{"id":"https://openalex.org/W2017876899","doi":"https://doi.org/10.1089/jir.1998.18.855","title":"Participation of Bax-\u03b1 in IFN-\u03b1-Mediated Apoptosis in Daudi B Lymphoma Cells","display_name":"Participation of Bax-\u03b1 in IFN-\u03b1-Mediated Apoptosis in Daudi B Lymphoma Cells","publication_year":1998,"publication_date":"1998-10-01","ids":{"openalex":"https://openalex.org/W2017876899","doi":"https://doi.org/10.1089/jir.1998.18.855","mag":"2017876899","pmid":"https://pubmed.ncbi.nlm.nih.gov/9809621"},"language":"en","primary_location":{"id":"doi:10.1089/jir.1998.18.855","doi":"https://doi.org/10.1089/jir.1998.18.855","is_oa":false,"landing_page_url":"https://doi.org/10.1089/jir.1998.18.855","pdf_url":null,"source":{"id":"https://openalex.org/S109620152","display_name":"Journal of Interferon & Cytokine Research","issn_l":"1079-9907","issn":["1079-9907","1557-7465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Interferon & Cytokine Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112057963","display_name":"Noriko Yanase","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158929114","display_name":"Tokyo Medical University","ror":"https://ror.org/00k5j5c86","country_code":"JP","type":"education","lineage":["https://openalex.org/I158929114"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"NORIKO YANASE","raw_affiliation_strings":["Department of Immunology, Tokyo Medical University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Tokyo Medical University, Japan","institution_ids":["https://openalex.org/I158929114"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040132639","display_name":"Eiko Takada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"EIKO TAKADA","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048055699","display_name":"Isao Yoshihama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ISAO YOSHIHAMA","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113546236","display_name":"Hakuo Ikegami","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HAKUO IKEGAMI","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108432702","display_name":"Junichiro Mizuguchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JUNICHIRO MIZUGUCHI","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.872,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.69736313,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"18","issue":"10","first_page":"855","last_page":"861"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.8420000076293945},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8040000200271606},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.8730000257492065},{"id":"https://openalex.org/keywords/daudi-cells","display_name":"Daudi cells","score":0.7870000004768372},{"id":"https://openalex.org/keywords/b-lymphoma","display_name":"B lymphoma","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cd40-ligand","display_name":"CD40 ligand","score":0.8659999966621399},{"id":"https://openalex.org/keywords/g1-cell-cycle-arrest","display_name":"G1 cell cycle arrest","score":0.878000020980835},{"id":"https://openalex.org/keywords/interferon-therapy","display_name":"interferon therapy","score":0.6650000214576721},{"id":"https://openalex.org/keywords/lymphomagenesis","display_name":"lymphomagenesis","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8116439580917358},{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.6337257623672485},{"id":"https://openalex.org/C2909179924","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Alpha interferon","level":3,"score":0.5784516334533691},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5683912634849548},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48072007298469543},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.48012304306030273},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4749460518360138},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4717484414577484},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45390310883522034},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43625402450561523},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.42696359753608704},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.41162145137786865},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40588077902793884},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.3506990671157837},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.33827051520347595},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3251115679740906},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22904396057128906},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12127873301506042},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07798847556114197},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013268","descriptor_name":"Stimulation, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016193","descriptor_name":"G1 Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/jir.1998.18.855","doi":"https://doi.org/10.1089/jir.1998.18.855","is_oa":false,"landing_page_url":"https://doi.org/10.1089/jir.1998.18.855","pdf_url":null,"source":{"id":"https://openalex.org/S109620152","display_name":"Journal of Interferon & Cytokine Research","issn_l":"1079-9907","issn":["1079-9907","1557-7465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Interferon & Cytokine Research","raw_type":"journal-article"},{"id":"pmid:9809621","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9809621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320317364","display_name":"BD","ror":"https://ror.org/048vrgr14"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W52816599","https://openalex.org/W197256889","https://openalex.org/W305784451","https://openalex.org/W1519382583","https://openalex.org/W1553334228","https://openalex.org/W1915857360","https://openalex.org/W1981066689","https://openalex.org/W1987811570","https://openalex.org/W1989778538","https://openalex.org/W2002503549","https://openalex.org/W2008597649","https://openalex.org/W2017835258","https://openalex.org/W2017941945","https://openalex.org/W2019454556","https://openalex.org/W2027683642","https://openalex.org/W2029535545","https://openalex.org/W2072140726","https://openalex.org/W2084072841","https://openalex.org/W2092575872","https://openalex.org/W2092759765","https://openalex.org/W2093290398","https://openalex.org/W2098160574","https://openalex.org/W2098776512","https://openalex.org/W2115487618","https://openalex.org/W2134979684","https://openalex.org/W2140589145","https://openalex.org/W2187096253","https://openalex.org/W2275275778","https://openalex.org/W2280821723","https://openalex.org/W2407238514"],"related_works":["https://openalex.org/W2083458702","https://openalex.org/W2013360427","https://openalex.org/W2012437466","https://openalex.org/W2098776512","https://openalex.org/W1978287208","https://openalex.org/W2052908504","https://openalex.org/W2040148899","https://openalex.org/W2027454094","https://openalex.org/W2090780358","https://openalex.org/W2050761539"],"abstract_inverted_index":{"Although":[0],"interferon-alpha":[1],"(IFN-alpha)":[2],"has":[3],"proved":[4],"beneficial":[5],"in":[6,34,55,123,132,138,153,174],"the":[7,12,24,29,37,56,60,66,101,105,119,139,149,158,175,184],"treatment":[8],"of":[9,26,31,40,52,59,68,85,107,118,143,151,162,186,194],"some":[10],"tumors,":[11],"basis":[13],"for":[14],"this":[15,20,170],"is":[16],"still":[17],"uncertain.":[18],"In":[19],"study,":[21],"we":[22],"examined":[23],"effects":[25],"IFN-alpha":[27],"on":[28,183],"growth":[30],"tumor":[32],"cells":[33,43,54,144],"vitro,":[35],"using":[36],"Daudi":[38],"line":[39],"B":[41],"lymphoma":[42],"as":[44,87],"a":[45,49,129,135,172],"model.":[46],"There":[47,126],"was":[48,73,104,127,165],"dose-dependent":[50],"accumulation":[51],"these":[53],"G1":[57],"phase":[58],"cell":[61,90],"cycle":[62],"24-48":[63],"h":[64,77,80],"from":[65],"time":[67],"exposure":[69],"to":[70,155,191],"IFN-alpha.":[71,156,198],"This":[72],"followed":[74],"between":[75],"48":[76],"and":[78,95,188],"96":[79],"by":[81,89],"an":[82,110],"increasing":[83],"degree":[84],"apoptosis,":[86,102],"assessed":[88],"survival,":[91],"propidium":[92],"iodine":[93],"staining,":[94],"transmission":[96],"electron":[97],"microscopy.":[98],"Concomitantly":[99],"with":[100,134,145,197],"there":[103],"appearance":[106],"pl8":[108],"Bax-alpha,":[109],"apparently":[111],"novel":[112],"variant":[113],"low":[114],"molecular":[115],"weight":[116],"form":[117],"p21":[120],"Bax-alpha":[121,164],"found":[122],"normal":[124],"cells.":[125],"also":[128],"slight":[130],"diminution":[131],"Bcl-xL,":[133],"resultant":[136],"drop":[137],"Bcl-xL:Bax-alpha":[140],"ratio.":[141],"Treatment":[142],"CD40-L":[146],"partially":[147],"inhibited":[148],"development":[150,185],"apoptosis":[152],"response":[154],"At":[157],"same":[159],"time,":[160],"generation":[161],"p18":[163],"reduced,":[166],"which":[167],"suggests":[168],"that":[169],"plays":[171],"part":[173],"apoptotic":[176],"process.":[177],"These":[178],"findings":[179],"may":[180],"throw":[181],"light":[182],"lymphomas":[187],"perhaps":[189],"point":[190],"future":[192],"ways":[193],"improving":[195],"therapy":[196]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}