{"id":"https://openalex.org/W2017947491","doi":"https://doi.org/10.1152/japplphysiol.00213.2004","title":"Inflection points of cardiovascular responses and oxygenation are correlated in the distal but not the proximal portions of muscle during incremental exercise","display_name":"Inflection points of cardiovascular responses and oxygenation are correlated in the distal but not the proximal portions of muscle during incremental exercise","publication_year":2004,"publication_date":"2004-04-27","ids":{"openalex":"https://openalex.org/W2017947491","doi":"https://doi.org/10.1152/japplphysiol.00213.2004","mag":"2017947491","pmid":"https://pubmed.ncbi.nlm.nih.gov/15107412"},"language":"en","primary_location":{"id":"doi:10.1152/japplphysiol.00213.2004","doi":"https://doi.org/10.1152/japplphysiol.00213.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.00213.2004","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080909826","display_name":"Masaki Mizuno","orcid":"https://orcid.org/0000-0003-4455-8084","observed_orcids":["https://orcid.org/0000-0003-4455-8084"]},"institutions":[{"id":"https://openalex.org/I150744194","display_name":"Waseda University","ror":"https://ror.org/00ntfnx83","country_code":"JP","type":"education","lineage":["https://openalex.org/I150744194"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Mizuno","raw_affiliation_strings":["Graduate School of Human Sciences, Waseda University, Tokorozawa, Saitama, 359-1192 Japan","Health Care Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Human Sciences, Waseda University, Tokorozawa, Saitama, 359-1192 Japan","institution_ids":["https://openalex.org/I150744194"]},{"raw_affiliation_string":"Health Care Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042113218","display_name":"Ken Tokizawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150744194","display_name":"Waseda University","ror":"https://ror.org/00ntfnx83","country_code":"JP","type":"education","lineage":["https://openalex.org/I150744194"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken Tokizawa","raw_affiliation_strings":["","Waseda University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Waseda University","institution_ids":["https://openalex.org/I150744194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110029690","display_name":"Takashi Iwakawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150744194","display_name":"Waseda University","ror":"https://ror.org/00ntfnx83","country_code":"JP","type":"education","lineage":["https://openalex.org/I150744194"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Iwakawa","raw_affiliation_strings":["","Waseda University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Waseda University","institution_ids":["https://openalex.org/I150744194"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050269951","display_name":"Isao Muraoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150744194","display_name":"Waseda University","ror":"https://ror.org/00ntfnx83","country_code":"JP","type":"education","lineage":["https://openalex.org/I150744194"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Isao Muraoka","raw_affiliation_strings":["","Waseda University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Waseda University","institution_ids":["https://openalex.org/I150744194"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I150744194"],"apc_list":null,"apc_paid":null,"fwci":4.1565,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.92432327,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"97","issue":"3","first_page":"867","last_page":"873"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10784","display_name":"Muscle activation and electromyography studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exercise-pressor-reflex","display_name":"exercise pressor reflex","score":0.9890000224113464},{"id":"https://openalex.org/keywords/muscle-oxygenation","display_name":"muscle oxygenation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/muscle-deoxygenation","display_name":"muscle deoxygenation","score":0.7889999747276306},{"id":"https://openalex.org/keywords/vastus-lateralis","display_name":"vastus lateralis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/incremental-exercise","display_name":"incremental exercise","score":0.6100000143051147},{"id":"https://openalex.org/keywords/knee-extension","display_name":"knee extension","score":0.609000027179718},{"id":"https://openalex.org/keywords/mean-arterial-pressure","display_name":"mean arterial pressure","score":0.9330000281333923},{"id":"https://openalex.org/keywords/near-infrared-spectroscopy","display_name":"near-infrared spectroscopy","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C74545648","wikidata":"https://www.wikidata.org/wiki/Q212794","display_name":"Inflection point","level":2,"score":0.6924577951431274},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5885328054428101},{"id":"https://openalex.org/C70289976","wikidata":"https://www.wikidata.org/wiki/Q17143603","display_name":"Oxygenation","level":2,"score":0.5438402891159058},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5375492572784424},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49788689613342285},{"id":"https://openalex.org/C2778856057","wikidata":"https://www.wikidata.org/wiki/Q6015458","display_name":"Incremental exercise","level":4,"score":0.4907546937465668},{"id":"https://openalex.org/C2910876585","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Deoxygenated Hemoglobin","level":3,"score":0.426724910736084},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.41144871711730957},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3333786129951477},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.28793615102767944},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.24261987209320068},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18081003427505493},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.1032654345035553},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.07641488313674927}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002320","descriptor_name":"Cardiovascular Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005080","descriptor_name":"Exercise Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005082","descriptor_name":"Physical Exertion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007719","descriptor_name":"Knee Joint","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010807","descriptor_name":"Physical Endurance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1152/japplphysiol.00213.2004","doi":"https://doi.org/10.1152/japplphysiol.00213.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.00213.2004","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:15107412","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15107412","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology (Bethesda, Md. : 1985)","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W112793013","https://openalex.org/W168836318","https://openalex.org/W1521294893","https://openalex.org/W1605182242","https://openalex.org/W1837367668","https://openalex.org/W1865992944","https://openalex.org/W1873568132","https://openalex.org/W1962816388","https://openalex.org/W1964730132","https://openalex.org/W1974992995","https://openalex.org/W1976619882","https://openalex.org/W1997740701","https://openalex.org/W2012793601","https://openalex.org/W2029406069","https://openalex.org/W2043373840","https://openalex.org/W2043651382","https://openalex.org/W2050747960","https://openalex.org/W2054781712","https://openalex.org/W2063344739","https://openalex.org/W2076506536","https://openalex.org/W2078649731","https://openalex.org/W2081544739","https://openalex.org/W2108939805","https://openalex.org/W2111623033","https://openalex.org/W2113875436","https://openalex.org/W2138121826","https://openalex.org/W2142215912","https://openalex.org/W2166747932","https://openalex.org/W2171980151","https://openalex.org/W2268952264","https://openalex.org/W2273927161","https://openalex.org/W2416563931","https://openalex.org/W2469324603","https://openalex.org/W2507734228"],"related_works":["https://openalex.org/W606613744","https://openalex.org/W2325918784","https://openalex.org/W2084729284","https://openalex.org/W2515590567","https://openalex.org/W7096667482","https://openalex.org/W168836318","https://openalex.org/W2055856594","https://openalex.org/W4389017881","https://openalex.org/W2070343202","https://openalex.org/W2049862543"],"abstract_inverted_index":{"To":[0],"test":[1],"whether":[2],"there":[3],"is":[4],"a":[5,14],"regional":[6],"difference":[7],"in":[8,74,90,169,197],"the":[9,19,22,75,96,122,164,170,194,198,209,222,231,235,241,246],"exercise":[10,227],"pressor":[11,242],"reflex":[12],"within":[13,221],"given":[15],"muscle,":[16],"we":[17],"investigated":[18],"relationship":[20,192],"between":[21,142,163,193,216],"inflection":[23,103,136,165,195,210],"points":[24,104],"of":[25,40,51,80,95,105,125,138,167,212,234],"cardiovascular":[26],"responses":[27],"and":[28,62,84,92,114,132,144,173,181,201,218,228],"muscle":[29,115,213],"oxygenation":[30],"during":[31,225],"exercise.":[32],"Seven":[33],"subjects":[34],"performed":[35],"incremental":[36,41,226],"exercise,":[37],"which":[38],"consisted":[39],"30-s":[42],"static":[43],"knee":[44],"extensions,":[45],"each":[46,68],"separated":[47],"by":[48,64,78,99],"30":[49],"s":[50],"recovery.":[52],"The":[53,102,135],"workload":[54],"started":[55],"at":[56,130],"5%":[57,65],"maximal":[58],"voluntary":[59],"contraction":[60],"(MVC)":[61],"increased":[63],"MVC":[66],"for":[67],"increment":[69],"until":[70],"exhaustion.":[71],"Changes":[72],"(Delta)":[73],"concentrations":[76],"(denoted":[77],"brackets)":[79],"oxygenated":[81],"Hb":[82,86],"(O2Hb)":[83],"deoxygenated":[85],"(HHb)":[87],"were":[88,119],"monitored":[89],"proximal":[91,143,199,217,247],"distal":[93,145,171,219,232],"portions":[94,146,220],"vastus":[97,223,236],"lateralis":[98,224,237],"near-infrared":[100],"spectroscopy.":[101],"mean":[106],"arterial":[107],"pressure":[108],"(MAP),":[109],"calf":[110],"vascular":[111],"resistance":[112],"(CVR),":[113],"deoxygenation":[116,214],"index":[117],"(Delta[O2Hb-HHb])":[118],"calculated":[120],"as":[121],"intersection":[123],"point":[124,137,166,196,211],"two":[126],"regression":[127,158],"equations":[128],"obtained":[129],"lower":[131],"higher":[133],"workloads.":[134],"Delta[O2Hb-HHb]":[139,168],"differed":[140],"significantly":[141],"(28.5":[147],"+/-":[148,152],"3.0":[149],"vs.":[150],"39.5":[151],"3.0%MVC,":[153],"P":[154,178,186],"<":[155,179,187],"0.05).":[156],"Linear":[157],"analysis":[159],"showed":[160],"significant":[161,191],"correlations":[162],"portion":[172,200,233],"MAP":[174,202],"(r":[175,183],"=":[176,184],"0.89;":[177,185],"0.01)":[180],"CVR":[182],"0.05),":[188],"but":[189],"no":[190],"or":[203],"CVR.":[204],"These":[205],"data":[206],"show":[207],"that":[208,230],"differs":[215],"suggest":[229],"contributes":[238],"more":[239],"to":[240],"response":[243],"than":[244],"does":[245],"portion.":[248]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}