{"id":"https://openalex.org/W2018073400","doi":"https://doi.org/10.1254/jjp.44.211","title":"Alpha-Human Atrial Natriuretic Peptide (\u03b1-hANP) Prevents Pulmonary Edema Induced by Arachidonic Acid Treatment in Isolated Perfused Lung from Guinea Pig","display_name":"Alpha-Human Atrial Natriuretic Peptide (\u03b1-hANP) Prevents Pulmonary Edema Induced by Arachidonic Acid Treatment in Isolated Perfused Lung from Guinea Pig","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W2018073400","doi":"https://doi.org/10.1254/jjp.44.211","mag":"2018073400","pmid":"https://pubmed.ncbi.nlm.nih.gov/2958647"},"language":"en","primary_location":{"id":"doi:10.1254/jjp.44.211","doi":"https://doi.org/10.1254/jjp.44.211","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jjp.44.211","pdf_url":null,"source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1254/jjp.44.211","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026312843","display_name":"Norio Inomata","orcid":"https://orcid.org/0000-0001-9370-8873","observed_orcids":["https://orcid.org/0000-0001-9370-8873"]},"institutions":[{"id":"https://openalex.org/I4210122276","display_name":"Suntory (Japan)","ror":"https://ror.org/02jg1fa85","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210122276"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norio INOMATA","raw_affiliation_strings":["Suntory Institute for Biomedical Research, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suntory Institute for Biomedical Research, Osaka, Japan","institution_ids":["https://openalex.org/I4210122276"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052543365","display_name":"Norio Ohnuma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122276","display_name":"Suntory (Japan)","ror":"https://ror.org/02jg1fa85","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210122276"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norio OHNUMA","raw_affiliation_strings":["Suntory Institute for Biomedical Research, Mishima, Osaka 618, Japan","Suntory Institute for Biomedical Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suntory Institute for Biomedical Research, Mishima, Osaka 618, Japan","institution_ids":[]},{"raw_affiliation_string":"Suntory Institute for Biomedical Research","institution_ids":["https://openalex.org/I4210122276"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111725185","display_name":"Mayumi Furuya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122276","display_name":"Suntory (Japan)","ror":"https://ror.org/02jg1fa85","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210122276"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mayumi FURUYA","raw_affiliation_strings":["Suntory Institute for Biomedical Research, Mishima, Osaka 618, Japan","Suntory Institute for Biomedical Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suntory Institute for Biomedical Research, Mishima, Osaka 618, Japan","institution_ids":[]},{"raw_affiliation_string":"Suntory Institute for Biomedical Research","institution_ids":["https://openalex.org/I4210122276"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103395772","display_name":"Yujiro Hayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122276","display_name":"Suntory (Japan)","ror":"https://ror.org/02jg1fa85","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210122276"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yujiro HAYASHI","raw_affiliation_strings":["Suntory Institute for Biomedical Research, Mishima, Osaka 618, Japan","Suntory Institute for Biomedical Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suntory Institute for Biomedical Research, Mishima, Osaka 618, Japan","institution_ids":[]},{"raw_affiliation_string":"Suntory Institute for Biomedical Research","institution_ids":["https://openalex.org/I4210122276"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yasushi KANAI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122276","display_name":"Suntory (Japan)","ror":"https://ror.org/02jg1fa85","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210122276"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasushi KANAI","raw_affiliation_strings":["Suntory Institute for Biomedical Research, Mishima, Osaka 618, Japan","Suntory Institute for Biomedical Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suntory Institute for Biomedical Research, Mishima, Osaka 618, Japan","institution_ids":[]},{"raw_affiliation_string":"Suntory Institute for Biomedical Research","institution_ids":["https://openalex.org/I4210122276"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062684087","display_name":"Takafumi Ishihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122276","display_name":"Suntory (Japan)","ror":"https://ror.org/02jg1fa85","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210122276"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takafumi ISHIHARA","raw_affiliation_strings":["Suntory Institute for Biomedical Research, Mishima, Osaka 618, Japan","Suntory Institute for Biomedical Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suntory Institute for Biomedical Research, Mishima, Osaka 618, Japan","institution_ids":[]},{"raw_affiliation_string":"Suntory Institute for Biomedical Research","institution_ids":["https://openalex.org/I4210122276"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060394697","display_name":"Teruhisa Noguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122276","display_name":"Suntory (Japan)","ror":"https://ror.org/02jg1fa85","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210122276"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Teruhisa NOGUCHI","raw_affiliation_strings":["Suntory Institute for Biomedical Research, Mishima, Osaka 618, Japan","Suntory Institute for Biomedical Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suntory Institute for Biomedical Research, Mishima, Osaka 618, Japan","institution_ids":[]},{"raw_affiliation_string":"Suntory Institute for Biomedical Research","institution_ids":["https://openalex.org/I4210122276"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103540959","display_name":"Hisayuki Matsuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisayuki MATSUO","raw_affiliation_strings":["Department of Biochemistry, Miyazaki Medical College, Kiyotake, Miyazaki, Miyazaki 889-16, Japan","Department of Biochemistry, Miyazaki Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Miyazaki Medical College, Kiyotake, Miyazaki, Miyazaki 889-16, Japan","institution_ids":["https://openalex.org/I118574687"]},{"raw_affiliation_string":"Department of Biochemistry, Miyazaki Medical College","institution_ids":["https://openalex.org/I118574687"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.1345,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.94999638,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"44","issue":"2","first_page":"211","last_page":"214"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.5723000168800354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.5723000168800354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.12809999287128448,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12082","display_name":"Takotsubo Cardiomyopathy and Associated Phenomena","score":0.08169999718666077,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-human-atrial-natriuretic-peptide","display_name":"alpha-human atrial natriuretic peptide","score":0.9739999771118164},{"id":"https://openalex.org/keywords/pulmonary-edema","display_name":"pulmonary edema","score":0.9750000238418579},{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.9860000014305115},{"id":"https://openalex.org/keywords/isolated-perfused-lung","display_name":"isolated perfused lung","score":0.8920000195503235},{"id":"https://openalex.org/keywords/natriuretic-peptide-receptors","display_name":"natriuretic peptide receptors","score":0.8519999980926514},{"id":"https://openalex.org/keywords/guinea-pig-lung","display_name":"guinea pig lung","score":0.5979999899864197},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.3269999921321869}],"concepts":[{"id":"https://openalex.org/C2776468924","wikidata":"https://www.wikidata.org/wiki/Q857667","display_name":"Pulmonary edema","level":3,"score":0.8028430938720703},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.7714569568634033},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.7362769246101379},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.7035810947418213},{"id":"https://openalex.org/C2778069365","wikidata":"https://www.wikidata.org/wiki/Q78185357","display_name":"Atrial natriuretic peptide","level":2,"score":0.5937353372573853},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5761312246322632},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.5562446713447571},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5151759386062622},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5015182495117188},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4551023542881012},{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.45373645424842834},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38450559973716736},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3452572226524353},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16588932275772095},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07087883353233337}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009320","descriptor_name":"Atrial Natriuretic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009320","descriptor_name":"Atrial Natriuretic Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011654","descriptor_name":"Pulmonary Edema","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011654","descriptor_name":"Pulmonary Edema","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1254/jjp.44.211","doi":"https://doi.org/10.1254/jjp.44.211","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jjp.44.211","pdf_url":null,"source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:2958647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2958647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1254/jjp.44.211","doi":"https://doi.org/10.1254/jjp.44.211","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jjp.44.211","pdf_url":null,"source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1971337562","https://openalex.org/W1972700689","https://openalex.org/W1990423314","https://openalex.org/W2006969256","https://openalex.org/W2010438419","https://openalex.org/W2012041356","https://openalex.org/W2015440303","https://openalex.org/W2019803365","https://openalex.org/W2035879817","https://openalex.org/W2041179424","https://openalex.org/W2047025106","https://openalex.org/W2053732325","https://openalex.org/W2057486694","https://openalex.org/W2059385211","https://openalex.org/W2065142882","https://openalex.org/W2076734878","https://openalex.org/W2082370756","https://openalex.org/W2409967665"],"related_works":["https://openalex.org/W2064292393","https://openalex.org/W2139411454","https://openalex.org/W2410121786","https://openalex.org/W7128516638","https://openalex.org/W2030279388","https://openalex.org/W2043820950","https://openalex.org/W2432751518","https://openalex.org/W2093992818","https://openalex.org/W3100244903","https://openalex.org/W2383577949"],"abstract_inverted_index":{"Protective":[0],"effect":[1],"of":[2,20,44,47,61,79,82],"alpha-human":[3],"atrial":[4],"natriuretic":[5],"peptide":[6],"(alpha-hANP)":[7],"on":[8],"pulmonary":[9,56],"edema":[10,33],"was":[11,63,73],"investigated":[12],"using":[13],"an":[14],"isolated":[15,36],"perfused":[16],"lung":[17,37,88],"model.":[18],"Infusion":[19],"alpha-hANP":[21,62],"(1.7":[22],"to":[23,28,65,75],"22":[24],"ng/ml":[25],"or":[26],"0.56":[27],"7.3":[29],"nM)":[30],"prevented":[31],"the":[32,55,70,76,80,83,87],"induced":[34],"in":[35,86],"from":[38],"guinea":[39],"pig":[40],"by":[41],"repeated":[42],"treatment":[43],"50":[45],"micrograms":[46],"arachidonic":[48],"acid":[49],"at":[50],"30":[51],"min":[52],"intervals":[53],"via":[54],"artery.":[57],"The":[58],"antiedematic":[59],"action":[60],"considered":[64],"be":[66],"receptor":[67],"mediated":[68],"because":[69],"effective":[71],"concentration":[72],"close":[74],"Kd":[77],"value":[78],"binding":[81],"ANP":[84],"receptors":[85],"homogenate.":[89]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}