{"id":"https://openalex.org/W2018094028","doi":"https://doi.org/10.1159/000218781","title":"Combined Locoregional and Systemic Adjuvant Chemotherapy of Stage II and III Rectal Carcinoma","display_name":"Combined Locoregional and Systemic Adjuvant Chemotherapy of Stage II and III Rectal Carcinoma","publication_year":2009,"publication_date":"2009-05-12","ids":{"openalex":"https://openalex.org/W2018094028","doi":"https://doi.org/10.1159/000218781","mag":"2018094028"},"language":"en","primary_location":{"id":"doi:10.1159/000218781","doi":"https://doi.org/10.1159/000218781","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000218781","pdf_url":null,"source":{"id":"https://openalex.org/S4210228507","display_name":"Onkologie","issn_l":"0378-584X","issn":["0378-584X","1423-0240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Onkologie","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109943025","display_name":"G.-V. Kornek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"G.V. Kornek","raw_affiliation_strings":["Klinische Abteilung f\u00fcr Onkologie, Universit\u00e4tsklinik f\u00fcr Innere Medizin I, Wien"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinische Abteilung f\u00fcr Onkologie, Universit\u00e4tsklinik f\u00fcr Innere Medizin I, Wien","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113610545","display_name":"Dieter Depisch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405253678","display_name":"Universit\u00e4tsklinikum Wiener Neustadt","ror":"https://ror.org/00yx1kx21","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4405253678"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"D. Depisch","raw_affiliation_strings":["Abteilung f\u00fcr Chirurgie, Allgemeines Krankenhaus Wr. Neustadt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abteilung f\u00fcr Chirurgie, Allgemeines Krankenhaus Wr. Neustadt","institution_ids":["https://openalex.org/I4405253678"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111508333","display_name":"Galena Salem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115084","display_name":"Universit\u00e4tsklinikum St. P\u00f6lten","ror":"https://ror.org/02g9n8n52","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210115084"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"G. Salem","raw_affiliation_strings":["Abteilung f\u00fcr Chirurgie, Allgemeines Krankenhaus St. P\u00f6lten, \u00d6sterreich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abteilung f\u00fcr Chirurgie, Allgemeines Krankenhaus St. P\u00f6lten, \u00d6sterreich","institution_ids":["https://openalex.org/I4210115084"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031034954","display_name":"M. Karall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405253678","display_name":"Universit\u00e4tsklinikum Wiener Neustadt","ror":"https://ror.org/00yx1kx21","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4405253678"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"M. Karall","raw_affiliation_strings":["Abteilung f\u00fcr Chirurgie, Allgemeines Krankenhaus Wr. Neustadt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abteilung f\u00fcr Chirurgie, Allgemeines Krankenhaus Wr. Neustadt","institution_ids":["https://openalex.org/I4405253678"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014312390","display_name":"Maren Rohrbacher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115084","display_name":"Universit\u00e4tsklinikum St. P\u00f6lten","ror":"https://ror.org/02g9n8n52","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210115084"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"M. Rohrbacher","raw_affiliation_strings":["Abteilung f\u00fcr Chirurgie, Allgemeines Krankenhaus St. P\u00f6lten, \u00d6sterreich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abteilung f\u00fcr Chirurgie, Allgemeines Krankenhaus St. P\u00f6lten, \u00d6sterreich","institution_ids":["https://openalex.org/I4210115084"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108460887","display_name":"Werner Scheithauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"W. Scheithauer","raw_affiliation_strings":["Klinische Abteilung f\u00fcr Onkologie, Universit\u00e4tsklinik f\u00fcr Innere Medizin I, Wien"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinische Abteilung f\u00fcr Onkologie, Universit\u00e4tsklinik f\u00fcr Innere Medizin I, Wien","institution_ids":["https://openalex.org/I76134821"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1739,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.57338872,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"147","last_page":"151"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13110","display_name":"Colorectal and Anal Carcinomas","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rectal-cancer","display_name":"rectal cancer","score":0.8259999752044678},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.9890000224113464},{"id":"https://openalex.org/keywords/locoregional-chemotherapy","display_name":"locoregional chemotherapy","score":0.7559999823570251},{"id":"https://openalex.org/keywords/mitoxantrone","display_name":"mitoxantrone","score":0.8690000176429749},{"id":"https://openalex.org/keywords/intrathecal-chemotherapy","display_name":"intrathecal chemotherapy","score":0.7730000019073486},{"id":"https://openalex.org/keywords/leucovorin","display_name":"leucovorin","score":0.8009999990463257},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.996999979019165},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.6610000133514404},{"id":"https://openalex.org/keywords/local-recurrence","display_name":"local recurrence","score":0.8149999976158142},{"id":"https://openalex.org/keywords/stage-ii-rectal-cancer","display_name":"stage II rectal cancer","score":0.8209999799728394},{"id":"https://openalex.org/keywords/stage-iii-rectal-cancer","display_name":"stage III rectal cancer","score":0.8510000109672546}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9339942336082458},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.609049916267395},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5915951132774353},{"id":"https://openalex.org/C2781074409","wikidata":"https://www.wikidata.org/wiki/Q158716","display_name":"Rectum","level":2,"score":0.5748304724693298},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5693944096565247},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.5549606680870056},{"id":"https://openalex.org/C2780923524","wikidata":"https://www.wikidata.org/wiki/Q239426","display_name":"Mitoxantrone","level":3,"score":0.521644651889801},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.49368318915367126},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.49067485332489014},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4447074830532074},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42582884430885315},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1159/000218781","doi":"https://doi.org/10.1159/000218781","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000218781","pdf_url":null,"source":{"id":"https://openalex.org/S4210228507","display_name":"Onkologie","issn_l":"0378-584X","issn":["0378-584X","1423-0240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Onkologie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2417825398","https://openalex.org/W2011162382","https://openalex.org/W2108165913","https://openalex.org/W28087387","https://openalex.org/W2119230025","https://openalex.org/W2097656606","https://openalex.org/W3003416832","https://openalex.org/W4386052117","https://openalex.org/W2029624572","https://openalex.org/W2597659162"],"abstract_inverted_index":{"Background:":[0],"Patients":[1,37],"with":[2,16,152,173,191,218,223],"stage":[3,153,260],"T3-4":[4],"and/or":[5],"N-positive":[6],"rectal":[7,155,262],"cancer":[8],"have":[9],"a":[10,22,100,107,131,254],"high":[11],"risk":[12],"for":[13,53],"local":[14,246],"recurrence":[15],"or":[17,63,174],"without":[18,175],"distant":[19,176],"metastases.":[20],"Despite":[21],"failure":[23,184],"rate":[24],"of":[25,55,67,70,84,104,113,116,139,162,168,182,187,201,210,221,233],"approximately":[26],"50%,":[27],"no":[28,219,239],"standard":[29],"adjuvant":[30,64,141,257],"therapy":[31],"has":[32],"been":[33],"defined":[34],"until":[35],"recently.":[36],"and":[38,43,130,198,247],"Methods:":[39],"Between":[40],"May":[41],"1988":[42],"December":[44],"1990,":[45],"62":[46],"patients":[47,151,190,204,234],"who":[48,205],"underwent":[49],"potential":[50],"curative":[51],"surgery":[52],"adenocarcinoma":[54],"the":[56,75,110,140,160,166,179,195,213,230],"rectum":[57],"were":[58,118],"randomly":[59],"assigned":[60],"to":[61,147,229,252],"observation":[62],"treatment,":[65],"consisting":[66],"perioperative":[68],"instillation":[69],"20":[71],"mg":[72],"mitoxantrone":[73],"into":[74],"sacral":[76],"cavity":[77],"followed":[78],"by":[79],"6":[80],"intravenous":[81,249],"treatment":[82,183,214],"cycles":[83],"leucovorin":[85],"(200":[86],"mg/m2)":[87,91],"plus":[88],"5-fluorouraciJ":[89],"(370":[90],"on":[92],"days":[93],"1-5":[94],"every":[95],"4":[96],"weeks.":[97],"Results:":[98],"After":[99],"median":[101],"follow-up":[102],"time":[103],"4.5":[105],"years,":[106],"comparison":[108],"between":[109],"two":[111],"groups":[112],"patients,":[114],"57":[115],"whom":[117],"eligible,":[119],"suggested":[120],"both":[121],"an":[122],"improvement":[123],"in":[124,137,150,164,185,194,199,212,235,259],"disease-free":[125],"survival":[126,132],"(68%":[127],"vs.":[128,135],"46%)":[129],"advantage":[133,161],"(70%":[134],"54%)":[136],"favor":[138],"chemotherapy":[142,163,211,250],"group.":[143],"The":[144,171],"benefit":[145],"appears":[146],"be":[148,243],"greatest":[149],"II":[154],"cancer.":[156,263],"Particularly":[157],"striking":[158],"was":[159,178,216],"decreasing":[165],"incidence":[167],"locoregional":[169],"failure:":[170],"pelvis":[172],"metastases":[177],"first":[180],"site":[181],"9":[186,202],"15":[188],"(60%)":[189],"documented":[192],"recurrences":[193],"control":[196],"group":[197],"3":[200],"(33%)":[203],"received":[206],"additional":[207],"treatment.":[208],"Tolerance":[209],"arm":[215],"remarkable,":[217],"evidence":[220],"interference":[222],"wound":[224],"healing.":[225],"Conclusions:":[226],"Although,":[227],"due":[228],"small":[231],"number":[232],"this":[236],"pilot":[237],"study,":[238],"definite":[240],"conclusions":[241],"can":[242],"drawn,":[244],"combined":[245],"systemic":[248],"seems":[251],"represent":[253],"potentially":[255],"effective":[256],"regimen":[258],"II/III":[261]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}