{"id":"https://openalex.org/W2018072361","doi":"https://doi.org/10.1157/13078491","title":"Enfermedad de Graves-Basedow en el ni\u00f1o preescolar","display_name":"Enfermedad de Graves-Basedow en el ni\u00f1o preescolar","publication_year":2005,"publication_date":"2005-09-01","ids":{"openalex":"https://openalex.org/W2018072361","doi":"https://doi.org/10.1157/13078491","mag":"2018072361","pmid":"https://pubmed.ncbi.nlm.nih.gov/16219281"},"language":"es","primary_location":{"id":"doi:10.1157/13078491","doi":"https://doi.org/10.1157/13078491","is_oa":true,"landing_page_url":"https://doi.org/10.1157/13078491","pdf_url":null,"source":{"id":"https://openalex.org/S136590224","display_name":"Anales de Pediatr\u00eda","issn_l":"1695-4033","issn":["1695-4033","1695-9531"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anales de Pediatr\u00eda","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1157/13078491","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106695331","display_name":"Ana Coca P\u00e9rez","orcid":"https://orcid.org/0000-0002-8666-7150","observed_orcids":["https://orcid.org/0000-0002-8666-7150"]},"institutions":[{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"A. Coca P\u00e9rez","raw_affiliation_strings":["Servicio de Pediatr\u00eda, Hospital Ram\u00f3n y Cajal, Madrid, Spain. pdacoca@hotmail.com","Unidad de Endocrinolog\u00eda Pedi\u00e1trica. Servicio de Pediatr\u00eda. Hospital Ram\u00f3n y Cajal. Madrid. Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Pediatr\u00eda, Hospital Ram\u00f3n y Cajal, Madrid, Spain. pdacoca@hotmail.com","institution_ids":["https://openalex.org/I4210161852"]},{"raw_affiliation_string":"Unidad de Endocrinolog\u00eda Pedi\u00e1trica. Servicio de Pediatr\u00eda. Hospital Ram\u00f3n y Cajal. Madrid. Espa\u00f1a","institution_ids":["https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087187088","display_name":"E. Colino Alcol","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"E. Colino Alcol","raw_affiliation_strings":["Unidad de Endocrinolog\u00eda Pedi\u00e1trica. Servicio de Pediatr\u00eda. Hospital Ram\u00f3n y Cajal. Madrid. Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de Endocrinolog\u00eda Pedi\u00e1trica. Servicio de Pediatr\u00eda. Hospital Ram\u00f3n y Cajal. Madrid. Espa\u00f1a","institution_ids":["https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048621969","display_name":"M. L\u00f3pez-Capap\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M. L\u00f3pez Capap\u00e9","raw_affiliation_strings":["Unidad de Endocrinolog\u00eda Pedi\u00e1trica. Servicio de Pediatr\u00eda. Hospital Ram\u00f3n y Cajal. Madrid. Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de Endocrinolog\u00eda Pedi\u00e1trica. Servicio de Pediatr\u00eda. Hospital Ram\u00f3n y Cajal. Madrid. Espa\u00f1a","institution_ids":["https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025874932","display_name":"Cristina Alonso\u2010Blanco","orcid":"https://orcid.org/0000-0002-6809-6534","observed_orcids":["https://orcid.org/0000-0002-6809-6534"]},"institutions":[{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M. Alonso Blanco","raw_affiliation_strings":["Unidad de Endocrinolog\u00eda Pedi\u00e1trica. Servicio de Pediatr\u00eda. Hospital Ram\u00f3n y Cajal. Madrid. Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de Endocrinolog\u00eda Pedi\u00e1trica. Servicio de Pediatr\u00eda. Hospital Ram\u00f3n y Cajal. Madrid. Espa\u00f1a","institution_ids":["https://openalex.org/I4210161852"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058463299","display_name":"Raquel Barrio Castellanos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"R. Barrio Castellanos","raw_affiliation_strings":["Unidad de Endocrinolog\u00eda Pedi\u00e1trica. Servicio de Pediatr\u00eda. Hospital Ram\u00f3n y Cajal. Madrid. Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de Endocrinolog\u00eda Pedi\u00e1trica. Servicio de Pediatr\u00eda. Hospital Ram\u00f3n y Cajal. Madrid. Espa\u00f1a","institution_ids":["https://openalex.org/I4210161852"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5106695331"],"corresponding_institution_ids":["https://openalex.org/I4210161852"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":{"value":0,"currency":"USD","value_usd":0},"fwci":0.1666,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.58179891,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"63","issue":"3","first_page":"259","last_page":"262"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11538","display_name":"Ophthalmology and Eye Disorders","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/graves-disease","display_name":"Graves' disease","score":0.9729999899864197},{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":0.7239999771118164},{"id":"https://openalex.org/keywords/preschool-children","display_name":"preschool children","score":0.8960000276565552},{"id":"https://openalex.org/keywords/pediatric-thyroid-disease","display_name":"pediatric thyroid disease","score":0.6060000061988831},{"id":"https://openalex.org/keywords/carbimazole","display_name":"carbimazole","score":0.7400000095367432},{"id":"https://openalex.org/keywords/thyroid-stimulating-antibodies","display_name":"thyroid-stimulating antibodies","score":0.9020000100135803},{"id":"https://openalex.org/keywords/tsh-suppression","display_name":"TSH suppression","score":0.7360000014305115},{"id":"https://openalex.org/keywords/tachycardia","display_name":"tachycardia","score":0.7929999828338623},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.75},{"id":"https://openalex.org/keywords/language-delay","display_name":"language delay","score":0.8519999980926514},{"id":"https://openalex.org/keywords/advanced-bone-age","display_name":"advanced bone age","score":0.6610000133514404},{"id":"https://openalex.org/keywords/goiter","display_name":"goiter","score":0.7160000205039978},{"id":"https://openalex.org/keywords/thyroid-ultrasound","display_name":"thyroid ultrasound","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9297648668289185},{"id":"https://openalex.org/C2779442721","wikidata":"https://www.wikidata.org/wiki/Q414013","display_name":"Carbimazole","level":4,"score":0.8847064971923828},{"id":"https://openalex.org/C2776652619","wikidata":"https://www.wikidata.org/wiki/Q16483","display_name":"Graves' disease","level":3,"score":0.556240439414978},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5134633183479309},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.5077537298202515},{"id":"https://openalex.org/C529618451","wikidata":"https://www.wikidata.org/wiki/Q234904","display_name":"Ultrasonography","level":2,"score":0.4358670711517334},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3641601502895355},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.329412579536438},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.28281864523887634}],"mesh":[{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006111","descriptor_name":"Graves Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006111","descriptor_name":"Graves Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006111","descriptor_name":"Graves Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1157/13078491","doi":"https://doi.org/10.1157/13078491","is_oa":true,"landing_page_url":"https://doi.org/10.1157/13078491","pdf_url":null,"source":{"id":"https://openalex.org/S136590224","display_name":"Anales de Pediatr\u00eda","issn_l":"1695-4033","issn":["1695-4033","1695-9531"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anales de Pediatr\u00eda","raw_type":"journal-article"},{"id":"pmid:16219281","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16219281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anales de pediatria (Barcelona, Spain : 2003)","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1157/13078491","doi":"https://doi.org/10.1157/13078491","is_oa":true,"landing_page_url":"https://doi.org/10.1157/13078491","pdf_url":null,"source":{"id":"https://openalex.org/S136590224","display_name":"Anales de Pediatr\u00eda","issn_l":"1695-4033","issn":["1695-4033","1695-9531"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anales de Pediatr\u00eda","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W286930382","https://openalex.org/W418612274","https://openalex.org/W1879128722","https://openalex.org/W1966820180","https://openalex.org/W1980902475","https://openalex.org/W1986024307","https://openalex.org/W1992904825","https://openalex.org/W2015151020","https://openalex.org/W2015220539","https://openalex.org/W2019796923","https://openalex.org/W2022002284","https://openalex.org/W2045216263","https://openalex.org/W2052408653","https://openalex.org/W2100591175","https://openalex.org/W2105598120","https://openalex.org/W2109975681","https://openalex.org/W2115097556","https://openalex.org/W2281360879"],"related_works":["https://openalex.org/W2105598120","https://openalex.org/W7029562187","https://openalex.org/W2063694246","https://openalex.org/W2017824236","https://openalex.org/W7132454923","https://openalex.org/W7197054819","https://openalex.org/W2407876009","https://openalex.org/W7025003600","https://openalex.org/W2441455550","https://openalex.org/W2944440647"],"abstract_inverted_index":{"La":[0,66],"enfermedad":[1,42],"de":[2,10,27,31,34,37,41,43,76,86,99,130,138],"Graves-Basedow,":[3],"que":[4],"es":[5,16],"la":[6,13,69,124],"causa":[7],"m\u00e1s":[8,122],"frecuente":[9],"hipertiroidismo":[11],"en":[12,19,74,91,109,148],"edad":[14],"pedi\u00e1trica,":[15],"muy":[17,87],"infrecuente":[18],"el":[20,120],"ni\u00f1o":[21],"preescolar.":[22],"Se":[23],"describen":[24],"los":[25,112],"casos":[26,111],"4":[28,78],"ni\u00f1as":[29],"menores":[30],"6":[32,186],"a\u00f1os":[33,137],"un":[35],"total":[36,192],"30":[38,194],"pacientes":[39,132],"diagnosticados":[40],"Graves-Basedow":[44],"entre":[45],"1985":[46,201],"y":[47,59,68,90,101,108,142],"2004.":[48,203],"El":[49,80],"motivo":[50],"del":[51,57,115],"estudio":[52,60],"fue":[53,85],"taquicardia,":[54],"diarrea,":[55],"retraso":[56],"lenguaje":[58],"fortuito":[61],"por":[62],"alteraciones":[63],"ecogr\u00e1ficas":[64],"tiroideas.":[65],"talla":[67],"maduraci\u00f3n":[70],"\u00f3sea":[71],"estaban":[72],"avanzadas":[73],"3":[75,110],"las":[77,131,143],"pacientes.":[79],"bocio":[81],"estuvo":[82],"ausente":[83],"o":[84],"peque\u00f1o":[88],"tama\u00f1o,":[89],"ning\u00fan":[92,153],"caso":[93,121],"existi\u00f3":[94],"oftalmopat\u00eda.":[95],"Todas":[96],"presentaron":[97],"elevaci\u00f3n":[98],"T4":[100,254],"T3":[102,252],"con":[103,140],"hormona":[104],"tiroestimulante":[105],"(TSH)":[106],"suprimida":[107],"anticuerpos":[113],"estimulantes":[114],"tiroides":[116],"fueron":[117],"positivos":[118],"(en":[119],"antiguo":[123],"t\u00e9cnica":[125],"no":[126,299],"estaba":[127],"disponible).":[128],"Dos":[129],"est\u00e1n":[133,146],"curadas":[134],"tras":[135],"5":[136,284],"tratamiento":[139],"carbimazol,":[141],"otras":[144],"dos":[145],"a\u00fan":[147],"tratamiento,":[149],"sin":[150],"haberse":[151],"evidenciado":[152],"efecto":[154],"secundario.":[155],"Graves\u2019":[156,198],"disease,":[157],"which":[158],"is":[159,170],"the":[160,166,178,224,243,275],"main":[161],"cause":[162],"of":[163,180,190,193,223,242,286],"hyperthyroidism":[164],"in":[165,173],"pediatric":[167],"age":[168,230],"group,":[169],"very":[171],"rare":[172],"pre-school":[174],"children.":[175],"We":[176],"describe":[177],"cases":[179],"four":[181,225],"girls,":[182],"aged":[183],"less":[184],"than":[185],"years":[187,285],"old,":[188],"out":[189],"a":[191],"patients":[195,226,235,244,250,263,279,293],"diagnosed":[196],"with":[197,288],"disease":[199],"between":[200],"and":[202,228,253,257,298],"Investigations":[204],"were":[205,231,255,264],"motivated":[206],"by":[207,218],"tachycardia,":[208],"chronic":[209],"diarrhea,":[210],"language":[211],"development":[212],"delay":[213],"or":[214,239],"thyroid":[215],"nodules":[216],"detected":[217],"cervical":[219],"ultrasonography.":[220],"In":[221,233,248],"three":[222],"height":[227],"bone":[229],"advanced.":[232],"all":[234,249],"goiter":[236],"was":[237,260,271],"small":[238],"absent.":[240],"None":[241],"had":[245],"ophthalmic":[246],"disease.":[247],"free":[251],"elevated":[256],"thyroid-stimulating":[258,267],"hormone":[259],"suppressed.":[261],"Three":[262],"positive":[265],"for":[266,274],"immunoglobulins":[268],"(the":[269],"method":[270],"not":[272],"available":[273],"oldest":[276],"case).":[277],"Two":[278],"showed":[280],"complete":[281],"resolution":[282],"after":[283],"treatment":[287,297],"carbimazole.":[289],"The":[290],"remaining":[291],"two":[292],"are":[294],"still":[295],"under":[296],"adverse":[300],"effects":[301],"have":[302],"been":[303],"documented.":[304]},"counts_by_year":[{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}