{"id":"https://openalex.org/W2018071210","doi":"https://doi.org/10.1097/00005344-198705000-00005","title":"Natriuretic Effect of Acute Nifedipine Administration Is Not Mediated by the Renal Kallikrein-Kinin System","display_name":"Natriuretic Effect of Acute Nifedipine Administration Is Not Mediated by the Renal Kallikrein-Kinin System","publication_year":1987,"publication_date":"1987-05-01","ids":{"openalex":"https://openalex.org/W2018071210","doi":"https://doi.org/10.1097/00005344-198705000-00005","mag":"2018071210","pmid":"https://pubmed.ncbi.nlm.nih.gov/2439833"},"language":"en","primary_location":{"id":"doi:10.1097/00005344-198705000-00005","doi":"https://doi.org/10.1097/00005344-198705000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-198705000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110161604","display_name":"Paolo Madeddu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159650629","display_name":"University of Sassari","ror":"https://ror.org/01bnjbv91","country_code":"IT","type":"education","lineage":["https://openalex.org/I159650629"]},{"id":"https://openalex.org/I4210094922","display_name":"MultiMedica","ror":"https://ror.org/01h8ey223","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094922","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P. Madeddu","raw_affiliation_strings":["Cattedra Patologia Medica II, Sassari University, Sassari, Italy","IRCCS Multimedica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra Patologia Medica II, Sassari University, Sassari, Italy","institution_ids":["https://openalex.org/I159650629"]},{"raw_affiliation_string":"IRCCS Multimedica","institution_ids":["https://openalex.org/I4210094922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110029971","display_name":"Mario Oppes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159650629","display_name":"University of Sassari","ror":"https://ror.org/01bnjbv91","country_code":"IT","type":"education","lineage":["https://openalex.org/I159650629"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Oppes","raw_affiliation_strings":["Cattedra Patologia Medica II, Sassari University, Sassari, Italy","University of Sassari"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra Patologia Medica II, Sassari University, Sassari, Italy","institution_ids":["https://openalex.org/I159650629"]},{"raw_affiliation_string":"University of Sassari","institution_ids":["https://openalex.org/I159650629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111350407","display_name":"A Soro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159650629","display_name":"University of Sassari","ror":"https://ror.org/01bnjbv91","country_code":"IT","type":"education","lineage":["https://openalex.org/I159650629"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Soro","raw_affiliation_strings":["Cattedra Patologia Medica II, Sassari University, Sassari, Italy","University of Sassari"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra Patologia Medica II, Sassari University, Sassari, Italy","institution_ids":["https://openalex.org/I159650629"]},{"raw_affiliation_string":"University of Sassari","institution_ids":["https://openalex.org/I159650629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111519856","display_name":"Paolo Dess\u0131\u0300-Fulgheri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159650629","display_name":"University of Sassari","ror":"https://ror.org/01bnjbv91","country_code":"IT","type":"education","lineage":["https://openalex.org/I159650629"]},{"id":"https://openalex.org/I4210161542","display_name":"Istituto Nazionale di Riposo e Cura per Anziani","ror":"https://ror.org/057aq1y25","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210161542"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P. Dessi'-Fulgheri","raw_affiliation_strings":["Cattedra Patologia Medica II, Sassari University, Sassari, Italy","Istituto Nazionale di Riposo e Cura per Anziani V.E. II"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra Patologia Medica II, Sassari University, Sassari, Italy","institution_ids":["https://openalex.org/I159650629"]},{"raw_affiliation_string":"Istituto Nazionale di Riposo e Cura per Anziani V.E. II","institution_ids":["https://openalex.org/I4210161542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003876992","display_name":"Nicola Glorioso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159650629","display_name":"University of Sassari","ror":"https://ror.org/01bnjbv91","country_code":"IT","type":"education","lineage":["https://openalex.org/I159650629"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"N. Glorioso","raw_affiliation_strings":["Cattedra Patologia Medica II, Sassari University, Sassari, Italy","University of Sassari"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra Patologia Medica II, Sassari University, Sassari, Italy","institution_ids":["https://openalex.org/I159650629"]},{"raw_affiliation_string":"University of Sassari","institution_ids":["https://openalex.org/I159650629"]}]},{"author_position":"middle","author":{"id":null,"display_name":"F. Bandiera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159650629","display_name":"University of Sassari","ror":"https://ror.org/01bnjbv91","country_code":"IT","type":"education","lineage":["https://openalex.org/I159650629"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Bandiera","raw_affiliation_strings":["Cattedra Patologia Medica II, Sassari University, Sassari, Italy","University of Sassari"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra Patologia Medica II, Sassari University, Sassari, Italy","institution_ids":["https://openalex.org/I159650629"]},{"raw_affiliation_string":"University of Sassari","institution_ids":["https://openalex.org/I159650629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055147850","display_name":"Paolo Manunta","orcid":"https://orcid.org/0000-0003-3976-9696","observed_orcids":["https://orcid.org/0000-0003-3976-9696"]},"institutions":[{"id":"https://openalex.org/I159650629","display_name":"University of Sassari","ror":"https://ror.org/01bnjbv91","country_code":"IT","type":"education","lineage":["https://openalex.org/I159650629"]},{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P. Manunta","raw_affiliation_strings":["Cattedra Patologia Medica II, Sassari University, Sassari, Italy","IRCCS Ospedale San Raffaele"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra Patologia Medica II, Sassari University, Sassari, Italy","institution_ids":["https://openalex.org/I159650629"]},{"raw_affiliation_string":"IRCCS Ospedale San Raffaele","institution_ids":["https://openalex.org/I4210133214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010927128","display_name":"Speranza Rubattu","orcid":"https://orcid.org/0000-0001-5921-7368","observed_orcids":["https://orcid.org/0000-0001-5921-7368"]},"institutions":[{"id":"https://openalex.org/I159650629","display_name":"University of Sassari","ror":"https://ror.org/01bnjbv91","country_code":"IT","type":"education","lineage":["https://openalex.org/I159650629"]},{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Rubattu","raw_affiliation_strings":["Cattedra Patologia Medica II, Sassari University, Sassari, Italy","Istituto Neurologico Mediterraneo Neuromed"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra Patologia Medica II, Sassari University, Sassari, Italy","institution_ids":["https://openalex.org/I159650629"]},{"raw_affiliation_string":"Istituto Neurologico Mediterraneo Neuromed","institution_ids":["https://openalex.org/I3018288129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047431034","display_name":"Chiara Troffa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159650629","display_name":"University of Sassari","ror":"https://ror.org/01bnjbv91","country_code":"IT","type":"education","lineage":["https://openalex.org/I159650629"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Troffa","raw_affiliation_strings":["Cattedra Patologia Medica II, Sassari University, Sassari, Italy","University of Sassari"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra Patologia Medica II, Sassari University, Sassari, Italy","institution_ids":["https://openalex.org/I159650629"]},{"raw_affiliation_string":"University of Sassari","institution_ids":["https://openalex.org/I159650629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059387383","display_name":"Giancarlo Tonolo","orcid":"https://orcid.org/0000-0002-6102-2233","observed_orcids":["https://orcid.org/0000-0002-6102-2233"]},"institutions":[{"id":"https://openalex.org/I159650629","display_name":"University of Sassari","ror":"https://ror.org/01bnjbv91","country_code":"IT","type":"education","lineage":["https://openalex.org/I159650629"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. C. Tonolo","raw_affiliation_strings":["Cattedra Patologia Medica II, Sassari University, Sassari, Italy","University of Sassari"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra Patologia Medica II, Sassari University, Sassari, Italy","institution_ids":["https://openalex.org/I159650629"]},{"raw_affiliation_string":"University of Sassari","institution_ids":["https://openalex.org/I159650629"]}]},{"author_position":"middle","author":{"id":null,"display_name":"G. F. Cocco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159650629","display_name":"University of Sassari","ror":"https://ror.org/01bnjbv91","country_code":"IT","type":"education","lineage":["https://openalex.org/I159650629"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. F. Cocco","raw_affiliation_strings":["Cattedra Patologia Medica II, Sassari University, Sassari, Italy","University of Sassari"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra Patologia Medica II, Sassari University, Sassari, Italy","institution_ids":["https://openalex.org/I159650629"]},{"raw_affiliation_string":"University of Sassari","institution_ids":["https://openalex.org/I159650629"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028175621","display_name":"ALESSANDRO RAPPELLI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159650629","display_name":"University of Sassari","ror":"https://ror.org/01bnjbv91","country_code":"IT","type":"education","lineage":["https://openalex.org/I159650629"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Rappelli","raw_affiliation_strings":["Cattedra Patologia Medica II, Sassari University, Sassari, Italy","University of Sassari"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra Patologia Medica II, Sassari University, Sassari, Italy","institution_ids":["https://openalex.org/I159650629"]},{"raw_affiliation_string":"University of Sassari","institution_ids":["https://openalex.org/I159650629"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7825,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.70285714,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"9","issue":"5","first_page":"536","last_page":"540"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.6689000129699707,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.6689000129699707,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.249099999666214,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.05950000137090683,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nifedipine","display_name":"nifedipine","score":1.0},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.9309999942779541},{"id":"https://openalex.org/keywords/sodium-excretion","display_name":"sodium excretion","score":0.8840000033378601},{"id":"https://openalex.org/keywords/renal-kallikrein-kinin-system","display_name":"renal kallikrein-kinin system","score":0.8930000066757202},{"id":"https://openalex.org/keywords/aprotinin","display_name":"aprotinin","score":0.8539999723434448},{"id":"https://openalex.org/keywords/plasma-renin-activity","display_name":"plasma renin activity","score":0.9350000023841858},{"id":"https://openalex.org/keywords/essential-hypertension","display_name":"essential hypertension","score":0.8859999775886536},{"id":"https://openalex.org/keywords/renal-sodium-excretion","display_name":"renal sodium excretion","score":0.6000000238418579},{"id":"https://openalex.org/keywords/blood-pressure-reduction","display_name":"blood pressure reduction","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6869603395462036},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6652364134788513},{"id":"https://openalex.org/C52853521","wikidata":"https://www.wikidata.org/wiki/Q423285","display_name":"Kallikrein","level":3,"score":0.6276479363441467},{"id":"https://openalex.org/C2776246183","wikidata":"https://www.wikidata.org/wiki/Q421924","display_name":"Kinin","level":4,"score":0.6215631365776062},{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.6055931448936462},{"id":"https://openalex.org/C2779066535","wikidata":"https://www.wikidata.org/wiki/Q39111","display_name":"Nifedipine","level":3,"score":0.5917538404464722},{"id":"https://openalex.org/C2780799893","wikidata":"https://www.wikidata.org/wiki/Q418625","display_name":"Aprotinin","level":2,"score":0.5525677800178528},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.504691481590271},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.4688709080219269},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.4652901887893677},{"id":"https://openalex.org/C142225936","wikidata":"https://www.wikidata.org/wiki/Q1129139","display_name":"Renal blood flow","level":3,"score":0.44897547364234924},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.4204555153846741},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4174245595932007},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37415093183517456},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.3270595371723175},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.3255477845668793},{"id":"https://openalex.org/C2779591629","wikidata":"https://www.wikidata.org/wiki/Q24745328","display_name":"Bradykinin","level":3,"score":0.22160226106643677},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004573","descriptor_name":"Electrolytes","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007610","descriptor_name":"Kallikreins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007610","descriptor_name":"Kallikreins","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007705","descriptor_name":"Kinins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009318","descriptor_name":"Natriuresis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009543","descriptor_name":"Nifedipine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/00005344-198705000-00005","doi":"https://doi.org/10.1097/00005344-198705000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-198705000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},{"id":"pmid:2439833","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2439833","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular pharmacology","raw_type":"Clinical Trial"},{"id":"pmh:oai:iris.uniroma1.it:11573/423297","doi":null,"is_oa":false,"landing_page_url":"http://www.scopus.com/inward/record.url?eid=2-s2.0-0023216447&partnerID=65&md5=4f5914a741c56aef8adeb269d790601f","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2033661586","https://openalex.org/W2415962853","https://openalex.org/W2423555106","https://openalex.org/W1822504671","https://openalex.org/W2056016079","https://openalex.org/W2416874965","https://openalex.org/W2081307516","https://openalex.org/W4321000998","https://openalex.org/W2416841222","https://openalex.org/W2081294377"],"abstract_inverted_index":{"Despite":[0],"their":[1],"vasodilating":[2],"action,":[3],"calcium":[4,23],"antagonists":[5],"increase":[6,131],"renal":[7,13,20,206],"sodium":[8],"excretion.":[9],"To":[10],"ascertain":[11],"whether":[12],"kallikrein":[14],"plays":[15,199],"a":[16,46,118,128],"role":[17,202],"in":[18,60,108,167,203,210],"the":[19,183,193,196,205],"effects":[21,207],"of":[22,49,63,115,170,177,186,208],"antagonists,":[24],"nifedipine":[25,209],"(N)":[26],"(10":[27],"mg":[28],"orally)":[29],"or":[30,53],"placebo":[31],"(P)":[32],"was":[33],"given":[34],"to":[35,41],"17":[36],"male":[37],"patients":[38],"with":[39,182],"mild":[40],"moderate":[42],"essential":[43],"hypertension":[44],"during":[45],"6-h":[47,109],"infusion":[48],"either":[50],"saline":[51],"(S)":[52],"aprotinin":[54],"(A)":[55],"(2":[56],"X":[57],"10(6)":[58],"KIU":[59],"200":[61],"ml":[62],"saline).":[64],"Blood":[65],"pressure":[66],"(BP)":[67],"and":[68,77,97,104,123,127,137,149,162,173],"heart":[69],"rate":[70],"(HR)":[71],"were":[72,80,106,138,153,159],"measured":[73,107],"every":[74],"10":[75],"min,":[76],"blood":[78],"samples":[79],"taken":[81],"at":[82,134],"-10,":[83],"0,":[84],"30,":[85],"60,":[86],"120,":[87],"240,":[88],"360":[89],"min":[90,136],"for":[91],"plasma":[92],"renin":[93],"activity":[94],"(PRA),":[95],"creatinine,":[96,103],"osmolarity":[98],"determinations.":[99],"Urinary":[100,144],"kallikrein,":[101],"aldosterone,":[102],"electrolytes":[105],"urine":[110],"collections.":[111],"The":[112],"acute":[113],"administration":[114],"N":[116],"induced":[117],"significant":[119,165],"systolic":[120],"BP":[121],"(SBP)":[122],"diastolic":[124],"(DBP)":[125],"fall":[126],"transient":[129],"PRA":[130],"that":[132,195],"peaked":[133],"30":[135],"not":[139,164,180,191],"modified":[140],"by":[141,156],"A":[142,178],"infusion.":[143],"volume":[145],"(+47%),":[146],"Na+":[147],"(+54%)":[148],"Cl-":[150],"(+58%)":[151],"excretion":[152,169],"significantly":[154],"enhanced":[155],"N.":[157,187],"There":[158],"less":[160],"pronounced":[161],"statistically":[163],"increases":[166],"urinary":[168],"Ca2+":[171],"(+38%)":[172],"K+":[174],"(+29%).":[175],"Infusion":[176],"did":[179],"interfere":[181],"natriuretic":[184],"effect":[185],"Our":[188],"data":[189],"do":[190],"support":[192],"hypothesis":[194],"kallikrein-kinin":[197],"system":[198],"an":[200],"important":[201],"mediating":[204],"humans.":[211]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}