{"id":"https://openalex.org/W2018042402","doi":"https://doi.org/10.1038/ng1273","title":"Conversion of biliary system to pancreatic tissue in Hes1-deficient mice","display_name":"Conversion of biliary system to pancreatic tissue in Hes1-deficient mice","publication_year":2003,"publication_date":"2003-12-14","ids":{"openalex":"https://openalex.org/W2018042402","doi":"https://doi.org/10.1038/ng1273","mag":"2018042402","pmid":"https://pubmed.ncbi.nlm.nih.gov/14702043"},"language":"en","primary_location":{"id":"doi:10.1038/ng1273","doi":"https://doi.org/10.1038/ng1273","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ng1273","pdf_url":null,"source":{"id":"https://openalex.org/S137905309","display_name":"Nature Genetics","issn_l":"1061-4036","issn":["1061-4036","1546-1718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014184709","display_name":"Ryo Sumazaki","orcid":"https://orcid.org/0000-0003-0128-8782","observed_orcids":["https://orcid.org/0000-0003-0128-8782"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Ryo Sumazaki","raw_affiliation_strings":["Department of Child Health, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Child Health, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050629953","display_name":"Nobuyoshi Shiojiri","orcid":"https://orcid.org/0000-0002-6278-3480","observed_orcids":["https://orcid.org/0000-0002-6278-3480"]},"institutions":[{"id":"https://openalex.org/I1298590031","display_name":"Shizuoka University","ror":"https://ror.org/01w6wtk13","country_code":"JP","type":"education","lineage":["https://openalex.org/I1298590031"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuyoshi Shiojiri","raw_affiliation_strings":["Biological Institute, Faculty of Science, Shizuoka University, Shizuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Institute, Faculty of Science, Shizuoka University, Shizuoka, Japan","institution_ids":["https://openalex.org/I1298590031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007360121","display_name":"Shigemi Isoyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigemi Isoyama","raw_affiliation_strings":["Department of Child Health, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Child Health, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079824102","display_name":"Masayuki Masu","orcid":"https://orcid.org/0000-0002-4726-7429","observed_orcids":["https://orcid.org/0000-0002-4726-7429"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Masu","raw_affiliation_strings":["Department of Molecular Neurobiology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Neurobiology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078201249","display_name":"Kazuko Keino\u2010Masu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuko Keino-Masu","raw_affiliation_strings":["Department of Molecular Neurobiology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Neurobiology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103358181","display_name":"Mitsujiro Osawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsujiro Osawa","raw_affiliation_strings":["Laboratory of Stem Cell Therapy, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Stem Cell Therapy, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059937255","display_name":"Hiromitsu Nakauchi","orcid":"https://orcid.org/0000-0002-9841-6973","observed_orcids":["https://orcid.org/0000-0002-9841-6973","https://orcid.org/0000-0002-8122-2566"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromitsu Nakauchi","raw_affiliation_strings":["Laboratory of Stem Cell Therapy, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Stem Cell Therapy, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018917055","display_name":"Ryoichiro Kageyama","orcid":"https://orcid.org/0000-0002-5985-1120","observed_orcids":["https://orcid.org/0000-0002-5985-1120"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryoichiro Kageyama","raw_affiliation_strings":["Institute for Virus Research, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Virus Research, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082554858","display_name":"Akira Matsui","orcid":"https://orcid.org/0000-0002-0174-914X","observed_orcids":["https://orcid.org/0000-0002-0174-914X"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Matsui","raw_affiliation_strings":["Department of Child Health, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Child Health, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5014184709"],"corresponding_institution_ids":["https://openalex.org/I146399215"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":3.563,"has_fulltext":true,"cited_by_count":234,"citation_normalized_percentile":{"value":0.93666116,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"36","issue":"1","first_page":"83","last_page":"87"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.4661000072956085,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.4661000072956085,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.24719999730587006,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.1428000032901764,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hes1","display_name":"Hes1","score":1.0},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.9480000138282776},{"id":"https://openalex.org/keywords/biliary-epithelium","display_name":"biliary epithelium","score":0.8230000138282776},{"id":"https://openalex.org/keywords/pancreatic-differentiation","display_name":"pancreatic differentiation","score":0.7080000042915344},{"id":"https://openalex.org/keywords/organogenesis","display_name":"organogenesis","score":0.5899999737739563},{"id":"https://openalex.org/keywords/gallbladder-agenesis","display_name":"gallbladder agenesis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/neurog3","display_name":"Neurog3","score":0.9890000224113464},{"id":"https://openalex.org/keywords/endocrine-cell-differentiation","display_name":"endocrine differentiation","score":0.7009999752044678},{"id":"https://openalex.org/keywords/foregut-endoderm","display_name":"foregut endoderm","score":0.8130000233650208},{"id":"https://openalex.org/keywords/alagille-syndrome","display_name":"Alagille syndrome","score":0.6850000023841858},{"id":"https://openalex.org/keywords/jag1","display_name":"JAG1","score":0.6819999814033508},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C2780283210","wikidata":"https://www.wikidata.org/wiki/Q18027301","display_name":"HES1","level":4,"score":0.9656458497047424},{"id":"https://openalex.org/C2778668844","wikidata":"https://www.wikidata.org/wiki/Q18251749","display_name":"JAG1","level":4,"score":0.8364351987838745},{"id":"https://openalex.org/C2780971011","wikidata":"https://www.wikidata.org/wiki/Q1544408","display_name":"Alagille syndrome","level":3,"score":0.7914217710494995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.785451352596283},{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.689839243888855},{"id":"https://openalex.org/C170774537","wikidata":"https://www.wikidata.org/wiki/Q2533722","display_name":"Foregut","level":2,"score":0.6541951894760132},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.568920373916626},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4718867540359497},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4686013460159302},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4468313157558441},{"id":"https://openalex.org/C2777148285","wikidata":"https://www.wikidata.org/wiki/Q64386","display_name":"Gallbladder","level":2,"score":0.43514588475227356},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.4318789839744568},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2271566092967987},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1533789336681366},{"id":"https://openalex.org/C2778593092","wikidata":"https://www.wikidata.org/wiki/Q1075923","display_name":"Cholestasis","level":2,"score":0.10593670606613159},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06683459877967834},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072056","descriptor_name":"Transcription Factor HES-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001659","descriptor_name":"Biliary Tract","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005704","descriptor_name":"Gallbladder","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/ng1273","doi":"https://doi.org/10.1038/ng1273","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ng1273","pdf_url":null,"source":{"id":"https://openalex.org/S137905309","display_name":"Nature Genetics","issn_l":"1061-4036","issn":["1061-4036","1546-1718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Genetics","raw_type":"journal-article"},{"id":"pmid:14702043","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14702043","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature genetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.428600013256073,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1488156534","https://openalex.org/W1516141972","https://openalex.org/W1568038787","https://openalex.org/W1573536022","https://openalex.org/W1589576417","https://openalex.org/W1721336579","https://openalex.org/W1918701699","https://openalex.org/W1974185766","https://openalex.org/W1986155425","https://openalex.org/W1993055783","https://openalex.org/W2021560018","https://openalex.org/W2023445515","https://openalex.org/W2025748388","https://openalex.org/W2025804504","https://openalex.org/W2033045615","https://openalex.org/W2040947899","https://openalex.org/W2064520670","https://openalex.org/W2071762105","https://openalex.org/W2088969512","https://openalex.org/W2091496842","https://openalex.org/W2092017486","https://openalex.org/W2092592893","https://openalex.org/W2099559573","https://openalex.org/W2110447217","https://openalex.org/W2136585808","https://openalex.org/W2137987484","https://openalex.org/W2159369466","https://openalex.org/W2162464438"],"related_works":["https://openalex.org/W2126381742","https://openalex.org/W4235450602","https://openalex.org/W4390568161","https://openalex.org/W2148986068","https://openalex.org/W1568038787","https://openalex.org/W2887144551","https://openalex.org/W2807458767","https://openalex.org/W2130795707","https://openalex.org/W2886949310","https://openalex.org/W2024955519"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":19}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}