{"id":"https://openalex.org/W2018133355","doi":"https://doi.org/10.1016/j.stemcr.2015.02.019","title":"Mitochondrial Alterations by PARKIN in Dopaminergic Neurons Using PARK2 Patient-Specific and PARK2 Knockout Isogenic iPSC Lines","display_name":"Mitochondrial Alterations by PARKIN in Dopaminergic Neurons Using PARK2 Patient-Specific and PARK2 Knockout Isogenic iPSC Lines","publication_year":2015,"publication_date":"2015-04-05","ids":{"openalex":"https://openalex.org/W2018133355","doi":"https://doi.org/10.1016/j.stemcr.2015.02.019","mag":"2018133355","pmid":"https://pubmed.ncbi.nlm.nih.gov/25843045","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4437475"},"language":"en","primary_location":{"id":"doi:10.1016/j.stemcr.2015.02.019","doi":"https://doi.org/10.1016/j.stemcr.2015.02.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.stemcr.2015.02.019","pdf_url":"http://www.cell.com/article/S2213671115000752/pdf","source":{"id":"https://openalex.org/S2764425922","display_name":"Stem Cell Reports","issn_l":"2213-6711","issn":["2213-6711"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2213671115000752/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032323085","display_name":"Atossa Shaltouki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Atossa Shaltouki","raw_affiliation_strings":["Buck Institute, Novato, CA 94945, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute, Novato, CA 94945, USA","institution_ids":["https://openalex.org/I1337826666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026482949","display_name":"Renuka Sivapatham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Renuka Sivapatham","raw_affiliation_strings":["Buck Institute, Novato, CA 94945, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute, Novato, CA 94945, USA","institution_ids":["https://openalex.org/I1337826666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103019305","display_name":"Ying Pei","orcid":"https://orcid.org/0000-0002-6664-7910","observed_orcids":["https://orcid.org/0000-0002-6664-7910"]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Pei","raw_affiliation_strings":["Buck Institute, Novato, CA 94945, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute, Novato, CA 94945, USA","institution_ids":["https://openalex.org/I1337826666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045604443","display_name":"Akos A. Gerencser","orcid":"https://orcid.org/0000-0002-8052-3711","observed_orcids":["https://orcid.org/0000-0002-8052-3711"]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akos\u00a0A. Gerencser","raw_affiliation_strings":["Buck Institute, Novato, CA 94945, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute, Novato, CA 94945, USA","institution_ids":["https://openalex.org/I1337826666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028371146","display_name":"Olga Mom\u010dilovi\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olga Mom\u010dilovi\u0107","raw_affiliation_strings":["Buck Institute, Novato, CA 94945, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute, Novato, CA 94945, USA","institution_ids":["https://openalex.org/I1337826666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111365293","display_name":"Mahendra S. Rao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125614","display_name":"XCell Science (United States)","ror":"https://ror.org/02vnj6d40","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahendra\u00a0S. Rao","raw_affiliation_strings":["NxCell Science, Novato, CA 94947, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NxCell Science, Novato, CA 94947, USA","institution_ids":["https://openalex.org/I4210125614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102153977","display_name":"Xianmin Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]},{"id":"https://openalex.org/I4210125614","display_name":"XCell Science (United States)","ror":"https://ror.org/02vnj6d40","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125614"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xianmin Zeng","raw_affiliation_strings":["Buck Institute, Novato, CA 94945, USA; XCell Science, Novato, CA 94947, USA. Electronic address: xzeng@buckinstitute.org","Buck Institute, Novato, CA 94945, USA","XCell Science, Novato, CA 94947, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute, Novato, CA 94945, USA; XCell Science, Novato, CA 94947, USA. Electronic address: xzeng@buckinstitute.org","institution_ids":["https://openalex.org/I4210125614"]},{"raw_affiliation_string":"Buck Institute, Novato, CA 94945, USA","institution_ids":["https://openalex.org/I1337826666"]},{"raw_affiliation_string":"XCell Science, Novato, CA 94947, USA","institution_ids":["https://openalex.org/I4210125614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102153977"],"corresponding_institution_ids":["https://openalex.org/I1337826666","https://openalex.org/I4210125614"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":11.4977,"has_fulltext":false,"cited_by_count":130,"citation_normalized_percentile":{"value":0.99061545,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"4","issue":"5","first_page":"847","last_page":"859"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.042399998754262924,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/park2","display_name":"PARK2","score":0.9430000185966492},{"id":"https://openalex.org/keywords/parkin","display_name":"Parkin","score":0.7770000100135803},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9319999814033508},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.9559999704360962},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.6449999809265137},{"id":"https://openalex.org/keywords/mitochondrial-volume-fraction","display_name":"mitochondrial volume fraction","score":0.7649999856948853},{"id":"https://openalex.org/keywords/neuronal-proliferation","display_name":"neuronal proliferation","score":0.890999972820282},{"id":"https://openalex.org/keywords/pink1","display_name":"PINK1","score":0.7350000143051147},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.6740000247955322},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.8679999709129333},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8923684358596802},{"id":"https://openalex.org/C2776804853","wikidata":"https://www.wikidata.org/wiki/Q18045837","display_name":"PINK1","level":5,"score":0.7661173343658447},{"id":"https://openalex.org/C2777668072","wikidata":"https://www.wikidata.org/wiki/Q2472777","display_name":"Parkin","level":4,"score":0.7566393613815308},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.748279333114624},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.7076971530914307},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.611931324005127},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.5643967390060425},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5245954394340515},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.367418110370636},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33158186078071594},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.2841672897338867},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2741587162017822},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.24670276045799255},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.20014700293540955},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.17798730731010437},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.17401790618896484},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14231789112091064},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.11621305346488953},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.08574467897415161},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.stemcr.2015.02.019","doi":"https://doi.org/10.1016/j.stemcr.2015.02.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.stemcr.2015.02.019","pdf_url":"http://www.cell.com/article/S2213671115000752/pdf","source":{"id":"https://openalex.org/S2764425922","display_name":"Stem Cell Reports","issn_l":"2213-6711","issn":["2213-6711"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3404843","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4437475","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4437475","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4437475","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Reports","raw_type":"Text"},{"id":"pmid:25843045","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25843045","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:09c9b6a82cb84787af6c448a4944fa27","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/09c9b6a82cb84787af6c448a4944fa27","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stem Cell Reports, Vol 4, Iss 5, Pp 847-859 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.stemcr.2015.02.019","doi":"https://doi.org/10.1016/j.stemcr.2015.02.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.stemcr.2015.02.019","pdf_url":"http://www.cell.com/article/S2213671115000752/pdf","source":{"id":"https://openalex.org/S2764425922","display_name":"Stem Cell Reports","issn_l":"2213-6711","issn":["2213-6711"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5799999833106995,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000877795","display_name":"Institutional Career Development Core","funder_award_id":"KL2TR001856","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018133355.pdf"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W62603772","https://openalex.org/W186181187","https://openalex.org/W1520955829","https://openalex.org/W1529474377","https://openalex.org/W1598892278","https://openalex.org/W1877873625","https://openalex.org/W1954514489","https://openalex.org/W1965018476","https://openalex.org/W1965653791","https://openalex.org/W1965778124","https://openalex.org/W1970248089","https://openalex.org/W1981938774","https://openalex.org/W1982969769","https://openalex.org/W1983892290","https://openalex.org/W1985461389","https://openalex.org/W1985953195","https://openalex.org/W1990048226","https://openalex.org/W1996971085","https://openalex.org/W1997847757","https://openalex.org/W2003428856","https://openalex.org/W2010478595","https://openalex.org/W2015606024","https://openalex.org/W2022997027","https://openalex.org/W2023174696","https://openalex.org/W2024043552","https://openalex.org/W2034087770","https://openalex.org/W2043276141","https://openalex.org/W2049248208","https://openalex.org/W2055124287","https://openalex.org/W2055557007","https://openalex.org/W2057364502","https://openalex.org/W2058645571","https://openalex.org/W2059718548","https://openalex.org/W2061113435","https://openalex.org/W2062251719","https://openalex.org/W2064917861","https://openalex.org/W2068806054","https://openalex.org/W2071473855","https://openalex.org/W2072754507","https://openalex.org/W2073351779","https://openalex.org/W2084334114","https://openalex.org/W2088962120","https://openalex.org/W2091265794","https://openalex.org/W2096286148","https://openalex.org/W2102136953","https://openalex.org/W2105043890","https://openalex.org/W2105249930","https://openalex.org/W2109291482","https://openalex.org/W2109326232","https://openalex.org/W2117335809","https://openalex.org/W2123431154","https://openalex.org/W2132291850","https://openalex.org/W2134073995","https://openalex.org/W2134645990","https://openalex.org/W2139425547","https://openalex.org/W2141069335","https://openalex.org/W2142460570","https://openalex.org/W2143161560","https://openalex.org/W2143410022","https://openalex.org/W2149364340","https://openalex.org/W2150656456","https://openalex.org/W2158480093","https://openalex.org/W2336578011","https://openalex.org/W2413253424"],"related_works":["https://openalex.org/W2518670444","https://openalex.org/W2149364340","https://openalex.org/W2936611581","https://openalex.org/W4200125174","https://openalex.org/W3165680352","https://openalex.org/W4390618177","https://openalex.org/W2951831260","https://openalex.org/W2119508244","https://openalex.org/W2771610239","https://openalex.org/W3136278406"],"abstract_inverted_index":{"In":[0],"this":[1],"study,":[2],"we":[3],"used":[4],"patient-specific":[5],"and":[6,107],"isogenic":[7,65],"PARK2-induced":[8],"pluripotent":[9],"stem":[10],"cells":[11],"(iPSCs)":[12],"to":[13],"show":[14],"that":[15,114],"mutations":[16,37],"in":[17,29,38,52,64,75,92],"PARK2":[18,39,66,81,112,126],"alter":[19],"neuronal":[20],"proliferation.":[21],"The":[22,59,69],"percentage":[23],"of":[24,89,101,125],"TH(+)":[25],"neurons":[26,34,77],"was":[27,48,62,72,85],"decreased":[28],"Parkinson's":[30],"disease":[31],"(PD)":[32],"patient-derived":[33],"carrying":[35],"various":[36,99],"compared":[40],"with":[41,122],"an":[42],"age-matched":[43],"control":[44],"subject.":[45],"This":[46],"reduction":[47],"accompanied":[49],"by":[50,111],"alterations":[51],"mitochondrial:cell":[53],"volume":[54,57],"fraction":[55],"(mitochondrial":[56],"fraction).":[58],"same":[60],"phenotype":[61,71,88,106],"confirmed":[63,103],"null":[67,82],"lines.":[68],"mitochondrial":[70,105],"also":[73],"seen":[74],"non-midbrain":[76],"differentiated":[78],"from":[79],"the":[80,86,104],"line,":[83],"as":[84],"functional":[87],"reduced":[90],"proliferation":[91],"culture.":[93],"Whole":[94],"genome":[95],"expression":[96],"profiling":[97],"at":[98],"stages":[100],"differentiation":[102],"identified":[108],"pathways":[109],"altered":[110],"dysfunction":[113],"include":[115],"PD-related":[116],"genes.":[117],"Our":[118],"results":[119],"are":[120,131],"consistent":[121],"current":[123],"model":[124],"function":[127],"where":[128],"damaged":[129],"mitochondria":[130],"targeted":[132],"for":[133],"degradation":[134],"via":[135],"a":[136],"PARK2/PINK1-mediated":[137],"mechanism.":[138]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":5},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}