{"id":"https://openalex.org/W2017901835","doi":"https://doi.org/10.1021/np060557d","title":"Coniothyrione, a Chlorocyclopentandienylbenzopyrone as a Bacterial Protein Synthesis Inhibitor Discovered by Antisense Technology","display_name":"Coniothyrione, a Chlorocyclopentandienylbenzopyrone as a Bacterial Protein Synthesis Inhibitor Discovered by Antisense Technology","publication_year":2007,"publication_date":"2007-03-09","ids":{"openalex":"https://openalex.org/W2017901835","doi":"https://doi.org/10.1021/np060557d","mag":"2017901835","pmid":"https://pubmed.ncbi.nlm.nih.gov/17346074"},"language":"en","primary_location":{"id":"doi:10.1021/np060557d","doi":"https://doi.org/10.1021/np060557d","is_oa":false,"landing_page_url":"https://doi.org/10.1021/np060557d","pdf_url":null,"source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082722387","display_name":"John G. Ondeyka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144418","display_name":"MSD (Spain)","ror":"https://ror.org/04thqez65","country_code":"ES","type":"company","lineage":["https://openalex.org/I1285764155","https://openalex.org/I4210144418"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"John G. Ondeyka","raw_affiliation_strings":["Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Centro de Investigaci\u00f3n B\u00e1sica, Merck Sharp & Dohme de Espa\u00f1a, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Centro de Investigaci\u00f3n B\u00e1sica, Merck Sharp & Dohme de Espa\u00f1a, Madrid, Spain","institution_ids":["https://openalex.org/I4210144418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072340051","display_name":"Deborah L. Zink","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144418","display_name":"MSD (Spain)","ror":"https://ror.org/04thqez65","country_code":"ES","type":"company","lineage":["https://openalex.org/I1285764155","https://openalex.org/I4210144418"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Deborah Zink","raw_affiliation_strings":["Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Centro de Investigaci\u00f3n B\u00e1sica, Merck Sharp & Dohme de Espa\u00f1a, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Centro de Investigaci\u00f3n B\u00e1sica, Merck Sharp & Dohme de Espa\u00f1a, Madrid, Spain","institution_ids":["https://openalex.org/I4210144418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111813742","display_name":"\u00c1ngela Basilio","orcid":"https://orcid.org/0000-0002-7023-3040","observed_orcids":["https://orcid.org/0000-0002-7023-3040"]},"institutions":[{"id":"https://openalex.org/I4210144418","display_name":"MSD (Spain)","ror":"https://ror.org/04thqez65","country_code":"ES","type":"company","lineage":["https://openalex.org/I1285764155","https://openalex.org/I4210144418"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Angela Basilio","raw_affiliation_strings":["Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Centro de Investigaci\u00f3n B\u00e1sica, Merck Sharp & Dohme de Espa\u00f1a, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Centro de Investigaci\u00f3n B\u00e1sica, Merck Sharp & Dohme de Espa\u00f1a, Madrid, Spain","institution_ids":["https://openalex.org/I4210144418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034583013","display_name":"Francisca Vicente","orcid":"https://orcid.org/0000-0003-3198-9205","observed_orcids":["https://orcid.org/0000-0003-3198-9205"]},"institutions":[{"id":"https://openalex.org/I4210144418","display_name":"MSD (Spain)","ror":"https://ror.org/04thqez65","country_code":"ES","type":"company","lineage":["https://openalex.org/I1285764155","https://openalex.org/I4210144418"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisca Vicente","raw_affiliation_strings":["Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Centro de Investigaci\u00f3n B\u00e1sica, Merck Sharp & Dohme de Espa\u00f1a, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Centro de Investigaci\u00f3n B\u00e1sica, Merck Sharp & Dohme de Espa\u00f1a, Madrid, Spain","institution_ids":["https://openalex.org/I4210144418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031888544","display_name":"Gerald F. Bills","orcid":"https://orcid.org/0000-0003-2352-8417","observed_orcids":["https://orcid.org/0000-0003-2352-8417"]},"institutions":[{"id":"https://openalex.org/I4210144418","display_name":"MSD (Spain)","ror":"https://ror.org/04thqez65","country_code":"ES","type":"company","lineage":["https://openalex.org/I1285764155","https://openalex.org/I4210144418"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Gerald Bills","raw_affiliation_strings":["Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Centro de Investigaci\u00f3n B\u00e1sica, Merck Sharp & Dohme de Espa\u00f1a, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Centro de Investigaci\u00f3n B\u00e1sica, Merck Sharp & Dohme de Espa\u00f1a, Madrid, Spain","institution_ids":["https://openalex.org/I4210144418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109946518","display_name":"Maria Teresa D\u0131\u0301ez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144418","display_name":"MSD (Spain)","ror":"https://ror.org/04thqez65","country_code":"ES","type":"company","lineage":["https://openalex.org/I1285764155","https://openalex.org/I4210144418"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Teresa Diez","raw_affiliation_strings":["Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Centro de Investigaci\u00f3n B\u00e1sica, Merck Sharp & Dohme de Espa\u00f1a, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Centro de Investigaci\u00f3n B\u00e1sica, Merck Sharp & Dohme de Espa\u00f1a, Madrid, Spain","institution_ids":["https://openalex.org/I4210144418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089366807","display_name":"Mary R. Motyl","orcid":"https://orcid.org/0000-0003-3142-8475","observed_orcids":["https://orcid.org/0000-0003-3142-8475"]},"institutions":[{"id":"https://openalex.org/I4210144418","display_name":"MSD (Spain)","ror":"https://ror.org/04thqez65","country_code":"ES","type":"company","lineage":["https://openalex.org/I1285764155","https://openalex.org/I4210144418"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mary Motyl","raw_affiliation_strings":["Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Centro de Investigaci\u00f3n B\u00e1sica, Merck Sharp & Dohme de Espa\u00f1a, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Centro de Investigaci\u00f3n B\u00e1sica, Merck Sharp & Dohme de Espa\u00f1a, Madrid, Spain","institution_ids":["https://openalex.org/I4210144418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034843361","display_name":"Gabe Dezeny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144418","display_name":"MSD (Spain)","ror":"https://ror.org/04thqez65","country_code":"ES","type":"company","lineage":["https://openalex.org/I1285764155","https://openalex.org/I4210144418"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Gabe Dezeny","raw_affiliation_strings":["Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Centro de Investigaci\u00f3n B\u00e1sica, Merck Sharp & Dohme de Espa\u00f1a, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Centro de Investigaci\u00f3n B\u00e1sica, Merck Sharp & Dohme de Espa\u00f1a, Madrid, Spain","institution_ids":["https://openalex.org/I4210144418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026801745","display_name":"Kevin M. Byrne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144418","display_name":"MSD (Spain)","ror":"https://ror.org/04thqez65","country_code":"ES","type":"company","lineage":["https://openalex.org/I1285764155","https://openalex.org/I4210144418"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Kevin Byrne","raw_affiliation_strings":["Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Centro de Investigaci\u00f3n B\u00e1sica, Merck Sharp & Dohme de Espa\u00f1a, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Centro de Investigaci\u00f3n B\u00e1sica, Merck Sharp & Dohme de Espa\u00f1a, Madrid, Spain","institution_ids":["https://openalex.org/I4210144418"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040571641","display_name":"Sheo Bux Singh","orcid":"https://orcid.org/0000-0002-6393-3583","observed_orcids":["https://orcid.org/0000-0002-6393-3583"]},"institutions":[{"id":"https://openalex.org/I4210144418","display_name":"MSD (Spain)","ror":"https://ror.org/04thqez65","country_code":"ES","type":"company","lineage":["https://openalex.org/I1285764155","https://openalex.org/I4210144418"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sheo B. Singh","raw_affiliation_strings":["Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Centro de Investigaci\u00f3n B\u00e1sica, Merck Sharp & Dohme de Espa\u00f1a, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Centro de Investigaci\u00f3n B\u00e1sica, Merck Sharp & Dohme de Espa\u00f1a, Madrid, Spain","institution_ids":["https://openalex.org/I4210144418"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082722387"],"corresponding_institution_ids":["https://openalex.org/I4210144418"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.4318,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.85912101,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"70","issue":"4","first_page":"668","last_page":"670"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ribosomal-protein-s4","display_name":"ribosomal protein S4","score":0.9359999895095825},{"id":"https://openalex.org/keywords/30s-ribosomal-subunit","display_name":"30S ribosomal subunit","score":0.9300000071525574},{"id":"https://openalex.org/keywords/fungal-secondary-metabolites","display_name":"fungal secondary metabolites","score":0.6399999856948853},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.8970000147819519},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.8980000019073486},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8529999852180481},{"id":"https://openalex.org/keywords/haemophilus-influenzae","display_name":"Haemophilus influenzae","score":0.7400000095367432},{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.9380000233650208},{"id":"https://openalex.org/keywords/enterococcus-faecalis","display_name":"Enterococcus faecalis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/bacillus-subtilis","display_name":"Bacillus subtilis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/natural-product-isolation","display_name":"natural product isolation","score":0.4410000145435333}],"concepts":[{"id":"https://openalex.org/C38062823","wikidata":"https://www.wikidata.org/wiki/Q3408228","display_name":"Ribosomal protein","level":5,"score":0.7984499931335449},{"id":"https://openalex.org/C2779895986","wikidata":"https://www.wikidata.org/wiki/Q140014","display_name":"Enterococcus faecalis","level":4,"score":0.7938050627708435},{"id":"https://openalex.org/C2776925733","wikidata":"https://www.wikidata.org/wiki/Q1141979","display_name":"Haemophilus influenzae","level":3,"score":0.7160574793815613},{"id":"https://openalex.org/C2777272437","wikidata":"https://www.wikidata.org/wiki/Q131238","display_name":"Bacillus subtilis","level":3,"score":0.6708685755729675},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6519181728363037},{"id":"https://openalex.org/C2781253189","wikidata":"https://www.wikidata.org/wiki/Q221179","display_name":"Streptococcus pneumoniae","level":3,"score":0.6465151309967041},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.6209641695022583},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6118434071540833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5902527570724487},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.5417265892028809},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.48951661586761475},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.42126744985580444},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.3935334086418152},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3434073328971863},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33084776997566223},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26629894971847534},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.22052288055419922},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16927683353424072},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.13365453481674194}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002867","descriptor_name":"Chromones","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D002867","descriptor_name":"Chromones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002867","descriptor_name":"Chromones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011500","descriptor_name":"Protein Synthesis Inhibitors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D011500","descriptor_name":"Protein Synthesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011500","descriptor_name":"Protein Synthesis Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012269","descriptor_name":"Ribosomal Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013030","descriptor_name":"Spain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016372","descriptor_name":"RNA, Antisense","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016373","descriptor_name":"DNA, Antisense","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/np060557d","doi":"https://doi.org/10.1021/np060557d","is_oa":false,"landing_page_url":"https://doi.org/10.1021/np060557d","pdf_url":null,"source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},{"id":"pmid:17346074","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17346074","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of natural products","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1952817825","https://openalex.org/W2032901850","https://openalex.org/W2052486912","https://openalex.org/W2071804506","https://openalex.org/W2086402273","https://openalex.org/W2120419643","https://openalex.org/W2129436053","https://openalex.org/W2129576051","https://openalex.org/W2164667097"],"related_works":["https://openalex.org/W2020511569","https://openalex.org/W2319142345","https://openalex.org/W2037365464","https://openalex.org/W2073715779","https://openalex.org/W2949762960","https://openalex.org/W2744956045","https://openalex.org/W2137149494","https://openalex.org/W1983529483","https://openalex.org/W3174360831","https://openalex.org/W3025922954"],"abstract_inverted_index":{"Bacterial":[0],"protein":[1,26,36],"synthesis":[2],"inhibitors":[3],"interact":[4],"mainly":[5],"with":[6],"rRNA":[7],"and":[8,84,87,96],"to":[9,52],"some":[10],"extent":[11],"ribosomal":[12,25,31,35],"proteins,":[13],"which":[14],"are":[15,101],"potential":[16],"targets":[17],"for":[18],"developing":[19],"new":[20],"antibacterial":[21,97],"agents.":[22],"Specifically,":[23],"the":[24,29,53],"S4":[27],"of":[28,55,72,99],"30s":[30],"subunit":[32],"known":[33],"as":[34,43],"small-subunit":[37],"D":[38],"(rpsD)":[39],"may":[40],"be":[41],"useful":[42],"a":[44,56],"target.":[45],"The":[46],"antisense-rpsD":[47],"gene-sensitized":[48],"two-plate":[49],"assay":[50],"led":[51],"discovery":[54],"novel":[57],"chlorinated":[58],"cyclopentandienylbenzopyrone":[59],"antibiotic,":[60],"coniothyrione,":[61],"C14H9ClO6,":[62],"isolated":[63],"from":[64],"Coniothyrium":[65],"cerealis":[66],"MF7209.":[67],"It":[68],"exhibited":[69],"liquid":[70],"MICs":[71],"16-32":[73],"microg/mL":[74,89],"against":[75,90],"Staphylococcus":[76],"aureus,":[77],"Bacillus":[78],"subtilis,":[79],"Haemophilus":[80],"influenzae,":[81],"Streptococcus":[82],"pneumoniae,":[83],"Enterococcus":[85],"faecalis":[86],">64":[88],"Escherichia":[91],"coli.":[92],"Isolation,":[93],"structure":[94],"elucidation,":[95],"activity":[98],"coniothyrione":[100],"described.":[102]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}