{"id":"https://openalex.org/W2018115363","doi":"https://doi.org/10.3892/ijmm.1.2.453","title":"The role of the soluble p53 antigen and its autoantibodies as markers for diagnosis of colon cancer: a comparative study.","display_name":"The role of the soluble p53 antigen and its autoantibodies as markers for diagnosis of colon cancer: a comparative study.","publication_year":1998,"publication_date":"1998-02-01","ids":{"openalex":"https://openalex.org/W2018115363","doi":"https://doi.org/10.3892/ijmm.1.2.453","mag":"2018115363","pmid":"https://pubmed.ncbi.nlm.nih.gov/9852249"},"language":"en","primary_location":{"id":"doi:10.3892/ijmm.1.2.453","doi":"https://doi.org/10.3892/ijmm.1.2.453","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijmm.1.2.453","pdf_url":null,"source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012769147","display_name":"Bella Sandler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"B Sandler","raw_affiliation_strings":["Laboratory of Teratology and Experimental Oncology, Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Teratology and Experimental Oncology, Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049665310","display_name":"Patricia Smirnoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"P Smirnoff","raw_affiliation_strings":["Laboratory of Teratology and Experimental Oncology, Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Teratology and Experimental Oncology, Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003790642","display_name":"Adi Shani","orcid":"https://orcid.org/0000-0003-3524-3128","observed_orcids":["https://orcid.org/0000-0003-3524-3128"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"A Shani","raw_affiliation_strings":["Laboratory of Teratology and Experimental Oncology, Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Teratology and Experimental Oncology, Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109416007","display_name":"E. Idelevich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"E Idelevich","raw_affiliation_strings":["Laboratory of Teratology and Experimental Oncology, Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Teratology and Experimental Oncology, Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058571974","display_name":"Reuven Pfefferman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"R Pfefferman","raw_affiliation_strings":["Laboratory of Teratology and Experimental Oncology, Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Teratology and Experimental Oncology, Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073239481","display_name":"B Davidovich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"B Davidovich","raw_affiliation_strings":["Laboratory of Teratology and Experimental Oncology, Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Teratology and Experimental Oncology, Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015990989","display_name":"Rivka Zusman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"R Zusman","raw_affiliation_strings":["Laboratory of Teratology and Experimental Oncology, Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Teratology and Experimental Oncology, Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066714669","display_name":"Itshak Zusman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"I Zusman","raw_affiliation_strings":["Laboratory of Teratology and Experimental Oncology, Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Teratology and Experimental Oncology, Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel","institution_ids":["https://openalex.org/I197251160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I197251160"],"apc_list":null,"apc_paid":null,"fwci":0.4385,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.64436985,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"2","first_page":"453","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.375,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.375,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.20919999480247498,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.19339999556541443,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53-autoantibodies","display_name":"p53 autoantibodies","score":0.9909999966621399},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9679999947547913},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.6809999942779541},{"id":"https://openalex.org/keywords/affinity-chromatography","display_name":"affinity chromatography","score":0.5950000286102295},{"id":"https://openalex.org/keywords/cancer-diagnosis","display_name":"cancer diagnosis","score":0.7319999933242798},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.8680438995361328},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.8132804036140442},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5835088491439819},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5617931485176086},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.528132975101471},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.4627898037433624},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3909355700016022},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38141822814941406},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.36516591906547546},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3449813723564148},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34401029348373413},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25614726543426514},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.18755781650543213}],"mesh":[{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001324","descriptor_name":"Autoantigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3892/ijmm.1.2.453","doi":"https://doi.org/10.3892/ijmm.1.2.453","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijmm.1.2.453","pdf_url":null,"source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},{"id":"pmid:9852249","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9852249","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular medicine","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2016535230","https://openalex.org/W4298066892","https://openalex.org/W1968884894","https://openalex.org/W2973993503","https://openalex.org/W2088973180","https://openalex.org/W1983430117","https://openalex.org/W2979062215","https://openalex.org/W2801841327","https://openalex.org/W2066610469","https://openalex.org/W2739387592"],"abstract_inverted_index":{"The":[0,74,96],"role":[1],"of":[2,18,32,35,54,62,70,77,79,83,98,105,132,139,145,150,158,165,173,178,193,210,219,224,238,242,248,278],"various":[3],"serological":[4],"tumor":[5],"markers,":[6],"p53":[7,36,99,106,140,151,159,179,194,202,211,220,225,250,279],"soluble":[8],"antigen":[9,141,180,203],"and":[10,90,116,136,147,154,175,189,199,204],"its":[11,205],"autoantibodies,":[12,206],"was":[13,26,85,101,111,126,167,245,281],"evaluated":[14],"for":[15,201,234],"the":[16,52,63,68,80,109,129,137,148,170,176,190,217,235,243,253,263,276,287],"detection":[17],"colon":[19,71,187],"cancer":[20,72,188,239],"in":[21,51,186],"humans.":[22],"An":[23],"HPLC":[24],"technique":[25],"used":[27],"to":[28,261],"measure":[29],"serum":[30,69,191],"levels":[31,192],"both":[33,156],"forms":[34,157,223],"protein":[37,65,160,195,226,280],"after":[38],"their":[39],"partial":[40],"isolation":[41,277],"on":[42],"gel":[43],"fiberglass":[44],"affinity":[45],"chromatography":[46],"columns.":[47],"Tumor-associated":[48],"proteins":[49,265],"(TAP)":[50],"form":[53],"either":[55],"antigens":[56,134],"or":[57],"autoantibodies":[58,100,152,212],"were":[59,196,259,267],"about":[60],"4%":[61],"total":[64,130,143,171],"isolated":[66,229,268],"from":[67],"patients.":[73],"absolute":[75],"amount":[76,97,131,138,144,149,172,177],"each":[78],"two":[81],"types":[82],"TAP":[84],"also":[86],"similar:":[87],"14.69":[88],"2.88":[89],"18.29":[91],"3.85":[92],"mg":[93],"ml-1,":[94],"respectively.":[95,207],"higher":[102,284],"than":[103,294],"those":[104,295],"antigen,":[107],"but":[108],"difference":[110],"not":[112],"significant:":[113],"9.35":[114],"3.48":[115],"6.":[117],"19":[118],"3.87":[119],"mg/ml,":[120],"respectively":[121],"(p>0.05).":[122],"A":[123,162],"good":[124],"correlation":[125],"found":[127,168],"between":[128,155,169,183],"tumor-associated":[133],"(TAA)":[135],"(r=0.69),":[142],"IgG":[146,293],"(r=0.46),":[153],"(r=0.46).":[161],"high":[163,232],"coefficient":[164],"regression":[166],"TAA":[174],"(b=2.4).":[181],"Relationships":[182],"Duke's":[184],"stage":[185],"weak:":[197],"0.33":[198],"-0.32":[200],"Serum":[208],"determination":[209,218],"has":[213],"no":[214],"advantage":[215],"over":[216],"antigen.":[221],"Both":[222],"can":[227],"be":[228],"with":[230,256,272,283,290,297],"extremely":[231],"accuracy":[233],"pathological":[236],"diagnosis":[237],"(87-93%).":[240],"Specificity":[241],"method":[244],"proved":[246],"using":[247,286],"commercial":[249,298],"PAb":[251],"OD1:":[252],"GFG":[254,270,288],"columns":[255,271,289,296],"this":[257],"antibody":[258],"able":[260],"isolate":[262],"same":[264],"which":[266],"by":[269],"anti-p53":[273,292],"IgG.":[274],"Moreover,":[275],"performed":[282],"effectiveness":[285],"entrapped":[291],"DO1":[299],"PAb.":[300]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}