{"id":"https://openalex.org/W2017878528","doi":"https://doi.org/10.1128/aac.46.1.144-150.2002","title":"Optimization of Xanthones for Antimalarial Activity: the 3,6-Bis-\u03c9-Diethylaminoalkoxyxanthone Series","display_name":"Optimization of Xanthones for Antimalarial Activity: the 3,6-Bis-\u03c9-Diethylaminoalkoxyxanthone Series","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2017878528","doi":"https://doi.org/10.1128/aac.46.1.144-150.2002","mag":"2017878528","pmid":"https://pubmed.ncbi.nlm.nih.gov/11751125","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/126978"},"language":"en","primary_location":{"id":"doi:10.1128/aac.46.1.144-150.2002","doi":"https://doi.org/10.1128/aac.46.1.144-150.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.46.1.144-150.2002","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC126978","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013149117","display_name":"Jane Xu Kelly","orcid":"https://orcid.org/0000-0001-8871-0207","observed_orcids":["https://orcid.org/0000-0001-8871-0207"]},"institutions":[{"id":"https://openalex.org/I126345244","display_name":"Portland State University","ror":"https://ror.org/00yn2fy02","country_code":"US","type":"education","lineage":["https://openalex.org/I126345244"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane Xu Kelly","raw_affiliation_strings":["Department of Chemistry, Portland State University, Portland, Oregon 97207-0751","Medical Research Service, Department of Veterans Affairs Medical Center, Portland, Oregon 97201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Portland State University, Portland, Oregon 97207-0751","institution_ids":["https://openalex.org/I126345244"]},{"raw_affiliation_string":"Medical Research Service, Department of Veterans Affairs Medical Center, Portland, Oregon 97201","institution_ids":["https://openalex.org/I2803065977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113213800","display_name":"Rolf Walter Winter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126345244","display_name":"Portland State University","ror":"https://ror.org/00yn2fy02","country_code":"US","type":"education","lineage":["https://openalex.org/I126345244"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rolf Winter","raw_affiliation_strings":["Department of Chemistry, Portland State University, Portland, Oregon 97207-0751","Medical Research Service, Department of Veterans Affairs Medical Center, Portland, Oregon 97201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Portland State University, Portland, Oregon 97207-0751","institution_ids":["https://openalex.org/I126345244"]},{"raw_affiliation_string":"Medical Research Service, Department of Veterans Affairs Medical Center, Portland, Oregon 97201","institution_ids":["https://openalex.org/I2803065977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088358643","display_name":"David H. Peyton","orcid":"https://orcid.org/0000-0001-5828-055X","observed_orcids":["https://orcid.org/0000-0001-5828-055X"]},"institutions":[{"id":"https://openalex.org/I126345244","display_name":"Portland State University","ror":"https://ror.org/00yn2fy02","country_code":"US","type":"education","lineage":["https://openalex.org/I126345244"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David H. Peyton","raw_affiliation_strings":["Department of Chemistry, Portland State University, Portland, Oregon 97207-0751"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Portland State University, Portland, Oregon 97207-0751","institution_ids":["https://openalex.org/I126345244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050597119","display_name":"David J. Hinrichs","orcid":"https://orcid.org/0000-0001-8525-5907","observed_orcids":["https://orcid.org/0000-0001-8525-5907"]},"institutions":[{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Hinrichs","raw_affiliation_strings":["Medical Research Service, Department of Veterans Affairs Medical Center, Portland, Oregon 97201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Service, Department of Veterans Affairs Medical Center, Portland, Oregon 97201","institution_ids":["https://openalex.org/I2803065977"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012463920","display_name":"Michael K. Riscoe","orcid":"https://orcid.org/0000-0002-1343-5279","observed_orcids":["https://orcid.org/0000-0002-1343-5279"]},"institutions":[{"id":"https://openalex.org/I126345244","display_name":"Portland State University","ror":"https://ror.org/00yn2fy02","country_code":"US","type":"education","lineage":["https://openalex.org/I126345244"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael Riscoe","raw_affiliation_strings":["Department of Chemistry, Portland State University, Portland, Oregon 97207-0751","Medical Research Service, Department of Veterans Affairs Medical Center, Portland, Oregon 97201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Portland State University, Portland, Oregon 97207-0751","institution_ids":["https://openalex.org/I126345244"]},{"raw_affiliation_string":"Medical Research Service, Department of Veterans Affairs Medical Center, Portland, Oregon 97201","institution_ids":["https://openalex.org/I2803065977"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012463920"],"corresponding_institution_ids":["https://openalex.org/I126345244","https://openalex.org/I2803065977"],"apc_list":null,"apc_paid":null,"fwci":4.4778,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.94019134,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"46","issue":"1","first_page":"144","last_page":"150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xanthones","display_name":"xanthones","score":0.9139999747276306},{"id":"https://openalex.org/keywords/antimalarial-drugs","display_name":"antimalarial drugs","score":0.824999988079071},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9779999852180481},{"id":"https://openalex.org/keywords/multidrug-resistant-malaria","display_name":"multidrug-resistant malaria","score":0.8669999837875366},{"id":"https://openalex.org/keywords/structure-activity-optimization","display_name":"structure-activity optimization","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.8799563646316528},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7966175675392151},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.7253013849258423},{"id":"https://openalex.org/C2775842281","wikidata":"https://www.wikidata.org/wiki/Q421789","display_name":"Xanthone","level":2,"score":0.7022331953048706},{"id":"https://openalex.org/C2776028358","wikidata":"https://www.wikidata.org/wiki/Q3144960","display_name":"Hemozoin","level":4,"score":0.6824830174446106},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6030137538909912},{"id":"https://openalex.org/C2777425658","wikidata":"https://www.wikidata.org/wiki/Q422438","display_name":"Chloroquine","level":3,"score":0.5836694836616516},{"id":"https://openalex.org/C2776309666","wikidata":"https://www.wikidata.org/wiki/Q408384","display_name":"Quinoline","level":2,"score":0.4821545481681824},{"id":"https://openalex.org/C2908859342","wikidata":"https://www.wikidata.org/wiki/Q521616","display_name":"Antimalarial Agent","level":4,"score":0.4641929864883423},{"id":"https://openalex.org/C2780014933","wikidata":"https://www.wikidata.org/wiki/Q422956","display_name":"Propionate","level":2,"score":0.45994940400123596},{"id":"https://openalex.org/C204921945","wikidata":"https://www.wikidata.org/wiki/Q899689","display_name":"Side chain","level":3,"score":0.44798001646995544},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.4160793423652649},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.36261647939682007},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.353950560092926},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.25171202421188354},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11080512404441833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10063832998275757},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.09657347202301025},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000473","descriptor_name":"Alkanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000473","descriptor_name":"Alkanes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014966","descriptor_name":"Xanthenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014966","descriptor_name":"Xanthenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021261","descriptor_name":"Parasitic Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044004","descriptor_name":"Xanthones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1128/aac.46.1.144-150.2002","doi":"https://doi.org/10.1128/aac.46.1.144-150.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.46.1.144-150.2002","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:107958","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC126978","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:126978","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/126978","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:11751125","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11751125","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:107958","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC126978","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320309493","display_name":"Portland State University","ror":"https://ror.org/00yn2fy02"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W194870295","https://openalex.org/W206142983","https://openalex.org/W310366126","https://openalex.org/W1493715460","https://openalex.org/W1557046906","https://openalex.org/W1591315337","https://openalex.org/W1969503178","https://openalex.org/W1974858723","https://openalex.org/W1976906219","https://openalex.org/W1998835931","https://openalex.org/W2002406067","https://openalex.org/W2005898614","https://openalex.org/W2007203174","https://openalex.org/W2032150053","https://openalex.org/W2038522569","https://openalex.org/W2040765604","https://openalex.org/W2045496629","https://openalex.org/W2052935978","https://openalex.org/W2063853826","https://openalex.org/W2066395419","https://openalex.org/W2085765714","https://openalex.org/W2089449548","https://openalex.org/W2091457715","https://openalex.org/W2114168178","https://openalex.org/W2121356018","https://openalex.org/W2127733438","https://openalex.org/W2128378359","https://openalex.org/W2130237950","https://openalex.org/W2146931552","https://openalex.org/W2154662005","https://openalex.org/W2156073214","https://openalex.org/W2180304002","https://openalex.org/W2412903130","https://openalex.org/W2495192653","https://openalex.org/W3137165843","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2126057071","https://openalex.org/W2063853826","https://openalex.org/W1979523299","https://openalex.org/W1990277993","https://openalex.org/W4210886486","https://openalex.org/W2593949236","https://openalex.org/W2595188355","https://openalex.org/W3142121752","https://openalex.org/W4385408849","https://openalex.org/W6976957552"],"abstract_inverted_index":{"Hydroxyxanthones":[0],"have":[1],"been":[2],"identified":[3],"as":[4],"novel":[5],"antimalarial":[6,35,108],"agents.":[7],"The":[8,110],"compounds":[9,114],"are":[10],"believed":[11],"to":[12,18,32,46,62,81,170],"exert":[13],"their":[14,34],"activity":[15],"by":[16],"complexation":[17],"heme":[19,48,91,149,172],"and":[20,61,87,107,120,124,137,154,168],"inhibition":[21],"of":[22,26,38,58,73,90,95,135,144],"hemozoin":[23],"formation.":[24],"Modification":[25],"the":[27,54,59,67,96,116],"xanthone":[28],"structure":[29],"was":[30,44],"pursued":[31],"improve":[33],"activity.":[36],"Attachment":[37],"R-groups":[39],"bearing":[40],"protonatable":[41],"nitrogen":[42],"atoms":[43,84],"conducted":[45],"enhance":[47],"affinity":[49,92,106,150],"through":[50],"ionic":[51],"interactions":[52],"with":[53,75],"propionate":[55],"side":[56,76,122],"chains":[57,77,123],"metalloporphyrin":[60],"facilitate":[63],"drug":[64],"accumulation":[65],"in":[66,115,141,173],"parasite":[68],"food":[69],"vacuole.":[70],"A":[71],"series":[72,117],"3,6-bis-omega-diethylaminoalkoxyxanthones":[74],"ranging":[78],"from":[79],"2":[80],"8":[82],"carbon":[83],"were":[85],"prepared":[86],"evaluated.":[88],"Measurement":[89],"for":[93],"each":[94],"derivatives":[97],"revealed":[98],"a":[99,174],"strong":[100],"correlation":[101],"(R(2)":[102],"=":[103],"0.97)":[104],"between":[105],"potency.":[109],"two":[111],"most":[112],"active":[113],"contained":[118],"5-":[119],"6-carbon":[121],"exhibited":[125],"low":[126],"nanomolar":[127],"50%":[128],"inhibitory":[129],"concentration":[130],"(IC(50))":[131],"values":[132],"against":[133],"strains":[134],"chloroquine-susceptible":[136],"multidrug-resistant":[138],"Plasmodium":[139],"falciparum":[140],"vitro.":[142],"Both":[143],"these":[145],"xanthones":[146],"exhibit":[147],"stronger":[148],"(8.26":[151],"x":[152,156],"10(5)":[153,157],"9.02":[155],"M(-1),":[158],"respectively)":[159],"than":[160],"either":[161],"chloroquine":[162],"or":[163],"quinine":[164],"under":[165],"similar":[166],"conditions":[167],"appear":[169],"complex":[171],"unique":[175],"manner.":[176]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}