],"has":[32,47,56],"been":[33,48,57],"primarily":[34],"known":[35],"transcriptional":[38,87],"activator":[39],"inducing":[40,204],"prostate-specific":[41],"gene":[42,66,77,183,191],"expression.":[43],"Although":[44],"androgen":[45,174,295],"stimulation":[46],"shown":[49],"to":[50,59,196,270],"also":[51],"suppress":[52],"genes,":[53,157],"little":[54],"attention":[55],"paid":[58],"the":[60,98,126,131,153,176,197,306],"mechanisms":[61],"and":[62,75,103,117,203,228,232,297],"functions":[63],"AR-mediated":[65,261],"repression.":[67],"Through":[68],"integrative":[69],"analysis":[70],"genome-wide":[72],"occupancy":[74],"androgen-regulated":[76],"expression,":[78],"here":[79],"we":[80,158,184],"report":[81],"globally":[85],"acting":[86],"repressor.":[88],"This":[89],"repression":[90],"dictated,":[92],"at":[93],"least":[94],"part,":[96],"by":[97,173],"Polycomb":[99,298],"group":[100],"protein":[101],"EZH2":[102],"repressive":[104,205],"chromatin":[105,206],"remodeling.":[106,207],"In":[107],"embryonic":[108],"stem":[109,147],"cells":[110],"(ESC),":[111],"AR-repressed":[112,156,164],"genes":[113,137],"harbor":[114],"bivalent":[115],"H3K4me3":[116],"H3K27me3":[118],"modifications":[119],"characteristic":[122],"developmental":[124],"regulators,":[125],"silencing":[127],"which":[129],"maintains":[130],"undifferentiated":[132],"ESC":[133],"state.":[134,150],"Similarly,":[135],"these":[136],"down-regulated":[139,214],"poorlydifferentiated,":[141],"castration-resistant":[142],"tumors":[144],"rendering":[145],"cell-like":[148],"cellular":[149],"To":[151],"characterize":[152],"function":[154],"nominated":[159],"NOV":[160,169,179,212,220],"top":[163],"gene.":[165],"We":[166,208],"show":[167],"robustly":[171],"suppressed":[172],"through":[175,193],"AR.":[177],"Using":[178],"model":[182],"present":[185],"evidence":[186],"directly":[189],"inhibits":[190,222],"expression":[192,221],"physically":[194],"binding":[195],"enhancer,":[198],"establishing":[199],"promoter-enhancer":[200],"DNA":[201],"looping,":[202],"further":[209],"demonstrate":[210],"aggressive":[216],"cancer.":[218],"Concordantly,":[219],"cancer":[224,272,301],"cell":[225],"growth,":[226],"migration,":[227],"invasion":[229],"vitro":[231],"xenograft":[233],"tumor":[234,264],"growth":[235],"mice.":[237],"Collectively,":[238],"our":[239],"data":[240],"reveal":[241],"an":[242],"unexpected":[243],"role":[244],"inhibiting":[248],"non-prostatic":[249],"differentiation":[250],"and,":[251],"upon":[252],"aberrant":[253],"signaling,":[254],"promoting":[255],"cancerous":[256],"de-differentiation.":[257],"Our":[258],"findings":[259],"support":[260],"inhibition":[262],"suppressors":[265],"novel":[268],"mechanism":[269],"progression.":[273],"Citation":[274],"Format:":[275],"Jonathan":[276],"C.":[277],"Zhao,":[278],"Christine":[279],"Runkle,":[280],"Jianjun":[281],"Yu,":[282],"Longtao":[283],"Wu,":[284],"Hongjian":[285],"Jin,":[286],"Timothy":[287],"Kuzel,":[288],"Chung":[289],"Lee,":[290],"Jindan":[291],"Yu.":[292],"Cooperation":[293],"between":[294],"[abstract].":[302],"In:":[303],"Proceedings":[304],"AACR":[307],"Special":[308],"Conference":[309],"on":[310],"Advances":[311],"Prostate":[313],"Cancer":[314,324],"Research;":[315],"2012":[316],"Feb":[317],"6-9;":[318],"Orlando,":[319],"FL.":[320],"Philadelphia":[321],"(PA):":[322],"AACR;":[323],"Res":[325],"2012;72(4":[326],"Suppl):Abstract":[327],"nr":[328],"IA19.":[329]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}