{"id":"https://openalex.org/W2018136416","doi":"https://doi.org/10.1196/annals.1383.016","title":"The Candidate Gene Approach to Susceptibility for Abdominal Aortic Aneurysm","display_name":"The Candidate Gene Approach to Susceptibility for Abdominal Aortic Aneurysm","publication_year":2006,"publication_date":"2006-11-01","ids":{"openalex":"https://openalex.org/W2018136416","doi":"https://doi.org/10.1196/annals.1383.016","mag":"2018136416","pmid":"https://pubmed.ncbi.nlm.nih.gov/17182944"},"language":"en","primary_location":{"id":"doi:10.1196/annals.1383.016","doi":"https://doi.org/10.1196/annals.1383.016","is_oa":false,"landing_page_url":"https://doi.org/10.1196/annals.1383.016","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067991106","display_name":"Martin David Tilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1321572752","display_name":"St. Luke's-Roosevelt Hospital Center","ror":"https://ror.org/011t2cn48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321572752"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M. DAVID TILSON","raw_affiliation_strings":["Department of Surgery, St. Luke's-Roosevelt Hospital Center, Continuum Health Partners, New York, New York 10019, USA. mdt1@columbia.edu","Columbia University in the City of New York, New York, USA","Department of Surgery, St. Luke's-Roosevelt Hospital Center, Continuum Health Partners, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, St. Luke's-Roosevelt Hospital Center, Continuum Health Partners, New York, New York 10019, USA. mdt1@columbia.edu","institution_ids":["https://openalex.org/I1321572752"]},{"raw_affiliation_string":"Columbia University in the City of New York, New York, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Surgery, St. Luke's-Roosevelt Hospital Center, Continuum Health Partners, New York, New York, USA","institution_ids":["https://openalex.org/I1321572752"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074108066","display_name":"Charles Y. Ro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1321572752","display_name":"St. Luke's-Roosevelt Hospital Center","ror":"https://ror.org/011t2cn48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321572752"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"CHARLES Y. RO","raw_affiliation_strings":["Department of Surgery, St. Luke's-Roosevelt Hospital Center, Continuum Health Partners, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, St. Luke's-Roosevelt Hospital Center, Continuum Health Partners, New York, New York, USA","institution_ids":["https://openalex.org/I1321572752"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067991106"],"corresponding_institution_ids":["https://openalex.org/I1321572752","https://openalex.org/I78577930"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":0.1249,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.13984169,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"1085","issue":"1","first_page":"282","last_page":"290"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.017999999225139618,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abdominal-aortic-aneurysm","display_name":"abdominal aortic aneurysm","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.9929999709129333},{"id":"https://openalex.org/keywords/candidate-genes","display_name":"candidate genes","score":0.8240000009536743},{"id":"https://openalex.org/keywords/gene-discovery","display_name":"gene discovery","score":0.7540000081062317},{"id":"https://openalex.org/keywords/timp-1","display_name":"TIMP-1","score":0.902999997138977},{"id":"https://openalex.org/keywords/hla-dr15","display_name":"HLA-DR15","score":0.9620000123977661},{"id":"https://openalex.org/keywords/ferritin-light-chain","display_name":"ferritin light chain","score":0.9879999756813049},{"id":"https://openalex.org/keywords/col11a1","display_name":"COL11A1","score":0.9290000200271606},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.38499999046325684}],"concepts":[{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.7426233291625977},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.46934354305267334},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4277690052986145},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3903008699417114},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.358765184879303},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2814270257949829},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2766616940498352},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005293","descriptor_name":"Ferritins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017544","descriptor_name":"Aortic Aneurysm, Abdominal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019715","descriptor_name":"Tissue Inhibitor of Metalloproteinase-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059810","descriptor_name":"HLA-DR Serological Subtypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1196/annals.1383.016","doi":"https://doi.org/10.1196/annals.1383.016","is_oa":false,"landing_page_url":"https://doi.org/10.1196/annals.1383.016","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:17182944","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17182944","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W316922183","https://openalex.org/W1641168222","https://openalex.org/W1979854257","https://openalex.org/W1982904427","https://openalex.org/W2002711138","https://openalex.org/W2002812037","https://openalex.org/W2024705346","https://openalex.org/W2028309145","https://openalex.org/W2029408064","https://openalex.org/W2029448654","https://openalex.org/W2030010731","https://openalex.org/W2032856782","https://openalex.org/W2049057533","https://openalex.org/W2057863858","https://openalex.org/W2067564236","https://openalex.org/W2073974696","https://openalex.org/W2100379825","https://openalex.org/W2117322783","https://openalex.org/W2133712226","https://openalex.org/W2147640802","https://openalex.org/W2167733736","https://openalex.org/W2171078178","https://openalex.org/W2411602822","https://openalex.org/W2411972046","https://openalex.org/W2432410087","https://openalex.org/W2467476724","https://openalex.org/W2513096455"],"related_works":["https://openalex.org/W2290807035","https://openalex.org/W1995938057","https://openalex.org/W7097095994","https://openalex.org/W4236263561","https://openalex.org/W2037949274","https://openalex.org/W2340287408","https://openalex.org/W2418174136","https://openalex.org/W2348454548","https://openalex.org/W1964552106","https://openalex.org/W4400800818"],"abstract_inverted_index":{"There":[0,153],"are":[1,96,224],"two":[2],"approaches":[3],"to":[4,176,186,201],"gene":[5],"discovery":[6],"for":[7],"diseases":[8],"when":[9],"genetic":[10,17],"susceptibility":[11],"has":[12,31],"been":[13],"implicated":[14],"by":[15,109,138],"clinical":[16,123],"or":[18,167],"case-control":[19],"studies:":[20],"(1)":[21],"genome-wide":[22,40],"screening":[23,41],"and":[24,34,78,87,117,125,220],"(2)":[25],"evaluation":[26],"of":[27,39,60,64,84,90,102,122,129,145,193,197,204,226],"candidate":[28,104],"genes.":[29],"Each":[30],"specific":[32,61,147],"advantages":[33],"disadvantages.":[35],"The":[36,68,99,132,212],"principal":[37,69],"advantage":[38],"is":[42,45,71,76,134,137,154],"that":[43,72,135,159,170],"it":[44,52,136],"impeccably":[46],"objective":[47],"in":[48,142,173,183],"as":[49,51,190],"much":[50],"proceeds":[53],"without":[54],"any":[55],"presuppositions":[56],"regarding":[57],"the":[58,65,143,174,202],"importance":[59],"pathobiological":[62],"features":[63],"disease":[66],"process.":[67],"disadvantage":[70,133],"such":[73],"a":[74,110,119,126,156,205,209],"study":[75],"expensive":[77],"resource":[79],"intensive.":[80],"A":[81],"large":[82],"population":[83],"enrolled":[85],"patients":[86],"multidisciplinary":[88],"teams":[89],"investigators":[91],"cooperating":[92],"from":[93],"several":[94],"institutions":[95],"usually":[97],"required.":[98],"alternative":[100],"approach":[101],"evaluating":[103],"genes":[105,189],"can":[106],"be":[107,163,177],"pursued":[108],"small":[111,120,127],"independent":[112],"laboratory":[113,185],"with":[114],"limited":[115],"funding":[116],"resources,":[118],"collection":[121],"specimens,":[124],"number":[128],"team":[130],"players.":[131],"necessity":[139],"highly":[140],"subjective":[141],"process":[144],"selecting":[146],"candidates":[148,169],"among":[149],"many":[150],"reasonable":[151],"possibilities.":[152],"no":[155],"priori":[157],"assurance":[158],"effort":[160],"will":[161],"not":[162,208],"expended":[164],"on":[165],"one":[166],"more":[168],"turn":[171],"out":[172],"end":[175],"failures.":[178],"This":[179],"report":[180],"reviews":[181],"efforts":[182],"our":[184],"evaluate":[187],"four":[188],"candidates.":[191],"One":[192],"these":[194],"tissue":[195],"inhibitor":[196],"metalloprotease":[198],"1(TIMP1)":[199],"led":[200],"description":[203],"polymorphism,":[206],"but":[207],"conclusive":[210],"mutation.":[211],"other":[213],"three":[214],"(HLA-DR-15,":[215],"ferritin":[216],"light":[217],"chain":[218],"(FTL),":[219],"collagen":[221],"XI-alpha-1":[222],"(COL11A1)":[223],"subjects":[225],"continuing":[227],"interest.":[228]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}