{"id":"https://openalex.org/W2018000179","doi":"https://doi.org/10.1016/s0006-291x(85)80040-1","title":"GRF is a highly potent activator of adenylate cyclase in the normal human, bovine and rat pituitary: Interaction with somatostatin","display_name":"GRF is a highly potent activator of adenylate cyclase in the normal human, bovine and rat pituitary: Interaction with somatostatin","publication_year":1985,"publication_date":"1985-03-01","ids":{"openalex":"https://openalex.org/W2018000179","doi":"https://doi.org/10.1016/s0006-291x(85)80040-1","mag":"2018000179","pmid":"https://pubmed.ncbi.nlm.nih.gov/2859017"},"language":"en","primary_location":{"id":"doi:10.1016/s0006-291x(85)80040-1","doi":"https://doi.org/10.1016/s0006-291x(85)80040-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0006-291x(85)80040-1","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062879543","display_name":"Florence Reyl-Desmars","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Florence Reyl-Desmars","raw_affiliation_strings":["Laboratories for Neuroendocrinology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratories for Neuroendocrinology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037 USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001537127","display_name":"Andrew Baird","orcid":"https://orcid.org/0000-0003-0027-9905","observed_orcids":["https://orcid.org/0000-0003-0027-9905"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Baird","raw_affiliation_strings":["Laboratories for Neuroendocrinology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratories for Neuroendocrinology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037 USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113670972","display_name":"F\u00fcs\u00fbn N. Zeytin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F\u00fcs\u00fbn N. Zeytin","raw_affiliation_strings":["Laboratories for Neuroendocrinology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratories for Neuroendocrinology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037 USA","institution_ids":["https://openalex.org/I1307098950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1307098950"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":2.3152,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.87300995,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"127","issue":"3","first_page":"977","last_page":"985"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.7134000062942505,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.7134000062942505,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.1738000065088272,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.05469999834895134,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-regulating-factors","display_name":"growth-regulating factors","score":0.7739999890327454},{"id":"https://openalex.org/keywords/grf","display_name":"GRF","score":0.6940000057220459},{"id":"https://openalex.org/keywords/adenylyl-cyclase-activation","display_name":"adenylate cyclase activation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/pituitary-gland","display_name":"pituitary gland","score":0.7300000190734863},{"id":"https://openalex.org/keywords/somatostatin","display_name":"somatostatin","score":0.9380000233650208},{"id":"https://openalex.org/keywords/growth-hormone-secretion","display_name":"growth hormone secretion","score":0.9409999847412109},{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":0.7739999890327454},{"id":"https://openalex.org/keywords/non-competitive-inhibition","display_name":"non-competitive inhibition","score":0.8759999871253967},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.8399531841278076},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.7727035284042358},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7644349336624146},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7351052761077881},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.6749244332313538},{"id":"https://openalex.org/C2779029589","wikidata":"https://www.wikidata.org/wiki/Q356002","display_name":"Anterior pituitary","level":3,"score":0.6435984373092651},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.4724709689617157},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4441894292831421},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44079530239105225},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.4296857416629791},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40424880385398865},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.23471859097480774},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.2283199429512024},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.16407138109207153},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06761273741722107}],"mesh":[{"descriptor_ui":"D000067956","descriptor_name":"Adenylyl Cyclase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013007","descriptor_name":"Growth Hormone-Releasing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014660","descriptor_name":"Vasoactive Intestinal Peptide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0006-291x(85)80040-1","doi":"https://doi.org/10.1016/s0006-291x(85)80040-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0006-291x(85)80040-1","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:2859017","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2859017","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2833466571","display_name":null,"funder_award_id":"HD-09690","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6101251267","display_name":"BRAIN PEPTIDES ON PITUITARY FUNCTIONS AND DIABETES","funder_award_id":"5p01am018811-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320313505","display_name":"Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation","ror":"https://ror.org/05r5zfp34"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1679386658","https://openalex.org/W1893651774","https://openalex.org/W1970433146","https://openalex.org/W1994121314","https://openalex.org/W1995079019","https://openalex.org/W2003064043","https://openalex.org/W2025610045","https://openalex.org/W2028470068","https://openalex.org/W2058170465","https://openalex.org/W2077280729","https://openalex.org/W2083096968","https://openalex.org/W2144743522","https://openalex.org/W2150568877","https://openalex.org/W2154476532"],"related_works":["https://openalex.org/W2079096172","https://openalex.org/W2025379242","https://openalex.org/W2083160832","https://openalex.org/W2150568877","https://openalex.org/W2028470068","https://openalex.org/W2009105849","https://openalex.org/W2015233872","https://openalex.org/W2144743522","https://openalex.org/W2046164801","https://openalex.org/W1975596693"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}