{"id":"https://openalex.org/W2018068686","doi":"https://doi.org/10.1254/jjp.11.54","title":"MECHANISM OF HISTAMINE-RELEASE INHIBITION BY NICOTINAMIDE IN IN VITRO ANTIGEN-ANTIBODY REACTION","display_name":"MECHANISM OF HISTAMINE-RELEASE INHIBITION BY NICOTINAMIDE IN IN VITRO ANTIGEN-ANTIBODY REACTION","publication_year":1961,"publication_date":"1961-01-01","ids":{"openalex":"https://openalex.org/W2018068686","doi":"https://doi.org/10.1254/jjp.11.54","mag":"2018068686","pmid":"https://pubmed.ncbi.nlm.nih.gov/14008896"},"language":"en","primary_location":{"id":"doi:10.1254/jjp.11.54","doi":"https://doi.org/10.1254/jjp.11.54","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jjp.11.54","pdf_url":null,"source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1254/jjp.11.54","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110058893","display_name":"Hidemasa Yamasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIDEMASA YAMASAKI","raw_affiliation_strings":["Department of Pharmacology, Okayama University Medical School, Okayama","Department of Pharmacology, Okayama University, Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Okayama University Medical School, Okayama","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Department of Pharmacology, Okayama University, Medical School","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032142941","display_name":"Saburo Muraoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SABURO MURAOKA","raw_affiliation_strings":["Department of Pharmacology, Okayama University Medical School, Okayama","Department of Pharmacology, Okayama University, Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Okayama University Medical School, Okayama","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Department of Pharmacology, Okayama University, Medical School","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075724632","display_name":"Mie Sugiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"MIE SUGIYAMA","raw_affiliation_strings":["Department of Pharmacology, Okayama University Medical School, Okayama","Department of Pharmacology, Okayama University, Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Okayama University Medical School, Okayama","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Department of Pharmacology, Okayama University, Medical School","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109977293","display_name":"Koiti ENDO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KOITI ENDO","raw_affiliation_strings":["Department of Pharmacology, Okayama University Medical School, Okayama","Department of Pharmacology, Okayama University, Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Okayama University Medical School, Okayama","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Department of Pharmacology, Okayama University, Medical School","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I163770644"],"apc_list":null,"apc_paid":null,"fwci":1.7027,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.81664099,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"11","issue":"1","first_page":"54","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nicotinamide","display_name":"nicotinamide","score":0.9919999837875366},{"id":"https://openalex.org/keywords/histamine-release-inhibition","display_name":"histamine release inhibition","score":0.9079999923706055},{"id":"https://openalex.org/keywords/antibody-antigen-interaction","display_name":"antigen-antibody reaction","score":0.9810000061988831},{"id":"https://openalex.org/keywords/niacin","display_name":"nicotinic acid","score":0.6840000152587891},{"id":"https://openalex.org/keywords/isoniazid","display_name":"isoniazid","score":0.8889999985694885},{"id":"https://openalex.org/keywords/iproniazid","display_name":"iproniazid","score":0.8730000257492065},{"id":"https://openalex.org/keywords/anaphylaxis","display_name":"anaphylaxis","score":0.7049999833106995},{"id":"https://openalex.org/keywords/passive-cutaneous-anaphylaxis","display_name":"passive cutaneous anaphylaxis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/desensitization","display_name":"desensitization","score":0.7929999828338623},{"id":"https://openalex.org/keywords/lung-tissue","display_name":"lung tissue","score":0.5950000286102295},{"id":"https://openalex.org/keywords/succinic-acid","display_name":"succinic acid","score":0.5799999833106995},{"id":"https://openalex.org/keywords/oxygen-consumption","display_name":"oxygen consumption","score":0.7239999771118164},{"id":"https://openalex.org/keywords/guinea-pig","display_name":"guinea pig","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.8061306476593018},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.729213297367096},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7079681158065796},{"id":"https://openalex.org/C2779728014","wikidata":"https://www.wikidata.org/wiki/Q192423","display_name":"Nicotinamide","level":3,"score":0.6137841939926147},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5703719854354858},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5160703063011169},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.49906158447265625},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3148770034313202},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29648357629776},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.253898024559021},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18356603384017944},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.055007874965667725},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.03386685252189636},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000937","descriptor_name":"Antigen-Antibody Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006636","descriptor_name":"Histamine Release","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009525","descriptor_name":"Niacin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009539","descriptor_name":"Nicotinic Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1254/jjp.11.54","doi":"https://doi.org/10.1254/jjp.11.54","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jjp.11.54","pdf_url":null,"source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:14008896","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14008896","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1254/jjp.11.54","doi":"https://doi.org/10.1254/jjp.11.54","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jjp.11.54","pdf_url":null,"source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W103189315","https://openalex.org/W123949601","https://openalex.org/W183985036","https://openalex.org/W654670957","https://openalex.org/W1565594466","https://openalex.org/W1975708453","https://openalex.org/W1992265935","https://openalex.org/W2039156251","https://openalex.org/W2058458661","https://openalex.org/W2062585680","https://openalex.org/W2068378358","https://openalex.org/W2082277431","https://openalex.org/W2092400963","https://openalex.org/W2313554343","https://openalex.org/W2328306341","https://openalex.org/W2328355603","https://openalex.org/W4214596271"],"related_works":["https://openalex.org/W2081272138","https://openalex.org/W3024117865","https://openalex.org/W1483933383","https://openalex.org/W3201073061","https://openalex.org/W2018699052","https://openalex.org/W2002006281","https://openalex.org/W2086511927","https://openalex.org/W2090154874","https://openalex.org/W2294233189","https://openalex.org/W2036863817"],"abstract_inverted_index":{"1.":[0],"Nicotinamide":[1,77,138],"inhibits":[2,33,78],"histamine":[3,21,94,157,205,239],"release":[4,22,35,47,95,158,203,240],"by":[5,52,75,101,159,241,267,277],"antigen":[6,135,160],"from":[7,48,68,110,209,219,281],"chopped":[8,211],"lung":[9,51,212],"tissue":[10,213],"of":[11,17,36,44,70,81,92,98,119,134,189,204,214,223,229,232,238,250,252,257,263,283],"a":[12,215,224,258,278],"sensitized":[13,172,190],"guinea":[14,49,82,175,191,216],"pig.":[15],"Addition":[16],"succinate":[18],"potentiates":[19],"this":[20],"and":[23,56,96,136,153,173],"accompanying":[24],"increase":[25,201],"in":[26,122,161,168,185,206,243],"oxygen":[27],"uptake.":[28],"However,":[29],"nicotinamide,":[30],"though":[31],"it":[32],"increased":[34,42],"histamine,":[37],"does":[38,103,129,179,199],"not":[39,61,104,130,180,200,247],"inhibit":[40,131,156],"the":[41,125,132,186,202,210,236,248,275],"uptake":[43],"oxygen.2.":[45],"Histamine":[46],"pig":[50,83,176,192,217],"sinomenine,":[53],"compound":[54],"48/80,":[55],"decylamine,":[57],"whose":[58],"action":[59],"is":[60,72,117,165,246,256],"considered":[62],"to":[63,124],"involve":[64],"enzymatic":[65],"process,":[66],"differing":[67],"that":[69,235,260,282],"antigen,":[71],"also":[73,155],"inhibited":[74],"nicotinamide.3.":[76],"anaphylactic":[79,93],"contraction":[80,97,121],"ileum":[84],"and,":[85],"apparently":[86],"weakens":[87],"passive":[88],"cutaneous":[89],"anaphylaxis.4.":[90],"Inhibition":[91],"plain":[99,108],"muscle":[100],"nicotinamide":[102,112,128,242],"prevent":[105],"desensitization.":[106],"The":[107,227],"muscle,":[109],"which":[111,140],"had":[113],"been":[114],"washed":[115],"off,":[116],"capable":[118],"undergoing":[120],"response":[123],"antigen.":[126],"Consequently,":[127],"union":[133],"antibody.5.":[137],"analogs":[139],"are":[141],"DPNase":[142,169,187,198,253],"inhibitor,":[143],"such":[144],"as":[145],"nicotinic":[146],"acid,":[147,152],"isonicotinic":[148],"acid":[149],"hydrazide,":[150],"pyridine-3-sulfonic":[151],"iproniazid,":[154],"various":[162],"degrees.6.":[163],"There":[164],"no":[166],"difference":[167],"activity":[170,188],"between":[171],"unsensitized":[174],"lungs.":[177],"Antigen":[178],"cause":[181],"any":[182],"observable":[183],"change":[184],"lung.":[193],"Partially":[194],"purified":[195],"bovine":[196],"spleen":[197],"vitro,":[207],"either":[208],"or":[218],"subcellular":[220],"large":[221],"granules":[222],"dog":[225],"liver.7.":[226],"result,":[228],"present":[230],"series":[231],"experiments":[233],"suggests":[234],"inhibition":[237,251],"antigen-antibody":[244,268],"reaction":[245],"result":[249],"but":[254],"rather":[255],"type":[259],"blocks":[261],"linking":[262],"chemical":[264],"stimulation,":[265],"caused":[266],"union,":[269],"with":[270],"allergic":[271],"changes":[272],"proceeding":[273],"inside":[274],"cell,":[276],"mechanism":[279],"different":[280],"respiratory":[284],"enzyme":[285],"inhibitors.":[286]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
