{"id":"https://openalex.org/W2018093936","doi":"https://doi.org/10.1021/ol047695j","title":"An Expeditious Synthesis of DPD and Boron Binding Studies","display_name":"An Expeditious Synthesis of DPD and Boron Binding Studies","publication_year":2005,"publication_date":"2005-01-19","ids":{"openalex":"https://openalex.org/W2018093936","doi":"https://doi.org/10.1021/ol047695j","mag":"2018093936","pmid":"https://pubmed.ncbi.nlm.nih.gov/15704896"},"language":"en","primary_location":{"id":"doi:10.1021/ol047695j","doi":"https://doi.org/10.1021/ol047695j","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ol047695j","pdf_url":null,"source":{"id":"https://openalex.org/S201989124","display_name":"Organic Letters","issn_l":"1523-7052","issn":["1523-7052","1523-7060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037542759","display_name":"Martin F. Semmelhack","orcid":"https://orcid.org/0000-0003-0277-3894","observed_orcids":["https://orcid.org/0000-0003-0277-3894"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin F. Semmelhack","raw_affiliation_strings":["Departments of Chemistry and Molecular Biology, Princeton University, Princeton, New Jersey 08544","Departments of Chemistry and Molecular Biology, Princeton University, Princeton, NJ 08544, USA. mfshack@princeton.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry and Molecular Biology, Princeton University, Princeton, New Jersey 08544","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Departments of Chemistry and Molecular Biology, Princeton University, Princeton, NJ 08544, USA. mfshack@princeton.edu","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025355779","display_name":"Shawn Robert Campagna","orcid":"https://orcid.org/0000-0001-6809-3862","observed_orcids":["https://orcid.org/0000-0001-6809-3862","https://orcid.org/0009-0008-5687-5507"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shawn R. Campagna","raw_affiliation_strings":["Departments of Chemistry and Molecular Biology, Princeton University, Princeton, New Jersey 08544"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry and Molecular Biology, Princeton University, Princeton, New Jersey 08544","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082921592","display_name":"Michael J. Federle","orcid":"https://orcid.org/0000-0002-4554-543X","observed_orcids":["https://orcid.org/0000-0002-4554-543X"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Federle","raw_affiliation_strings":["Departments of Chemistry and Molecular Biology, Princeton University, Princeton, New Jersey 08544"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry and Molecular Biology, Princeton University, Princeton, New Jersey 08544","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034726213","display_name":"Bonnie L. Bassler","orcid":"https://orcid.org/0000-0002-0043-746X","observed_orcids":["https://orcid.org/0000-0002-0043-746X"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bonnie L. Bassler","raw_affiliation_strings":["Departments of Chemistry and Molecular Biology, Princeton University, Princeton, New Jersey 08544"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry and Molecular Biology, Princeton University, Princeton, New Jersey 08544","institution_ids":["https://openalex.org/I20089843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I20089843"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.3075,"has_fulltext":false,"cited_by_count":134,"citation_normalized_percentile":{"value":0.93200443,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"4","first_page":"569","last_page":"572"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11441","display_name":"Organoboron and organosilicon chemistry","score":0.029500000178813934,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10532","display_name":"Molecular Sensors and Ion Detection","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dpd","display_name":"DPD","score":0.753000020980835},{"id":"https://openalex.org/keywords/quorum-sensing","display_name":"quorum sensing","score":0.7860000133514404},{"id":"https://openalex.org/keywords/bacterial-signaling-molecules","display_name":"bacterial signaling molecules","score":0.6980000138282776},{"id":"https://openalex.org/keywords/borate-complexes","display_name":"borate complexes","score":0.656000018119812},{"id":"https://openalex.org/keywords/vibrio-harveyi","display_name":"Vibrio harveyi","score":0.9789999723434448},{"id":"https://openalex.org/keywords/marine-bacteria","display_name":"marine bacteria","score":0.8220000267028809},{"id":"https://openalex.org/keywords/small-molecule-synthesis","display_name":"small molecule synthesis","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8257061243057251},{"id":"https://openalex.org/C2781275326","wikidata":"https://www.wikidata.org/wiki/Q3761158","display_name":"Vibrio harveyi","level":4,"score":0.7700048685073853},{"id":"https://openalex.org/C501308230","wikidata":"https://www.wikidata.org/wiki/Q618","display_name":"Boron","level":2,"score":0.7517029643058777},{"id":"https://openalex.org/C118687296","wikidata":"https://www.wikidata.org/wiki/Q905754","display_name":"Quorum sensing","level":4,"score":0.6925014853477478},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.6180337071418762},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.6050850749015808},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.4585210680961609},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.42366713285446167},{"id":"https://openalex.org/C2776154503","wikidata":"https://www.wikidata.org/wiki/Q753490","display_name":"Vibrio","level":3,"score":0.29850637912750244},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23657673597335815},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1803700029850006},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.04870319366455078},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.047766298055648804},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001895","descriptor_name":"Boron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007659","descriptor_name":"Ketones","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010420","descriptor_name":"Pentanes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D014733","descriptor_name":"Vibrio","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018407","descriptor_name":"Bacterial Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ol047695j","doi":"https://doi.org/10.1021/ol047695j","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ol047695j","pdf_url":null,"source":{"id":"https://openalex.org/S201989124","display_name":"Organic Letters","issn_l":"1523-7052","issn":["1523-7052","1523-7060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Letters","raw_type":"journal-article"},{"id":"pmid:15704896","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15704896","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1005440252","display_name":"Structure-Function Analysis of AI-2 Quorum Sensing","funder_award_id":"R01AI054442","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320331993","display_name":"Life Sciences Research Board","ror":"https://ror.org/04meft248"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W241063502","https://openalex.org/W1997118588","https://openalex.org/W2000930830","https://openalex.org/W2010912571","https://openalex.org/W2015700034","https://openalex.org/W2017779647","https://openalex.org/W2053074787","https://openalex.org/W2054394946","https://openalex.org/W2070050109","https://openalex.org/W2098064749","https://openalex.org/W2144640625","https://openalex.org/W2167808578","https://openalex.org/W2313658489","https://openalex.org/W2327587979"],"related_works":["https://openalex.org/W1997330987","https://openalex.org/W1969227686","https://openalex.org/W2287278175","https://openalex.org/W4293408094","https://openalex.org/W2085737838","https://openalex.org/W2001766071","https://openalex.org/W2058685303","https://openalex.org/W2055653889","https://openalex.org/W2952029710","https://openalex.org/W2087295705"],"abstract_inverted_index":{"A":[0],"practical":[1],"synthesis":[2,30],"has":[3],"been":[4],"developed":[5],"for":[6,24,58],"DPD":[7,36],"(4,5-dihydroxypentane-2,3-dione),":[8],"an":[9],"unstable":[10],"small":[11],"molecule":[12],"that":[13],"is":[14],"proposed":[15],"to":[16,47,49],"be":[17],"the":[18,51,56],"source":[19],"of":[20,33,44],"universal":[21],"signaling":[22],"agents":[23],"quorum":[25],"sensing":[26],"in":[27],"bacteria.":[28],"The":[29],"allows":[31],"preparation":[32],"isotopically":[34],"labeled":[35],"and":[37],"ent-DPD":[38],"as":[39,41,62],"well":[40],"detailed":[42],"studies":[43],"spontaneous":[45],"binding":[46],"borate":[48,53],"give":[50],"unusual":[52],"complex":[54],"6,":[55],"signal":[57],"marine":[59],"bacteria":[60],"such":[61],"Vibrio":[63],"harveyi.":[64],"[reaction:":[65],"see":[66],"text]":[67]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}