{"id":"https://openalex.org/W2018091449","doi":"https://doi.org/10.1016/s0140-6736(98)06343-0","title":"Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial","display_name":"Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W2018091449","doi":"https://doi.org/10.1016/s0140-6736(98)06343-0","mag":"2018091449","pmid":"https://pubmed.ncbi.nlm.nih.gov/10466665"},"language":"en","primary_location":{"id":"doi:10.1016/s0140-6736(98)06343-0","doi":"https://doi.org/10.1016/s0140-6736(98)06343-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0140-6736(98)06343-0","pdf_url":null,"source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2018091449"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110030025","display_name":"BJ Rembacken","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"BJ Rembacken","raw_affiliation_strings":["Centre for Digestive Diseases, The General Infirmary at Leeds, UK. BJR@thecafe.co.uk","Centre for Digestive Diseases, The General Infirmary at Leeds, Great George Street, Leeds LS1 SEX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Digestive Diseases, The General Infirmary at Leeds, UK. BJR@thecafe.co.uk","institution_ids":["https://openalex.org/I1295121038"]},{"raw_affiliation_string":"Centre for Digestive Diseases, The General Infirmary at Leeds, Great George Street, Leeds LS1 SEX, UK","institution_ids":["https://openalex.org/I1295121038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110092972","display_name":"A.M. Snelling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"AM Snelling","raw_affiliation_strings":["Department of Microbiology, University of Leeds, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109174328","display_name":"P M Hawkey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"PM Hawkey","raw_affiliation_strings":["Department of Microbiology, University of Leeds, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110481214","display_name":"Douglas M. Chalmers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"DM Chalmers","raw_affiliation_strings":["Centre for Digestive Diseases, The General Infirmary at Leeds, Great George Street, Leeds LS1 SEX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Digestive Diseases, The General Infirmary at Leeds, Great George Street, Leeds LS1 SEX, UK","institution_ids":["https://openalex.org/I1295121038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110159325","display_name":"ATR Axon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"ATR Axon","raw_affiliation_strings":["Centre for Digestive Diseases, The General Infirmary at Leeds, Great George Street, Leeds LS1 SEX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Digestive Diseases, The General Infirmary at Leeds, Great George Street, Leeds LS1 SEX, UK","institution_ids":["https://openalex.org/I1295121038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":7890,"currency":"USD","value_usd":7890},"apc_paid":null,"fwci":28.9389,"has_fulltext":false,"cited_by_count":1111,"citation_normalized_percentile":{"value":0.99852202,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"354","issue":"9179","first_page":"635","last_page":"639"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13569","display_name":"Microscopic Colitis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":1.0},{"id":"https://openalex.org/keywords/non-pathogenic-escherichia-coli","display_name":"non-pathogenic Escherichia coli","score":0.9179999828338623},{"id":"https://openalex.org/keywords/nissle-1917","display_name":"Nissle 1917","score":0.9950000047683716},{"id":"https://openalex.org/keywords/5-aminosalicylic-acid","display_name":"5-aminosalicylic acid","score":0.9700000286102295},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.5870000123977661},{"id":"https://openalex.org/keywords/remission","display_name":"remission","score":0.503000020980835},{"id":"https://openalex.org/keywords/relapse-prevention","display_name":"relapse prevention","score":0.9200000166893005}],"concepts":[{"id":"https://openalex.org/C2779174533","wikidata":"https://www.wikidata.org/wiki/Q412479","display_name":"Mesalazine","level":4,"score":0.9925419092178345},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.915424108505249},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7632778882980347},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.7317197918891907},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7248167991638184},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.47606366872787476},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4543861150741577},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.08619242906570435}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019804","descriptor_name":"Mesalamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0140-6736(98)06343-0","doi":"https://doi.org/10.1016/s0140-6736(98)06343-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0140-6736(98)06343-0","pdf_url":null,"source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet","raw_type":"journal-article"},{"id":"pmid:10466665","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10466665","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lancet (London, England)","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W92958171","https://openalex.org/W1497617769","https://openalex.org/W1872561150","https://openalex.org/W1971737706","https://openalex.org/W1995574368","https://openalex.org/W2004732286","https://openalex.org/W2028251093","https://openalex.org/W2028851330","https://openalex.org/W2032299180","https://openalex.org/W2033535624","https://openalex.org/W2040444333","https://openalex.org/W2047076379","https://openalex.org/W2058746051","https://openalex.org/W2060859971","https://openalex.org/W2065780155","https://openalex.org/W2078077899","https://openalex.org/W2087529531","https://openalex.org/W2089162409","https://openalex.org/W2098013182","https://openalex.org/W2114344731","https://openalex.org/W2114959701","https://openalex.org/W2126499833","https://openalex.org/W2130865831","https://openalex.org/W2137109050","https://openalex.org/W2148583189","https://openalex.org/W2163330250","https://openalex.org/W2166930089","https://openalex.org/W2171789845","https://openalex.org/W2339570827","https://openalex.org/W4251680152"],"related_works":["https://openalex.org/W2047046599","https://openalex.org/W2022011264","https://openalex.org/W1971737706","https://openalex.org/W2124334818","https://openalex.org/W4238557184","https://openalex.org/W2043364035","https://openalex.org/W2402738951","https://openalex.org/W4250628636","https://openalex.org/W2078892008","https://openalex.org/W1974088117"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":25},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":35},{"year":2020,"cited_by_count":33},{"year":2019,"cited_by_count":23},{"year":2018,"cited_by_count":22},{"year":2017,"cited_by_count":32},{"year":2016,"cited_by_count":32},{"year":2015,"cited_by_count":33},{"year":2014,"cited_by_count":53},{"year":2013,"cited_by_count":39},{"year":2012,"cited_by_count":49}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
