{"id":"https://openalex.org/W2017973216","doi":"https://doi.org/10.1111/j.1087-0024.2005.200415.x","title":"Co-expression of p16INK4A and Laminin 5 by Keratinocytes: A Wound-Healing Response Coupling Hypermotility with Growth Arrest that Goes Awry During Epithelial Neoplastic Progression","display_name":"Co-expression of p16INK4A and Laminin 5 by Keratinocytes: A Wound-Healing Response Coupling Hypermotility with Growth Arrest that Goes Awry During Epithelial Neoplastic Progression","publication_year":2005,"publication_date":"2005-10-13","ids":{"openalex":"https://openalex.org/W2017973216","doi":"https://doi.org/10.1111/j.1087-0024.2005.200415.x","mag":"2017973216","pmid":"https://pubmed.ncbi.nlm.nih.gov/16358814"},"language":"en","primary_location":{"id":"doi:10.1111/j.1087-0024.2005.200415.x","doi":"https://doi.org/10.1111/j.1087-0024.2005.200415.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1087-0024.2005.200415.x","pdf_url":null,"source":{"id":"https://openalex.org/S116973605","display_name":"Journal of Investigative Dermatology Symposium Proceedings","issn_l":"1087-0024","issn":["1087-0024","1529-1774"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology Symposium Proceedings","raw_type":"journal-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1111/j.1087-0024.2005.200415.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080778051","display_name":"Easwar Natarajan","orcid":"https://orcid.org/0000-0002-1253-9578","observed_orcids":["https://orcid.org/0000-0002-1253-9578"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Easwar Natarajan","raw_affiliation_strings":["Department of Dermatology and Harvard Skin Disease Research Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA","Department of Dermatology and Harvard Skin Disease Research Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Harvard Skin Disease Research Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Dermatology and Harvard Skin Disease Research Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057380005","display_name":"John D. Omobono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John D. Omobono","raw_affiliation_strings":["Department of Dermatology and Harvard Skin Disease Research Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Harvard Skin Disease Research Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035402807","display_name":"Jonathan Jones","orcid":"https://orcid.org/0000-0002-1496-4922","observed_orcids":["https://orcid.org/0000-0002-1496-4922"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan C. Jones","raw_affiliation_strings":["Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108202793","display_name":"James G. Rheinwald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James G. Rheinwald","raw_affiliation_strings":["Department of Dermatology and Harvard Skin Disease Research Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Harvard Skin Disease Research Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5108202793"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":{"value":3200,"currency":"USD","value_usd":3200},"apc_paid":null,"fwci":23.6746,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.99271845,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"10","issue":"2","first_page":"72","last_page":"85"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.7211999893188477,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.7211999893188477,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.13609999418258667,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.01860000006854534,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p16ink4a","display_name":"p16INK4a","score":1.0},{"id":"https://openalex.org/keywords/laminin-5","display_name":"laminin-5","score":0.8600000143051147},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.9760000109672546},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.5210000276565552},{"id":"https://openalex.org/keywords/growth-arrest","display_name":"growth arrest","score":0.8889999985694885},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8769999742507935},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.8370000123977661},{"id":"https://openalex.org/keywords/precancerous-lesions","display_name":"precancerous lesions","score":0.699999988079071},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.6800000071525574},{"id":"https://openalex.org/keywords/p14arf","display_name":"p14ARF","score":0.8420000076293945},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8640000224113464},{"id":"https://openalex.org/keywords/re-epithelialization","display_name":"re-epithelialization","score":0.843999981880188},{"id":"https://openalex.org/keywords/oral-keratinocytes","display_name":"oral keratinocytes","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C2779814568","wikidata":"https://www.wikidata.org/wiki/Q58345","display_name":"Laminin","level":3,"score":0.6590975522994995},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.6128770709037781},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.533137321472168},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5173327326774597},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4042690396308899},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3579542636871338},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28582143783569336},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23985758423805237},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.06703177094459534},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.04696834087371826},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007797","descriptor_name":"Laminin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D007797","descriptor_name":"Laminin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009375","descriptor_name":"Neoplasms, Glandular and Epithelial","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1087-0024.2005.200415.x","doi":"https://doi.org/10.1111/j.1087-0024.2005.200415.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1087-0024.2005.200415.x","pdf_url":null,"source":{"id":"https://openalex.org/S116973605","display_name":"Journal of Investigative Dermatology Symposium Proceedings","issn_l":"1087-0024","issn":["1087-0024","1529-1774"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology Symposium Proceedings","raw_type":"journal-article"},{"id":"pmid:16358814","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16358814","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of investigative dermatology. Symposium proceedings","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.467.8508","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.467.8508","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rheinwaldlab.bwh.harvard.edu/pdf/Natarajan 2005 JID Suppl%2C Montagna monograph.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1111/j.1087-0024.2005.200415.x","doi":"https://doi.org/10.1111/j.1087-0024.2005.200415.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1087-0024.2005.200415.x","pdf_url":null,"source":{"id":"https://openalex.org/S116973605","display_name":"Journal of Investigative Dermatology Symposium Proceedings","issn_l":"1087-0024","issn":["1087-0024","1529-1774"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology Symposium Proceedings","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4804635369","display_name":"Senescence bypass in epithelial neoplastic progression","funder_award_id":"R01DE013178","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W31151557","https://openalex.org/W94111269","https://openalex.org/W1533194003","https://openalex.org/W1571410968","https://openalex.org/W1632349675","https://openalex.org/W1802437470","https://openalex.org/W1832833607","https://openalex.org/W1839350769","https://openalex.org/W1858263251","https://openalex.org/W1903224084","https://openalex.org/W1973277018","https://openalex.org/W1977706798","https://openalex.org/W1978837916","https://openalex.org/W1980311461","https://openalex.org/W1983348452","https://openalex.org/W1983628734","https://openalex.org/W1989697191","https://openalex.org/W1989842611","https://openalex.org/W1992934869","https://openalex.org/W1998218812","https://openalex.org/W1998225685","https://openalex.org/W1999774666","https://openalex.org/W2004552129","https://openalex.org/W2008800104","https://openalex.org/W2009568983","https://openalex.org/W2012241714","https://openalex.org/W2017235640","https://openalex.org/W2018334474","https://openalex.org/W2022358833","https://openalex.org/W2029080338","https://openalex.org/W2030140400","https://openalex.org/W2030221392","https://openalex.org/W2030614613","https://openalex.org/W2033386479","https://openalex.org/W2038098182","https://openalex.org/W2043343878","https://openalex.org/W2044736642","https://openalex.org/W2045934824","https://openalex.org/W2048845152","https://openalex.org/W2049043712","https://openalex.org/W2050060735","https://openalex.org/W2052912081","https://openalex.org/W2052949054","https://openalex.org/W2056862856","https://openalex.org/W2066848701","https://openalex.org/W2075965099","https://openalex.org/W2084912361","https://openalex.org/W2092048582","https://openalex.org/W2093279686","https://openalex.org/W2094693609","https://openalex.org/W2105428856","https://openalex.org/W2105556214","https://openalex.org/W2107145416","https://openalex.org/W2109582895","https://openalex.org/W2111450457","https://openalex.org/W2115044953","https://openalex.org/W2116236493","https://openalex.org/W2121513486","https://openalex.org/W2123626443","https://openalex.org/W2124380422","https://openalex.org/W2125169413","https://openalex.org/W2131213444","https://openalex.org/W2132149260","https://openalex.org/W2133032561","https://openalex.org/W2137652101","https://openalex.org/W2138316626","https://openalex.org/W2142266008","https://openalex.org/W2145512359","https://openalex.org/W2146958914","https://openalex.org/W2147915516","https://openalex.org/W2148142890","https://openalex.org/W2150909312","https://openalex.org/W2152806358","https://openalex.org/W2153650716","https://openalex.org/W2155021601","https://openalex.org/W2159195088","https://openalex.org/W2161135924","https://openalex.org/W2161243045","https://openalex.org/W2162982642","https://openalex.org/W2167970431","https://openalex.org/W2301787246","https://openalex.org/W2312584840","https://openalex.org/W2409614837","https://openalex.org/W6603741839","https://openalex.org/W6631780215","https://openalex.org/W6634092313","https://openalex.org/W6638457322","https://openalex.org/W6639671199","https://openalex.org/W6678632498","https://openalex.org/W6697768135"],"related_works":["https://openalex.org/W1964289345","https://openalex.org/W2150909312","https://openalex.org/W2094314931","https://openalex.org/W1975100641","https://openalex.org/W3031553099","https://openalex.org/W7097897666","https://openalex.org/W2116236493","https://openalex.org/W2053366738","https://openalex.org/W94111269","https://openalex.org/W2606493866"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
