{"id":"https://openalex.org/W2017872634","doi":"https://doi.org/10.1158/1538-7445.am2013-3181","title":"Abstract 3181: The genomic evolution of prostate cancer under the selective pressure of anti-androgen therapy.","display_name":"Abstract 3181: The genomic evolution of prostate cancer under the selective pressure of anti-androgen therapy.","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W2017872634","doi":"https://doi.org/10.1158/1538-7445.am2013-3181","mag":"2017872634"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2013-3181","doi":"https://doi.org/10.1158/1538-7445.am2013-3181","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-3181","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108718537","display_name":"Joel R. Gsponer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Joe\u0308l R. Gsponer","raw_affiliation_strings":["1Institute of Pathology - University Hospital Basel, Basel, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Pathology - University Hospital Basel, Basel, Switzerland;","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055190872","display_name":"Tanja Dietsche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Tanja Dietsche","raw_affiliation_strings":["1Institute of Pathology - University Hospital Basel, Basel, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Pathology - University Hospital Basel, Basel, Switzerland;","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111665429","display_name":"Alexander Rufle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Alexander Rufle","raw_affiliation_strings":["1Institute of Pathology - University Hospital Basel, Basel, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Pathology - University Hospital Basel, Basel, Switzerland;","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057043502","display_name":"Elizabeth Lenkiewicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elisabeth Lenkiewicz","raw_affiliation_strings":["2Translational Genomics Research Institute (TGen), Scottsdale, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Translational Genomics Research Institute (TGen), Scottsdale, AZ;","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024459881","display_name":"Tobias Zellweger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135747","display_name":"St. Claraspital","ror":"https://ror.org/04ahnxd67","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210135747"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Tobias Zellweger","raw_affiliation_strings":["3Department of Urology - St. Clara Hospital, Basel, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Urology - St. Clara Hospital, Basel, Switzerland;","institution_ids":["https://openalex.org/I4210135747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067950171","display_name":"Alexander Bachmann","orcid":"https://orcid.org/0000-0001-7161-3507","observed_orcids":["https://orcid.org/0000-0001-7161-3507"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Alexander Bachmann","raw_affiliation_strings":["4Department of Urology - University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Urology - University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080900202","display_name":"Daniel D. Von Hoff","orcid":"https://orcid.org/0000-0003-4723-7681","observed_orcids":["https://orcid.org/0000-0003-4723-7681"]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel D. Von Hoff","raw_affiliation_strings":["2Translational Genomics Research Institute (TGen), Scottsdale, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Translational Genomics Research Institute (TGen), Scottsdale, AZ;","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079412164","display_name":"Michael T. Barrett","orcid":"https://orcid.org/0000-0002-5646-1530","observed_orcids":["https://orcid.org/0000-0002-5646-1530"]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M T. Barrett","raw_affiliation_strings":["2Translational Genomics Research Institute (TGen), Scottsdale, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Translational Genomics Research Institute (TGen), Scottsdale, AZ;","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090764243","display_name":"Cyrill A. Rentsch","orcid":"https://orcid.org/0000-0002-8085-6006","observed_orcids":["https://orcid.org/0000-0002-8085-6006"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Cyrill Rentsch","raw_affiliation_strings":["4Department of Urology - University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Urology - University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083379418","display_name":"Christian Felipe Ruiz","orcid":"https://orcid.org/0000-0003-1470-8061","observed_orcids":["https://orcid.org/0000-0003-1470-8061"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Christian Ruiz","raw_affiliation_strings":["1Institute of Pathology - University Hospital Basel, Basel, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Pathology - University Hospital Basel, Basel, Switzerland;","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000570624","display_name":"Lukas Bubendorf","orcid":"https://orcid.org/0000-0001-5970-1803","observed_orcids":["https://orcid.org/0000-0001-5970-1803"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Lukas Bubendorf","raw_affiliation_strings":["1Institute of Pathology - University Hospital Basel, Basel, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Pathology - University Hospital Basel, Basel, Switzerland;","institution_ids":["https://openalex.org/I2802542264"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"8_Supplement","first_page":"3181","last_page":"3181"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.04600000008940697,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/clonal-evolution","display_name":"clonal evolution","score":0.8140000104904175},{"id":"https://openalex.org/keywords/intratumor-heterogeneity","display_name":"intratumoral heterogeneity","score":0.9089999794960022},{"id":"https://openalex.org/keywords/antiandrogen-therapy","display_name":"antiandrogen therapy","score":0.8889999985694885},{"id":"https://openalex.org/keywords/castration-resistance","display_name":"castration resistance","score":0.8560000061988831},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.7990000247955322},{"id":"https://openalex.org/keywords/chromothripsis","display_name":"chromothripsis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/aneuploidy","display_name":"aneuploidy","score":0.9559999704360962},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5649999976158142},{"id":"https://openalex.org/keywords/hormone-ablation-therapy","display_name":"hormone ablation therapy","score":0.5389999747276306},{"id":"https://openalex.org/keywords/whole-exome-sequencing","display_name":"exome sequencing","score":0.8500000238418579},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.41100001335144043},{"id":"https://openalex.org/keywords/nuclear-dna-content","display_name":"nuclear DNA content","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C99983632","wikidata":"https://www.wikidata.org/wiki/Q1087765","display_name":"Chromothripsis","level":5,"score":0.8261743783950806},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7631903886795044},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7255001068115234},{"id":"https://openalex.org/C113968399","wikidata":"https://www.wikidata.org/wiki/Q7559241","display_name":"Somatic evolution in cancer","level":3,"score":0.6164450645446777},{"id":"https://openalex.org/C124942203","wikidata":"https://www.wikidata.org/wiki/Q656638","display_name":"Comparative genomic hybridization","level":4,"score":0.6125668287277222},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5913563966751099},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.5789768695831299},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5708463191986084},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.5249452590942383},{"id":"https://openalex.org/C205003668","wikidata":"https://www.wikidata.org/wiki/Q17113442","display_name":"Chromoplexy","level":5,"score":0.5081987380981445},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.47917261719703674},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4666796922683716},{"id":"https://openalex.org/C10590036","wikidata":"https://www.wikidata.org/wiki/Q417664","display_name":"Exome","level":5,"score":0.43934163451194763},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4174410104751587},{"id":"https://openalex.org/C140752955","wikidata":"https://www.wikidata.org/wiki/Q1087752","display_name":"Chromosome instability","level":4,"score":0.4164387583732605},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.41044679284095764},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3354756236076355},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2623522877693176},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.22154733538627625},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.12834537029266357},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1259261965751648},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.11616921424865723},{"id":"https://openalex.org/C87874733","wikidata":"https://www.wikidata.org/wiki/Q18039844","display_name":"PCA3","level":4,"score":0.11560884118080139},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2013-3181","doi":"https://doi.org/10.1158/1538-7445.am2013-3181","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-3181","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6200000047683716,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2915849681","https://openalex.org/W4200030457","https://openalex.org/W2161253116","https://openalex.org/W4207062250","https://openalex.org/W4386841744","https://openalex.org/W4407902330","https://openalex.org/W3180580764","https://openalex.org/W2091181677","https://openalex.org/W4229735474","https://openalex.org/W2887792120"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"The":[2,131,145,331],"implementation":[3],"of":[4,23,27,52,118,134,141,147,158,171,201,217,227,231,238,247,254,266,278,299,334,341,347,352],"novel":[5],"technologies":[6],"such":[7],"as":[8],"array":[9],"comparative":[10],"genomic":[11,25,50,132,204,239,290,332],"hybridization":[12],"(aCGH)":[13],"and":[14,59,72,109,123,252,281],"next-generation":[15],"sequencing":[16,113],"has":[17],"led":[18],"to":[19,66,95,105,110,153,195],"a":[20,43,167,213,221,228,244],"deeper":[21],"understanding":[22],"the":[24,49,64,116,124,135,139,162,176,189,199,207,282,297,338,348,353],"nature":[26],"cancer.":[28],"However,":[29],"these":[30],"analyses":[31,114,133],"have":[32],"classically":[33],"been":[34],"done":[35],"without":[36],"respecting":[37],"intra-tumor":[38],"heterogeneity.":[39,144],"Here,":[40],"we":[41],"applied":[42],"methodology":[44],"that":[45,224,292],"allows":[46,275],"us":[47,152],"analyzing":[48],"profile":[51],"distinct":[53,267],"tumor":[54,90,101,136,149,159,172,183,218,222,261,269],"populations":[55,91,102,209,270],"from":[56,86],"individual":[57],"tumors":[58],"their":[60,96],"clonal":[61,260,268,284],"evolution":[62,160,219,333],"during":[63,161,271],"progression":[65,163,274],"castration-resistant":[67,259],"disease.":[68],"Methods:":[69],"Matched":[70],"pre-":[71],"post-":[73],"hormone":[74,300],"treated":[75],"fresh":[76],"frozen":[77],"and/or":[78],"formalin":[79],"fixed":[80],"prostate":[81,272,335],"cancer":[82,273,336],"samples":[83,137],"were":[84,92,103,293],"selected":[85,294],"our":[87],"biobank.":[88],"Clonal":[89],"flow-sorted":[93],"according":[94],"nuclear":[97],"DNA":[98],"content.":[99],"Sorted":[100],"subjected":[104],"whole":[106],"genome":[107],"CGH":[108],"full":[111],"exome":[112],"by":[115,198],"use":[117],"Agilent":[119],"SurePrint":[120],"2x400k":[121],"microarrays":[122],"SureSelect":[125],"All":[126],"Exon":[127],"Kit,":[128],"respectively.":[129],"Results:":[130],"underscore":[138],"presence":[140],"significant":[142],"intra-tumoral":[143,279],"analysis":[146,277],"matched":[148],"specimens":[150],"allowed":[151],"identify":[154],"two":[155],"particular":[156],"patterns":[157],"after":[164],"treatment:":[165],"First,":[166],"more":[168,214],"parallel":[169],"pattern":[170,216],"evolution,":[173],"in":[174,258],"which":[175],"ancestor":[177,191],"population":[178,192,223,234],"is":[179,193],"breeding":[180],"multiple":[181],"aneuploid":[182,208],"clones.":[184,232],"In":[185],"this":[186,287],"case,":[187],"only":[188],"2N":[190],"able":[194],"withstand":[196],"therapy":[197],"acquisition":[200],"few":[202],"specific":[203],"aberrations":[205,291],"whereas":[206],"are":[210],"eradicated.":[211],"Second,":[212],"sequential":[215],"with":[220,243],"evolves":[225],"out":[226],"continuous":[229],"line":[230],"This":[233],"shows":[235],"increasing":[236],"signs":[237],"instability":[240],"over":[241],"time,":[242],"punctual":[245],"event":[246],"chromothripsis":[248],"(a":[249],"massive":[250],"destruction":[251],"rearrangement":[253],"chromosomal":[255],"structures)":[256],"resulting":[257],"populations.":[262],"Conclusions:":[263],"Genomic":[264],"profiling":[265],"for":[276,295,356],"heterogeneity":[280],"underlying":[283],"evolution.":[285],"Importantly,":[286],"approach":[288],"identifies":[289],"under":[296,337],"pressure":[298,340],"ablation":[301],"therapy.":[302,343],"Citation":[303],"Format:":[304],"Joe\u0308l":[305],"R.":[306],"Gsponer,":[307],"Tanja":[308],"Dietsche,":[309],"Alexander":[310,316],"Rufle,":[311],"Elisabeth":[312],"Lenkiewicz,":[313],"Tobias":[314],"Zellweger,":[315],"Bachmann,":[317],"Daniel":[318],"D.":[319],"Von":[320],"Hoff,":[321],"M":[322],"T.":[323],"Barrett,":[324],"Cyrill":[325],"Rentsch,":[326],"Christian":[327],"Ruiz,":[328],"Lukas":[329],"Bubendorf.":[330],"selective":[339],"anti-androgen":[342],"[abstract].":[344],"In:":[345],"Proceedings":[346],"104th":[349],"Annual":[350],"Meeting":[351],"American":[354],"Association":[355],"Cancer":[357,367],"Research;":[358],"2013":[359],"Apr":[360],"6-10;":[361],"Washington,":[362],"DC.":[363],"Philadelphia":[364],"(PA):":[365],"AACR;":[366],"Res":[368],"2013;73(8":[369],"Suppl):Abstract":[370],"nr":[371],"3181.":[372],"doi:10.1158/1538-7445.AM2013-3181":[373]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}