{"id":"https://openalex.org/W2017947769","doi":"https://doi.org/10.1021/bc100483k","title":"99mTc-Bisphosphonate-Iron Oxide Nanoparticle Conjugates for Dual-Modality Biomedical Imaging","display_name":"99mTc-Bisphosphonate-Iron Oxide Nanoparticle Conjugates for Dual-Modality Biomedical Imaging","publication_year":2011,"publication_date":"2011-02-21","ids":{"openalex":"https://openalex.org/W2017947769","doi":"https://doi.org/10.1021/bc100483k","mag":"2017947769","pmid":"https://pubmed.ncbi.nlm.nih.gov/21338098","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6205601"},"language":"en","primary_location":{"id":"doi:10.1021/bc100483k","doi":"https://doi.org/10.1021/bc100483k","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bc100483k","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC6205601","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067037009","display_name":"Rafael T. M. de Rosales","orcid":"https://orcid.org/0000-0003-0431-0535","observed_orcids":["https://orcid.org/0000-0003-0431-0535"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Rafael Torres Martin de Rosales","raw_affiliation_strings":["Division of Imaging Sciences & Biomedical Engineering, King's College London, 4th Floor Lambeth Wing, St. Thomas\u2019 Hospital, SE1 7EH, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Imaging Sciences & Biomedical Engineering, King's College London, 4th Floor Lambeth Wing, St. Thomas\u2019 Hospital, SE1 7EH, London, United Kingdom","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035326990","display_name":"Richard Tavar\u00e9","orcid":"https://orcid.org/0000-0001-5150-5963","observed_orcids":["https://orcid.org/0000-0001-5150-5963"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard Tavar\u00e9","raw_affiliation_strings":["Division of Imaging Sciences & Biomedical Engineering, King's College London, 4th Floor Lambeth Wing, St. Thomas\u2019 Hospital, SE1 7EH, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Imaging Sciences & Biomedical Engineering, King's College London, 4th Floor Lambeth Wing, St. Thomas\u2019 Hospital, SE1 7EH, London, United Kingdom","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042098427","display_name":"Arnaud Glaria","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Arnaud Glaria","raw_affiliation_strings":["Division of Imaging Sciences & Biomedical Engineering, King's College London, 4th Floor Lambeth Wing, St. Thomas\u2019 Hospital, SE1 7EH, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Imaging Sciences & Biomedical Engineering, King's College London, 4th Floor Lambeth Wing, St. Thomas\u2019 Hospital, SE1 7EH, London, United Kingdom","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065846432","display_name":"Gopal Varma","orcid":"https://orcid.org/0000-0002-7060-1982","observed_orcids":["https://orcid.org/0000-0002-7060-1982"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gopal Varma","raw_affiliation_strings":["Division of Imaging Sciences & Biomedical Engineering, King's College London, 4th Floor Lambeth Wing, St. Thomas\u2019 Hospital, SE1 7EH, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Imaging Sciences & Biomedical Engineering, King's College London, 4th Floor Lambeth Wing, St. Thomas\u2019 Hospital, SE1 7EH, London, United Kingdom","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016491110","display_name":"Andrea Protti","orcid":"https://orcid.org/0000-0001-5461-5826","observed_orcids":["https://orcid.org/0000-0001-5461-5826"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrea Protti","raw_affiliation_strings":["Division of Imaging Sciences & Biomedical Engineering, King's College London, 4th Floor Lambeth Wing, St. Thomas\u2019 Hospital, SE1 7EH, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Imaging Sciences & Biomedical Engineering, King's College London, 4th Floor Lambeth Wing, St. Thomas\u2019 Hospital, SE1 7EH, London, United Kingdom","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049873829","display_name":"Philip J. Blower","orcid":"https://orcid.org/0000-0001-6290-1590","observed_orcids":["https://orcid.org/0000-0001-6290-1590"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Philip J. Blower","raw_affiliation_strings":["Division of Imaging Sciences & Biomedical Engineering, King's College London, 4th Floor Lambeth Wing, St. Thomas\u2019 Hospital, SE1 7EH, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Imaging Sciences & Biomedical Engineering, King's College London, 4th Floor Lambeth Wing, St. Thomas\u2019 Hospital, SE1 7EH, London, United Kingdom","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067037009"],"corresponding_institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":15.8909,"has_fulltext":false,"cited_by_count":203,"citation_normalized_percentile":{"value":0.99591815,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"22","issue":"3","first_page":"455","last_page":"465"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12405","display_name":"Characterization and Applications of Magnetic Nanoparticles","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/technetium-99m","display_name":"technetium-99m","score":0.8389999866485596},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.8529999852180481},{"id":"https://openalex.org/keywords/superparamagnetic-iron-oxide-nanoparticles","display_name":"superparamagnetic iron oxide nanoparticles","score":0.8930000066757202},{"id":"https://openalex.org/keywords/spio","display_name":"Spio","score":0.4729999899864197},{"id":"https://openalex.org/keywords/alendronate","display_name":"alendronate","score":0.8130000233650208},{"id":"https://openalex.org/keywords/dipicolylamine","display_name":"dipicolylamine","score":0.8759999871253967},{"id":"https://openalex.org/keywords/endorem","display_name":"Endorem","score":0.6439999938011169},{"id":"https://openalex.org/keywords/feridex","display_name":"Feridex","score":0.9509999752044678},{"id":"https://openalex.org/keywords/radiolabeling","display_name":"radiolabeling","score":0.6880000233650208},{"id":"https://openalex.org/keywords/dextran-coating","display_name":"dextran coating","score":0.6909999847412109},{"id":"https://openalex.org/keywords/liver-imaging","display_name":"liver imaging","score":0.7620000243186951},{"id":"https://openalex.org/keywords/splenic-imaging","display_name":"spleen imaging","score":0.9380000233650208},{"id":"https://openalex.org/keywords/fe3o4-core","display_name":"Fe3O4 core","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6648616790771484},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.6495121717453003},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.561830461025238},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.5488324165344238},{"id":"https://openalex.org/C2778889443","wikidata":"https://www.wikidata.org/wiki/Q6073014","display_name":"Iron oxide nanoparticles","level":3,"score":0.5308954119682312},{"id":"https://openalex.org/C2984398910","wikidata":"https://www.wikidata.org/wiki/Q849737","display_name":"Spect imaging","level":2,"score":0.500755786895752},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.5002970695495605},{"id":"https://openalex.org/C2778064278","wikidata":"https://www.wikidata.org/wiki/Q5372630","display_name":"Emission computed tomography","level":3,"score":0.45474740862846375},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4353238046169281},{"id":"https://openalex.org/C2780441642","wikidata":"https://www.wikidata.org/wiki/Q849737","display_name":"Single-photon emission computed tomography","level":2,"score":0.41912174224853516},{"id":"https://openalex.org/C29331040","wikidata":"https://www.wikidata.org/wiki/Q7239554","display_name":"Preclinical imaging","level":3,"score":0.41610971093177795},{"id":"https://openalex.org/C557651011","wikidata":"https://www.wikidata.org/wiki/Q1832","display_name":"Gadolinium","level":2,"score":0.41456738114356995},{"id":"https://openalex.org/C2777339698","wikidata":"https://www.wikidata.org/wiki/Q423123","display_name":"Dextran","level":2,"score":0.4106637239456177},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.4044702351093292},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3522675037384033},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2916144132614136},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.25076013803482056},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.1455957591533661},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08788284659385681},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005290","descriptor_name":"Ferric Compounds","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005290","descriptor_name":"Ferric Compounds","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005290","descriptor_name":"Ferric Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008280","descriptor_name":"Magnetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011877","descriptor_name":"Radionuclide Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015609","descriptor_name":"Organotechnetium Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1021/bc100483k","doi":"https://doi.org/10.1021/bc100483k","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bc100483k","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},{"id":"pmid:21338098","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21338098","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5151268","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6205601","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6205601","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6205601","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Bioconjug Chem","raw_type":"Text"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/9b1fe6b1-b7d6-44f2-9d14-26bfb6dc7ea0","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/9b1fe6b1-b7d6-44f2-9d14-26bfb6dc7ea0","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"de Rosales, R T M, Tavare, R, Glaria, A, Varma, G, Protti, A & Blower, P J 2011, 'Tc-99m-Bisphosphonate-Iron Oxide Nanoparticle Conjugates for Dual-Modality Biomedical Imaging', Bioconjugate Chemistry, vol. 22, no. 3, pp. 455 - 465. https://doi.org/10.1021/bc100483k","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5151268","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6205601","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2607941924","display_name":"King's College London Medical Engineering Centre.","funder_award_id":"088641","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3302335665","display_name":null,"funder_award_id":"C789/A7649","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G3337424878","display_name":null,"funder_award_id":"WT088641 \u2044Z \u2044 09 \u2044 Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G4190816479","display_name":null,"funder_award_id":"A7649","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G8922868798","display_name":"King's College London Medical Engineering Centre.","funder_award_id":"088641/Z/09/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1510613202","https://openalex.org/W1522819451","https://openalex.org/W1967725246","https://openalex.org/W1970452931","https://openalex.org/W1971399307","https://openalex.org/W1976178939","https://openalex.org/W1976936512","https://openalex.org/W1978787886","https://openalex.org/W1995439267","https://openalex.org/W1998802638","https://openalex.org/W2004685020","https://openalex.org/W2009228997","https://openalex.org/W2010401718","https://openalex.org/W2011809692","https://openalex.org/W2013449197","https://openalex.org/W2015447436","https://openalex.org/W2018307798","https://openalex.org/W2023690203","https://openalex.org/W2025445497","https://openalex.org/W2026096421","https://openalex.org/W2037948892","https://openalex.org/W2040689444","https://openalex.org/W2044764673","https://openalex.org/W2049542641","https://openalex.org/W2052187359","https://openalex.org/W2054483247","https://openalex.org/W2054653889","https://openalex.org/W2056334971","https://openalex.org/W2056612255","https://openalex.org/W2061690699","https://openalex.org/W2065725244","https://openalex.org/W2066077854","https://openalex.org/W2074289610","https://openalex.org/W2076212755","https://openalex.org/W2076296304","https://openalex.org/W2077624459","https://openalex.org/W2087867387","https://openalex.org/W2089546212","https://openalex.org/W2089553795","https://openalex.org/W2090401889","https://openalex.org/W2092726542","https://openalex.org/W2093696593","https://openalex.org/W2095993498","https://openalex.org/W2098692583","https://openalex.org/W2099525573","https://openalex.org/W2105254502","https://openalex.org/W2108340668","https://openalex.org/W2112794532","https://openalex.org/W2118220658","https://openalex.org/W2124429304","https://openalex.org/W2128778774","https://openalex.org/W2143758702","https://openalex.org/W2143896522","https://openalex.org/W2154964751","https://openalex.org/W2155636592","https://openalex.org/W2162247723","https://openalex.org/W2183746534","https://openalex.org/W2328251192","https://openalex.org/W2503265655","https://openalex.org/W2783103906","https://openalex.org/W4242599454"],"related_works":["https://openalex.org/W2115044056","https://openalex.org/W4362554003","https://openalex.org/W4318215248","https://openalex.org/W2284608159","https://openalex.org/W2056334971","https://openalex.org/W4292454434","https://openalex.org/W1989398396","https://openalex.org/W2166791981","https://openalex.org/W2197295599","https://openalex.org/W2593991524"],"abstract_inverted_index":{"The":[0,102,151,205],"combination":[1],"of":[2,31,43,56,64,72,83,104,147,153,198,212,239,244,249,257,267,275,294],"radionuclide-based":[3],"imaging":[4,22,58,207,296],"modalities":[5],"such":[6],"as":[7,135,137,143,235],"single":[8],"photon":[9],"emission":[10,16],"computed":[11],"tomography":[12,17],"(SPECT)":[13],"and":[14,45,92,166,178,190,200,209,219,225,231,242,263,280,313],"positron":[15],"(PET)":[18],"with":[19,106,123,260],"magnetic":[20],"resonance":[21],"(MRI)":[23],"is":[24,36,120,128,140,185,253],"likely":[25],"to":[26,69,187,194,306,309,315,324],"become":[27],"the":[28,41,62,70,80,118,131,138,145,154,183,188,195,229,240,247,254,264,273,276,288,300],"next":[29],"generation":[30,293],"clinical":[32],"scanners.":[33],"Hence,":[34],"there":[35],"a":[37,53,89,94,291],"growing":[38],"interest":[39],"in":[40,111,144,149,228,298],"development":[42],"SPECT-":[44],"PET-MRI":[46],"agents.":[47],"To":[48,246],"this":[49,252],"end,":[50],"we":[51],"report":[52],"new":[54,292],"class":[55],"dual-modality":[57],"agents":[59,297],"based":[60,99],"on":[61,100],"conjugation":[63,86],"radiolabeled":[65,155],"bisphosphonates":[66],"(BP)":[67],"directly":[68,271],"surface":[71,274],"superparamagnetic":[73],"iron":[74,277],"oxide":[75,85,278],"(SPIO)":[76],"nanoparticles.":[77],"We":[78],"demonstrate":[79,181],"high":[81],"potential":[82],"BP-iron":[84],"using":[87,217,318],"(\u2079\u2079m)Tc-dipicolylamine(DPA)-alendronate,":[88],"BP-SPECT":[90],"agent,":[91],"Endorem/Feridex,":[93],"liver":[95,230],"MRI":[96,218],"contrast":[97],"agent":[98],"SPIO.":[101],"labeling":[103],"SPIOs":[105,259],"(\u2079\u2079m)Tc-DPA-alendronate":[107],"can":[108],"be":[109,304],"performed":[110],"one":[112],"step":[113],"at":[114],"room":[115],"temperature":[116],"if":[117,130],"SPIO":[119,269],"not":[121,201,281],"coated":[122],"an":[124],"organic":[125],"polymer.":[126],"Heating":[127],"needed":[129],"nanoparticles":[132,189,214,270,317],"are":[133],"coated,":[134],"long":[136],"coating":[139],"weakly":[141],"bound":[142,186],"case":[146],"dextran":[148,203],"Endorem.":[150],"size":[152,243],"Endorem":[156,226],"(\u2079\u2079m)Tc-DPA-ale-Endorem)":[157],"was":[158],"characterized":[159],"by":[160],"TEM":[161],"(5":[162],"nm,":[163,171],"Fe\u2083O\u2084":[164,172,196,316],"core)":[165],"DLS":[167],"(106":[168],"\u00b1":[169],"60":[170],"core":[173],"+":[174],"dextran).":[175],"EDX,":[176],"Dittmer-Lester,":[177],"radiolabeling":[179,258,268],"studies":[180],"that":[182,191,223],"BP":[184,261,301],"it":[192],"binds":[193],"cores":[197],"Endorem,":[199],"its":[202,282],"coating.":[204,283],"bimodal":[206],"capabilities":[208],"excellent":[210],"stability":[211],"these":[213],"were":[215],"confirmed":[216],"nanoSPECT-CT":[220],"imaging,":[221],"showing":[222],"(\u2079\u2079m)Tc":[224],"co-localize":[227],"spleen":[232],"In":[233],"Vivo,":[234],"expected":[236],"for":[237,290],"particles":[238],"composition":[241],"(\u2079\u2079m)Tc-DPA-ale-Endorem.":[245],"best":[248],"our":[250],"knowledge,":[251],"first":[255,265],"example":[256,266],"conjugates":[262],"onto":[272],"core,":[279],"This":[284],"work":[285],"lays":[286],"down":[287],"basis":[289],"SPECT/PET-MR":[295],"which":[299],"group":[302],"could":[303],"used":[305],"attach":[307],"functionality":[308],"provide":[310],"targeting,":[311],"stealth/stability,":[312],"radionuclides":[314],"very":[319],"simple":[320],"methodology":[321],"readily":[322],"amenable":[323],"GMP.":[325]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":24},{"year":2014,"cited_by_count":23},{"year":2013,"cited_by_count":24},{"year":2012,"cited_by_count":13}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
