{"id":"https://openalex.org/W2018048121","doi":"https://doi.org/10.1021/ja963971g","title":"Tritiated Chiral Alkanes as Substrates for Soluble Methane Monooxygenase fromMethylococcus capsulatus(Bath): Probes for the Mechanism of Hydroxylation","display_name":"Tritiated Chiral Alkanes as Substrates for Soluble Methane Monooxygenase fromMethylococcus capsulatus(Bath): Probes for the Mechanism of Hydroxylation","publication_year":1997,"publication_date":"1997-02-01","ids":{"openalex":"https://openalex.org/W2018048121","doi":"https://doi.org/10.1021/ja963971g","mag":"2018048121"},"language":"en","primary_location":{"id":"doi:10.1021/ja963971g","doi":"https://doi.org/10.1021/ja963971g","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja963971g","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043842704","display_name":"Ann M. Valentine","orcid":"https://orcid.org/0000-0002-5943-5493","observed_orcids":["https://orcid.org/0000-0002-5943-5493"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann M. Valentine","raw_affiliation_strings":["Contribution from the Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Department of Chemistry, Box 351700, University of Washington, Seattle, Washington 98195, and National Tritium Labelling Facility and Structural Biology Division, E. O. Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Department of Chemistry, Box 351700, University of Washington, Seattle, Washington 98195, and National Tritium Labelling Facility and Structural Biology Division, E. O. Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720","institution_ids":["https://openalex.org/I148283060","https://openalex.org/I201448701","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010830567","display_name":"Barrie M. Wilkinson","orcid":"https://orcid.org/0000-0001-7646-7174","observed_orcids":["https://orcid.org/0000-0001-7646-7174"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barrie Wilkinson","raw_affiliation_strings":["Contribution from the Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Department of Chemistry, Box 351700, University of Washington, Seattle, Washington 98195, and National Tritium Labelling Facility and Structural Biology Division, E. O. Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Department of Chemistry, Box 351700, University of Washington, Seattle, Washington 98195, and National Tritium Labelling Facility and Structural Biology Division, E. O. Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720","institution_ids":["https://openalex.org/I148283060","https://openalex.org/I201448701","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081546530","display_name":"Katherine E. Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine E. Liu","raw_affiliation_strings":["Contribution from the Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Department of Chemistry, Box 351700, University of Washington, Seattle, Washington 98195, and National Tritium Labelling Facility and Structural Biology Division, E. O. Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Department of Chemistry, Box 351700, University of Washington, Seattle, Washington 98195, and National Tritium Labelling Facility and Structural Biology Division, E. O. Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720","institution_ids":["https://openalex.org/I148283060","https://openalex.org/I201448701","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048879997","display_name":"Sonja Komar\u2010Panicucci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonja Komar-Panicucci","raw_affiliation_strings":["Contribution from the Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Department of Chemistry, Box 351700, University of Washington, Seattle, Washington 98195, and National Tritium Labelling Facility and Structural Biology Division, E. O. Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Department of Chemistry, Box 351700, University of Washington, Seattle, Washington 98195, and National Tritium Labelling Facility and Structural Biology Division, E. O. Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720","institution_ids":["https://openalex.org/I148283060","https://openalex.org/I201448701","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041549776","display_name":"Nigel D. Priestley","orcid":"https://orcid.org/0000-0002-2791-0958","observed_orcids":["https://orcid.org/0000-0002-2791-0958"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nigel D. Priestley","raw_affiliation_strings":["Contribution from the Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Department of Chemistry, Box 351700, University of Washington, Seattle, Washington 98195, and National Tritium Labelling Facility and Structural Biology Division, E. O. Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Department of Chemistry, Box 351700, University of Washington, Seattle, Washington 98195, and National Tritium Labelling Facility and Structural Biology Division, E. O. Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720","institution_ids":["https://openalex.org/I148283060","https://openalex.org/I201448701","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047930678","display_name":"Philip G. Williams","orcid":"https://orcid.org/0000-0001-8987-0683","observed_orcids":["https://orcid.org/0000-0001-8987-0683"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip G. Williams","raw_affiliation_strings":["Contribution from the Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Department of Chemistry, Box 351700, University of Washington, Seattle, Washington 98195, and National Tritium Labelling Facility and Structural Biology Division, E. O. Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Department of Chemistry, Box 351700, University of Washington, Seattle, Washington 98195, and National Tritium Labelling Facility and Structural Biology Division, E. O. Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720","institution_ids":["https://openalex.org/I148283060","https://openalex.org/I201448701","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057489985","display_name":"Hiromi Morimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiromi Morimoto","raw_affiliation_strings":["Contribution from the Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Department of Chemistry, Box 351700, University of Washington, Seattle, Washington 98195, and National Tritium Labelling Facility and Structural Biology Division, E. O. Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Department of Chemistry, Box 351700, University of Washington, Seattle, Washington 98195, and National Tritium Labelling Facility and Structural Biology Division, E. O. Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720","institution_ids":["https://openalex.org/I148283060","https://openalex.org/I201448701","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027410094","display_name":"Heinz G. Floss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heinz G. Floss","raw_affiliation_strings":["Contribution from the Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Department of Chemistry, Box 351700, University of Washington, Seattle, Washington 98195, and National Tritium Labelling Facility and Structural Biology Division, E. O. Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Department of Chemistry, Box 351700, University of Washington, Seattle, Washington 98195, and National Tritium Labelling Facility and Structural Biology Division, E. O. Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720","institution_ids":["https://openalex.org/I148283060","https://openalex.org/I201448701","https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034625027","display_name":"Stephen J. Lippard","orcid":"https://orcid.org/0000-0002-2693-4982","observed_orcids":["https://orcid.org/0000-0002-2693-4982"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen J. Lippard","raw_affiliation_strings":["Contribution from the Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Department of Chemistry, Box 351700, University of Washington, Seattle, Washington 98195, and National Tritium Labelling Facility and Structural Biology Division, E. O. Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Department of Chemistry, Box 351700, University of Washington, Seattle, Washington 98195, and National Tritium Labelling Facility and Structural Biology Division, E. O. Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720","institution_ids":["https://openalex.org/I148283060","https://openalex.org/I201448701","https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":8.9329,"has_fulltext":false,"cited_by_count":104,"citation_normalized_percentile":{"value":0.98880234,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"119","issue":"8","first_page":"1818","last_page":"1827"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12688","display_name":"Microbial metabolism and enzyme function","score":0.03189999982714653,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soluble-methane-monooxygenase","display_name":"soluble methane monooxygenase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/methylococcus-capsulatus","display_name":"Methylococcus capsulatus","score":0.968999981880188},{"id":"https://openalex.org/keywords/alkane-hydroxylation","display_name":"alkane hydroxylation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/stereochemical-retention","display_name":"stereochemical retention","score":0.7450000047683716},{"id":"https://openalex.org/keywords/alkyl-radicals","display_name":"alkyl radicals","score":0.44699999690055847},{"id":"https://openalex.org/keywords/coupling-protein","display_name":"coupling protein","score":0.5699999928474426},{"id":"https://openalex.org/keywords/reductase","display_name":"reductase","score":0.8799999952316284},{"id":"https://openalex.org/keywords/c-h-activation","display_name":"C\u2013H activation","score":0.6589999794960022},{"id":"https://openalex.org/keywords/catalytic-mechanism","display_name":"catalytic mechanism","score":0.546999990940094},{"id":"https://openalex.org/keywords/butane-oxidation","display_name":"butane oxidation","score":0.4819999933242798},{"id":"https://openalex.org/keywords/ethane-oxidation","display_name":"ethane oxidation","score":0.9330000281333923}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9443684220314026},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.7558114528656006},{"id":"https://openalex.org/C2778717364","wikidata":"https://www.wikidata.org/wiki/Q134192","display_name":"Butane","level":3,"score":0.7027792930603027},{"id":"https://openalex.org/C23296010","wikidata":"https://www.wikidata.org/wiki/Q417187","display_name":"Methane monooxygenase","level":3,"score":0.6415973901748657},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5625602602958679},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.5468035936355591},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.41721653938293457},{"id":"https://openalex.org/C187921627","wikidata":"https://www.wikidata.org/wiki/Q2469470","display_name":"Stereospecificity","level":3,"score":0.4113170802593231},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.3742380142211914},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.26074132323265076},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.22523784637451172},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/ja963971g","doi":"https://doi.org/10.1021/ja963971g","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja963971g","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W236473729","https://openalex.org/W1544877614","https://openalex.org/W1822040134","https://openalex.org/W1964906367","https://openalex.org/W1976445040","https://openalex.org/W1978601471","https://openalex.org/W1985497562","https://openalex.org/W1996442918","https://openalex.org/W2004582035","https://openalex.org/W2004962085","https://openalex.org/W2011607516","https://openalex.org/W2015055975","https://openalex.org/W2020658436","https://openalex.org/W2036174531","https://openalex.org/W2050631703","https://openalex.org/W2059603559","https://openalex.org/W2062019949","https://openalex.org/W2075979069","https://openalex.org/W2080391896","https://openalex.org/W2087585058","https://openalex.org/W2088195424","https://openalex.org/W2091675012","https://openalex.org/W2153169050","https://openalex.org/W2168548284","https://openalex.org/W2172844043","https://openalex.org/W2203199023","https://openalex.org/W2203827897","https://openalex.org/W2395967499","https://openalex.org/W2414074618","https://openalex.org/W2949402221","https://openalex.org/W2952734624","https://openalex.org/W3007515103","https://openalex.org/W4252282252"],"related_works":["https://openalex.org/W2060178418","https://openalex.org/W2020268468","https://openalex.org/W2087585058","https://openalex.org/W2197249118","https://openalex.org/W1970544432","https://openalex.org/W2011457541","https://openalex.org/W2040576842","https://openalex.org/W1822040134","https://openalex.org/W1765792623","https://openalex.org/W2062175218"],"abstract_inverted_index":{"The":[0,211,237],"tritiated":[1],"chiral":[2],"alkanes":[3],"(":[4,12,20,28,36,41],"S":[5,21,37],")-[1-":[6,14,22,30],"2":[7,15,23,31],"H":[8,16,24,32,148],"1,1-":[9,17,25,33],"3":[10,18,26,34,39,44,49,222],"H]ethane,":[11,19],"R":[13,29,42],"H]butane,":[27,35,40,45],")-[2-":[38,43],"and":[46,62,87,108,155,161,182],"racemic":[47],"[2-":[48,221],"H]butane":[50],"were":[51,90,157,167,188],"oxidized":[52],"by":[53,197,224,268,279],"soluble":[54],"methane":[55],"monooxygenase":[56],"(sMMO)":[57],"from":[58,256],"Methylococcus":[59],"capsulatus":[60],"(Bath),":[61],"the":[63,67,77,92,101,105,112,116,165,180,204,208,225,234,243,252,262,276,288],"absolute":[64],"stereochemistry":[65,99,232],"of":[66,79,98,133,153,200,207,213,220,231,239,246,259,283],"resulting":[68],"product":[69,93,127,186,209],"alcohols":[70],"was":[71],"determined":[72,158],"in":[73,287],"order":[74],"to":[75,140,142],"probe":[76],"mechanism":[78,245],"substrate":[80,260],"hydroxylation.":[81],"When":[82,164],"purified":[83,170,176],"hydroxylase,":[84],"coupling":[85,181],"protein,":[86],"reductase":[88,183],"components":[89],"used,":[91],"alcohol":[94],"displayed":[95],"72%":[96],"retention":[97,110,230],"at":[100,115,203,233],"labeled":[102,114,235],"carbon":[103,206],"for":[104,111,159,179,242,267],"ethane":[106,160],"substrates":[107],"77%":[109],"butanes":[113],"primary":[117],"carbon.":[118,236],"A":[119],"putative":[120],"alkyl":[121],"radical":[122],"which":[123],"would":[124,129],"yield":[125],"these":[126,240],"distributions":[128,187],"have":[130],"a":[131,136,143,174,257,269],"lifetime":[132],"100":[134],"fs,":[135],"value":[137],"too":[138],"short":[139],"correspond":[141],"discrete":[144],"intermediate.":[145],"Intramolecular":[146],"k":[147,150],"/":[149],"D":[151],"ratios":[152],"3.4":[154],"2.2":[156],"butane,":[162],"respectively.":[163],"hydroxylations":[166],"performed":[168],"with":[169,251],"hydroxylase":[171],"but":[172],"only":[173],"partially":[175],"cellular":[177],"extract":[178],"proteins,":[184],"different":[185],"observed.":[189],"These":[190],"apparently":[191],"anomalous":[192],"results":[193,241,263],"could":[194],"be":[195],"explained":[196],"invoking":[198],"exchange":[199,215],"hydrogen":[201],"atoms":[202],"\u03b1":[205],"alcohols.":[210],"characteristics":[212],"this":[214],"reaction":[216],"are":[217,264],"discussed.":[218,249],"Hydroxylation":[219],"H]butanes":[223],"latter":[226],"system":[227],"yielded":[228],"\u223c90%":[229],"implication":[238],"catalytic":[244],"sMMO":[247],"is":[248],"Together":[250],"mechanistic":[253],"information":[254],"available":[255],"range":[258],"probes,":[261],"best":[265],"accounted":[266],"nonsynchronous":[270],"concerted":[271],"process":[272],"involving":[273],"attack":[274],"on":[275],"C\u2212H":[277],"bond":[278],"one":[280],"or":[281],"more":[282],"several":[284],"pathways":[285],"discussed":[286],"text.":[289]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2016-06-24T00:00:00"}