{"id":"https://openalex.org/W2018044921","doi":"https://doi.org/10.1152/japplphysiol.00617.2003","title":"Regulation of brain water during acute glucose-induced hyperosmolality in ovine fetuses, lambs, and adults","display_name":"Regulation of brain water during acute glucose-induced hyperosmolality in ovine fetuses, lambs, and adults","publication_year":2004,"publication_date":"2004-01-31","ids":{"openalex":"https://openalex.org/W2018044921","doi":"https://doi.org/10.1152/japplphysiol.00617.2003","mag":"2018044921","pmid":"https://pubmed.ncbi.nlm.nih.gov/14578364"},"language":"en","primary_location":{"id":"doi:10.1152/japplphysiol.00617.2003","doi":"https://doi.org/10.1152/japplphysiol.00617.2003","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.00617.2003","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011689741","display_name":"Barbara S. Stonestreet","orcid":"https://orcid.org/0000-0002-6532-7683","observed_orcids":["https://orcid.org/0000-0002-6532-7683"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I4210133025","display_name":"Women & Infants Hospital of Rhode Island","ror":"https://ror.org/03z8sn326","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133025"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara S. Stonestreet","raw_affiliation_strings":["Department of Pediatrics, Women and Infants' Hospital of Rhode Island, Brown University Medical School, Providence, Rhode Island 02905, USA. bstonest@wihri.org","Department of Pediatrics, Women and Infants' Hospital of Rhode Island, Brown University Medical School, Providence, Rhode Island 02905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Women and Infants' Hospital of Rhode Island, Brown University Medical School, Providence, Rhode Island 02905, USA. bstonest@wihri.org","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I4210133025"]},{"raw_affiliation_string":"Department of Pediatrics, Women and Infants' Hospital of Rhode Island, Brown University Medical School, Providence, Rhode Island 02905, USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I4210133025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017935898","display_name":"Katherine H. Petersson","orcid":"https://orcid.org/0000-0003-3888-983X","observed_orcids":["https://orcid.org/0000-0003-3888-983X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katherine H. Petersson","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025733362","display_name":"Grazyna Barbara Sadowska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Grazyna B. Sadowska","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113606098","display_name":"Clifford S. Patlak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clifford S. Patlak","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1176,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.44627958,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"96","issue":"2","first_page":"553","last_page":"560"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.2703000009059906,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.2703000009059906,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.19470000267028809,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.14059999585151672,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-volume-regulation","display_name":"brain volume regulation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/hyperosmolarity","display_name":"hyperosmolarity","score":0.8709999918937683},{"id":"https://openalex.org/keywords/osmometer","display_name":"osmometer","score":0.6439999938011169},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.746999979019165},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.9990000128746033},{"id":"https://openalex.org/keywords/medulla","display_name":"medulla","score":0.9120000004768372},{"id":"https://openalex.org/keywords/fetal-brain","display_name":"fetal brain","score":0.7649999856948853},{"id":"https://openalex.org/keywords/premature-lambs","display_name":"premature lambs","score":0.8939999938011169},{"id":"https://openalex.org/keywords/newborn-lambs","display_name":"newborn lambs","score":0.9810000061988831},{"id":"https://openalex.org/keywords/sheep","display_name":"sheep","score":0.41999998688697815},{"id":"https://openalex.org/keywords/brain-shrinkage","display_name":"brain shrinkage","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7402328252792358},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.714024543762207},{"id":"https://openalex.org/C2780762869","wikidata":"https://www.wikidata.org/wiki/Q7201783","display_name":"Plasma osmolality","level":3,"score":0.6930131912231445},{"id":"https://openalex.org/C91973860","wikidata":"https://www.wikidata.org/wiki/Q905105","display_name":"Osmometer","level":2,"score":0.6800769567489624},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.631953239440918},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.5596418976783752},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.5301650166511536},{"id":"https://openalex.org/C161457703","wikidata":"https://www.wikidata.org/wiki/Q3317402","display_name":"Renal physiology","level":3,"score":0.5019018650054932},{"id":"https://openalex.org/C129900496","wikidata":"https://www.wikidata.org/wiki/Q643555","display_name":"Osmotic concentration","level":2,"score":0.4420907199382782},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41379380226135254},{"id":"https://openalex.org/C65835030","wikidata":"https://www.wikidata.org/wiki/Q1030681","display_name":"Brain size","level":3,"score":0.41113489866256714},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40801531076431274},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.29679614305496216},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.294793963432312},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.206750750541687},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C2776370428","wikidata":"https://www.wikidata.org/wiki/Q21124841","display_name":"Vasopressin","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001834","descriptor_name":"Body Water","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003681","descriptor_name":"Dehydration","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005950","descriptor_name":"Glucose Solution, Hypertonic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014882","descriptor_name":"Water-Electrolyte Balance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014882","descriptor_name":"Water-Electrolyte Balance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1152/japplphysiol.00617.2003","doi":"https://doi.org/10.1152/japplphysiol.00617.2003","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.00617.2003","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:14578364","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14578364","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology (Bethesda, Md. : 1985)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.528.3651","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.528.3651","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jap.physiology.org/content/96/2/553.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1409541856","display_name":null,"funder_award_id":"P50-HD-11343","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G3061439306","display_name":"DIABETES DURING PREGNANCY:  EFFECTS ON THE OFFSPRING","funder_award_id":"5p50hd011343-17","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3971373079","display_name":"HORMONAL REGULATION OF BRAIN MATURATION","funder_award_id":"R01HD034618","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W20526226","https://openalex.org/W50059298","https://openalex.org/W142841967","https://openalex.org/W147652536","https://openalex.org/W149124968","https://openalex.org/W172501834","https://openalex.org/W834413716","https://openalex.org/W1967958202","https://openalex.org/W1976536825","https://openalex.org/W2005998235","https://openalex.org/W2022934297","https://openalex.org/W2033608018","https://openalex.org/W2037904496","https://openalex.org/W2045614683","https://openalex.org/W2050172397","https://openalex.org/W2069497280","https://openalex.org/W2082080632","https://openalex.org/W2105954292","https://openalex.org/W2136853370","https://openalex.org/W2149789317","https://openalex.org/W2229993998","https://openalex.org/W2256933540","https://openalex.org/W2278527848","https://openalex.org/W2283540231","https://openalex.org/W2292126253","https://openalex.org/W2300751502","https://openalex.org/W2336737725","https://openalex.org/W2340415279","https://openalex.org/W2402066685","https://openalex.org/W2421694447","https://openalex.org/W2486004967","https://openalex.org/W2764367733"],"related_works":["https://openalex.org/W2105954292","https://openalex.org/W2001342268","https://openalex.org/W192864621","https://openalex.org/W2283540231","https://openalex.org/W1997582811","https://openalex.org/W149124968","https://openalex.org/W2135038519","https://openalex.org/W2085857210","https://openalex.org/W2033608018","https://openalex.org/W2289000567"],"abstract_inverted_index":{"We":[0,232],"tested":[1],"the":[2,9,16,44,71,109,133,137,191,197,204,216,220,238,245],"hypothesis":[3],"that,":[4,234],"during":[5,229,235],"acute":[6],"glucose-induced":[7,39,230,236],"hyperosmolality,":[8,237],"brain":[10,24,81,114,217,239],"shrinks":[11,240],"less":[12,241],"than":[13,242],"predicted":[14,243],"on":[15,244],"basis":[17,246],"of":[18,50,54,61,70,111,136,141,199,206,219,247,259],"an":[19,105,248],"ideal":[20,88,249],"osmometer":[21,89,250],"and":[22,32,48,65,83,174,193,226,251,265],"that":[23,210],"volume":[25,112,211,253],"regulation":[26,212,254],"is":[27,90],"present":[28,214],"in":[29,43,75,93,102,132,190,196,215,255],"fetuses,":[30,221],"premature":[31,56,152,222,261],"newborn":[33,63,163,224,263],"lambs.":[34],"Brain":[35],"water":[36,82],"responses":[37],"to":[38,73,104],"hyperosmolality":[40],"were":[41,85,188],"measured":[42],"cerebral":[45,134],"cortex,":[46],"cerebellum,":[47],"medulla":[49],"fetuses":[51,138,256],"at":[52,59,139,257],"60%":[53,140,258],"gestation,":[55,62,260],"ventilated":[57],"lambs":[58,153,164],"90%":[60],"lambs,":[64,223,225,262,264],"adult":[66,175,227,266],"sheep.":[67,267],"After":[68],"exposure":[69],"sheep":[72,176,228],"increases":[74],"osmolality":[76,119,131],"with":[77,129],"glucose":[78],"plus":[79],"NaCl,":[80],"electrolytes":[84],"measured.":[86],"The":[87,121],"a":[91],"system":[92],"which":[94],"impermeable":[95],"solutes":[96],"do":[97],"not":[98],"enter":[99],"or":[100],"leave":[101],"response":[103],"osmotic":[106],"stress.":[107],"In":[108],"absence":[110],"regulation,":[113],"solute":[115,124,202],"remains":[116],"constant":[117],"as":[118],"changes.":[120],"osmotically":[122,200],"active":[123,201],"demonstrated":[125],"direct":[126],"linear":[127],"correlations":[128],"plasma":[130,207],"cortex":[135],"gestation":[142],"(r":[143,154,165,177],"=":[144,147,150,155,158,161,166,169,172,178,181,184],"0.72,":[145],"n":[146,157,168,180],"24,":[148,170],"P":[149,160,171,183],"0.0001),":[151],"0.58,":[156],"22,":[159],"0.005),":[162],"0.57,":[167],"0.004),":[173],"0.70,":[179],"18,":[182],"0.001).":[185],"Similar":[186],"findings":[187],"observed":[189],"cerebellum":[192],"medulla.":[194],"Increases":[195],"quantity":[198],"over":[203],"range":[205],"osmolalities":[208],"indicate":[209],"was":[213],"regions":[218],"hyperosmolality.":[231],"conclude":[233],"exhibits":[252]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}