{"id":"https://openalex.org/W2018012000","doi":"https://doi.org/10.1016/0300-483x(82)90029-4","title":"Acetaminophen-induced hypothermia in mice: Evidence for a central action of the parent compound","display_name":"Acetaminophen-induced hypothermia in mice: Evidence for a central action of the parent compound","publication_year":1982,"publication_date":"1982-01-01","ids":{"openalex":"https://openalex.org/W2018012000","doi":"https://doi.org/10.1016/0300-483x(82)90029-4","mag":"2018012000","pmid":"https://pubmed.ncbi.nlm.nih.gov/7157399"},"language":"en","primary_location":{"id":"doi:10.1016/0300-483x(82)90029-4","doi":"https://doi.org/10.1016/0300-483x(82)90029-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0300-483x(82)90029-4","pdf_url":null,"source":{"id":"https://openalex.org/S128555845","display_name":"Toxicology","issn_l":"0300-483X","issn":["0300-483X","1879-3185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103403228","display_name":"Thomas E. Massey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Thomas E. Massey","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Queen's University, Kingston, Ontario K7L 3N6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Queen's University, Kingston, Ontario K7L 3N6, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071795686","display_name":"Robin M. Walker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]},{"id":"https://openalex.org/I2801322873","display_name":"Hotel Dieu Hospital","ror":"https://ror.org/01s7w1z60","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801322873"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Robin M. Walker","raw_affiliation_strings":["Department of Pathology, Hotel Dieu Hospital, Kingston, Ontario, Canada","Department of Pathology, Queen's University, Kingston, Ontario K7L 3N6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hotel Dieu Hospital, Kingston, Ontario, Canada","institution_ids":["https://openalex.org/I2801322873"]},{"raw_affiliation_string":"Department of Pathology, Queen's University, Kingston, Ontario K7L 3N6, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029933293","display_name":"Timothy F. McElligott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]},{"id":"https://openalex.org/I2801322873","display_name":"Hotel Dieu Hospital","ror":"https://ror.org/01s7w1z60","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801322873"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Timothy F. McElligott","raw_affiliation_strings":["Department of Pathology, Hotel Dieu Hospital, Kingston, Ontario, Canada","Department of Pathology, Queen's University, Kingston, Ontario K7L 3N6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hotel Dieu Hospital, Kingston, Ontario, Canada","institution_ids":["https://openalex.org/I2801322873"]},{"raw_affiliation_string":"Department of Pathology, Queen's University, Kingston, Ontario K7L 3N6, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029088066","display_name":"William J. Racz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"William J. Racz","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Queen's University, Kingston, Ontario K7L 3N6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Queen's University, Kingston, Ontario K7L 3N6, Canada","institution_ids":["https://openalex.org/I204722609"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5029088066"],"corresponding_institution_ids":["https://openalex.org/I204722609"],"apc_list":{"value":4250,"currency":"USD","value_usd":4250},"apc_paid":null,"fwci":0.5692,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.55225653,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"25","issue":"2-3","first_page":"187","last_page":"200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.6636000275611877,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.6636000275611877,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.2117999941110611,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.09030000120401382,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paracetamol","display_name":"paracetamol","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hypothermia","display_name":"hypothermia","score":0.902999997138977},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"central nervous system","score":0.5},{"id":"https://openalex.org/keywords/mixed-function-oxidase","display_name":"mixed function oxidase","score":0.7519999742507935},{"id":"https://openalex.org/keywords/piperonyl-butoxide","display_name":"piperonyl butoxide","score":0.9139999747276306},{"id":"https://openalex.org/keywords/skf-525a","display_name":"SKF 525-A","score":0.9700000286102295},{"id":"https://openalex.org/keywords/metyrapone","display_name":"metyrapone","score":0.9869999885559082},{"id":"https://openalex.org/keywords/phenobarbital","display_name":"phenobarbital","score":0.9729999899864197},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.4339999854564667},{"id":"https://openalex.org/keywords/intracerebroventricular-injection","display_name":"intracerebroventricular administration","score":0.7829999923706055},{"id":"https://openalex.org/keywords/brain-drug-levels","display_name":"brain drug levels","score":0.7089999914169312},{"id":"https://openalex.org/keywords/body-temperature-monitoring","display_name":"body temperature monitoring","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C2777390192","wikidata":"https://www.wikidata.org/wiki/Q1036696","display_name":"Hypothermia","level":2,"score":0.7334799766540527},{"id":"https://openalex.org/C2778722691","wikidata":"https://www.wikidata.org/wiki/Q57055","display_name":"Acetaminophen","level":2,"score":0.5824467539787292},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.5438001155853271},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4838036894798279},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39772024750709534},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.34869104623794556},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000082","descriptor_name":"Acetaminophen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000082","descriptor_name":"Acetaminophen","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007035","descriptor_name":"Hypothermia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010634","descriptor_name":"Phenobarbital","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010882","descriptor_name":"Piperonyl Butoxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011335","descriptor_name":"Proadifen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0300-483x(82)90029-4","doi":"https://doi.org/10.1016/0300-483x(82)90029-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0300-483x(82)90029-4","pdf_url":null,"source":{"id":"https://openalex.org/S128555845","display_name":"Toxicology","issn_l":"0300-483X","issn":["0300-483X","1879-3185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"journal-article"},{"id":"pmid:7157399","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7157399","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319989","display_name":"Canadian Liver Foundation","ror":"https://ror.org/05bz3w661"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1496471943","https://openalex.org/W1762750516","https://openalex.org/W1775749144","https://openalex.org/W1997383098","https://openalex.org/W2006499219","https://openalex.org/W2008170222","https://openalex.org/W2016671139","https://openalex.org/W2032149167","https://openalex.org/W2038673987","https://openalex.org/W2041408150","https://openalex.org/W2043697915","https://openalex.org/W2055598466","https://openalex.org/W2066243639","https://openalex.org/W2067245473","https://openalex.org/W2074368593","https://openalex.org/W2076584391","https://openalex.org/W2107947237","https://openalex.org/W2117354924","https://openalex.org/W2138162004","https://openalex.org/W2222772859","https://openalex.org/W2245167357","https://openalex.org/W2409474453","https://openalex.org/W2913632035","https://openalex.org/W3024007472","https://openalex.org/W4251495518"],"related_works":["https://openalex.org/W2109551775","https://openalex.org/W2558875584","https://openalex.org/W2076017590","https://openalex.org/W2096196129","https://openalex.org/W2030671390","https://openalex.org/W2739481111","https://openalex.org/W4220665390","https://openalex.org/W2811147961","https://openalex.org/W1968851963","https://openalex.org/W2019175190"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}