{"id":"https://openalex.org/W2018129369","doi":"https://doi.org/10.1016/s0016-5085(03)80545-0","title":"T cell activation induced TNF, iNOS, cryptdin, and matrilysin (MMP-7) gene expression in intestinal epithelial cells are down-regulated in inducible mutant IKBA transgenic mice","display_name":"T cell activation induced TNF, iNOS, cryptdin, and matrilysin (MMP-7) gene expression in intestinal epithelial cells are down-regulated in inducible mutant IKBA transgenic mice","publication_year":2003,"publication_date":"2003-04-01","ids":{"openalex":"https://openalex.org/W2018129369","doi":"https://doi.org/10.1016/s0016-5085(03)80545-0","mag":"2018129369"},"language":"en","primary_location":{"id":"doi:10.1016/s0016-5085(03)80545-0","doi":"https://doi.org/10.1016/s0016-5085(03)80545-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0016-5085(03)80545-0","pdf_url":"https://doi.org/10.1016/s0016-5085(03)80545-0","source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/s0016-5085(03)80545-0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103199442","display_name":"Yueming Tang","orcid":"https://orcid.org/0009-0009-3079-0756","observed_orcids":["https://orcid.org/0009-0009-3079-0756"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yueming Tang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5039618231","display_name":"Terrence A. Barrett","orcid":"https://orcid.org/0000-0001-6428-3271","observed_orcids":["https://orcid.org/0000-0001-6428-3271"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Terrence Barrett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4180,"currency":"USD","value_usd":4180},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09358713,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"124","issue":"4","first_page":"A111","last_page":"A111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.413100004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.413100004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.32589998841285706,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.03139999881386757,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8610000014305115},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cryptdins","display_name":"cryptdins","score":0.9580000042915344},{"id":"https://openalex.org/keywords/matrilysin","display_name":"matrilysin","score":0.8949999809265137},{"id":"https://openalex.org/keywords/mmp-7","display_name":"MMP-7","score":0.984000027179718},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.8320000171661377},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.6620000004768372},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.5889999866485596},{"id":"https://openalex.org/keywords/bile-acids","display_name":"bile acids","score":0.7680000066757202},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/upa","display_name":"uPA","score":0.9610000252723694},{"id":"https://openalex.org/keywords/upar","display_name":"uPAR","score":0.8209999799728394},{"id":"https://openalex.org/keywords/gene-downregulation","display_name":"gene downregulation","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C2779939298","wikidata":"https://www.wikidata.org/wiki/Q18029191","display_name":"Matrilysin","level":3,"score":0.8753505349159241},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5854821801185608},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5740510821342468},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5404755473136902},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5317992568016052},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5316726565361023},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4890647828578949},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4527646601200104},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.42468762397766113},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.40240588784217834},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2122250199317932},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12487265467643738}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0016-5085(03)80545-0","doi":"https://doi.org/10.1016/s0016-5085(03)80545-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0016-5085(03)80545-0","pdf_url":"https://doi.org/10.1016/s0016-5085(03)80545-0","source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/s0016-5085(03)80545-0","doi":"https://doi.org/10.1016/s0016-5085(03)80545-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0016-5085(03)80545-0","pdf_url":"https://doi.org/10.1016/s0016-5085(03)80545-0","source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.6899999976158142}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018129369.pdf","grobid_xml":"https://content.openalex.org/works/W2018129369.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4251793172","https://openalex.org/W2153225911","https://openalex.org/W1997090289","https://openalex.org/W2120162614","https://openalex.org/W2112162638","https://openalex.org/W1986679152","https://openalex.org/W2105013832","https://openalex.org/W7100192638","https://openalex.org/W2168313879","https://openalex.org/W2014995450"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}