{"id":"https://openalex.org/W2017867969","doi":"https://doi.org/10.1159/000115765","title":"Preventive Treatment of Cerebral Transient Ischemia: Comparative Randomized Trial of Pentoxifylline versus Conventional Antiaggregants","display_name":"Preventive Treatment of Cerebral Transient Ischemia: Comparative Randomized Trial of Pentoxifylline versus Conventional Antiaggregants","publication_year":2008,"publication_date":"2008-02-01","ids":{"openalex":"https://openalex.org/W2017867969","doi":"https://doi.org/10.1159/000115765","mag":"2017867969","pmid":"https://pubmed.ncbi.nlm.nih.gov/3881263"},"language":"en","primary_location":{"id":"doi:10.1159/000115765","doi":"https://doi.org/10.1159/000115765","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000115765","pdf_url":null,"source":{"id":"https://openalex.org/S162735375","display_name":"European Neurology","issn_l":"0014-3022","issn":["0014-3022","1421-9913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083365131","display_name":"Ernesto Herskovits","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145255","display_name":"Hospital Posadas","ror":"https://ror.org/05cwdc397","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210145255"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"E. Herskovits","raw_affiliation_strings":["Hospitals Juan A. Fern\u00e1ndez, Prof. Posadas, and Sirio-Liban\u00e9s, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospitals Juan A. Fern\u00e1ndez, Prof. Posadas, and Sirio-Liban\u00e9s, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I4210145255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088005291","display_name":"Arturo L. Famulari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145255","display_name":"Hospital Posadas","ror":"https://ror.org/05cwdc397","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210145255"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"A. Famulari","raw_affiliation_strings":["Hospitals Juan A. Fern\u00e1ndez, Prof. Posadas, and Sirio-Liban\u00e9s, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospitals Juan A. Fern\u00e1ndez, Prof. Posadas, and Sirio-Liban\u00e9s, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I4210145255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057879066","display_name":"Leopoldo Tamaroff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145255","display_name":"Hospital Posadas","ror":"https://ror.org/05cwdc397","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210145255"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"L. Tamaroff","raw_affiliation_strings":["Hospitals Juan A. Fern\u00e1ndez, Prof. Posadas, and Sirio-Liban\u00e9s, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospitals Juan A. Fern\u00e1ndez, Prof. Posadas, and Sirio-Liban\u00e9s, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I4210145255"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A.M. Gonzalez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145255","display_name":"Hospital Posadas","ror":"https://ror.org/05cwdc397","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210145255"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"A.M. Gonzalez","raw_affiliation_strings":["Hospitals Juan A. Fern\u00e1ndez, Prof. Posadas, and Sirio-Liban\u00e9s, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospitals Juan A. Fern\u00e1ndez, Prof. Posadas, and Sirio-Liban\u00e9s, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I4210145255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026958433","display_name":"A. V\u00e1zquez","orcid":"https://orcid.org/0000-0002-3578-2247","observed_orcids":["https://orcid.org/0000-0002-3578-2247"]},"institutions":[{"id":"https://openalex.org/I4210145255","display_name":"Hospital Posadas","ror":"https://ror.org/05cwdc397","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210145255"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"A. V\u00e1zquez","raw_affiliation_strings":["Hospitals Juan A. Fern\u00e1ndez, Prof. Posadas, and Sirio-Liban\u00e9s, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospitals Juan A. Fern\u00e1ndez, Prof. Posadas, and Sirio-Liban\u00e9s, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I4210145255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111853800","display_name":"R. Dom\u0131\u0301nguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145255","display_name":"Hospital Posadas","ror":"https://ror.org/05cwdc397","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210145255"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"R. Dominguez","raw_affiliation_strings":["Hospitals Juan A. Fern\u00e1ndez, Prof. Posadas, and Sirio-Liban\u00e9s, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospitals Juan A. Fern\u00e1ndez, Prof. Posadas, and Sirio-Liban\u00e9s, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I4210145255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070660433","display_name":"H. Fraiman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145255","display_name":"Hospital Posadas","ror":"https://ror.org/05cwdc397","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210145255"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"H. Fraiman","raw_affiliation_strings":["Hospitals Juan A. Fern\u00e1ndez, Prof. Posadas, and Sirio-Liban\u00e9s, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospitals Juan A. Fern\u00e1ndez, Prof. Posadas, and Sirio-Liban\u00e9s, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I4210145255"]}]},{"author_position":"last","author":{"id":null,"display_name":"J. Vila","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Vila","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4339,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.66838403,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"24","issue":"1","first_page":"73","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.03269999846816063,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transient-ischemic-attack","display_name":"transient ischemic attack","score":0.8389999866485596},{"id":"https://openalex.org/keywords/pentoxifylline","display_name":"pentoxifylline","score":0.8799999952316284},{"id":"https://openalex.org/keywords/antiplatelet-therapy","display_name":"antiplatelet therapy","score":0.8659999966621399},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9779999852180481},{"id":"https://openalex.org/keywords/dipyridamole","display_name":"dipyridamole","score":1.0},{"id":"https://openalex.org/keywords/stroke-prevention","display_name":"stroke prevention","score":0.7929999828338623},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.49000000953674316},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.875},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.9629999995231628},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.984000027179718}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9314090013504028},{"id":"https://openalex.org/C2780404050","wikidata":"https://www.wikidata.org/wiki/Q416331","display_name":"Pentoxifylline","level":2,"score":0.8856473565101624},{"id":"https://openalex.org/C2776890861","wikidata":"https://www.wikidata.org/wiki/Q419374","display_name":"Dipyridamole","level":2,"score":0.5025272369384766},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5002193450927734},{"id":"https://openalex.org/C2779450755","wikidata":"https://www.wikidata.org/wiki/Q1209150","display_name":"Cerebral infarction","level":3,"score":0.4893333315849304},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.48603540658950806},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47981834411621094},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.4787696897983551},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.4559429883956909},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.44426360726356506},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3958747386932373},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.37524086236953735},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.35276949405670166},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.33928507566452026},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004176","descriptor_name":"Dipyridamole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010431","descriptor_name":"Pentoxifylline","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013805","descriptor_name":"Theobromine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000115765","doi":"https://doi.org/10.1159/000115765","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000115765","pdf_url":null,"source":{"id":"https://openalex.org/S162735375","display_name":"European Neurology","issn_l":"0014-3022","issn":["0014-3022","1421-9913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Neurology","raw_type":"journal-article"},{"id":"pmid:3881263","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3881263","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European neurology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2058840955","https://openalex.org/W2416777013","https://openalex.org/W2078084898","https://openalex.org/W2162946472","https://openalex.org/W2175430454","https://openalex.org/W2073014582","https://openalex.org/W2391213324","https://openalex.org/W1986476483","https://openalex.org/W2521106647","https://openalex.org/W2415168165"],"abstract_inverted_index":{"A":[0],"comparative":[1],"study":[2,162],"of":[3,6,8,27,65,81,88,160,168,172],"the":[4,57,94,98,155,161,173],"prevention":[5],"recurrences":[7],"cerebral":[9],"transient":[10],"ischemic":[11],"attacks":[12],"during":[13],"a":[14,25,109,165],"6-month":[15],"observation":[16],"period":[17],"was":[18],"conducted":[19],"in":[20,39,71,79,93,97,128,137,154,170,175],"73":[21],"patients":[22,41,52,103,107,131],"treated":[23,42],"with":[24,43,117,121,133],"combination":[26],"acetylsalicylic":[28],"acid":[29],"and":[30,38,69,86,104,119],"dipyridamole":[31],"(ASAD,":[32],"1,050":[33],"mg":[34],"+":[35],"150":[36],"mg/day)":[37],"65":[40],"pentoxifylline":[44],"(PTX":[45],"1,200":[46],"mg/day,":[47],"Trental":[48],"400":[49],"t.d.s.).":[50],"The":[51,74,141,158],"were":[53,77,112,126,147],"randomly":[54],"assigned":[55],"to":[56,164],"treatments.":[58],"Risk":[59],"factor":[60],"analysis":[61],"showed":[62],"high":[63],"prevalence":[64],"arterial":[66],"hypertension,":[67],"hyperlipidemia":[68],"smoking":[70],"these":[72],"patients.":[73],"two":[75],"groups":[76],"matched":[78],"terms":[80,171],"age,":[82],"sex,":[83],"blood":[84],"pressure":[85],"site":[87],"TIA":[89,176],"origin":[90],"(carotid":[91],"63%":[92],"ASAD,":[95],"65%":[96],"PTX":[99,106,139,156,169],"group).":[100],"23":[101],"ASAD":[102,118,130],"9":[105,138],"suffered":[108],"recurrence.":[110],"There":[111],"4":[113],"nonfatal":[114],"stroke":[115],"events":[116],"2":[120],"PTX.":[122],"80":[123],"recurrent":[124],"TIAs":[125],"recorded":[127],"19":[129,134],"compared":[132],"such":[135],"episodes":[136],"subjects.":[140],"morbidity":[142],"rates":[143],"(life":[144],"table":[145],"analysis)":[146],"significantly":[148],"lower":[149],"(p":[150],"less":[151],"than":[152],"0.05)":[153],"group.":[157],"results":[159],"point":[163],"preventive":[166],"effect":[167],"reduction":[174],"recurrences.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}