{"id":"https://openalex.org/W2017943982","doi":"https://doi.org/10.1016/0735-1097(88)90166-0","title":"Effects of aging on asynchronous left ventricular regional function and global ventricular filling in normal human subjects","display_name":"Effects of aging on asynchronous left ventricular regional function and global ventricular filling in normal human subjects","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W2017943982","doi":"https://doi.org/10.1016/0735-1097(88)90166-0","mag":"2017943982","pmid":"https://pubmed.ncbi.nlm.nih.gov/3335706"},"language":"en","primary_location":{"id":"doi:10.1016/0735-1097(88)90166-0","doi":"https://doi.org/10.1016/0735-1097(88)90166-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0735-1097(88)90166-0","pdf_url":null,"source":{"id":"https://openalex.org/S60865174","display_name":"Journal of the American College of Cardiology","issn_l":"0735-1097","issn":["0735-1097","1558-3597"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Cardiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/0735-1097(88)90166-0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028576363","display_name":"Robert O. Bonow","orcid":"https://orcid.org/0000-0003-2277-3605","observed_orcids":["https://orcid.org/0000-0003-2277-3605","https://orcid.org/0000-0003-1458-1515"]},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert O Bonow","raw_affiliation_strings":["Cardiology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007901747","display_name":"Dino Franco Vitale","orcid":"https://orcid.org/0000-0003-2754-3438","observed_orcids":["https://orcid.org/0000-0003-2754-3438"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dino F Vitale","raw_affiliation_strings":["From the Cardiology Branch, National Heart, Lung, and Blood Institute and the Department of Nuclear Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiology Branch, National Heart, Lung, and Blood Institute and the Department of Nuclear Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210155647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108212397","display_name":"Stephen L. Bacharach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen L Bacharach","raw_affiliation_strings":["From the Cardiology Branch, National Heart, Lung, and Blood Institute and the Department of Nuclear Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland USA","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiology Branch, National Heart, Lung, and Blood Institute and the Department of Nuclear Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210155647"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048131213","display_name":"Barry J. Maron","orcid":"https://orcid.org/0000-0002-1710-8670","observed_orcids":["https://orcid.org/0000-0002-1710-8670"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barry J Maron","raw_affiliation_strings":["From the Cardiology Branch, National Heart, Lung, and Blood Institute and the Department of Nuclear Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland USA","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiology Branch, National Heart, Lung, and Blood Institute and the Department of Nuclear Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210155647"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043649313","display_name":"Michael V. Green","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael V Green","raw_affiliation_strings":["From the Cardiology Branch, National Heart, Lung, and Blood Institute and the Department of Nuclear Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland USA","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiology Branch, National Heart, Lung, and Blood Institute and the Department of Nuclear Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210155647"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5028576363"],"corresponding_institution_ids":["https://openalex.org/I4210106489"],"apc_list":{"value":7166,"currency":"USD","value_usd":7166},"apc_paid":null,"fwci":4.9508,"has_fulltext":false,"cited_by_count":146,"citation_normalized_percentile":{"value":0.95453977,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"11","issue":"1","first_page":"50","last_page":"58"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8450000286102295},{"id":"https://openalex.org/keywords/left-ventricular-diastolic-function","display_name":"left ventricular diastolic function","score":0.9789999723434448},{"id":"https://openalex.org/keywords/left-ventricular-filling","display_name":"left ventricular filling","score":0.828000009059906},{"id":"https://openalex.org/keywords/left-ventricular-synchrony","display_name":"left ventricular synchrony","score":0.7730000019073486},{"id":"https://openalex.org/keywords/time-to-peak-filling-rate","display_name":"time to peak filling rate","score":0.753000020980835},{"id":"https://openalex.org/keywords/normal-volunteers","display_name":"normal volunteers","score":0.44999998807907104},{"id":"https://openalex.org/keywords/systolic-function","display_name":"systolic function","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7985271215438843},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7876904606819153},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7266292572021484},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.6493736505508423},{"id":"https://openalex.org/C2779019669","wikidata":"https://www.wikidata.org/wiki/Q25203946","display_name":"Asynchrony (computer programming)","level":3,"score":0.5651330351829529},{"id":"https://openalex.org/C2780088680","wikidata":"https://www.wikidata.org/wiki/Q7281300","display_name":"Radionuclide angiography","level":4,"score":0.554854691028595},{"id":"https://openalex.org/C2776002628","wikidata":"https://www.wikidata.org/wiki/Q1628627","display_name":"Left ventricular hypertrophy","level":3,"score":0.5331774353981018},{"id":"https://openalex.org/C2780185194","wikidata":"https://www.wikidata.org/wiki/Q1364270","display_name":"Hypertrophic cardiomyopathy","level":2,"score":0.47435224056243896},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.4386565089225769},{"id":"https://openalex.org/C2780829959","wikidata":"https://www.wikidata.org/wiki/Q30314111","display_name":"Diastolic function","level":4,"score":0.4295099973678589},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.39936456084251404},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.2632887065410614},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.17272096872329712},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0},{"id":"https://openalex.org/C151319957","wikidata":"https://www.wikidata.org/wiki/Q752739","display_name":"Asynchronous communication","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002306","descriptor_name":"Cardiac Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004452","descriptor_name":"Echocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011875","descriptor_name":"Radionuclide Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0735-1097(88)90166-0","doi":"https://doi.org/10.1016/0735-1097(88)90166-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0735-1097(88)90166-0","pdf_url":null,"source":{"id":"https://openalex.org/S60865174","display_name":"Journal of the American College of Cardiology","issn_l":"0735-1097","issn":["0735-1097","1558-3597"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Cardiology","raw_type":"journal-article"},{"id":"pmid:3335706","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3335706","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Cardiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/0735-1097(88)90166-0","doi":"https://doi.org/10.1016/0735-1097(88)90166-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0735-1097(88)90166-0","pdf_url":null,"source":{"id":"https://openalex.org/S60865174","display_name":"Journal of the American College of Cardiology","issn_l":"0735-1097","issn":["0735-1097","1558-3597"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Cardiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1957793119","https://openalex.org/W1967640021","https://openalex.org/W1970097180","https://openalex.org/W1975853889","https://openalex.org/W1983121469","https://openalex.org/W2078831437","https://openalex.org/W2152849227","https://openalex.org/W2164106155","https://openalex.org/W2335913961","https://openalex.org/W2398391355","https://openalex.org/W2402759223"],"related_works":["https://openalex.org/W1975779140","https://openalex.org/W2000359020","https://openalex.org/W2410913598","https://openalex.org/W2192129647","https://openalex.org/W2164106155","https://openalex.org/W1487866713","https://openalex.org/W2305306989","https://openalex.org/W2038346941","https://openalex.org/W2255265641","https://openalex.org/W1975222570"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}