{"id":"https://openalex.org/W2018014677","doi":"https://doi.org/10.1371/journal.pone.0039691","title":"Loss of Hairless Confers Susceptibility to UVB-Induced Tumorigenesis via Disruption of NF-kappaB Signaling","display_name":"Loss of Hairless Confers Susceptibility to UVB-Induced Tumorigenesis via Disruption of NF-kappaB Signaling","publication_year":2012,"publication_date":"2012-06-25","ids":{"openalex":"https://openalex.org/W2018014677","doi":"https://doi.org/10.1371/journal.pone.0039691","mag":"2018014677","pmid":"https://pubmed.ncbi.nlm.nih.gov/22761871","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3382590"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0039691","doi":"https://doi.org/10.1371/journal.pone.0039691","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0039691","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0039691&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0039691&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100724835","display_name":"Hyun-Mi Kim","orcid":"https://orcid.org/0000-0002-5596-4320","observed_orcids":["https://orcid.org/0000-0002-5596-4320"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyunmi Kim","raw_affiliation_strings":["Department of Genetics & Development, Columbia University, College of Physicians & Surgeons, New York, New York, United States of America","Department of Dermatology, Columbia University, College of Physicians & Surgeons, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics & Development, Columbia University, College of Physicians & Surgeons, New York, New York, United States of America","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Dermatology, Columbia University, College of Physicians & Surgeons, New York, New York, United States of America","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031854731","display_name":"Alexandre Casta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandre Casta","raw_affiliation_strings":["Institute of Human Nutrition, Columbia University, College of Physicians & Surgeons, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Nutrition, Columbia University, College of Physicians & Surgeons, New York, New York, United States of America","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029160030","display_name":"Xiuwei Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiuwei Tang","raw_affiliation_strings":["Department of Dermatology, Columbia University, College of Physicians & Surgeons, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Columbia University, College of Physicians & Surgeons, New York, New York, United States of America","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016810637","display_name":"Courtney T. Luke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Courtney T. Luke","raw_affiliation_strings":["Department of Dermatology, Columbia University, College of Physicians & Surgeons, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Columbia University, College of Physicians & Surgeons, New York, New York, United States of America","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061796830","display_name":"Arianna L. Kim","orcid":"https://orcid.org/0000-0003-4609-1182","observed_orcids":["https://orcid.org/0000-0003-4609-1182"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arianna L. Kim","raw_affiliation_strings":["Department of Dermatology, Columbia University, College of Physicians & Surgeons, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Columbia University, College of Physicians & Surgeons, New York, New York, United States of America","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109978711","display_name":"David R. Bickers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David R. Bickers","raw_affiliation_strings":["Department of Dermatology, Columbia University, College of Physicians & Surgeons, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Columbia University, College of Physicians & Surgeons, New York, New York, United States of America","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079917691","display_name":"Mohammad Athar","orcid":"https://orcid.org/0000-0001-5829-7992","observed_orcids":["https://orcid.org/0000-0001-5829-7992"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad Athar","raw_affiliation_strings":["Department of Dermatology, Columbia University, College of Physicians & Surgeons, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Columbia University, College of Physicians & Surgeons, New York, New York, United States of America","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044490713","display_name":"Angela M. Christiano","orcid":"https://orcid.org/0000-0002-6071-9784","observed_orcids":["https://orcid.org/0000-0002-6071-9784"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Angela M. Christiano","raw_affiliation_strings":["Department of Dermatology, Columbia University, College of Physicians & Surgeons, New York, New York, United States of America","Department of Genetics & Development, Columbia University, College of Physicians & Surgeons, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Columbia University, College of Physicians & Surgeons, New York, New York, United States of America","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Genetics & Development, Columbia University, College of Physicians & Surgeons, New York, New York, United States of America","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044490713"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.0548,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.76075539,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"7","issue":"6","first_page":"e39691","last_page":"e39691"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.8270999789237976,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.8270999789237976,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.13539999723434448,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hairless-gene","display_name":"hairless gene","score":0.8700000047683716},{"id":"https://openalex.org/keywords/skh-1-mice","display_name":"SKH-1 mice","score":0.800000011920929},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.7979999780654907},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.9120000004768372},{"id":"https://openalex.org/keywords/epidermal-proliferation","display_name":"epidermal proliferation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cyclin-e","display_name":"cyclin E","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.996999979019165},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.8759999871253967},{"id":"https://openalex.org/keywords/mouse-tumor-model","display_name":"mouse tumor model","score":0.3720000088214874}],"concepts":[{"id":"https://openalex.org/C2779156968","wikidata":"https://www.wikidata.org/wiki/Q17141495","display_name":"Hairless","level":2,"score":0.9918627738952637},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.7150053977966309},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.6293411254882812},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5925636887550354},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.5780264735221863},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5109807252883911},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4901028573513031},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.4854050576686859},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4675648808479309},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.4422563314437866},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.41764742136001587},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3380015790462494},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.3146686553955078},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20712468028068542},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1578146517276764},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009381","descriptor_name":"Neoplasms, Radiation-Induced","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0039691","doi":"https://doi.org/10.1371/journal.pone.0039691","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0039691","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0039691&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2394912","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3382590","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3382590","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3382590","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:22761871","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22761871","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5b57d14eff4344a795633e0ac58868fc","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5b57d14eff4344a795633e0ac58868fc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 6, p e39691 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/123546","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Loss_of_Hairless_Confers_Susceptibility_to_UVB_Induced_Tumorigenesis_via_Disruption_of_NF_kappaB_Signaling/123546","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0039691","doi":"https://doi.org/10.1371/journal.pone.0039691","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0039691","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0039691&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2360139478","display_name":"Role of p53 and ptc tumor suppressive pathways in BCCs development and prevention","funder_award_id":"R01ES015323","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G3161744502","display_name":"Columbia University Medical Center Skin Disease Research Center (CUMCSDRC)","funder_award_id":"P30AR044535","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G3269659400","display_name":"Inhibiting Multiple Molecular Targets for Preventing Non-Melanoma Skin Cancer","funder_award_id":"R01CA138998","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4578922579","display_name":"UAB Skin Diseases Research Center","funder_award_id":"P30AR050948","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G8099268744","display_name":"Genetic Mechanisms in Skin Diseases","funder_award_id":"T32AR007605","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G8180442606","display_name":"Functional Analysis of the Hairless Protein","funder_award_id":"R01AR047338","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320315091","display_name":"Stanford Diabetes Research Center","ror":"https://ror.org/03gjd9f16"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018014677.pdf","grobid_xml":"https://content.openalex.org/works/W2018014677.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W947843024","https://openalex.org/W1550772045","https://openalex.org/W1904705252","https://openalex.org/W1962517589","https://openalex.org/W1968283278","https://openalex.org/W1981495889","https://openalex.org/W1983288937","https://openalex.org/W1988929732","https://openalex.org/W1989142525","https://openalex.org/W1997546288","https://openalex.org/W2002321849","https://openalex.org/W2014729294","https://openalex.org/W2015083674","https://openalex.org/W2028326553","https://openalex.org/W2032275493","https://openalex.org/W2035635507","https://openalex.org/W2041693867","https://openalex.org/W2043118554","https://openalex.org/W2047863507","https://openalex.org/W2049525522","https://openalex.org/W2050793665","https://openalex.org/W2051831012","https://openalex.org/W2053178902","https://openalex.org/W2062433670","https://openalex.org/W2070394850","https://openalex.org/W2073746138","https://openalex.org/W2075346086","https://openalex.org/W2080075181","https://openalex.org/W2083122160","https://openalex.org/W2086997734","https://openalex.org/W2090610758","https://openalex.org/W2099199536","https://openalex.org/W2105354163","https://openalex.org/W2105907483","https://openalex.org/W2106295560","https://openalex.org/W2107748647","https://openalex.org/W2108183675","https://openalex.org/W2109365948","https://openalex.org/W2110767549","https://openalex.org/W2114288384","https://openalex.org/W2118986158","https://openalex.org/W2135201878","https://openalex.org/W2137772137","https://openalex.org/W2138348020","https://openalex.org/W2148953261","https://openalex.org/W2154721481","https://openalex.org/W2159567970","https://openalex.org/W2748956263","https://openalex.org/W4249195545"],"related_works":["https://openalex.org/W2140540805","https://openalex.org/W1968054429","https://openalex.org/W2000039710","https://openalex.org/W1484619402","https://openalex.org/W2404833319","https://openalex.org/W385570619","https://openalex.org/W1986082476","https://openalex.org/W2074783334","https://openalex.org/W253965757","https://openalex.org/W2052696175"],"abstract_inverted_index":{"In":[0],"order":[1],"to":[2,97,134],"model":[3],"squamous":[4],"cell":[5,145],"carcinoma":[6],"development":[7],"in":[8,45,53,78,105,114,128,166],"vivo,":[9],"researchers":[10],"have":[11,22],"long":[12],"preferred":[13],"hairless":[14,36,55,187],"mouse":[15,62],"models":[16],"such":[17],"as":[18,26],"SKH-1":[19,59],"mice":[20,28,180],"that":[21,43,77,88,117,173,205],"traditionally":[23],"been":[24],"classified":[25],"'wild-type'":[27,188],"irrespective":[29],"of":[30,57,69,126,140,169],"the":[31,46,54,58,79,129,135,144,153,158],"genetic":[32],"factors":[33],"underlying":[34],"their":[35],"phenotype.":[37],"The":[38],"work":[39],"presented":[40],"here":[41],"shows":[42],"mutations":[44],"Hairless":[47],"(Hr)":[48],"gene":[49,87,197],"not":[50],"only":[51],"result":[52],"phenotype":[56],"and":[60,71,92,150,157,177,198],"Hr(-/-)":[61],"lines":[63],"but":[64],"also":[65],"cause":[66],"aberrant":[67],"activation":[68,91,125],"NF\u03baB":[70,90,115,127],"its":[72,199],"downstream":[73,141],"effectors.":[74],"We":[75],"show":[76],"epidermis,":[80],"Hr":[81,101,106,130,163,178,191],"is":[82,103,110,118,192],"an":[83],"early":[84],"UVB":[85,121,195],"response":[86,196],"regulates":[89],"thereby":[93],"controls":[94],"cellular":[95],"responses":[96],"irradiation.":[98,122],"Therefore,":[99,162],"when":[100],"expression":[102],"decreased":[104],"mutant":[107,131,179],"animals":[108],"there":[109],"a":[111,137,167,193,202],"corresponding":[112],"increase":[113],"activity":[116],"augmented":[119],"by":[120],"This":[123],"constitutive":[124],"epidermis":[132],"leads":[133],"stimulation":[136],"large":[138],"variety":[139],"effectors":[142],"including":[143],"cycle":[146],"regulators":[147],"cyclin":[148,151],"D1":[149],"E,":[152],"anti-apoptosis":[154],"protein":[155,160],"Bcl-2,":[156],"pro-inflammatory":[159],"Cox-2.":[161],"loss":[164,200],"results":[165],"state":[168],"uncontrolled":[170],"epidermal":[171],"proliferation":[172],"promotes":[174],"tumor":[175],"development,":[176],"should":[181],"no":[182],"longer":[183],"be":[184],"considered":[185],"merely":[186],"mice.":[189],"Instead,":[190],"crucial":[194],"creates":[201],"permissive":[203],"environment":[204],"potentiates":[206],"increased":[207],"tumorigenesis.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}